ライフサイエンスコーパス: phenytoin

1 and vehicle, vehicle and phenytoin, CORT and phenytoin).

2 d with lamotrigine (but not carbamazepine or phenytoin).

3 r deaths in control mice after withdrawal of phenytoin.

4 rmine the total and ionized concentration of phenytoin.

5 R) and selective permeability to sucrose and phenytoin.

6 cing/increasing the ionized concentration of phenytoin.

7 R)-6 and (R)-7 in rats (po) exceeded that of phenytoin.

8 and rats that compared favorably to that of phenytoin.

9 the anticonvulsant drugs, carbamazepine and phenytoin.

10 current exhibited either of two responses to phenytoin.

11 henobarbital and 3 microg per milliliter for phenytoin.

12 pilepticus, lorazepam is more effective than phenytoin.

13 nventional antiepileptic drugs, diazepam and phenytoin.

14 whether volumetric changes can be blocked by phenytoin.

15 nges can, as in animal models, be blocked by phenytoin.

16 ppocampal changes that can be prevented with phenytoin.

17 or clarithromycin; dronedarone; rifampin; or phenytoin.

18 r for lamotrigine and levetiracetam than for phenytoin.

19 o dose effects were seen for lamotrigine and phenytoin.

20 5), lamotrigine (108, 105-110; p=0.0003), or phenytoin (108, 104-112; p=0.0006).

21 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per ki

22 am), phenobarbital (15 mg per kilogram), and phenytoin (18 mg per kilogram).

23 ts), phenobarbitone/primidone (72 patients), phenytoin (184 patients) or valproate (228 patients) in

24 maintenance dose 3.0 mg/kg daily; n = 47) or phenytoin (2.5 mg/kg daily then 5.0 mg/kg daily; n = 47)

25 29 were assigned to phenytoin 4 mg/kg and 13 to phenytoin 6 mg/kg.

26 ml), and half were given daily injections of phenytoin (40 mg/kg), an antiepileptic drug that prevent

27 nd 13 of the 29 neonates assigned to receive phenytoin (45 percent; P=1.00).

28 Both diazepam (10 mg/kg i.v.) and phenytoin (50 mg/kg i.v.) prevented the establishment of

29 were assigned to phenytoin 4 mg/kg and 13 to phenytoin 6 mg/kg.

30 nts lower than the score of those exposed to phenytoin (95% CI, 0.2 to 14.0; P=0.04), and 6 points lo

31 osed to lamotrigine, 99 for those exposed to phenytoin, 98 for those exposed to carbamazepine, and 92

32 The model analyte was phenytoin, a typical small drug molecule.

33 al firing and behavior in GEPR-9s, following phenytoin administration.

34 is by 33% and 37% greater than the effect of phenytoin alone (n = 3; P < 0.01).

35 drostenedione when compared to the effect of phenytoin alone (n = 3; P < 0.01).

36 olled clinical trial: 20 patients were given phenytoin and 22 acted as controls.

37 sis included 81 participants (39 assigned to phenytoin and 42 to placebo).

38 eb 3, 2012, and May 22, 2014 (42 assigned to phenytoin and 44 to placebo).

39 between plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPP

40 and therapeutic index comparable to those of phenytoin and carbamazepine and greater than those of so

41 The widely prescribed anticonvulsants phenytoin and carbamazepine are potent inducers of cytoc

42 Therapeutic levels of phenytoin and carbamazepine displace T4 and T3 from seru

43 These findings suggest that phenytoin and carbamazepine may substantially increase t

44 causes loss of bone mass in women, and both phenytoin and carbamazepine produce increases in serum l

45 Both phenytoin and carbamazepine significantly improved the c

46 control serum concentration (P<.001 for both phenytoin and carbamazepine); free T4 fraction (by ultra

47 Combinations of phenytoin and EGF stimulated DHT and 4-androstenedione s

48 Two sodium channel blockers, phenytoin and flecainide, have been reported to protect

49 quid chromatography for the determination of phenytoin and HPPH concentrations.

50 Mean plasma and saliva concentrations of phenytoin and HPPH did not differ significantly between

51 Both phenytoin and lamotrigine increased functional expressio

52 with a prescription of antiepileptic drugs, phenytoin and levetiracetam were prescribed most often.

53 Phenytoin and lignocaine (membrane stabilizing drugs) ar

54 gher affinity blockade of T-type currents by phenytoin and MPS may require additional regulatory fact

55 IL-6 secretion, and this effect is shared by phenytoin and nifedipine.

56 These mice were given phenytoin and rifampicin for 3 days, after which monocro

57 with females, including greater induction by phenytoin and rifampicin of cytochrome P450 3A4 isoform

58 values and a selective permeability to [14C] phenytoin and the well-known paracellular marker [3H] su

59 crog/mL/h) of O(6)-BG for patients receiving phenytoin and those not treated with this drug.

60 only used drugs (carbamazepine, lamotrigine, phenytoin and valproate).

61 herapy, which was the case for barbiturates, phenytoin and valproate.

62 ythmic drug lidocaine and the anticonvulsant phenytoin and, to a lesser extent, reduce the sensitivit

63 many important drugs including tolbutamide, phenytoin, and (S)-warfarin.

64 f the administration of cyclosporin A (CSA), phenytoin, and calcium blockers.

65 Mice were treated with rifampicin, phenytoin, and monocrotaline.

66 enzyme (cP450) inducing AED (carbamazepine, phenytoin, and phenobarbital), a cP450 inhibiting AED (v

67 ly less in subjects receiving carbamazepine, phenytoin, and valproate than in those receiving lamotri

68 ne-step CEDIA for three AEDs (carbamazepine, phenytoin, and valproic acid), in the presence of serum,

69 lower than the control concentration in both phenytoin- and carbamazepine-treated patients.

70 um free T3 and serum TSH were also normal in phenytoin- and carbamazepine-treated patients.

71 microcolumn containing a small layer of anti-phenytoin antibodies.

72 (IC50 = 68 microM), and the anti-convulsant phenytoin ( approximately 50% inhibition at 200 microM).

73 Phenobarbital and phenytoin are equally but incompletely effective as anti

74 hree known ligands (ibuprofen, warfarin, and phenytoin) are involved to demonstrate the concept and t

75 bout the speciation of ionizable drugs, with phenytoin as a model example.

76 study, we report the electrical detection of phenytoin as an antiepileptic medication with a narrow t

77 Phenytoin blocked the volume reduction associated with h

78 This approach is not limited to phenytoin but can be adapted for other analytes through

79 en exposed to carbamazepine, lamotrigine, or phenytoin but not among those exposed to valproate.

80 ment is usually with either phenobarbital or phenytoin, but the efficacy of the two drugs has not bee

81 bound phenytoin, the rate of capture of free phenytoin by immunoextraction microcolumns, the behavior

82 owth is caused by the antiseizure medication phenytoin, calcium channel blockers, and ciclosporin.

83 The tricyclic anticonvulsant drugs phenytoin, carbamazepine, and lamotrigine block neuronal

84 sy receiving antiepileptic drug monotherapy (phenytoin, carbamazepine, valproate, and lamotrigine).

85 in; phenobarbital promoted liver tumours and phenytoin caused lymphoid cell and liver tumours in rats

86 Specifically, phenytoin causes loss of bone mass in women, and both ph

87 ileptic drugs (AEDs; i.e., carbamazepine and phenytoin (CBZ, PHT)).

88 cases of hepatotoxicity caused by isoniazid, phenytoin, clavulanate/amoxicillin, or valproate occurri

89 0% reduction in the extent of RNFL loss with phenytoin compared with placebo.

90 se of amiodarone, fluconazole, rifampin, and phenytoin compared with the use of NOACs alone, was asso

91 significantly reduced in subjects receiving phenytoin compared with those receiving lamotrigine (p =

92 (only one, severe rash, was attributable to phenytoin) compared with two (5%) of 44 in the placebo g

93 glaucoma, a subset of animals was placed on phenytoin-containing chow; this treatment continued for

94 t observed (vehicle and vehicle, vehicle and phenytoin, CORT and phenytoin).

95 In BU/CY patients (who also received phenytoin), CY clearance was 112% greater (P = .0014), h

96 s an iatrogenic disease caused by the use of phenytoin, cyclosporine, nifedipine, and other medicatio

97 450 2C because of observed interactions with phenytoin, diazepam, and other drugs metabolized by thes

98 Cyclic sulfate 2, like topiramate and phenytoin, did not interfere with seizures induced by pe

99 ; and 56.07 for NOAC use alone vs 108.52 for phenytoin (difference, 52.31 [99% CI, 32.18-72.44]; P <

100 g daily oral doses of the antiepileptic drug phenytoin (Dilantin, Sigma, St.

101 ver biosensors showed a solid correlation of phenytoin drug detection with that in the clinically use

102 e/R-oxazepam hemisuccinate, and L-tryptophan/phenytoin during their binding to HSA.

103 mpared favorably to the ED50 value found for phenytoin (ED50 = 6.5 mg/kg).

104 (18, ED50 = 3.9 mg/kg; 19, ED50 = 19 mg/kg; phenytoin, ED50 = 23 mg/kg).

105 herapeutic hypothermia significantly reduces phenytoin elimination in children with severe traumatic

106 Phenytoin exhibits a different binding distribution owin

107 Hepatocytes isolated from the phenytoin-exposed donors exhibited marked declines in UG

108 ors with the highest levels had a history of phenytoin exposure.

109 o be risks associated with phenobarbital and phenytoin exposure.

110 18 (62 percent) of those assigned to receive phenytoin first (P=0.67).

111 g individuals treated with isoniazid (nine), phenytoin (five), clavulanate/amoxicillin (15), and valp

112 inding of diverse drugs including lidocaine, phenytoin, flecainide, and quinidine, suggesting that th

113 lt epileptic patients who had been receiving phenytoin for greater than 6 months without a recent cha

114 Higher CTGF staining in phenytoin gingival overgrowth tissues was accompanied by

115 Cellular and extracellular CTGF content in phenytoin gingival overgrowth tissues was significantly

116 at 6 months was 81.46 mum (SD 16.27) in the phenytoin group (a mean decrease of 16.69 mum [SD 13.73]

117 tients having a serious adverse event in the phenytoin group (only one, severe rash, was attributable

118 significantly between the phenobarbital and phenytoin groups (Conners 2.64 [SD 0.71] vs 2.65 [0.89],

119 level (p = 0.0004), whereas those taken off phenytoin had a decrease in homocysteine level (-1.7 mic

120 Subjects receiving phenytoin had significantly greater levels of bone-speci

121 Phenytoin has been causally implicated in three human ca

122 Recently, (11)C-phenytoin has been evaluated preclinically as a tracer f

123 The anticonvulsant phenytoin has been reported to be an inducer of human CY

124 with a number of advantages over intravenous phenytoin, has been released.

125 diazepam plus phenytoin in 55.8 percent, and phenytoin in 43.6 percent (P=0.02 for the overall compar

126 phenobarbital in 58.2 percent, diazepam plus phenytoin in 55.8 percent, and phenytoin in 43.6 percent

127 Lorazepam was significantly superior to phenytoin in a pairwise comparison (P=0.002).

128 Phenytoin in doses (mean, 6.3 mg/kg) that suppressed TE

129 al plasticity and fibrosis were regulated by phenytoin in gingival epithelial tissues and in connecti

130 nylhydantoin (HPPH), the major metabolite of phenytoin in man, and the prevalence and severity of gin

131 34 epilepsy patients taking carbamazepine or phenytoin in monotherapy whose physicians had elected to

132 e, mediated luciferase reporter induction by phenytoin in mouse livers in vivo and was activated by C

133 support the concept of neuroprotection with phenytoin in patients with acute optic neuritis at conce

134 This protocol was applied to measure phenytoin in pharmaceutical tables (100mg per tablet).

135 y using it to determine the free fraction of phenytoin in serum or samples containing the binding pro

136 biosensor was approved for the detection of phenytoin in solutions of deionized water and 100% fetal

137 Phenobarbital and MK-801 were superior to phenytoin in suppressing SE and in preventing chronic ep

138 a signal proportional to the amount of free phenytoin in the sample.

139 We detected weak transport of phenytoin in two of the transport systems (MDCK and LLC-

140 Hepatic CYP2C29 mRNA was induced by phenytoin in wild-type but not in CAR-null mice, indicat

141 s with the concentration of a model analyte (phenytoin) in the sample stream.

142 Treatment of cells with phenytoin increased cell surface expression of WT-Na(V)1

143 Although phenytoin increased surface expression of G1674R, channe

144 Our previous investigations concerning phenytoin-induced effects on platelet-derived growth fac

145 the ability of a mouse model to mimic human phenytoin-induced gingival overgrowth and assess the abi

146 Data indicate that phenytoin-induced gingival overgrowth in mice mimics mol

147 y show significantly higher CTGF staining in phenytoin-induced gingival overgrowth tissues compared t

148 promoting development of fibrotic lesions in phenytoin-induced gingival overgrowth.

149 a or saliva and the extent, or prevalence of phenytoin-induced gingival overgrowth.

150 Data are consistent with characterization of phenytoin-induced human gingival overgrowth in vivo and

151 We found that phenytoin-induced human gingival overgrowth tissues, the

152 at statins may serve to prevent or attenuate phenytoin-induced human gingival overgrowth, although sp

153 little fibrosis, nifedipine- and especially phenytoin-induced lesions are highly fibrotic.

154 nflammatory exudate may have implications on phenytoin-induced overgrowth via the steroid metabolic p

155 ctive or androstane receptor (CAR) regulates phenytoin-induced transcription of the Cyp2c29 gene.

156 However, the molecular mechanism mediating phenytoin induction remains unclear.

157 erapeutic intervention with phenobarbital or phenytoin ineffective, whereas intervention with vigabat

158 Na(+) currents with tetrodotoxin, QX-314, or phenytoin inhibited bursting before inhibiting action po

159 assigned to receive either phenobarbital or phenytoin intravenously, at doses sufficient to achieve

160 Phenytoin is a commonly used anticonvulsant drug for the

161 Our results demonstrate that phenytoin is associated with changes in bone metabolism

162 Phenytoin is ineffective in the management of seizures s

163 blish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic

164 Dilantin (phenytoin) is a commonly used antiepileptic agent that i

165 icacious than phenobarbital or diazepam plus phenytoin, it is easier to use.

166 Our aim was to investigate transport of phenytoin, lamotrigine and carbamazepine by using seven

167 ugs with proapoptotic action (phenobarbital, phenytoin, lamotrigine) and without proapoptotic action

168 two commonly prescribed antiepileptic drugs (phenytoin, lamotrigine), as well as the cystic fibrosis

169 ate the impact of therapeutic hypothermia on phenytoin levels and pharmacokinetics in children with s

170 A trend toward elevated free phenytoin levels in the hypothermia group (p=0.051) to a

171 A sum of 121 total and 114 free phenytoin levels were evaluated retrospectively in 10 hy

172 minimisation via a web-based service to oral phenytoin (maintenance dose 4 mg/kg per day if randomise

173 Doses of phenytoin (mean, 8.3 mg/kg), which completely blocked AG

174 variant component of the maximum velocity of phenytoin metabolism (Vmax) 4.6-fold (11.6-2.53 mg/hr) a

175 tained from patients undergoing therapy with phenytoin (n = 9), nifedipine (n = 4), cyclosporin A (n

176 Treatment with intravenous phenytoin (n=32) as a second-line therapy was associated

177 Gingival overgrowth induced by drugs such as phenytoin, nifedipine, and cyclosporin develops due to a

178 Medication with phenytoin, nifedipine, and cyclosporine-A often causes g

179 sions occur principally as side-effects from phenytoin, nifedipine, or ciclosporin therapy in approxi

180 Experimental assay results for the drug phenytoin, obtained using surface plasmon resonance imag

181 These include the effect of phenytoin on alveolar bone, the antibacterial effect of

182 xons was performed to examine the effects of phenytoin on glaucoma-induced adverse neurodegeneration.

183 The differential effects of phenytoin on structures requisite to the seizure network

184 Phenytoin, one of the most widely used antiepileptic dru

185 In the epilepsy patients, switch from either phenytoin or carbamazepine produced significant declines

186 Addition of phenytoin or carbamazepine to normal human serum in vitr

187 ns of free T4 and free T3 in patients taking phenytoin or carbamazepine vs normal controls.

188 edications, including an antiepileptic drug (phenytoin or carbamazepine), dexamethasone, and ranitidi

189 ed free T4 concentrations in patients taking phenytoin or carbamazepine, clinicians should rely on se

190 In patients taking phenytoin or carbamazepine, serum total T4 decreased sig

191 rocyte glycoprotein-induced EAE treated with phenytoin or carbamazepine.

192 with seizure disorders who were treated with phenytoin or carbamazepine.

193 found no evidence of a relationship between phenytoin or HPPH concentrations in plasma or saliva and

194 establish the relationship, if any, between phenytoin or HPPH levels and gingival overgrowth.

195 th either plasma or saliva concentrations of phenytoin or HPPH.

196 se family of enzymes have been documented in phenytoin or nifedipine lesions.

197 pacing to restore synchrony; 4) digoxin; 5) phenytoin or propranolol or verapamil; 6) procainamide o

198 levels through exposure to the antiepileptic phenytoin or the inhibitory transmitter GABA.

199 sed at P7 to a single dose of phenobarbital, phenytoin, or lamotrigine.

200 rug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and Febr

201 epileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational

202 monotherapy (ie, carbamazepine, lamotrigine, phenytoin, or valproate) were enrolled from October 14,

203 tologic samples support the concept that the phenytoin overgrowth tissues are fibrotic.

204 reased 65% and 44%, respectively (P<.001 for phenytoin, P<.01 for carbamazepine); and free T4 remaine

205 Dynamic (11)C-phenytoin PET scans of 6 healthy volunteers with arteria

206 ntitative parametric images of dynamic (11)C-phenytoin PET studies was evaluated.

207 ethods: Double-baseline 60-min dynamic (11)C-phenytoin PET studies, including online arterial samplin

208 Double-baseline 60-min dynamic (11)C-phenytoin PET studies, including online arterial samplin

209 erone (DHT) from testosterone in response to phenytoin (Ph), interleukin-1 (IL-1), and epidermal grow

210 Among old-generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone are potent induc

211 Among old generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone induce the activ

212 as trimethoprim, triamterene, carbamazepine, phenytoin, phenobarbital, and primidone, may increase th

213 ved for the traditional antiepileptic agents phenytoin, phenobarbital, and valproate.

214 for 30 days or longer with anticonvulsants (phenytoin, phenobarbital, carbamazepine, or a combinatio

215 tive index in mice than the prototype drugs, phenytoin, phenobarbital, valproate, and ethosuximide.

216 cally in rodent models for phenobarbital and phenytoin; phenobarbital promoted liver tumours and phen

217 Phenytoin (pht) is an anticonvulsant drug commonly used

218 A common side effect of phenytoin (PHT) therapy is connective tissue hyperplasia

219 Phenytoin (PHY), a widely used antiepileptic drug, is a

220 try allows one to assess the ionized form of phenytoin (pKa~8.2) that corresponds to a negatively mon

221 eceived hydrocortisone (160 mg/day)/placebo, phenytoin/placebo, both medications together, or placebo

222 adout appears to be the diffusion of ionized phenytoin preceded by comparatively rapid deprotonation

223 The anticonvulsant phenytoin preferentially blocked the sustained phase, bu

224 AAs (including carbamazepine, phenobarbital, phenytoin, primidone, sulfasalazine, triamterene, and tr

225 In addition, fosphenytoin, a water-soluble phenytoin prodrug with a number of advantages over intra

226 In one subpopulation of cells, phenytoin produced a partial, higher affinity block (IC(

227 In other cells, phenytoin produced complete, but lower affinity, blockad

228 tiepileptic drugs tested in this model, only phenytoin proved ineffective, while valproate, gabapenti

229 demonstrate here that oral administration of phenytoin provides long-term (up to 180 days) protection

230 These observations demonstrate that phenytoin provides long-term protection of CNS axons and

231 crofluidic device, we demonstrate assays for phenytoin ranging in concentration from 75 to 1000 nM in

232 In this study, prophylaxis with phenytoin reduced the frequency of such seizure activity

233 agents, including valproate, gabapentin and phenytoin, reduced the ability of astrocytes to transmit

234 ays of the Cyp2c29 promoter to delineate the phenytoin-response activity to a phenytoin-responsive mo

235 lineate the phenytoin-response activity to a phenytoin-responsive module located at -1371 kb upstream

236 The phenytoin-responsive module, consisting of two motifs of

237 Withdrawal of phenytoin resulted in acute exacerbation, accompanied by

238 However, these doses of phenytoin resulted in significant (51.6% of control) sup

239 (including samples from donors treated with phenytoin) revealed a general absence of CYP24A1 mRNA.

240 Together, phenytoin, rifampicin, and monocrotaline caused further

241 Phenytoin, rifampicin, and monocrotaline produced injury

242 Prior administration of BU and/or phenytoin significantly alters exposure to CY and HCY.

243 lar to that observed for the anticonvulsants phenytoin (slowly binds to the fast-inactivated state) a

244 ma kinetic model for quantification of (11)C-phenytoin studies in humans.

245 te model for quantification of dynamic (11)C-phenytoin studies.

246 icle and vehicle, CORT and vehicle, CORT and phenytoin), supporting the interpretations that CORT lev

247 ak for a NIR-fluorescent-labeled analogue of phenytoin that appeared within 2-3 min of sample injecti

248 included the dissociation rate of HSA-bound phenytoin, the rate of capture of free phenytoin by immu

249 er time (benzocaine, phenacetin, metribuzin, phenytoin, thiacloprid, valproic acid).

250 a randomised comparison of phenobarbital and phenytoin to assess the acceptability and efficacy of ph

251 ts from the enzyme-inducers carbamazepine or phenytoin to the noninducing drugs levetiracetam or lamo

252 loss in the optic nerve was also reduced in phenytoin-treated animals, compared to controls.

253 In phenytoin-treated animals, however, the loss of RGCs was

254 of CST axons are lost at 90 and 180 days in phenytoin-treated C57/BL6 mice with EAE.

255 90 days, and only 8% are lost at 180 days in phenytoin-treated C57/BL6 mice with EAE; only 21-29% of

256 (ICP) were also seen less frequently in the phenytoin-treated group compared with the controls (5 an

257 enuated epithelial gingival tissue growth in phenytoin-treated mice and altered the expressions of ma

258 erior gingival tissue overgrowth occurred in phenytoin-treated mice based on gross tissue observation

259 ation into the dorsal columns was reduced in phenytoin-treated mice with EAE compared with untreated

260 gns of cerebral edema in only 2 (22%) of the phenytoin-treated patients compared with 7 (70%) of the

261 status was also significantly enhanced with phenytoin treatment at 90 and 180 days in this model.

262 oride (8) exceeded that of phenobarbital and phenytoin upon oral administration to rats.

263 (adjusted OR = 1.15, 95% CI 1.03-1.29), and phenytoin use (adjusted OR = 2.93, 95% CI 1.04-8.30) wer

264 One had congenital abnormalities caused by phenytoin use by the mother.

265 Phenytoin was effective in aborting SSSE when injected 1

266 Orally delivered phenytoin was effective in protecting neurons in an anim

267 the final UFIDA method, the free fraction of phenytoin was extracted in approximately 100 ms by a mic

268 Phenytoin was the most common antiepileptic drug prescri

269 o for behavioural problems (phenobarbital vs phenytoin) was 0.51 (95% CI 0.16-1.59).

270 Phenobarbital, MK-801, and phenytoin were administered at 1, 2, and 4 hours after i

271 Nifedipine and phenytoin were also tested to further support findings w

272 sion and that the neuroprotective actions of phenytoin were not through CORT alterations.

273 o-salko-to); and decreased concentrations of phenytoin when combined with the Ayurvedic syrup shankha

274 We compare results obtained using phenytoin (which induces cleft lip) and 6-aminonicotinam

275 tiepileptic drugs, such as carbamazepine and phenytoin, which are sodium channel blockers.

276 For lidocaine and phenytoin, which bind preferentially to inactivated Na+

277 in contrast to drugs like carbamazepine and phenytoin, which bind tightly to fast-inactivated states

278 ease was related to elevated serum levels of phenytoin, which had been administered for seizure disor

279 The anticonvulsant, phenytoin, which partially blocks DRG T current, blocked

280 on of PAG and PRF neuronal firing induced by phenytoin with complete seizure blockade is consistent w

281 se of amiodarone, fluconazole, rifampin, and phenytoin with NOACs had a significant increase in adjus

282 "green" synthesis of the antiepileptic drug Phenytoin, with no use of any harmful organic solvent.

283 ic administration of the antiepileptic agent phenytoin would reduce its occurrence.

284 hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal gan