ライフサイエンスコーパス: phorbol ester

1 matory lesions after topical applications of phorbol ester.

2 , and displayed translocation in response to phorbol ester.

3 ve to Rol, while retaining responsiveness to phorbol ester.

4 , a mediator of the cell death effect by the phorbol ester.

5 ive C1 domains and has been reported to bind phorbol ester.

6 of the two MRCK isoforms alpha and beta with phorbol ester.

7 tion as well as a weaker initial response to phorbol ester.

8 y 30% at baseline and after stimulation with phorbol ester.

9 ercome by signals bypassing the TCR, such as phorbol ester.

10 in the deltaC1b domain conferred response to phorbol ester.

11 arkers and was not slowed in the presence of phorbol ester.

12 RI or combination of Ca (2)(+) ionophore and phorbol ester.

13 rotein kinase C (PKC)-Ras-Erk signaling with phorbol esters.

14 y inhibit the dephosphorylation triggered by phorbol esters.

15 lation and down-regulation of PKC induced by phorbol esters.

16 n but also as a consequence of activation by phorbol esters.

17 kinase activation and cannot be triggered by phorbol esters.

18 through a heterologous mechanism mediated by phorbol esters.

19 P1 KO cells even after 60 min of exposure to phorbol esters.

20 affinity to diacylglycerol analogs like the phorbol esters.

21 in the absence of chemical inducers such as phorbol esters.

22 ow extracellular calcium and facilitation by phorbol esters.

23 cal structure and the medicinal potential of phorbol esters.

24 second messenger diacylglycerol (DAG) or the phorbol esters.

25 lglycerol and its ultrapotent analogues, the phorbol esters.

26 lglycerol and its ultrapotent analogues, the phorbol esters.

27 ated the levels of isozymes that cannot bind phorbol esters.

28 cytes induced to differentiate by calcium or phorbol esters.

29 europeptide signalling and responsiveness to phorbol esters.

30 d in the absence of promoting agents such as phorbol esters.

31 ubiquitination or endocytosis in response to phorbol esters.

32 0 micromol/L) and phorbol myristate acetate (phorbol ester, 10 micromol/L), and inhibited by H-89 (pr

33 sing ex vivo retinal explants, we found that phorbol ester 12-myristate 13-acetate and insulin-like g

34 surface localization of GLUT1 induced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA

35 -)/Tg.AC mice exposed to the proinflammatory phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)

36 on that is reversed with the addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA,

37 o extracellular stimuli (serum, EGF, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) that

38 an mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a we

39 Forced depletion of Cx43, by tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate, is a

40 y 80%) produced following promotion with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

41 Cleavage was stimulated by phorbol ester (12-O-tetradecanoylphorbol-13-acetate (TPA

42 and current responses to the TRPV4 agonists phorbol ester 4alpha-phorbol 12,13-didecanoate (4alphaPD

43 dulatory domains, including a diacylglycerol/phorbol ester [4beta-phorbol-12, 13-dibutyrate (PDBu)] b

44 ligation of the BCR or after treatment with phorbol esters (a diacylglycerol mimetic).

45 Ba2+, a substitute for Ca2+, and phorbol ester, a mimic for diacylglycerol, have a synerg

46 Using NIH 3T3 cells, we show that phorbol esters, acting through protein kinase C-delta (P

47 the alpha-subtype of PKC as the mediator of phorbol ester action on FR recycling and provide evidenc

48 ignaling versus the chronic hyperactivity of phorbol ester-activated PKC.

49 In Aplysia, there are two major phorbol ester-activated PKCs, Ca2+-activated PKC Apl I a

50 Signal was increased by a phorbol ester activator of glucose transport.

51 otein kinase C activity, whose activation by phorbol ester also promoted ERRalpha protein loss.

52 Activation of PKC by phorbol esters also resulted in phosphorylation of the s

53 ) and erbB2/4-Akt pathways was mimicked by a phorbol ester and blocked by pharmacological inhibition

54 PKCdelta upon stimulation by ligands of the phorbol ester and bryostatin classes.

55 e depressed in mice in vivo and in humans to phorbol ester and calcium ionophore stimulation in vitro

56 re-B cells are inhibited by a combination of phorbol ester and calcium ionophore, agents that bypass

57 ctors could be restored after treatment with phorbol ester and calcium ionophore.

58 gh levels of superoxide when stimulated with phorbol ester and efficiently ingest immunoglobulin (Ig)

59 tained oxidative burst upon stimulation with phorbol ester and fMLP, Gsr-deficient neutrophils displa

60 effects of NADH and NAD+ were mimicked by a phorbol ester and forskolin, respectively.

61 Cells were stimulated with phorbol ester and ionomycin in the presence of brefeldin

62 factor alpha gene expression in response to phorbol ester and ionophore, while signal-responsive gen

63 Phorbol ester and moderate alpha1A-AR stimulation enhanc

64 a and endotoxin) or tumor promoters (such as phorbol ester and okadaic acid), 3-FC suppressed NF-kapp

65 Phorbol ester and RTA transgene induction were used to i

66 tic cycle in EBV-positive AGS/BX1 cells with phorbol ester and sodium butyrate treatment led to a tra

67 s independent of Src and can be triggered by phorbol esters and 2) agonist-stimulated activation in t

68 Although structurally related to phorbol esters and a protein kinase C activator, topical

69 It was shown previously that phorbol esters and angiotensin II and serotonin induce t

70 igand shedding by two commonly used stimuli, phorbol esters and calcium influx.

71 in alpha2-chimaerin that restricts access of phorbol esters and DAG, thereby limiting its activation.

72 PKC isozymes and responsible for binding of phorbol esters and diacylglycerol, interact with the Gol

73 Phorbol esters and Group I metabotropic glutamate recept

74 otection was enhanced by PKD activation with phorbol esters and limited by PKD inhibition with CID756

75 ometry of ~50% and was strongly increased by phorbol esters and protein phosphatase inhibitors, demon

76 enous Pcyt2 were dramatically increased with phorbol esters and reduced by specific PKC inhibitors.

77 cells undergo apoptosis upon treatment with phorbol esters and related analogs, an effect primarily

78 internalization was observed in response to phorbol esters and sphingosine 1-phosphate.

79 itutively active PKCdelta can substitute for phorbol esters and support exocytosis.

80 we used the stimulation of MLP29 cells with phorbol esters and the in vivo activation after partial

81 ta2-chimaerin is that it can be activated by phorbol esters and the lipid second messenger diacylglyc

82 erins possess a C1 domain capable of binding phorbol esters and the lipid second messenger diacylglyc

83 hage-like cells (D-U1) by costimulation with phorbol esters and urokinase-type plasminogen activator.

84 eceptor-mediated signaling pathways (but not phorbol esters) and differs from signaling at plasma mem

85 aB activation induced by lipopolysaccharide, phorbol ester, and cigarette smoke, was also abolished i

86 s (C1A and C1B) that bind diacylglycerol and phorbol ester, and the C2 domain that is responsible for

87 phosphorylated in response to high glucose, phorbol esters, and analogs of cAMP, all key insulin sec

88 promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations.

89 Phorbol ester- and TNF-alpha-dependent activation of the

90 Phorbol esters, anti-immunoglobulin G (anti-IgG), and, s

91 assays to study directional cell migration, phorbol esters are frequently used as a chemotactic agen

92 Phorbol esters are without effect in BHK cells.

93 e second messenger diacylglycerol and of the phorbol esters, are classified as typical (ligand-respon

94 e vesicles for fusion, which are targeted by phorbol esters, are different for the spontaneous and ev

95 if the C1 domains of MRCK are to respond to phorbol ester at concentrations comparable with those th

96 lacental trophoblast cells revealed that the phorbol ester (beta-PMA)-induced phosphorylation of NET

97 We show that stolonidiol binds to the phorbol ester binding site of protein kinase C (PKC), in

98 Phorbol ester binding with C1b alone activates classical

99 th the mutated C1 domains also showed strong phorbol ester binding, albeit modestly weaker than that

100 reduced acidic phospholipid requirement for phorbol ester binding.

101 GRP3 is redistributed upon diacylglycerol or phorbol ester binding.

102 ta C1b (deltaC1b) conferred high potency for phorbol ester binding.

103 e gene encoding Munc13-2, which has calcium-/phorbol ester-binding domains and controls presynaptic f

104 sponse and partially reduced the response to phorbol ester but not to forskolin.

105 rotein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activi

106 deltaC1a and deltaC1b domains potently bound phorbol esters, but the binding of [(3)H]phorbol 12,13-d

107 ent signaling response to diacylglycerol and phorbol esters by protein kinase C (PKC) and by several

108 ctroscopy, we dissect the contribution of DG/phorbol esters (C1 ligand) and PS in driving the associa

109 -delta, and -epsilon) were down-regulated by phorbol ester, cells remained responsive to FGF2 with Er

110 We also show that the affinity for phorbol ester-containing membranes is 2 orders of magnit

111 affinity of the C1b domain for DAG- (but not phorbol ester-) containing membranes.

112 binds to the NMDA receptor NR2A subunit in a phorbol ester-dependent manner.

113 The diacylglycerol (DG)/phorbol ester-dependent translocation of conventional pr

114 sesses Rac-GAP activity and a C1 domain with phorbol ester/diacylglycerol-binding capability.

115 Interestingly, phorbol esters did not accelerate endocytosis of axonal

116 ab downregulates cell-surface CD33 by 80% in phorbol-ester differentiated U937 cells, at concentratio

117 diacylglycerol (DAG) signaling pathways with phorbol esters dramatically enhances Ca2+-triggered exoc

118 ty-based lymphoma-1 cells are treated with a phorbol ester during S phase of the cell cycle.

119 l-length RasGRP2 with the mutated C1 domain, phorbol ester enhanced the ability of the mutated RasGRP

120 equired 50-100-fold higher concentrations of phorbol ester for induction of membrane translocation.

121 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Ep

122 fibrosarcoma cells and that proinflammatory phorbol esters further enhanced this effect.

123 inases are major targets for tumor-promoting phorbol esters, G protein-coupled receptors, and activat

124 mediated by endogenous CD44 in response to a phorbol ester gradient.

125 ession is essential for chemotaxis towards a phorbol ester gradient.

126 Na(+)/H(+) exchange activity in response to phorbol esters, growth factors or protein phosphatase in

127 PKC) activators including diacylglycerol and phorbol ester have previously been reported to increase

128 isplayed properties indistinguishable from a phorbol ester in a proliferation/attachment assay.

129 that the activation of viral replication by phorbol ester in latently infected monocytic cells requi

130 he recognition module for diacylglycerol and phorbol esters in protein kinase C, Ras guanine nucleoti

131 decreased effectiveness of DG compared with phorbol esters in retaining the C1 domain on membranes c

132 IGF-1 and phorbol ester increased hBVR/PKCdelta binding; hBVR was

133 enylephrine or direct activation of PKC with phorbol ester increased HERG channel protein abundance a

134 ng cells expressing low levels of Wnt5A with phorbol ester increased Snail expression inhibiting PKC

135 Angiotensin II and phorbol ester increased superoxide/H2O2 generation in PM

136 on of a melanocyte-lineage signature, drives phorbol ester-independent growth in vitro, and promotes

137 ular production of HOCl when stimulated with phorbol ester, indicating that CF neutrophils had the no

138 However, in p53-null K562 cells, phorbol esters induce miR-34a expression independently o

139 ) as well as the protein kinase C activator, phorbol ester, induce rapid phosphorylation of hSphK2 wh

140 In addition, PKC activation by phorbol ester induced agonist-independent KOPR phosphory

141 ng RasGRP3 but not in control cells, whereas phorbol ester induced phosphorylation in both.

142 In addition, phorbol esters induced a Shh-regulated reporter gene.

143 Enzastaurin specifically inhibits phorbol ester-induced activation of PKC isoforms, as wel

144 e known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nu

145 s after PE stimulation, but had no effect on phorbol ester-induced CPI-17 phosphorylation.

146 sphorylation sites (S396A, S402A) were used, phorbol ester-induced desensitization of the calcium res

147 CRYP-alpha was downregulated during the phorbol ester-induced differentiation of BM2 cells.

148 Ets-2 also increased dramatically following phorbol ester-induced differentiation of the v-Myb-trans

149 mechanism to protect cells from ischemia and phorbol ester-induced down-regulation of channel conduct

150 orter degradation fragments and to increased phorbol ester-induced down-regulation, further supportin

151 In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCa

152 urnover is further slowed in the presence of phorbol ester-induced ERK activation, resulting in Mcl-1

153 SSeCKS suppressed phorbol ester-induced ERK1/2 activity only if it encoded

154 a cells was associated with constitutive and phorbol ester-induced expression and secretion of active

155 this report, we show that PKCdelta mediates phorbol ester-induced G1 arrest in lung adenocarcinoma c

156 a unique and critical role in wound healing, phorbol ester-induced hyperplasia, and tumor development

157 UNX-1-containing multiprotein complexes from phorbol ester-induced L8057 murine megakaryoblastic cell

158 miR-34a is strongly up-regulated during phorbol ester-induced megakaryocyte differentiation, but

159 Conversely, KLF4 knockdown blocked phorbol ester-induced monocyte differentiation.

160 armacologic inhibition of Akt also abrogated phorbol ester-induced O(2)(-) production, which was unaf

161 Phorbol ester-induced sequential phosphorylation of both

162 Mouse CD163 resisted endotoxin- and phorbol ester-induced shedding, and ex vivo analysis of

163 n attenuates P2X(7) agonist-induced, but not phorbol ester-induced, ERK1/2 phosphorylation.

164 Cyclopropylmethanol inhibited phorbol-ester-induced PKCdelta activity, but failed to d

165 ely, activation of myosin II or treatment of phorbol ester induces macropinocytosis in the axons and

166 domains of the atypical PKC members are DAG/phorbol ester-insensitive.

167 D2 confers PLD activity that is activated by phorbol ester, ionomycin, and okadaic acid.

168 C (PKC) attendant to prolonged activation by phorbol esters is a widely described property of this ke

169 collagen XVII shedding was not stimulated by phorbol esters, known activators of ADAM17, (b) constitu

170 ressing the IL-1 family member, IL-1F6, with phorbol ester leads to an inflammatory condition with ma

171 d stimulation of protein kinase C (PKC) with phorbol esters led to sequestration of recycling endosom

172 rticipation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate

173 ponse, however, does not distinguish between phorbol ester-like and bryostatin-like behavior.

174 eration and cell attachment assays displayed phorbol ester-like and/or toxic behavior, including WN-8

175 iated TGF-beta activation can be enhanced by phorbol esters, likely because of the increased activity

176 The phorbol ester-mediated dephosphorylation of the hydropho

177 etic depletion of RINCK had no effect on the phorbol ester-mediated down-regulation and, additionally

178 n of PKC occurs independently of the classic phorbol ester-mediated down-regulation: genetic depletio

179 ucture-function studies of this inhibitor of phorbol ester-mediated ornithine decarboxylase induction

180 infection of fibroblast cells and following phorbol ester-mediated reactivation from a latently infe

181 TSP1 causes a significant increase in phorbol ester-mediated superoxide generation from differ

182 Phorbol ester mimicked the effect of M-CSF, activating E

183 PKC activation by phorbol ester mimicked Wnt5A effects, and Wnt5A treatmen

184 For these studies, we examined phorbol ester modulation of GABA(A) and glycine receptor

185 When stimulated with phorbol ester, nonlytic TIL bind purified ICAM-1 equival

186 Moreover, treatment with a phorbol ester or a calmodulin inhibitor induces Pmel17 s

187 We show here that phorbol ester or angiotensin II-induced proteolytic rele

188 sed cutaneous inflammation following topical phorbol ester or CFA injection.

189 out 30%), but increases after application of phorbol ester or during PTP.

190 racellular release of superoxide elicited by phorbol ester or formyl-methionyl-leucyl-phenylalanine (

191 Treatment of cells with phorbol ester or histone deacetylase inhibitors triggere

192 glucagon-like peptide 1 and KCl, but not by phorbol ester or nerve growth factor.

193 rved that the remnant induced in response to phorbol ester or platelet-derived growth factor has a re

194 a release upon pro-inflammatory priming with phorbol ester or Toll-like receptor stimulation.

195 ingestible beta-glucan-containing particles, phorbol esters or live yeast hyphae.

196 nated following activation induced by either phorbol esters or natural agonists.

197 and BCL2A1, mediate the apoptotic effect of phorbol esters or the chemotherapeutic agent etoposide i

198 Phorbol esters or the engagement of the T cell antigen r

199 tor molecules constitutively, in response to phorbol esters or through bystander activation by innate

200 with mitochondria following stimulation with phorbol esters or, in L6 myocytes, with insulin via a me

201 i of ectodomain cleavage--hypertonic stress, phorbol ester, or activation of G-protein-coupled recept

202 y, spermatozoa exposed to calcium ionophore, phorbol ester, or H(2)O(2) exhibited superoxide anion pr

203 n with vasoactive intestinal peptide (V) and phorbol ester (P) synergistically activated viral infect

204 The phorbol ester PDBu, which blocks ClC-3-mediated Cl- curr

205 o study the complex regulation of NCC by the phorbol ester (PE) 12-O-tetradecanoylphorbol-13-acetate

206 A phorbol ester phorbol 12,13-dibutyrate (PDBu) (a diacylg

207 By activating PKC with the phorbol ester phorbol 12,13-dibutyrate (PDBu) or a natur

208 SOCs stimulated by CPA, BAPTA-AM and the phorbol ester phorbol 12,13-dibutyrate (PDBu) were reduc

209 inhibitor chelerythrine and activated by the phorbol ester phorbol 12,13-dibutyrate (PDBu), the diacy

210 f IL-23R was induced by stimulation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), but

211 s in which PKC was directly activated by the phorbol ester phorbol 12-myristate 13-acetate (PMA).

212 Epidermal growth factor or the phorbol ester phorbol 12-myristate 13-acetate caused rap

213 d muscarinic receptor mimetic carbachol, the phorbol ester phorbol 12-myristate 13-acetate, the Ca(2+

214 on in B95-8 marmoset lymphoblastoid cells by phorbol ester phorbol-12-myristate-13-acetate (TPA).

215 Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces

216 lasts displayed increased relative basal and phorbol ester (phorbol 12-myristate 13-acetate)-induced

217 PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced

218 ort that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-different

219 Phorbol ester [phorbol 12-myristate 13-acetate (PMA)] tr

220 increase in NP(o) of SOCs stimulated by the phorbol ester, phorbol 12,13-dibutyrate (PDBu) in inside

221 ome-like structures after stimulation with a phorbol ester, phorbol-12,13-dibutyrate (PDBu).

222 ort induced by unprocessed PKCs activated by phorbol ester, PKCalpha-CT directly drives HDAC cytosoli

223 l receptor (TCR) cross-linking antibodies or phorbol ester plus ionomycin.

224 r187 in the enhancement of exocytosis by the phorbol ester PMA (phorbol 12-myristate 13-acetate).

225 In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a ph

226 activation of protein kinase C (PKC) by the phorbol ester PMA has been shown to down-regulate cell s

227 al transactivator region is inducible by the phorbol ester PMA, a potent activator of the protein kin

228 The typical phorbol ester PMA, in contrast to bryostatin 1, had no e

229 In contrast, the PKC-activating phorbol ester PMA, often used as a strong inducer of ADA

230 promoter activity was stimulated by IBMX and phorbol ester (PMA) in Raw264.7 monocytes, but only by I

231 In this study, we show that phorbol ester (PMA)-induced internalization of the LPA(1

232 regulated in a rapid and transient manner in phorbol ester (PMA)-stimulated B-1a cells, whereas cycli

233 ciates upon activation of gene expression by phorbol ester (PMA).

234 Activating PKC with the phorbol ester, PMA, enhanced Ca(2+) entry, and potentiat

235 Phorbol esters predominantly activate ADAM17, thereby tr

236 Although phorbol esters promote a strong apoptotic response in LN

237 following exposure to a tumor initiator and phorbol ester promoter.

238 The non-tumor-inducing phorbol esters prostratin and 12-deoxyphorbol-13-phenyla

239 upon sustained stimulation (30-60 min) with phorbol esters, protein kinase C (PKC) alpha and betaII

240 As the predominant cellular receptor for phorbol esters, protein kinase C (PKC) is assumed to pla

241 Here, we show that the nonkinase phorbol ester receptor alpha1-chimerin is present in den

242 ucleotide exchange factor and diacylglycerol/phorbol ester receptor expressed in mast cells (MCs) and

243 Like other DAG/phorbol ester receptors, including protein kinase C isoz

244 we found that short-term exposure of CAFs to phorbol esters reduced the number of stress fibers and t

245 array using RNAi depletion of diacylglycerol/phorbol ester-regulated PKCs.

246 Optimal stimulation of the u-PAR promoter by phorbol ester required this enhancer.

247 in the 9-kb promoter did not affect Dex and phorbol ester responses.

248 ntial homology to that of the diacylglycerol/phorbol ester-responsive C1 domains and has been reporte

249 endently of p53 by activating an alternative phorbol ester-responsive promoter to produce a longer pr

250 Cepsilon (PKCepsilon), a diacyglycerol- and phorbol ester-responsive serine-threonine kinase, has be

251 hus, PS drives the initial encounter, and DG/phorbol esters retain the domain on membranes.

252 Thus, the phorbol esters selectively regulate the activity-depende

253 Compared with the DAG/phorbol ester-sensitive C1 domains, the rim of the bindi

254 PMA and active phorbol esters stimulate the proliferation of various tu

255 Additionally, phorbol ester stimulated the production of abnormal PrP

256 In this study, two distinct models, phorbol ester-stimulated adhesion of U937 monocytoid cel

257 ion is integrin mediated, but in contrast to phorbol ester-stimulated adhesion, it is not dependent o

258 ping yet distinct from clusters based on the phorbol ester-stimulated B cell reactivation time course

259 during de novo fibroblast infection and upon phorbol ester-stimulated B cell reactivation, highlighti

260 ase activities were successfully detected in phorbol ester-stimulated neutrophils and eosinophils usi

261 CAT-1 ubiquitination and endocytosis in phorbol ester-stimulated porcine aorthic endothelial and

262 ADAM17, even though ADAM17 is essential for phorbol ester-stimulated shedding of these EGFR-ligands.

263 nts, only the C1B domain is required for the phorbol ester-stimulated translocation of PKCdelta to ot

264 h NHERF-1 in live cells that is triggered by phorbol ester stimulation and, importantly, differs stri

265 rsistent activation of PKC family members by phorbol ester stimulation in cells leads to phosphorylat

266 We show that complexinI/II deficiency or phorbol ester stimulation indeed affects responses to hy

267 Finally, phorbol ester stimulation of PEA-15-null lymphocytes res

268 ancer cells undergo apoptosis in response to phorbol ester stimulation via PKCdelta-mediated release

269 orm in controlling the induction of genes by phorbol ester stimulation, whereas PKCepsilon predominan

270 in cells growing in serum or in response to phorbol ester stimulation.

271 a) had no apparent effect on the response to phorbol esters, suggesting that the specific position of

272 D (PKD) is a family of novel diacylglycerol/phorbol ester targets that regulate many important cellu

273 latent virus can occur by treatment with the phorbol ester tetradecanoyl phorbol acetate (TPA) or wit

274 the second messenger diacylglycerol and the phorbol esters that is yet poorly characterized, particu

275 nducing agents, like activating cytokines or phorbol esters that stimulate host cell signal transduct

276 However, when treated with phorbol ester, the conjugation frequency of nonlytic TIL

277 Upon cell stimulation with phorbol ester, the NF-kappaB soluble complex exchanges F

278 nger sn-1,2-diacylglycerol (DAG) and for the phorbol esters, the C1 domain has been an important targ

279 Consistent with the ability of phorbol ester to induce translocation of the full-length

280 stitutions was reduced in cells treated with phorbol ester to the levels detected in nonstimulated ce

281 veral JNK upstream activators, including the phorbol ester TPA, anisomycin and MAPK kinase kinase-1 (

282 n transcription in 8-bromo-cAMP, insulin and phorbol ester-treated cells.

283 cell rounding and/or decreased apoptosis in phorbol ester-treated LNCaP, LNCaP-C4-2, and MAT-LyLu pr

284 Inactivation of transport activity by phorbol ester treatment of intact platelets relocates SE

285 for APP when TACE activity was enhanced via phorbol ester treatment or if APP was modified such that

286 trigger compensation by the other form, and phorbol ester treatment rescued the endocytotic activity

287 Our results show that phorbol ester treatment stimulated the formation of pall

288 nd impaired stratum corneum thickening after phorbol ester treatment.

289 d enhanced ubiquitination of mutant PKC upon phorbol ester treatment.

290 1 HIR fibroblast cells more than insulin and phorbol ester treatment.

291 down of PHLPP expression reduces the rate of phorbol ester-triggered dephosphorylation of the hydroph

292 mbrane-sensing role of the C2 domain, causes phorbol ester-triggered redistribution of PKCalpha to ot

293 The phorbol ester tumor promoter induced higher mitogenic an

294 pharmacological differences with the typical phorbol ester tumor promoters.

295 mulated by growth factors or tumor-promoting phorbol esters, we analyzed its role in amino acid-depen

296 lastic and inflammatory responses to topical phorbol ester were significantly suppressed, suggesting

297 A 10 min application of either 5-HT or phorbol ester, which activates PKC, produced persistent

298 e protein kinase C pathway by treatment with phorbol ester, which has been shown previously to result

299 active compounds were identified, including phorbol esters, which likely act through protein kinase

300 lycerol-binding site, such as bryostatin and phorbol esters, which produce prolonged down-regulation,