ライフサイエンスコーパス: phenylglycine

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1 ole neurons revealed that (RS)-3,5-dihydroxy-phenylglycine 0.5 H(2)O (DHPG)-stimulated fluorescence w

2 (cat)/K(M) for the enantiomers of N-succinyl phenylglycine, 2.0 x 10(5) M(-1) s(-1), is comparable to

3 horyl]oxy]ethyl]sulfonyl]propionyl]-(R)-(-)-phenylglycine (3) have been designed, synthesized, and e

4 lyzed reaction to access 3,4,5-trifluoro-(S)-phenylglycine, a 1-pot activation/displacement/deprotect

5 ming chiral species (N-(2-methylbenzylidene)-phenylglycine amide, NMPA) evolves from an initial perfe

6 irect binding of three his-tagged enzymes, D-phenylglycine aminotransferase (D-PhgAT), Halomonas elon

7 The reactions of the slower substrates L-phenylglycine and 1-aminocyclohexane-1-carboxylate may h

8 type and position of the substituents on the phenylglycine and phenylalanine side chains has a signif

9 alysis with EREDs, using readily available N-phenylglycines and cyclohexenones that can be obtained f

10 clearly demonstrate that S-phenylglycine (R-phenylglycine) binds only to chains rotated 19.5 degrees

11 RP with concurrent formation of 2a but not N-phenylglycine, but under anaerobic, peroxide-free condit

12 xchange the alpha-hydrogen of N-succinyl-(R)-phenylglycine, consistent with formation of a Mn2+-stabi

13 The action of HRP on N-alkyl-N-phenylglycine derivatives 1b-1e (PhN(R)CH(2)COOH; R = Me

14 protease that incorporate phenylalanine and phenylglycine derivatives as arginine-mimicking groups w

15 Interestingly, several phenylglycine derivatives including the metabotropic glu

16 of glutamate by gliomas may be prevented by phenylglycine derivatives, which may thus be useful as a

17 hetic strategy featuring ethylbenzylamine or phenylglycine-derived chiral BP synthons incorporating a

18 stage racemization of carboxylate-activated phenylglycine-derived residues, and to enlist beta-sheet

19 ion of group I mGluRs with (S)-3,5-dihydroxy-phenylglycine (DHPG) induced a Ca(2+)-calmodulin-depende

20 of P1 novaline and the aromatic ring of P2' phenylglycine formed a C-shaped clamp around the Lys136

21 functionalization of mandelic acid and alpha-phenylglycine is reported.

22 phorodiamidate)-sulfonyl-propionyl-( R)- (-) phenylglycine] is a novel nitrogen mustard prodrug that

23 ses predict the incorporation of p-hydroxy-L-phenylglycine (L-pHPG) into positions 1, 3, and 5 and L-

24 c bismuth-rhodium paddlewheel complexes with phenylglycine ligands carrying TIPS-groups at the meta-p

25 t, orally bioavailable OX(2) agonists with a phenylglycine-like scaffold.

26 I/II antagonist (+/-)-alpha-methyl-4-carboxy-phenylglycine (MCPG), and group III agonist L-2-amino-4-

27 methoxy-alpha-phenylacetic acid (MPA) or (S)-phenylglycine methyl ester (PGME) linked through anilide

28 tiomeric interaction involves double rows of phenylglycine molecules and the adenine chains.

29 al phases for libraries of target molecules (phenylglycine, praziquantel) with different chemical mod

30 STM images clearly demonstrate that S-phenylglycine (R-phenylglycine) binds only to chains rot

31 nylacetic acids, including mandelic acid and phenylglycine, react smoothly with various aryl iodides

32 he chirality, and that the alpha-amino acid, phenylglycine, shows a strong chiral preference in its i

33 tase inhibitor difluorophenacetyl-l-alanyl-S-phenylglycine t-butyl ester (DAPT) or dimethyl sulfoxide

34 or N-(N-[3,5-difluorophenacetyl]-l-alanyl)-S-phenylglycine t-butyl ester (DAPT) or following stable t

35 N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester (DAPT) preferentially inhibi

36 or N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) significantly rescued

37 ly N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), a chemical inhibitor

38 of N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a gamma-secretase in

39 r, N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT), or Notch1 short hair

40 r, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), which significantly

41 rs N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester and L-685,458.

42 or N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester failed to promote the direct

43 T (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) diminished these effects.

44 T (N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester), reduces the survival of GC

45 N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester, a potent gamma-secretase in

46 or N-(N-(3,5-difluorophenacetyl)-l-alanyl)-S-phenylglycine t-butyl ester, supporting the concept that

47 (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester; DAPT) was administered subc

48 N-[N-(3,5-difluorophenylacetyl-l-alanyl)]-S-phenylglycine t-butylester (DAPT), a specific gamma-secr

49 I) N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine-t-butylester (DAPT), at a dose that reduce

50 tor N-[N-(3,5-Difluorophenacetyl-L-alanyl)-S-phenylglycine]-t-butyl ester, which blocks Notch signali

51 tra-methyl-2,6-dioxo-4-oxylpiperazin-1-yl)-l-phenylglycine (TOPP).

52 ange of the alpha-hydrogen of N-succinyl-(S)-phenylglycine with solvent hydrogen, and K263R and K263