ライフサイエンスコーパス: phlebovirus

1 r to those of viruses belonging to the genus Phlebovirus.

2 nstitute a single novel species in the genus Phlebovirus.

3 strain entirely from cDNA, the first for any phlebovirus.

4 gnificant advance in the study of tick-borne phleboviruses.

5 groups) and from the mosquito/sandfly-borne phleboviruses.

6 tools to detect these genetically divergent phleboviruses.

7 n our understanding of viral pathogenesis of phleboviruses.

8 cribed to date, two new clades of tick-borne phleboviruses, a mononegavirus, and viruses with similar

9 eover, based on the genomic diversity of the phleboviruses and given the low correlation observed bet

10 al and parasitic agents like Bartonella sp., Phleboviruses and Leishmania spp., respectively.

11 mber of the Bunyaviridae virus family (genus Phlebovirus) and is considered to be one of the most imp

12 with other recently characterized tick-borne phleboviruses are described using full-length genome seq

13 Evolutionary insights into the phleboviruses are limited because of an imprecise classi

14 s for future research on not only tick-borne phleboviruses but also all viruses and other pathogens t

15 syndrome virus (SFTSV) is a newly discovered Phlebovirus causing an emerging hemorrhagic fever in Eas

16 Our results suggest a rationale for phlebovirus entry in late endosomes.

17 that of nucleoproteins (NPs) from the genus Phlebovirus (family Bunyaviridae), a group of enveloped

18 Many phleboviruses (family Bunyaviridae) are emerging as medi

19 Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) causes mosquito-borne

20 Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negat

21 Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negat

22 (RVFV) is a negative-sense RNA virus (genus Phlebovirus, family Bunyaviridae) that infects livestock

23 ver virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, has a tripartite negat

24 y fever virus (RVFV), belonging to the genus Phlebovirus, family Bunyaviridae, is endemic to sub-Saha

25 h led to the identification of several novel phleboviruses from previously uncharacterized tick-assoc

26 ights into the structure of the encapsidated phlebovirus genome.

27 i virus (UUKV) is a tick-borne member of the Phlebovirus genus (family Bunyaviridae) and has been wid

28 The Phlebovirus genus (family Bunyaviridae) is composed of a

29 t Valley fever virus (RVFV), a member in the Phlebovirus genus of the family Bunyaviridae, is endemic

30 sion protein was discovered in the unrelated phlebovirus genus, and two unexpectedly divergent envelo

31 mmetry and suggest that other members of the Phlebovirus genus, as well as of the Bunyaviridae family

32 TS virus represents a new lineage within the Phlebovirus genus, distinct from the existing sandfly fe

33 entified the viruses as novel members of the phlebovirus genus.

34 ukuniemi virus, a bunyavirus also within the Phlebovirus genus.

35 osomes, we observed that the conformation of phlebovirus glycoprotein capsomers changes from the nati

36 ever virus (RVFV; family Bunyaviridae, genus Phlebovirus) has a tripartite negative-stranded RNA geno

37 lley fever virus (family Bunyaviridae, genus Phlebovirus) has an antiapoptotic function and affects v

38 FTS virus (SFTSV; family Bunyaviridae, genus Phlebovirus) has caused significant morbidity and mortal

39 Valley fever virus (RVFV), a mosquito-borne phlebovirus, has been detected in Madagascar since 1979,

40 Recently, a number of new tick-borne phleboviruses have been discovered, some of which, like

41 Recently, new tick-borne phleboviruses have emerged, such as severe fever with th

42 These and other phleboviruses have segmented negative-sense RNA genomes

43 ur understanding of how the novel tick-borne phleboviruses hijack cellular machineries to establish i

44 nd functional evidence that the mechanism of phlebovirus-host cell fusion is conserved among genetica

45 ency as RVFV, while infection with the other phleboviruses-i.e., Punta Toro virus, sandfly fever Sici

46 related highly pathogenic Rift Valley fever phlebovirus in humans and domesticated ungulates.

47 us is a newly recognized member of the genus Phlebovirus in the family Bunyaviridae.

48 the last decade, novel tick-borne pathogenic phleboviruses in the family Bunyaviridae, all closely re

49 ever virus (RVFV, family Bunyaviridae, genus Phlebovirus) is a relevant pathogen of both humans and l

50 ever virus (RVFV; family Bunyaviridae, genus Phlebovirus) is an important emerging pathogen of humans

51 nse member of the family Bunyaviridae, genus Phlebovirus, is the causative agent of Rift Valley fever

52 Phlebovirus L, M, and N mRNAs are synthesized from the v

53 r the N, NSs, and GPC mRNAs in three diverse phleboviruses, namely, Rift Valley fever, sandfly Sicili

54 he main difference between potexvirus CP and phlebovirus NP is in their C-terminal extensions, which

55 apsid (N) mRNA of Rift Valley fever virus, a phlebovirus of the Bunyaviridae family, also can effecti

56 s a model system for investigating the genus Phlebovirus of the Bunyaviridae.

57 to vertebrate-infecting viruses in the genus Phlebovirus of the Bunyaviridae.

58 The genus Phlebovirus of the family Bunyaviridae consists of appro

59 Valley fever virus (RVFV), belongs to genus Phlebovirus of the family Bunyaviridae, causes high rate

60 Like other members of the genus Phlebovirus of the family Bunyaviridae, TOSV encodes a n

61 es many properties with viruses in the genus Phlebovirus of the family Bunyaviridae.

62 from the genera Bunyavirus, Tospovirus, and Phlebovirus or Nairovirus.

63 is study contributes to our understanding of Phlebovirus pathogenesis and identifies potential target

64 aused by the RVF virus (RVFV) (Bunyaviridae: Phlebovirus), presents significant threats to global pub

65 RVFV NSm protein is the first identified Phlebovirus protein that has an antiapoptotic function.

66 Phlebovirus proteins are translated from virally transcr

67 Heartland virus (HRTV) is a tick-borne phlebovirus recently described in Missouri that is assoc

68 a convenient model to investigate aspects of phlebovirus replication.

69 Tick-borne phleboviruses represent a growing threat to humans globa

70 The nonhelical appearance of phlebovirus RNP, the heterogeneous approximately 100-kDa

71 Rift Valley fever phlebovirus (RVFV) is a clinically and economically impo

72 ures was found at the ambisense junctions of phlebovirus S RNA segments.

73 ely related to the novel emerging tick-borne phleboviruses severe fever with thrombocytopenia syndrom

74 uses for vaccination studies.IMPORTANCE SFTS phlebovirus (SFTSV) and related tick-borne viruses have

75 SFTS phlebovirus (SFTSV) is an emerging tick-borne bunyavirus

76 Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc,

77 om sand flies, we isolated most of the known Phlebovirus strains that potentially cause human infecti

78 SFTSV and related tick-borne phleboviruses such as Heartland virus are emerging virus

79 emergence of two human-pathogenic tick-borne phleboviruses (TBPVs) (severe fever with thrombocytopeni

80 Tick-borne phleboviruses (TBPVs) have been largely neglected until

81 Uukuniemi virus (UUKV) is a tick-borne phlebovirus that is apathogenic for humans and has been

82 l surveillance for other, similar tick-borne phleboviruses that may represent unrecognized causes of

83 Viral RNA elements that control phlebovirus transcriptional terminations are largely unk

84 minimal fusion requirements of a prototypic phlebovirus, Uukuniemi virus, in an in vitro virus-lipos

85 lop a more precise classification system for phleboviruses, we are attempting to sequence most of the

86 (>99% complete) in the genera Nairovirus and Phlebovirus were also identified and found to be present

87 roteins that are conserved among other known phleboviruses were also identified in proteins of the BH

88 ever virus (RVFV; family Bunyaviridae, genus Phlebovirus), which has a tripartite negative-stranded R

89 n completely fulfilled, we believe that this phlebovirus, which is novel in the Americas, is the caus

90 fever virus (RVFV) is a member of the genus Phlebovirus within the family Bunyaviridae.