ライフサイエンスコーパス: phenylalanyl

1 anism of hydrolysis of the nitrile (N-acetyl-phenylalanyl-2-amino-propionitrile, I) catalyzed by Gln1

2 namide (probe 1) and N,beta,beta-trimethyl-l-phenylalanyl-4-benzoyl-N-[(1S,2E)-3-carboxy-1-isop ropyl

3 in the PheATE catalyzed chemical pathway: L-phenylalanyl-adenosine-5'-monophosphate diester (L-Phe-A

4 t (by adenylation domain) as tightly bound L-phenylalanyl-adenosine-5'-monophosphate diester (L-Phe-A

5 Michaelis complex through the AMP moiety of phenylalanyl-adenylate substrate.

6 supercooled water: the flipping kinetics of phenylalanyl and tyrosinyl rings of the 6 kDa protein BP

7 Phenylalanyl-arginine beta-naphthylamide (PAbetaN), is a

8 Each contains a photoreactive p-benzoyl-phenylalanyl (Bpa) residue in close proximity to the RGD

9 nti-proliferative effects of N-alpha-tosyl-l-phenylalanyl chloromethyl ketone (TPCK) have been known

10 esicles was inhibited by TPCK (tolylsullonyl phenylalanyl chloromethyl ketone), PMSF (phenylmethylsul

11 te-directed chymotryptic inhibitor N-tosyl-L-phenylalanyl-chloromethyl ketone (TPCK) suppressed DNA f

12 efficacy than the nonhydroxylated 4-(malonyl)phenylalanyl-containing congener in blocking the associa

13 as observed that the 4-(alpha-hydroxymalonyl)phenylalanyl-containing peptide exhibited greater effica

14 ipeptides of the methyl ester of 4-benzoyl-l-phenylalanyl-F(n)()Ys at pH 4 were examined with a nanos

15 otency when Xxx = 4-(phosphonodifluoromethyl)phenylalanyl (F2Pmp) (K(i) = 0.2 microM) and when Xxx =

16 specificities (valyl, methionyl, alanyl, and phenylalanyl) from higher plants or Escherichia coli wer

17 ically disordered proteins (IDPs) containing phenylalanyl-glycyl (FG)-rich repeats line the pore and

18 The phenylalanyl-glycyl-glycyl-alanyl-prolyl (FG-GAP) domain

19 Several ester derivatives of hydrocinnamoyl-phenylalanyl-homocysteine, one of the most potent PAM in

20 It was proposed that thaxtomin A phenylalanyl hydroxylation was catalyzed by the monooxyg

21 Six days of treatment with N-CBZ-L-phenylalanyl-L-alanine-diazomethylketone (ZPAD) resulted

22 A 2-day exposure to N-CBZ-L-phenylalanyl-L-alanine-diazomethylketone (ZPAD), a selec

23 N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L- phenylalanine did not inhibit b

24 Another FPR antagonist, N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L- phenyla

25 ues for L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester HCl (MF13), were de

26 III, HCII, alpha1-proteinase inhibitor, or d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone.

27 samples anticoagulated with citrate versus D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPA

28 sted the binding of enzymatically inactive D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPA

29 ed with turbidimetric aggregometry in both D-phenylalanyl-L-prolyl-L-arginine chloromethylketone and

30 lood was collected in buffered citrate and D-phenylalanyl-L-prolyl-L-arginine chloromethylketone anti

31 the direct thrombin inhibitors hirudin and D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone, ind

32 a a tripeptide tether to yield fluorescein-D-phenylalanyl-L-prolyl-L-arginyl-fVIIa (Fl-FPR-fVIIa).

33 lysine-fluorescein and N-formyl-valyl-leucyl-phenylalanyl-lysine-fluorescein to the N-formyl peptide

34 Here, through comparative investigations of phenylalanyl, methionyl, and arginyl ternary complexes,

35 equilibrates the Calpha configuration of the phenylalanyl moiety presented as Phe-S-4'-phosphopanteth

36 ase may have structural homology, tyrosyl to phenylalanyl mutants of MAO A at positions 377, 402, 407

37 designated 4-benzoyl-N,beta,beta-trimethyl-l-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-i sopropylbut-2-e

38 site inhibitors, RWJ-50353 10080(N-methyl-D-phenylalanyl-N-[5-[(aminoiminomethyl)amino]-1- [[(2-benz

39 orescent peptide ligand CHO-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine-fluorescein (CHO-N

40 inding kinetics of N-formyl-methionyl-leucyl-phenylalanyl-phenylalanyl-lysine-fluorescein and N-formy

41 ns with the S1-S3 sites are similar to the D-phenylalanyl-prolyl-arginyl chloromethylketone structure

42 sociate with ribosomes in sucrose gradients: phenylalanyl-RS (FRS), and the 9 ARSs that form the mult

43 Hydrocinnamoyl-phenylalanyl-(S-benzoyl-homocysteine) benzyl ester was i

44 Notably, a phenylalanyl side chain pointing toward the metal may hi

45 ic binding surface, not a pocket, for the P1 phenylalanyl side-chain of chymostatin.

46 12,15-N-dimethylcyclo-(L-4-nitrotryptophyl-L-phenylalanyl), the didehydroxy analog of thaxtomin A.

47 luoromethyl ketone (AcLF-CF3) and N-acetyl-L-phenylalanyl trifluoromethyl ketone (AcF-CF3) were deter

48 195 in chymotrypsin with N-acetyl-L-leucyl-L-phenylalanyl trifluoromethyl ketone (AcLF-CF3) and N-ace

49 ares 45% identity with the yeast cytoplasmic phenylalanyl tRNA synthetase (PheRS) regulatory alpha-su

50 Inhibition of purified yeast phenylalanyl-tRNA synthetase (FRS) catalyzed aminoacylat

51 ficity in AcKRS and in a PylRS variant [iodo-phenylalanyl-tRNA synthetase (IFRS)] that displays both

52 Human mitochondrial phenylalanyl-tRNA synthetase (mtPheRS) has been identifi

53 the amino acid binding and recognition step, phenylalanyl-tRNA synthetase (PheRS) faces the challenge

54 Phenylalanyl-tRNA synthetase (PheRS) is a multidomain (a

55 Phenylalanyl-tRNA synthetase (PheRS) maintains specifici

56 For example phenylalanyl-tRNA synthetase (PheRS) proofreads the non-

57 olutionary divergence of tyrosine editing by phenylalanyl-tRNA synthetase (PheRS) was used as a model

58 n its acceptor stem that prevents editing by phenylalanyl-tRNA synthetase (PheRS), leading to the acc

59 that of the heterotetrameric (alphabeta)(2) phenylalanyl-tRNA synthetase (PheRS).

60 ies of binding of phenylalanine analogues to phenylalanyl-tRNA synthetase (PheRS).

61 molog of one subunit of prokaryote and yeast phenylalanyl-tRNA synthetase (PheRS).

62 A designed yeast phenylalanyl-tRNA synthetase (yPheRS (T415G)) activates

63 or tRNA (ytRNA(Phe)(CUA)) and a mutant yeast phenylalanyl-tRNA synthetase (yPheRS (T415G)) into an Es

64 -acetyllysyl-tRNA synthetase [AcKRS], 3-iodo-phenylalanyl-tRNA synthetase [IFRS], a broad specific Py

65 we have engineered a Caenorhabditis elegans phenylalanyl-tRNA synthetase capable of tagging proteins

66 e we report that wild-type E. coli EF-Tu and phenylalanyl-tRNA synthetase collaborate with these muta

67 c azetidines targeting Plasmodium falciparum phenylalanyl-tRNA synthetase comprise one promising new

68 The phenylalanyl-tRNA synthetase editing mechanism is also a

69 crimination in vivo revealed that editing by phenylalanyl-tRNA synthetase is essential for faithful t

70 We show that phenylalanyl-tRNA synthetase misactivates tyrosine and t

71 computationally designed mutant form of the phenylalanyl-tRNA synthetase of the host.

72 The phenylalanyl-tRNA synthetase variants S57C and N280S bot

73 To define the mechanism of editing, phenylalanyl-tRNA synthetase was used to investigate dif

74 nthesized in nature (by Thermus thermophilus phenylalanyl-tRNA synthetase), and many disubstituted tR

75 n of the nucleus-encoded human mitochondrial phenylalanyl-tRNA synthetase, which aminoacylates hmt-tR

76 from the active site of human mitochondrial phenylalanyl-tRNA synthetase.

77 lanyl-tRNA is formed by Thermus thermophilus phenylalanyl-tRNA synthetase.

78 ines that inhibit a new antimalarial target, phenylalanyl-tRNA synthetase.

79 lyclonal antibodies raised against mammalian phenylalanyl-tRNA synthetase.

80 a proofreading ("editing") activity, such as phenylalanyl-tRNA synthetases (PheRS) that hydrolyze mis

81 tivity of aminoacyl-tRNA synthetases such as phenylalanyl-tRNA synthetases (PheRS), which edit misact

82 In addition, seryl- and phenylalanyl-tRNA synthetases that are only marginally r

83 erminal module that resembles the OB-fold of phenylalanyl-tRNA synthetases.

84 The leucyl/phenylalanyl-tRNA-protein transferase (L/F-transferase)

85 ize aminoacyl-tRNA recognition by the leucyl/phenylalanyl-tRNA-protein transferase (L/Ftransferase).

86 tes diacetyl-[14C]lysyl-tRNA and acetyl-[14C]phenylalanyl-tRNA.