ライフサイエンスコーパス: phosphatase

1 ously expressed cytoplasmic protein tyrosine phosphatase.

2 Calcineurin is an essential Ca(2+)-dependent phosphatase.

3 The dephosphorylation requires a PPP-family phosphatase.

4 tor of calcineurin, a well-characterized tau phosphatase.

5 iveness and drug sensitivity of the anchored phosphatase.

6 ilon is activated by the PP2A/PR61varepsilon phosphatase.

7 sociated with reduced expression of alkaline phosphatase.

8 target subunit-1 (MYPT1) as an eNOS(pThr497) phosphatase.

9 member of the intracellular serine/threonine phosphatases.

10 th 15-60-fold selectivity across a series of phosphatases.

11 volutionary and structural relatives of PP2C phosphatases.

12 that are interconverted by lipid kinases and phosphatases.

13 tivation by inhibiting PP2C.D family protein phosphatases.

14 which are degraded by cellular and secreted phosphatases.

15 ession via the induction of dual-specificity phosphatase 1 (DUSP1), which dephosphorylates and inacti

16 (c-FOS, encoded by Fos) and dual-specificity phosphatase 1 (DUSP1).

17 ology domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) as a regulatory phosphatase that

18 ory subunit 1A (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor; however, its role in tumo

19 ka1 C-terminal domain (CTD) recruits protein phosphatase 1 (PP1) to kinetochores to promote timely an

20 , we investigated the interaction of protein phosphatase 1 (PP1) with the SR protein splicing factor

21 cificity of the catalytic subunit of protein phosphatase 1 (PP1c) is dictated by PP1c-interacting pro

22 homology region 2 domain-containing tyrosine phosphatase 1 (SHP-1) along with the T. cruzi Tc24 antig

23 which recruits the alpha-isoform of protein phosphatase 1 catalytic subunit (PP1alpha) and eIF2alpha

24 , increased mitogen-activated protein kinase phosphatase 1 expression, and increased glucocorticoid r

25 osphate lyase 1, and sphingosine-1-phosphate phosphatase 1 in normal human liver and cirrhotic liver

26 d the expression and localization of protein phosphatase 1 regulatory inhibitor subunit 11 (PPP1R11,

27 Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a poten

28 augments the expression of dual specificity phosphatase 1, impairs the activity of mitogen-activated

29 k5), glycogen synthase kinase 3beta, protein phosphatase 1, or protein phosphatase 2A, but reduces p3

30 phorylation by kinetochore-localized protein phosphatase 1, which allows Cdc20 to activate the APC/C.

31 ein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1).

32 tion-dependent mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (

33 the Src homology region 2 domain-containing phosphatase-1 (SHP-1) and limits the activation of MAPK

34 ding Src homology region 2 domain-containing phosphatase-1 (SHP-1) and TXNIP (thioredoxin-interacting

35 hatase (MP) holoenzyme consisting of protein phosphatase-1 catalytic subunit (PP1c) and MP target sub

36 s patients, mitogen activated protein kinase phosphatase-1 messenger RNA levels were down-regulated.

37 Inhibiting protein phosphatase-1 through the overexpression of a constituti

38 3 (A20) and mitogen activated protein kinase phosphatase-1 were determined in neutrophils and periphe

39 We show that AR recruits protein phosphatase 1alpha (PP1alpha), resulting in P-TEFb mobil

40 into hepatocytes to inhibit protein-tyrosine phosphatase 1B (PTP1B) activity, which acts to suppress

41 in via its substrate protein phosphotyrosine phosphatase 1B (PTP1B), and the relevance of this pathwa

42 rabidopsis thaliana) Shewanella-like protein phosphatase 2 (AtSLP2) is a bona fide Ser/Thr protein ph

43 iated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation o

44 The Src homology domain containing phosphatase 2 (SHP2) and the three-membered family of ph

45 rosine phosphatase (VE-PTP) and Src homology phosphatase 2 (SHP2), both of which are implicated in va

46 J-1 reduced Src homology 2 domain-containing phosphatase 2 phosphatase activity by scavenging reactiv

47 Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase that inhibi

48 eracts with Src homology domain 2-containing phosphatase-2 (SHP-2), and SHP-2 down-regulation via sil

49 Here, we show that protein phosphatase 2A (PP2A) acts as opsin phosphatase in both

50 Protein phosphatase 2A (PP2A) is a member of the intracellular s

51 Protein phosphatase 2A (PP2A), YAP, Src family tyrosine kinases,

52 to be mediated by recruitment of the protein phosphatase 2A B' (PP2A B').

53 T166 phosphorylation is regulated by protein phosphatase 2A but not by the Sds23-PP6 pathway.

54 Protein phosphatase 2A mediated the reduction in NF-kappaB trans

55 ase 3beta, protein phosphatase 1, or protein phosphatase 2A, but reduces p35 subunit of Cdk5.

56 Protein phosphatase-2A (PP2A) is an abundant serine/threonine ph

57 Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates

58 Dual-specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly

59 sphoenolpyruvate carboxykinase and glucose-6-phosphatase, above the levels in control livers.

60 hylated tail and perturbing/inactivating the phosphatase active site.

61 Chlamydomonas GPD2 showed both reductase and phosphatase activities in vitro and it can work as a bif

62 ies of the bifunctional 5-InsP7 kinase/InsP8 phosphatase activities of full-length diphosphoinositol

63 Moreover, we report that InsP8 phosphatase activities of PPIP5Ks are strongly inhibited

64 We hypothesize that the reductase and phosphatase activities of PSP-GPD multidomain enzymes ma

65 only tyrosine phosphatase activity, has dual phosphatase activities, and both the N- and C-terminal d

66 8(MAPK) determines signal amplitude, whereas phosphatase activity affects both signal amplitude and d

67 e found an inverse relationship between root phosphatase activity and AM colonization in field-collec

68 esulting in significantly increased alkaline phosphatase activity and calcium deposition of encapsula

69 cleaved by calpain-2, which inactivates its phosphatase activity and generates stable breakdown prod

70 R306, of EYA1 are essential for its in vitro phosphatase activity and in vivo function during Drosoph

71 competition, however, AM colonization, root phosphatase activity and N2 fixation increased in the N2

72 mains of Pah1 are required for phosphatidate phosphatase activity and the in vivo function of the enz

73 c homology 2 domain-containing phosphatase 2 phosphatase activity by scavenging reactive oxygen speci

74 the N2 fixer with high N2 fixation and root phosphatase activity grew best on organic P, whereas the

75 tion uncover a novel mechanism whereby lipid phosphatase activity in the nucleus can regulate mammali

76 nteraction with AtMIA40 is necessary for the phosphatase activity of AtSLP2 and is dependent on the f

77 steine residue, which inhibited the tyrosine-phosphatase activity of SHP-1.

78 oadly conserved mechanism that regulates the phosphatase activity of the largest family of bifunction

79 tations in these allosteric clusters altered phosphatase activity with changes in kcat/KM ranging fro

80 ulation of organic acids, enhanced secretory phosphatase activity, and depletion of ATP in overexpres

81 hich has been reported to have only tyrosine phosphatase activity, has dual phosphatase activities, a

82 hanced differentiation indicated by alkaline phosphatase activity, mineral deposition, and transcript

83 rovascular integrity by enabling VEC-related phosphatase activity, thereby preventing vascular leak d

84 iptional coactivators with intrinsic protein phosphatase activity.

85 ts SRC basal activation independently of its phosphatase activity.

86 duced type 1 collagen secretion and alkaline phosphatase activity.

87 ose production despite the loss of glucose-6-phosphatase activity.

88 ority of them stained intensely for alkaline phosphatase activity.

89 of the Ciona intestinalis voltage-sensitive phosphatase, against experimental data.

90 ion was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotr

91 ne, encoding the tissue-nonspecific alkaline phosphatase (ALP) enzyme.

92 prostate-specific antigen (PSA) and alkaline phosphatase (ALP), as well as the correlation of PSA cha

93 f both carboxylesterases (CESs) and alkaline phosphatases (ALPs).

94 ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme expressed in bone, teeth, liver,

95 It is caused by the deficiency of glucose-6-phosphatase, an enzyme which catalyses the final step of

96 termined crystal structures containing the 5-phosphatase and a proximal region adopting a C2 fold.

97 Both the phosphatase and C2 domains bind phosphatidylserine lipid

98 Of 868 phosphatase and kinase genes assayed, we discovered 79 w

99 e collective data indicate that VHR is a FAK phosphatase and participates in regulating the formation

100 ession is associated with phosphorylation of phosphatase and tensin homolog (PTEN) at residues Ser380

101 We find here, using the phosphatase and tensin homolog (PTEN) pseudogene as a mo

102 endent p38 phosphorylation, higher levels of phosphatase and tensin homolog (PTEN), and diminished Ak

103 s resulted in Zn(2+)-mediated degradation of phosphatase and tensin homolog (PTEN), which impaired in

104 nesin-1 whereas mitochondrial damage induces Phosphatase and Tensin Homolog (PTEN)-induced Putative K

105 aR trafficking and localization, we define a phosphatase and tensin homolog (PTEN)-regulated checkpoi

106 ot analyses showed that the loss of LKB1 and phosphatase and tensin homolog deleted on chromosome 10

107 regulation of the inositol phosphatase PTEN (phosphatase and tensin homolog) as primarily responsible

108 o insulin, caused by altered IRS-1 and PTEN (phosphatase and tensin homologue on chromosome 10) activ

109 fibromas, a cutaneous manifestation of PTEN (phosphatase and tensin homologue) hamartoma-tumor syndro

110 Here we show a function of Pten (phosphatase and tensin homologue) in quiescent SCs.

111 are associated with a unique combination of phosphatase and transactivation activities.

112 bles through substrate-triggered movement of phosphatase and transferase domains creating a solvent i

113 and 3 are Mg(2+)-dependent phosphatidic acid phosphatases and catalyze the penultimate step of triacy

114 itional substrates for related S. cerevisiae phosphatases and describe the overall phosphoproteomic c

115 are the roles of two outer-kinetochore bound phosphatases and find that BubR1-associated PP2A, unlike

116 ive stress and oxidation of protein tyrosine phosphatases, and ameliorated activation of peroxisome p

117 te modification of siRNAs protects them from phosphatases, and improves silencing activity.

118 ved inorganic phosphorus (DIP), and alkaline phosphatase (AP) has been the major research focus as a

119 , hypocotyl segments overexpressing a PP2C.D phosphatase are specifically impaired in auxin-mediated

120 However, Tap42-associated phosphatases are required only under nitrogen limitation

121 ression of tartrate-sensitive prostatic acid phosphatase as a broadly acting ectonucleotidase.

122 4 (phosphatidylinositol (3,5)-bisphosphate 5-phosphatase) as significantly up-regulated after ES trea

123 that CD45 exclusion shifts the local kinase-phosphatase balance to favor TCR phosphorylation.

124 protegerin (OPG), and bone-specific alkaline phosphatase (BALP) serum levels were determined by enzym

125 ow that PTEN also functions as a PI(3,4)P2 3-phosphatase, both in vitro and in vivo.

126 phorylation, we investigated the role of the phosphatase calcineurin (CaN) using electrophysiological

127 Classical protein-tyrosine phosphatases can exhibit substrate specificity in vivo b

128 te carboxykinase 1 (PCK1), and the glucose-6-phosphatase catalytic subunit (G6PC).

129 eaction kinetics of calf intestinal alkaline phosphatase (CIAP) immobilized in benzophenone-modified

130 he primary-and likely sole-S. cerevisiae PDC phosphatase, closing a key knowledge gap about the regul

131 bunit (PP1alpha) and eIF2alpha to assemble a phosphatase complex catalyzing eIF2alpha dephosphorylati

132 hrough counteracting the STRIPAK(SLMAP) PP2A phosphatase complex.

133 PP2C phosphatases control biological processes including stre

134 Expression of wild-type, but not 5-phosphatase-dead, INPP5E restored TZ molecular organizat

135 the coiled coil of one WipA molecule and the phosphatase domain of another.

136 ted by the CABIT modules, which bound to the phosphatase domain of SHP-1 and promoted or stabilized o

137 allus voltage-sensitive phosphatase with the phosphatase domain removed and a circularly permuted GFP

138 sidue in the substrate binding pocket of the phosphatase domain that confers specificity for phosphop

139 lts in significant structural changes in the phosphatase domain.

140 We show that the X-linked MAPK phosphatase DUSP9 is upregulated in female compared to m

141 Dual specificity phosphatases (DUSPs) inactivate ERK 1/2 through dephosph

142 that ANXA2 forms a complex with VEC and its phosphatases, EC-specific protein tyrosine phosphatase (

143 appended to an APE2 endonuclease/exonuclease/phosphatase (EEP) catalytic core.

144 rupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2

145 -specific phosphocholine/phosphoethanolamine phosphatase enriched in mineralizing cells and within MV

146 otope ratios of phosphate in vegetation, and phosphatase enzyme activity in soil to shed light on pot

147 Phosphatase expression is also spatially regulated in vi

148 ) then expels the Cdk1-cyclin B antagonistic phosphatase Flp1/Clp1 from the SPB.

149 , this structure revealed a serine/threonine phosphatase fold that unexpectedly targets tyrosine-phos

150 to envelope stress; CpxA is a sensor kinase/phosphatase for CpxR, a response regulator.

151 cing target clustering and exclusion of CD45 phosphatase from the synapse.

152 ate free d-ribulose generated by promiscuous phosphatases from d-ribulose 5-phosphate.

153 ruvate carboxykinase 1 (Pck-1) and glucose 6-phosphatase (G6Pase) and this effect was absent in mice

154 ic and metagenomic approaches to investigate phosphatase genes within soils.

155 New albumin, bilirubin, and alkaline phosphatase grade 3/4 toxicities were, respectively, 3%,

156 Protein tyrosine phosphatases have received little attention in the study

157 Nonetheless, given their likely importance, phosphatases have recently become the focus of research

158 r aging and clearance of intestinal alkaline phosphatase (IAP).

159 terize a mitochondrial IMS-localized protein phosphatase identified in photosynthetic eukaryotes as w

160 protein phosphatase 2A (PP2A) acts as opsin phosphatase in both rods and cones.

161 viors, pointing to an important role of this phosphatase in depression.

162 PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTEN and INPP

163 hemistry, we define Ptc6p as the primary PDC phosphatase in S. cerevisiae Our analyses further sugges

164 to data from deletion mutants of kinases and phosphatases in S. cerevisiae we show that epistatic NEM

165 /beta-catenin signaling pathway and relevant phosphatases in VE-cadherin expression and function, vas

166 ve oxygen species-catalyzed protein-tyrosine phosphatase inactivation have remained largely unclear,

167 tigue (eight [2%] of 370 patients), alkaline phosphatase increase (five [1%]), colitis, and muscle we

168 We investigated glucose-6-phosphatase-independent endogenous glucose production in

169 ty via vascular endothelial-protein tyrosine phosphatase inhibition limits mycobacterial growth, sugg

170 el was experimentally validated by employing phosphatase inhibitors and the p38(MAPK) inhibitor SB203

171 Protein phosphatase inhibitors are often considered as tumor pro

172 mice, and the impairment could be rescued by phosphatase inhibitors, which also restored Arc translat

173 tion to translocate inositol polyphosphate 5-phosphatase (Inp54p) to plasma membranes in the presence

174 its paralog type 2 inositol polyphosphate-5-phosphatase (INPP5B).

175 The inositol polyphosphate 5-phosphatase INPP5E localizes to cilia and is mutated in

176 hed by the cilia-enriched phosphoinositide 5-phosphatase, Inpp5e.

177 odulate GPCR signaling, how serine/threonine phosphatases integrate with G protein signaling pathways

178 INPP5K encodes the inositol polyphosphate-5-phosphatase K, also known as SKIP (skeletal muscle and k

179 ents across a comprehensive panel of kinases/phosphatases knockouts and time-resolved perturbations t

180 loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulation of PI(3,4

181 TERPRETATION: Seladelpar normalised alkaline phosphatase levels in patients who completed 12 weeks of

182 D) and affecting the expression level of CTD phosphatase-like 3 (CPL3), AtCPSF100 is shown to potenti

183 tically inactive mutants of protein-tyrosine phosphatase-like myo-inositol phosphatases (PTPLPs) from

184 ecting the sites bound by these domains from phosphatase-mediated dephosphorylation.

185 nducible nuclear dual-specificity MAP kinase phosphatase (MKP) DUSP2, a known regulator of the ERK an

186 oprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP).

187 lthough it is known that protein kinases and phosphatases modulate GPCR signaling, how serine/threoni

188 This study identifies myosin phosphatase (MP) holoenzyme consisting of protein phosph

189 actors that inhibit the myotubularin-related phosphatase MTMR14/Jumpy, a negative regulator of autoph

190 PTEN and PHLPP form a phosphatase network that is polarized at the immunologic

191 panel testing: a pathogenic protein tyrosine phosphatase, non-receptor type 11 (PTPN11) variant and v

192 The protein tyrosine phosphatase nonreceptor type 12 (PTPN12) is a multifunct

193 Cdc25 family member A (Cdc25A) is a phosphatase normally activated during cell division in p

194 that result from mutations of the inositol 5-phosphatase oculocerebrorenal syndrome of Lowe (OCRL) an

195 sed on a central laboratory ULN for alkaline phosphatase of 116 U/L.

196 led, phase 2 trial of patients with alkaline phosphatase of at least 1.67 times the upper limit of no

197 se 2 (SHP2) and the three-membered family of phosphatases of regenerating liver (PRL) are infamously

198 a strong structural similarity to the human phosphatases of regenerating liver (PRL-1, -2, and -3) t

199 Phosphatases of regenerating liver (PRLs), the most onco

200 els postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactiv

201 on threshold via the recruitment of tyrosine phosphatases, our results suggest a significant role for

202 our inability to visualize protein-tyrosine phosphatase oxidation in cells.

203 dence for the importance of protein-tyrosine phosphatase oxidation in signal transduction, the cell b

204 The PAH1-encoded phosphatidate phosphatase (PAP), which catalyzes the committed step fo

205 luation of the role(s) of myosin light-chain phosphatase partner polypeptides in regulation of vascul

206 ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1.

207 The data imply that an allosteric SR protein-phosphatase platform balances phosphorylation levels in

208 NHEJ relies on polynucleotide kinase/phosphatase (PNKP), which generates 5-phosphate/3-hydrox

209 along with elevated tartrate-resistant acid phosphatase-positive (TRAP+) OCs and alveolar bone loss.

210 p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but

211 n by a mechanism involving the impairment of phosphatase PP2A catalytic activity and the subsequent a

212 o hypermethylation of histones and the major phosphatase PP2A, dependency on cysteine, and sensitivit

213 On the other hand, phosphatase PP2A-PP2R3B can remove this inhibitory phosp

214 tly of Galphai, the kinase Aurora A, and the phosphatase PP2A.

215 ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A.

216 ng A subunit of the serine/threonine protein phosphatase, PP2A, and that phosphorylation of ARPP-16 a

217 infection upregulated expression of the host phosphatase PPM1A, which impairs the antibacterial respo

218 lective inhibitors for each serine/threonine phosphatase (PPP) are essential to investigate the biolo

219 Moreover, phosphatase PPP6C is responsible for RIG-I dephosphoryla

220 ed signaling, consisting of WHIP and protein phosphatase PPP6C.

221 lar DNA content and is a novel cell survival phosphatase preventing both thermal and oxidative stress

222 ments identify up-regulation of the inositol phosphatase PTEN (phosphatase and tensin homolog) as pri

223 Protein tyrosine phosphatases (PTP) are exciting and novel targets for ca

224 ic sites is demonstrated in protein tyrosine phosphatases (PTP) by creation of single alanine mutatio

225 suppressor function for the protein tyrosine phosphatase PTP1B in myeloid lineage cells, with evidenc

226 Protein tyrosine phosphatase PTP1B is a critical regulator of signaling p

227 C1-Ten acts as a protein tyrosine phosphatase (PTPase) at the nephrin-PI3K binding site an

228 otein-tyrosine phosphatase-like myo-inositol phosphatases (PTPLPs) from the non-pathogenic bacteria S

229 The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repres

230 proper signal transduction.Protein-tyrosine phosphatases (PTPs) are thought to be major targets of r

231 reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction

232 , the most oncogenic of all protein-tyrosine phosphatases (PTPs), play a critical role in metastatic

233 tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs).

234 gnaling through presynaptic protein tyrosine phosphatase receptor delta.

235 ansduced through the CLR-1 Lar-like tyrosine phosphatase receptor.

236 Our findings highlight that the phosphatase regulator, GADD34, also functions as a kinas

237 myosin light chain or of myosin light chain phosphatase regulatory subunit.

238 phorylation catalyzed by protein kinases and phosphatases represents the most prolific and well-chara

239 biochemical characterization of the L. major phosphatase revealed that the enzyme is redox sensitive.

240 n-related (Lar), a receptor protein tyrosine phosphatase (RPTP) and the only known Drosophila HSPG re

241 sis, requiring the receptor protein tyrosine phosphatases (RPTPs): LAR and RPTPsigma.

242 Alkaline phosphatase shifted the Fpassive-sarcomere length relati

243 g-lived negative signals driven by the lipid phosphatase Ship1; and slower degradation of Ship1 co-fa

244 l T cell proliferation in vitro via tyrosine phosphatase SHP-1-dependent uncoupling of IL-2Rbeta sign

245 lated the catalytic activity of the tyrosine phosphatase SHP-1.

246 eptor with the potential to mediate tyrosine phosphatases SHP-1/-2 dependent signaling.

247 omology 2 domain-containing protein-tyrosine phosphatases Shp1 and Shp2, knockout and transgenic mous

248 the present study, we show that the protein phosphatase Shp2 is an important mediator of oligodendro

249 and immediately activate auto-inhibited Shp2 phosphatase, Shp2-iSNAP, is designed through modular ass

250 00 novel proteins enriched at a DSB were the phosphatase Sit4, the RNA pol II degradation factor Def1

251 ation by kinases (Kin28, Bur1, and Ctk1) and phosphatases (Ssu72, Rtr1, and Fcp1), which act through

252 asts were counted in tartrate-resistant acid phosphatase-stained sections.

253 d DMP1 associated with an increased alkaline phosphatase staining in the XLH cultures.

254 xpressed widely, and tartrate-resistant acid phosphatase staining notably was absent in the subarticu

255 tivity of striatal-enriched protein tyrosine phosphatase (STEP) in the brain has been detected in num

256 man protein interaction network to infer new phosphatase substrates at the proteome level.

257 In this study we identified several phosphatase subunits as potential DSB-associated protein

258 to be a zinc metalloprotein with an alkaline phosphatase/sulphatase fold containing three disulphide

259 otosynthetic eukaryotes as well as a protein phosphatase target of the highly conserved eukaryotic MI

260 n binding subunit 85 (MBS85), another myosin phosphatase targeting subunit (MYPT) family member, in a

261 One Cyclin A/Cdk1 substrate is myosin phosphatase targeting subunit 1 (MYPT1), and we show tha

262 , we have identified T cell protein tyrosine phosphatase (TC-PTP), also known as PTPN2, as a negative

263 The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events

264 PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signal

265 Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic vesicle endocytosis to

266 otein phosphatase 1 (PHLPP1) as a regulatory phosphatase that facilitates proper kinetochore assembly

267 PPM1D is a type 2C phosphatase that functions as a negative regulator of ce

268 inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream o

269 ed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in the developmental disorde

270 se 2 (AtSLP2) is a bona fide Ser/Thr protein phosphatase that is targeted to the mitochondrial interm

271 To determine the functional importance of phosphatases that control the PI3K pathway, we assessed

272 e receptor and non-receptor protein-tyrosine phosphatases that down-regulate Met phosphorylation.

273 ish a functional precedent for CDC25 protein phosphatases that lies outside of their canonical role i

274 roteins (Sts-1 and Sts-2) are two homologous phosphatases that negatively regulate signaling pathways

275 three calcineurin A genes, calcium-dependent phosphatases that regulate multiple aspects of muscle bi

276 (3,4,5)P3 can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P2.

277 hways converge at clade A of type 2C protein phosphatases.The DOG1 protein is a major regulator of se

278 bumin, fetuin-A, apolipoprotein-A1, alkaline phosphatase, TNFR1 and CD63.

279 site, the AMPs can be activated by bacterial phosphatase to restore the helical structure, thus contr

280 leoprotein complex, but mechanisms targeting phosphatases to P-TEFb are unclear.

281 Methylation of the phosphatase-transcription activator EYA1 by protein argi

282 phoresis (SDS-PAGE), which was eliminated by phosphatase treatment.

283 LPA-degrading enzyme phospholipid phosphate phosphatase type 1 (PLPP1) had a 2-fold increase in endo

284 ation with Tap42, rendering Tap42-associated phosphatases unresponsive to nitrogen limitation.

285 seladelpar for 12 weeks had normal alkaline phosphatase values at the end of treatment, based on a c

286 s phosphatases, EC-specific protein tyrosine phosphatase (VE-PTP) and Src homology phosphatase 2 (SHP

287 din-5, vascular endothelial-protein tyrosine phosphatase (VE-PTP), and von Willebrand factor (vWf).

288 of the substrate selectivity of a particular phosphatase was previously unappreciated and exemplifies

289 tivity of transcription factors, kinases and phosphatases were estimated in silico and these were cap

290 system in which various phosphatidylinositol phosphatases were recruited to the PM.

291 OCRL1 encodes an inositol polyphosphate 5-phosphatase which preferentially dephosphorylates phosph

292 skeletal muscle and kidney enriched inositol phosphatase), which is highly expressed in the brain and

293 s suppressed by inactivation of PhpP protein phosphatase, which concomitantly restores protein phosph

294 te that it associates with the Ptpn11 (Shp2) phosphatase, which in turn regulates ShcD tyrosine phosp

295 estrates the activity of several kinases and phosphatases, which interact in a coordinated fashion to

296 Calcineurin is a phosphatase whose primary targets in T cells are NFAT tr

297 se-2A (PP2A) is an abundant serine/threonine phosphatase with anti-inflammatory activity.

298 specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly known physiological functions an

299 based on the Gallus gallus voltage-sensitive phosphatase with the phosphatase domain removed and a ci

300 vival cues controlled by the lipid phosphate phosphatases Wunen and Wunen2.