ライフサイエンスコーパス: phenylalanine

1 f cystine/methionine, histidine and tyrosine/phenylalanine.

2 but did show enhancement next to proline and phenylalanine.

3 the biosynthesis of amino acids tyrosine and phenylalanine.

4 y discriminated with a minor conversion of l-phenylalanine.

5 rst step in the catabolism of the amino acid phenylalanine.

6 rmophilus and higher levels of galactose and phenylalanine.

7 of secondary metabolites that originate from phenylalanine.

8 alysis to focus solely on the metabolites of phenylalanine.

9 cemates, including mandelic acid (Man), Fmoc-phenylalanine, 1,1'-bi-2-naphthol (binol), and TTSBI.

10 FCGR3A dimorphism resulting in CD16A-valine/phenylalanine-158 allotypes with different IgG affinity,

11 c approach to 6-(18)F-fluoro-3,4-dihydroxy-L-phenylalanine ((18)F-DOPA), involving the nucleophilic s

12 e accuracy of 6-(18)F-fluoro-3,4-dihydroxy-l-phenylalanine ((18)F-FDOPA) PET for insulinoma diagnosis

13 calculations predict that UQ interacts with phenylalanine 211 and pinpoints the location of the bind

14 We also showed that replacing the phenylalanine 3.33 in CCR5 TM3 by the corresponding hist

15 himeras revealed that human URAT1 serine-35, phenylalanine-365 and isoleucine-481 are necessary and s

16 Moreover, serine-35 and phenylalanine-365 are important for high-affinity intera

17 mutation of Tyr-113, Tyr-128, and Tyr-145 to phenylalanine (3Y3F).

18 fibrosis (CF) causing mutation, deletion of phenylalanine 508 (DeltaF508 or Phe508del), results in f

19 In cystic fibrosis, deletion of phenylalanine 508 (F508del) in the cystic fibrosis trans

20 Deletion of phenylalanine 508 (F508del), the most frequent CF mutati

21 Deletion of phenylalanine 670 (DeltaF670) in the yeast oligomycin re

22 ragine (5987.5microg/kg) and the lowest from phenylalanine (9.25microg/kg).

23 w that peptides incorporating the amino acid phenylalanine, a functional group that is conspicuously

24 lamine and phenylacetaldehyde in mixtures of phenylalanine, a lipid oxidation product, and a second a

25 incorporating p-azido-phenylalanine, benzoyl-phenylalanine, acetyl-lysine, and phosphoserine into sel

26 Lower levels of phenylalanine, acetylhistidine, and cyclic adenosine mon

27 uantitation of the first hydrolysis product, phenylalanine, after a short period of treatment.

28 1), which were assigned in the literature to phenylalanine, albeit with dispute.

29 e Src-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa and granulo

30 al compounds (proline, cysteine, tryptophan, phenylalanine, alpha-terpineol and geraniol).

31 Starting from Fmoc-tyrosine phosphate and phenylalanine amide in the presence of an amidase and ph

32 The assay detects the release of phenylalanine amino acid in a reaction with the yeast en

33 ivatives, respectively), and also eukaryotic phenylalanine aminomutases (PAMs) for the synthesis of t

34 Isoflavonoid compositions, phenylalanine ammonia lyase (PAL) activity and antioxida

35 H2O2 accumulation was concurrent with higher phenylalanine ammonia lyase (PAL) enzyme activity leadin

36 ynthetic and therapeutic relevance, five new phenylalanine ammonia lyase (PAL) enzymes were discovere

37 e, is derived from chorismate via either the phenylalanine ammonia lyase (PAL) or the isochorismate s

38 und treatment at 25 and 29W, the activity of phenylalanine ammonia lyase (PAL) was increased signific

39 acid in a reaction with the yeast enzyme of phenylalanine ammonia lyase (PAL).

40 Recent examples include the use of phenylalanine ammonia lyases (PALs), either alone or as

41 pruning triggered a transient expression of phenylalanine ammonia-lyase (PAL) and stilbene synthase

42 L-Phenylalanine ammonia-lyase (PAL) is the first enzyme in

43 Phenylalanine ammonia-lyase (PAL) is the first enzyme of

44 eatment induced significant decreases in the phenylalanine ammonia-lyase activity and significantly i

45 Simultaneously, reduced phenylalanine ammonia-lyase and tyrosine ammonia-lyase a

46 fied with multiwalled carbon nanotubes where phenylalanine ammonia-lyase enzyme was immobilized using

47 and defense enzymes (polyphenol oxidase and phenylalanine ammonia-lyase).

48 e in the enzymatic (peroxidase, catalase and phenylalanine ammonium lyase (PAL)) and non enzymatic (t

49 proximately 3-fold increases in catalase and phenylalanine ammonium lyase activity.

50 ved through the incorporation of non-natural phenylalanine analogues.

51 tPheRS) at 2.6 A resolution, in complex with phenylalanine and antibiotic puromycin mimicking the A76

52 ncreased DNA affinity of both the translated phenylalanine and aspartate Runx1 variants.

53 sis studies supported the importance of this phenylalanine and confirmed the essential residues used

54 nt amino acids, glycine, valine, methionine, phenylalanine and cysteine were examined as inhibitors a

55 In conclusion, foliar application of phenylalanine and especially urea, could be an interesti

56 sis of intermolecular NOEs between unlabeled phenylalanine and isotopically labeled protein.

57 ts received primed continuous l-[ring-(2)H5]-phenylalanine and l-[1-(13)C]-leucine infusions and inge

58 s)] received primed continuous l-[ring-(2)H5]phenylalanine and l-[1-(13)C]leucine infusions and perfo

59 s suggest that the pathways to lignin from L-phenylalanine and L-tyrosine are distinct beyond the for

60 Two of these were identified as L-phenylalanine and L-tyrosine but it may be that metaboli

61 89)Ala-Ser-Gly(191) residues and the bound l-phenylalanine and l-tyrosine, conferring the deamination

62 acids with different partition coefficients (phenylalanine and leucine) in emulsions.

63 anoid contents, resulting in accumulation of phenylalanine and lignin.

64 stronger hydrophobic interaction between the phenylalanine and the methyl group of pyruvate.

65 orresponding to aromatic amino acids such as phenylalanine and tryptophan as well as cysteine moietie

66 y, levels of the neurotransmitter precursors phenylalanine and tryptophan were decreased.

67 Peptide congeners containing norvaline, phenylalanine and tyrosine (instead of valine in B2088)

68 of taurine, isoglutamine, choline, lactate, phenylalanine and tyrosine and decreased levels of lipid

69 All three aromatic amino acids (tryptophan, phenylalanine and tyrosine) serve as substrates for the

70 ion not only for aspartic acid, but also for phenylalanine and tyrosine, inconsistent with racemizati

71 te and the amino acids glutamate, glutamine, phenylalanine and tyrosine.

72 tudy the influence of foliar applications of phenylalanine and urea, at two different doses, on grape

73 activity for synthesizing amino acids (e.g., phenylalanine) and thus, needs rich medium for cell grow

74 eucine and isoleucine, the AAAs tyrosine and phenylalanine, and 4 other amino acids.

75 at the racemization ratios of aspartic acid, phenylalanine, and tyrosine can be used as biomarkers fo

76 ociations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopropionate using gene-

77 and ingested 25 g intrinsically l-[1-(13)C]-phenylalanine- and l-[1-(13)C]-leucine-labeled whey prot

78 Plasma leucine concentrations and exogenous phenylalanine appearance rates increased after protein i

79 rine, asparagine, and the previously studied phenylalanine, are balanced among various intrinsic prop

80 evels of IgG hydrolyzing the generic proline-phenylalanine-arginine-methylcoumarinamide (PFR-MCA) sub

81 compounds, such as 4-hydroxybenzoic acid and phenylalanine, as well as nucleosides (e.g. thymidine, 5

82 eric activators, through the substitution of phenylalanine at position 327 with tryptophan (F327W).

83 h for apoflavodoxin variant F44Y, in which a phenylalanine at position 44 is changed to a tyrosine.

84 requent cftr mutation in humans, deletion of phenylalanine at position 508 (DeltaF508), on glucose ho

85 the peptide bond between the proline and the phenylalanine at the carboxyl terminus of Ang II.

86 A conserved extracellular phenylalanine at this gate was a prime location for prod

87 Plasma exogenous phenylalanine availability over the 5-h postprandial per

88 raviolet-induced crosslinking with p-azido-L-phenylalanine (azF) at selected positions in hSERT to ma

89 rporate the photoactive amino acid p-azido-l-phenylalanine (azF) into N-terminal residues of a full-l

90 In particular, the sharp phenylalanine band was found to be an applicable marker

91 S also reveal several isotopic shifts of the phenylalanine band, of which the positions correlate wel

92 decreased the affinity of RDPheH(25-117) for phenylalanine based on the ability to stabilize the dime

93 In summary, four metabolites related to phenylalanine, benzoate, and glutamate metabolism may be

94 pathogen Salmonella by incorporating p-azido-phenylalanine, benzoyl-phenylalanine, acetyl-lysine, and

95 PheH(25-117) were identified as being in the phenylalanine-binding site on the basis of intermolecula

96 was active only inside nodules, whereas the phenylalanine bioreporter showed a high signal also in t

97 the dilution effect of different pathways of phenylalanine biosynthesis in Pseudomonas sp.

98 in the absence of editing, activation of the phenylalanine biosynthetic operon becomes less responsiv

99 sis reveals that flux through the plastidial phenylalanine biosynthetic pathway is reduced in PhpCAT

100 f Fmoc-protected aryl/heteroaryl-substituted phenylalanines (Bip derivatives) using the nonaqueous pa

101 recommended up to the age of 12 years if the phenylalanine blood concentration is between 360 mumol/L

102 d during pregnancy (maternal PKU), untreated phenylalanine blood concentrations of more than 360 mumo

103 by using a NF-kappaB inhibitor (N-p-Tosyl-L-phenylalanine chloromethyl ketone) that restored PGC-1al

104 We find that the phenylalanine clamp (varphi-clamp), the known conductanc

105 ucts of LFN, in mutant channels in which the phenylalanine clamp residues were mutated to alanines.

106 nnel stem (but is stopped, of course, at the phenylalanine clamp) during protein translocation.

107 f polypeptide clamp sites: an alpha clamp, a phenylalanine clamp, and a charge clamp.

108 ctions at the sites adjacent to the heme and phenylalanine cluster in the ligand binding process.

109 over 10 y was inversely associated with the phenylalanine concentration in men (P = 0.007) but not i

110 The serum phenylalanine concentration is associated with telomere

111 No intervention is required if the blood phenylalanine concentration is less than 360 mumol/L.

112 inverse association was observed between the phenylalanine concentration that was measured 5 y earlie

113 Untreated blood phenylalanine concentrations determine management of peo

114 ous symptoms associated with high biological phenylalanine concentrations that occur with the genetic

115 ia the PAL pathway correlates inversely with phenylalanine concentrations.

116 ion of individual tryptophan-, tyrosine- and phenylalanine-containing dipeptides, 50-80% of the total

117 evels of phenylalanine, its derivatives, and phenylalanine-containing peptides, providing evidence fo

118 Buckwheat was the cereal with the highest phenylalanine content (862mg/100g).

119 Among them, phenylalanine content was considerably increased; this a

120 ned TMZ-effect cells whereas the lysine-II&V/phenylalanine degradation and sonic hedgehog (Hh) pathwa

121 on were performed to improve the activity of phenylalanine dehydrogenase toward its native substrate.

122 model systems that mimic the PS2 moiety and phenylalanine demonstrate that an edge-on interaction be

123 eRS) proofreads the non-protein hydroxylated phenylalanine derivative m-Tyr after its attachment to t

124 emization cascades (giving (S)- or (R)-alpha-phenylalanine derivatives, respectively), and also eukar

125 (Tyr) and replaced the otherwise ubiquitous phenylalanine-derived anthocyanins.

126 Our results support a role for phenylalanine-derived small molecules in preformed and i

127 Phenylpropanoids are phenylalanine-derived specialized metabolites and includ

128 a one-pot Knoevenagel-IMDA reaction of an l-phenylalanine-derived tetramic acid and (R)-2-methyl-dec

129 A reduction in phenylalanine deuteration in Pseudomonas sp. compared to

130 peptidase activities that cleave the proline-phenylalanine dipeptide bond in Ang II.

131 Here we show the formation of tryptophan-phenylalanine dipeptide nanoparticles (DNPs) that can sh

132 With a fast-reacting A-site nucleophile, phenylalanine, effects did not correlate at all with ele

133 the Phe43 cavity, where residue 43 of CD4 (a phenylalanine) engages with gp120.

134 rine atom introduced in the para-position of phenylalanine enhanced the binding affinity as much as 1

135 ryptophan was replaced with a non-oxidizable phenylalanine exhibited higher catalase activity and les

136 pCAT RNAi lines, suggesting that the rate of phenylalanine export from plastids contributes to regula

137 While its phosphodeficient phenylalanine (F) mutant activated both transcription an

138 pothesis by generating mice with FAK Y397-to-phenylalanine (F) mutations in the germline.

139 ing those containing an amidated arginine(R)-phenylalanine(F) motif at their C-termini (RFamide pepti

140 Notably, replacement of a phenylalanine, F208, belonging to an evolutionary conser

141 termined for elicited sprouts obtained after phenylalanine feeding.

142 directly to proteins containing a FFAT [two phenylalanines (FF) in an acidic tract (AT)] motif.

143 ficantly increased N-formyl-methionyl-leucyl phenylalanine (fMLF)-stimulated superoxide release to an

144 d absence of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) (1 muM) stimulation.

145 ry chemoattractant N--formylmethionyl-leucyl-phenylalanine (fMLP) is mediated by leukotriene B4 (LTB4

146 sed in response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) stimulation.

147 d also reduces the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced neutrophil respiratory burs

148 e the mechanism of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-mediated formation of CysLT.

149 llosteric enzyme that requires activation by phenylalanine for full activity.

150 strated the importance of a highly conserved phenylalanine for Pur-alpha's unwinding and neuroprotect

151 rmally treated and the formation of fructose-phenylalanine (Fru-Phe) and fructose-leucine (Fru-Leu) w

152 Then a biomarker panel consisting of phenylalanine, glutamine, tyrosine, citrate, N-acetyl-gl

153 atively unfolded polypeptides, which contain phenylalanine-glycine (FG) binding sites for nuclear tra

154 e and mutant strains with various subsets of phenylalanine-glycine (FG) domains and different levels

155 ols the passage of molecules via hydrophobic phenylalanine-glycine (FG) domains on nucleoporins.

156 n of transport factors (TFs) with disordered phenylalanine-glycine (FG) repeats that fill the central

157 One-third of these Nups contain phenylalanine-glycine (FG)-rich repeats, forming a diffu

158 Nup98 is a glycine-leucine-phenylalanine-glycine (GLFG) repeat-containing nucleopor

159 It consists of nucleoporin domains rich in phenylalanine-glycine motifs (FG domains).

160 inned by the binding affinity of Kapbeta1 to phenylalanine-glycine nucleoporins (FG Nups), which is c

161 compromises interactions with Nup98a/b, two phenylalanine-glycine repeat nucleoporins implicated in

162 [l-Phe-Gly + M + H](+) (where l-Phe-Gly is l-phenylalanine-glycine), and [Mn(II) + (l-Phe-Gly - H) +

163 bic selectivity filter comprising disordered phenylalanine-glycine-rich repeats of nuclear pore prote

164 ly-dipeptide binds to polymeric forms of the phenylalanine:glycine (FG) repeat domain, which is share

165 Gene sequencing revealed a phenylalanine-->isoleucine mutation in the 33rd position

166 Tyrosine and phenylalanine had positive correlations with their DPPH

167 The location of the allosteric site for phenylalanine has not been established.

168 cture, dynamics, and function for the enzyme phenylalanine hydroxylase (PAH) can lead to needed new t

169 The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylat

170 th HPA harbor mutations in the gene encoding phenylalanine hydroxylase (PAH), and a small proportion

171 Mammalian phenylalanine hydroxylase (PheH) is an allosteric enzyme

172 Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme

173 Phenylketonuria (PKU, phenylalanine hydroxylase deficiency), an inborn error o

174 that the replacement of tryptophan 237 with phenylalanine imparts higher fidelity, but replacements

175 lly, a glycine residue in GCC is replaced by phenylalanine in MCC, which blocks access by the larger

176 An elevated concentration of phenylalanine in the blood can result in Phenylketonuria

177 The Strecker-type degradation of phenylalanine in the presence of 2-pentanal and phenolic

178 id homeostasis through interactions with two phenylalanines in an acidic track (FFAT) binding signals

179 ation, we designed point-mutants (alanine to phenylalanine) in the predicted, tightly packed TM domai

180 e substitution of leucine at position 752 to phenylalanine, in PLAA, which causes disruption of the p

181 Two peptides also included tryptophan and phenylalanine, in which the phenolic group could also se

182 To better understand the mechanism of phenylalanine increase upon PPTT, we combined metabolomi

183 autoinhibition because mutation of Tyr97 to phenylalanine increases Nek7 activity independently of N

184 f protein variant H163A in the presence of l-phenylalanine indicated a functional role of His(163) in

185 The degradation of phenylalanine initiated by 2-pentenal, 2,4-heptadienal,

186 ation to the At5g63620 locus, resulting in a phenylalanine instead of serine on position 223.

187 -bonded radical cation due to the methionine-phenylalanine interaction, which is consistent with a sm

188 s catalyzing the BH4-activated conversion of phenylalanine into tyrosine, tyrosine into L-dopa (the p

189 eactive, non-natural amino acid, p-benzoyl-l-phenylalanine, into various positions of the structurall

190 This phenylalanine is also required for CD36 to interact with

191 s 1-24) of the rat enzyme in the presence of phenylalanine is consistent with formation of a side-by-

192 Phenylalanine is the only amino acid known to self-assem

193 ived from glycine, alanine, valine, leucine, phenylalanine, isoleucine, serine, tryptophan, methionin

194 , N-acetyl-glycoproteins, citrate, tyrosine, phenylalanine, isoleucine, valine and glucose were ident

195 abolomics results showed increased levels of phenylalanine, its derivatives, and phenylalanine-contai

196 and 2 has been implicated in 3,4-dihydroxy-l-phenylalanine (L-DOPA)-induced dyskinesia (LID), a motor

197 on (<2min) and accurate quantifications of L-phenylalanine (L-Phe) in plasma and whole-blood newborns

198 The potential of three amino acids (l-phenylalanine, l-tyrosine, l-tryptophan) and a polypepti

199 ic amino acids (alanine, glycine, histidine, phenylalanine, leucine, isoleucine, valine, and tyrosine

200 Inability to control elevated phenylalanine levels in the blood leads to increased ris

201 Following allosteric activation by high phenylalanine levels, the enzyme catalyzes the pterin-de

202 osynthetic operon becomes less responsive to phenylalanine limitation.

203 for cystine/methionine, isoleucine, tyrosine/phenylalanine, lysine and threonine.

204 amino acids) with the most predominant being phenylalanine, lysine and valine.

205 consistent with the proposed role of altered phenylalanine metabolism in inducing apoptosis.

206 through network analysis, which proved that phenylalanine metabolism was perturbed.

207 ingolipid metabolism, tryptophan metabolism, phenylalanine metabolism, lysine biosynthesis and degrad

208 Phenylalanine, methionine and maybe, cysteine, seem to b

209 man measurements of (12)C/(13)C-glucose and -phenylalanine mixtures were performed to elucidate the f

210 In contrast, mutation of these residues to phenylalanine modestly increased HDAC interaction, modes

211 ling in large prospective cohorts identified phenylalanine, monounsaturated fatty acids, and polyunsa

212 A single tyrosine-to-phenylalanine mutation revealed that rat nephrin Tyr(112

213 mino acids in the PtD14b protein including a phenylalanine near the catalytic triad of D14 proteins.

214 neurotransmitter in learning and memory) and phenylalanine (neurotransmitter precursor) after alpha-H

215 ring the reaction between alpha-amino acids (phenylalanine or methionine) and either gallic acid, caf

216 acid, valine, isoleucine, leucine, tyrosine, phenylalanine, ornithine and histidine were low, while v

217 IL-4-induced gene-1 (IL4I1), a secreted l-phenylalanine oxidase expressed by APCs, has been detect

218 The large hydrophobic amino acid p-benzoyl phenylalanine (pBzF) was substituted for Tyr72, which le

219 h a nonnatural amino acid, p-carboxymethyl-l-phenylalanine (pCMF), we demonstrated that Y54 phosphory

220 eplacing tyrosine 48 with p-carboxy-methyl-l-phenylalanine (pCMF).

221 oly(ethylene glycol)-b-poly(l-histidine-co-l-phenylalanine) (PEGbPHF).

222 ation of methyl jasmonate (MeJ) supported by phenylalanine (Phe) as a precursor feeding (MeJ+Phe) and

223 atial interchange of the aromatic amino acid phenylalanine (Phe) between human retinal pigment epithe

224 present evidence of a critical role for the phenylalanine (Phe) biosynthetic activity of AROGENATE D

225 onuria requires lifelong management of blood phenylalanine (Phe) concentration with a low-Phe diet.

226 hyperaccumulation of the aromatic amino acid phenylalanine (Phe) in animals, known as phenylketonuria

227 Vine foliar applications of phenylalanine (Phe) or methyl jasmonate (MeJ) could impr

228 AH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine.

229 e (MeJ), supported by precursor feeding with phenylalanine (Phe), in order to improve Garnacha grape

230 nd to allosteric activation by the substrate phenylalanine (Phe); the allosteric regulation is necess

231 iscrimination factors based upon the source (phenylalanine, Phe) and trophic (glutamic acid, Glu) AAs

232 a (FVIIai) was obtained by inactivation with phenylalanine-phenylalanine-arginine-chloromethyl ketone

233 the second amino acid in the degradation of phenylalanine produced by lipid-derived reactive carbony

234 In this work, we show that the amino acid phenylalanine produces increased membrane permeability,

235 c and succinic acids), amino acids (alanine, phenylalanine, proline and tyrosine), carbohydrates (alp

236 , methionine, methylmalonic acid, ornithine, phenylalanine, proline, sarcosine, serine, threonine, tr

237 catalyzed stereoselective beta-arylations of phenylalanine, proline- and pipecolinic acid-containing

238 acid diisoamyl ester phenoxy prodrug and a l-phenylalanine propyl ester phosphonobisamidate prodrug t

239 ntaining the phosphorylated serine-proline-x-phenylalanine (pSPxF) motif including Abraxas, Bach1/Fan

240 ntact protein increased the concentration of phenylalanine required for activation.

241 residues (E678 and E686) in this motif and a phenylalanine residue (F680) that resides between the tw

242 Our results indicate that the elimination of phenylalanine residue 211 or 213 abolishes the UQ-depend

243 PfEMP1 protein family to bind to a conserved phenylalanine residue at the membrane distal tip of CD36

244 ed that 2,6-DTBP interacted with a conserved phenylalanine residue in the membrane-associated stretch

245 ed were functionalized with a perfluorinated phenylalanine residue to promote anion-pi interactions w

246 on of oxoG by Fpg and its mutants with a key phenylalanine residue, which intercalates next to the da

247 edge-to-face" orientation with a neighboring phenylalanine residue.

248 lectrocatalyst containing either tyrosine or phenylalanine residues is reported.

249 icted pi-pi stacking interaction between two phenylalanine residues leading to a destabilized uS12 th

250 Two phenylalanine residues located adjacent to the substitut

251 hat 'aromatic clamps' formed by tyrosine and phenylalanine residues located within the substrate bind

252 In particular, the two phenylalanine residues within the FYXWF motif of S519C16

253 for lysine, arginine, leucine, tyrosine, and phenylalanine residues.

254 T189 in the ion selectivity filter, and all phenylalanine residues.

255 of mutating two conserved F(-)-coordinating phenylalanine residues.

256 n comparison to a control complex containing phenylalanine residues.

257 L150; and almost undetectable with L179 and phenylalanine residues.

258 three critical and evolutionarily invariant phenylalanine residues.

259 ptides characterized by an amidated arginine-phenylalanine (RFamide) C-terminus motif.

260 The pyranopyridines bind within a phenylalanine-rich cage that branches from the deep bind

261 the protease through recognition of a short phenylalanine-rich motif, and the presence of similar mo

262 ially positive gamma-methylene in mimicry of phenylalanine's quadrupolar interaction.

263 ain, and central to the interaction, the DFP phenylalanine side-chain inserts into a major hydrophobi

264 Substitution of each phenylalanine specifically extinguishes its associated F

265 pport a model for allostery in PheH in which phenylalanine stabilizes the dimerization of the regulat

266 fourth aromatic amino acid to redox-inactive phenylalanines still leads to light-induced radical pair

267 At alphaY198 a phenylalanine substitution had no effect, but at alphaY1

268 Two critical central phenylalanines that directly coordinate F(-) through a q

269 whereas replacement of C932 with leucine or phenylalanine, the latter of a size comparable to argini

270 and soluble UV-protective metabolites) from phenylalanine through the phenylpropanoid biosynthetic p

271 we make use of an azido group of a p-azido-l-phenylalanine to achieve chemical orthogonality.

272 e nonoxidative elimination of ammonia from l-phenylalanine to give trans-cinnamate.

273 hich changes the position 10 amino acid from phenylalanine to leucine, reduces protein expression by

274 cells, whereas mutation of these residues to phenylalanine to prevent phosphorylation obviates these

275 catalyzes the pterin-dependent conversion of phenylalanine to tyrosine.

276 cific incorporation of a clickable p-azido-L-phenylalanine to Uox and strain-promoted azide-alkyne cy

277 a nonproteinogenic P1 residue (4-guanidyl-l-phenylalanine) to produce a potent (Ki = 1.6 nM) and the

278 did#1 attenuation is entirely dependent on a phenylalanine-to-isoleucine substitution at position 427

279 indicated that methionine+cysteine (57.6%), phenylalanine+tyrosine (32.6%), leucine (45.7%) and isol

280 A repair and combination, purine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, rib

281 Mutants with phenylalanine, tyrosine, and methionine substitutions we

282 -chaperone family member that interacts with phenylalanine, tyrosine, and tryptophan hydroxylases cat

283 of amino acids (arginine, histidine, lysine, phenylalanine, tyrosine, and tryptophan) makes it a viab

284 lanine, valine, leucine, methionine, lysine, phenylalanine, tyrosine, and tryptophan.

285 cation, i.e., histidine, serine, tryptophan, phenylalanine, tyrosine, asparagine, methionine, and lys

286 re composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline significantl

287 eotide metabolites like tryptophan, proline, phenylalanine, uridine, and guanosine was found.

288 ne, lysine, isoleucine, leucine, methionine, phenylalanine, valine, GABA, glutamine, alanine, glycine

289 Mutation of Trp(233) to phenylalanine (W233F) completely abolishes the Cc-depend

290 pon stimulation with formyl-methionyl-leucyl phenylalanine was found to identify sputum eosinophilia

291 al, isotopically labeled p-((13)C(15)N-cyano)phenylalanine was synthesized, site-selectively incorpor

292 A series of racemic aryl-substituted phenylalanines was synthesized and evaluated in vitro at

293 oxyphenylalanine, a hydroxylation product of phenylalanine, was identified and quantified as a new pr

294 f valine, leucine, isoleucine, tyrosine, and phenylalanine were measured in a longitudinal and a cros

295 ne(973) in the juxtamembrane region of IR to phenylalanine, which is present in IGF1R, mimics many of

296 from delta (15)N values of glutamic acid and phenylalanine, which range from 8.3-33.1 per thousand an

297 heparin affinities of AAV2-based tyrosine-to-phenylalanine (Y-F) and threonine-to-valine (T-V) capsid

298 intravitreal (IVit) delivery of tyrosine to phenylalanine (Y-F) capsid mutant AAV8.

299 nt in which tyrosine 729 had been mutated to phenylalanine (Y729F) promoted monocyte rather than neut

300 , chemotaxis receptor, vimentin, fibrin, and phenylalanine zippers that vary in size and topology of