ライフサイエンスコーパス: phorbol ester receptor

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1 lso suggest that RasGRP4 is a diacylglycerol/phorbol ester receptor.

2 RasGRP thus represents a novel, non-kinase phorbol ester receptor.

3 he intracellular localization of these novel phorbol ester receptors.

4 of both muscarinic cholinergic receptors and phorbol ester receptors.

5 Here, we show that the nonkinase phorbol ester receptor alpha1-chimerin is present in den

6 nted expression of the high affinity non-PKC phorbol ester receptor and Ras activator RasGRP1 in mous

7 Moreover, the novel phorbol ester receptors are also subject to subcellular

8 The novel phorbol ester receptor beta2-chimaerin is a Rac-GAP prot

9 ly regulated by phorbol esters and that each phorbol ester receptor class has distinct pharmacologica

10 identification of selective ligands for each phorbol ester receptor class represents an important ste

11 ependent, guanine nucleotide exchange factor/phorbol ester receptor (designated RasGRP4) that is requ

12 ucleotide exchange factor and diacylglycerol/phorbol ester receptor expressed in mast cells (MCs) and

13 g structural motif for design of ligands for phorbol ester receptor family members.

14 We found that PKD is a high-affinity phorbol ester receptor for a range of structurally and f

15 hat RasGRP3 functions as an endothelial cell phorbol ester receptor in a pathway whose stimulation pe

16 that RasGRP1 is an additional diacylglycerol/phorbol ester receptor in epidermal keratinocytes and su

17 These novel "nonkinase" phorbol ester receptors include chimaerins (a family of

18 Like other DAG/phorbol ester receptors, including protein kinase C isoz

19 We conclude that PKD is a high-affinity phorbol ester receptor; its lipid requirements for ligan

20 Last, the discovery of novel phorbol ester receptors lacking kinase activity allows u

21 The phorbol ester receptors, protein kinase C (PKC) and beta

22 s of the binding of PKC ligands to the novel phorbol ester receptor RasGRP.

23 The expansion of the family of phorbol ester receptors strongly suggests a potential fo

24 ting both protein kinase C (PKC) and non-PKC phorbol ester receptors such as RasGRP3.

25 SC 631939 and NSC 631941 bound to RasGRP3, a phorbol ester receptor that directly links diacylglycero

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