ライフサイエンスコーパス: pheomelanin

1 hair growth produces the red/yellow pigment pheomelanin.

2 the two major melanin classes, eumelanin and pheomelanin.

3 g protein (ASP) results in the production of pheomelanin.

4 and red hair contains 67% eumelanin and 33% pheomelanin.

5 withc in melanin synthesis from eumelanin to pheomelanin.

6 After ultraviolet A irradiation pheomelanin absorbance decreases both in the visible and

7 Reduced production of pheomelanin allows more antioxidants to mitigate the oxi

8 ondestructively differentiates eumelanin and pheomelanin and can be used to quantify melanin distribu

9 the case of pigments containing a mixture of pheomelanin and eumelanin, of which NM is an example, ph

10 and blond hair contain 95% eumelanin and 5% pheomelanin; and red hair contains 67% eumelanin and 33%

11 results demonstrate that both eumelanin and pheomelanin are redox-active, they can rapidly (sec-min)

12 Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interact

13 However, production of pheomelanin, as opposed to its dark alternative, eumelan

14 model would predict a structural motif with pheomelanin at the core and eumelanin at the surface, wh

15 contains approximately 99% eumelanin and 1% pheomelanin, brown and blond hair contain 95% eumelanin

16 lanocytes switch from producing eumelanin to pheomelanin concomitant with the down-regulation of mela

17 We also propose that eumelanin and pheomelanin could be differentiated according to their s

18 nt for md or mg synthesize very little or no pheomelanin depending on Agouti gene background.

19 extended that work for imaging eumelanin and pheomelanin distributions on a subcellular scale, allowi

20 resent differing pigmentation types, such as pheomelanin, eumelanin, and non-pigmented areas within t

21 in and eumelanin, of which NM is an example, pheomelanin formation occurs first with eumelanin format

22 ee times that of pheomelanin in yellow mice, pheomelanin had 3-fold greater specific activity.

23 Pheomelanin has been implicated in the increased suscept

24 is is the first time, to our knowledge, that pheomelanin has been visualized and spatially localized

25 Pheomelanin has weak shielding capacity against ultravio

26 ypes of melanin found in hair--eumelanin and pheomelanin--have been established.

27 Here we show that the distribution of pheomelanin in cells and tissues can be visually charact

28 elanin in black mice was three times that of pheomelanin in yellow mice, pheomelanin had 3-fold great

29 e of pigment synthesized, i.e., eumelanin vs pheomelanin, in mice carrying the black-and-tan mutation

30 duced photoprotection due to less eumelanin, pheomelanin-induced phototoxicity, and lower protection

31 cytes between the production of eumelanin or pheomelanin involve the opposing action of two intercell

32 Pheomelanin is a pink to red version of melanin pigment

33 Therefore, decreased expression of pheomelanin is expected in organisms exposed to severe o

34 strategy in vitro to in vivo with synthetic pheomelanin, isolated melanocytes, and the Mc1r(e/e), re

35 ce suggesting the red/blond pigment known as pheomelanin may elevate melanoma risk through both UV ra

36 ude that UV-irradiated melanin, particularly pheomelanin, photosensitizes adjacent cells to caspase-3

37 the Slc7a11 gene controls the production of pheomelanin pigment directly.

38 that Slc7a11 is a major genetic regulator of pheomelanin pigment in hair and melanocytes, with minima

39 These data suggest that the pheomelanin pigment pathway produces ultraviolet-radiati

40 skin polymorphisms, produces the red/yellow pheomelanin pigment, whereas increasing MC1R activity st

41 that modulate the production of eumelanin or pheomelanin pigments involve the opposing effects of two

42 Due to its bright colour, pheomelanin plays a crucial function in signalling, in p

43 Dopa (5-CysDopa) compose the majority of the pheomelanin polymer.

44 cle between oxidized and reduced states, and pheomelanin possesses a more oxidative redox potential.

45 Nevertheless, genes that directly regulate pheomelanin production have not been described.

46 complex mechanisms involved in the switch to pheomelanin production, and that these modulated genes m

47 stine transport into sut melanocytes reduces pheomelanin production.

48 sed as the ratio of the loge of eumelanin to pheomelanin ratio, with a dosage effect evident: MC1R ho

49 ay to melanoma carcinogenesis and implicated pheomelanin's pro-oxidant properties that act through th

50 This study suggests that pheomelanin's redox-based pro-oxidant activity may contr

51 Photo-oxidation of pheomelanin solutions presents distinctively different s

52 wn melanogenic genes during the eumelanin to pheomelanin switch in murine hair follicle melanocytes a

53 strate that up-regulation of ITF2 during the pheomelanin switch is functionally significant and revea

54 Selective absence of pheomelanin synthesis was protective against melanoma de

55 s the switch between synthesis of red-yellow pheomelanin vs. black-brown eumelanin.

56 s upon hydriodic acid hydrolysis showed that pheomelanin was also not produced by the fungus in vivo.

57 f a significant fraction of the red pigment, pheomelanin, which is characterized by a higher oxidatio

58 o compare the redox properties of human hair pheomelanin with model synthetic pigments and natural eu

59 ility to identify, characterize, and monitor pheomelanin within skin is vital for improving our under

60 This photosensitization is greater for pheomelanin (yellow and red melanin) than for eumelanin