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1 r factor-kappaB ligand (RANKL), and alkaline phosphatase activity.
2 ated PTEN mutations block its essential PIP3 phosphatase activity.
3 nd B subunits were stable and uncoupled from phosphatase activity.
4 iptional coactivators with intrinsic protein phosphatase activity.
5 ad deficient mineral apposition and alkaline phosphatase activity.
6 Asn394 as a critical amino acid involved in phosphatase activity.
7 e that help decipher the mechanism of glucan phosphatase activity.
8 phosphorylation of Shp2, which inhibits Shp2 phosphatase activity.
9 ed ligands and inhibits its protein-tyrosine phosphatase activity.
10 brane electrical potential to inositol lipid phosphatase activity.
11 y with Ssu72 and strongly stimulates its CTD phosphatase activity.
12 roximately 5-fold increase in Cps2B-mediated phosphatase activity.
13 nsport, PSRP1-sRNPC is stable against phloem phosphatase activity.
14 mplex and reduces but does not fully abolish phosphatase activity.
15 sociated with significant reduction in local phosphatase activity.
16 ase activity must be counteracted by protein phosphatase activity.
17 means for modulating the balance of CDK and phosphatase activity.
18 duced type 1 collagen secretion and alkaline phosphatase activity.
19 in the stimulation (6-fold) of phosphatidate phosphatase activity.
20 XNWD motif, results in maximal activation of phosphatase activity.
21 0 has been shown to bind PP5 to activate its phosphatase activity.
22 lkaline phosphatase has an enhanced alkaline phosphatase activity.
23 ts SRC basal activation independently of its phosphatase activity.
24 nserved domain is not sufficient for maximal phosphatase activity.
25 fects of Ssu72 with respect to its Ser(P)(5) phosphatase activity.
26 e its subcellular location and phosphatidate phosphatase activity.
27 ose production despite the loss of glucose-6-phosphatase activity.
28 h GADD34-PP1 holoenzymes, thereby inhibiting phosphatase activity.
29 reased protein abundance but suppressed PTEN phosphatase activity.
30 regulation of both FGFR2's kinase and Shp2's phosphatase activity.
31 which occurs in cells lacking phosphatidate phosphatase activity.
32 on of proteotoxic stress and loss of protein phosphatase activity.
33 PPP1CB protein that demonstrated diminished phosphatase activity.
34 h FliM is not required for binding CheY-P or phosphatase activity.
35 irectly binds to RapP and inhibits its Spo0F phosphatase activity.
36 EOPARD syndrome SHP2 mutants exhibit reduced phosphatase activity.
37 pathway and inhibition of myosin light chain phosphatase activity.
38 abundance of PTEN protein but increased PTEN phosphatase activity.
39 ority of them stained intensely for alkaline phosphatase activity.
40 membrane and nucleus without affecting lipid phosphatase activity.
41 calcium release on its way to activation of phosphatase activity.
42 ssed by staining for tartrate-resistant acid phosphatase activity.
43 human Treg cells and provides complementary phosphatase activity.
44 tion of purified PP2Ac with CIN85 suppressed phosphatase activity.
45 ons leads to significant or complete loss of phosphatase activity.
46 SUMOylated, yet is independent of its lipid phosphatase activity.
47 dependent platelet function by dampening the phosphatase activity.
48 f LC20 upon inhibition of myosin light chain phosphatase activity.
49 or and OC protein addition enhanced alkaline phosphatase activity.
50 e effect associated with intestinal alkaline phosphatase activity.
51 , which occurs independently of antagonizing phosphatase activity.
52 ction networks depends on protein kinase and phosphatase activities.
53 SIK2-PP2A complex preserves both kinase and phosphatase activities.
54 nonrobust phosphorylation due to diminished phosphatase activities.
55 regulation of HisKA and HisKA_3 transmitter phosphatase activities.
56 tion of the local balance between kinase and phosphatase activities.
59 8(MAPK) determines signal amplitude, whereas phosphatase activity affects both signal amplitude and d
60 receptors interacted with and inhibited PP2C phosphatase activity against the SnRK2-type kinase, rele
61 genic related markers (osteopontin, alkaline phosphatase activity, Alizarin red, and Von Kossa) compa
62 ssential for parental levels of capsule, but phosphatase activity alone could be eliminated without a
64 osphorylation of Synj at S1029 enhances Synj phosphatase activity, alters interaction between Synj an
65 tional model that combines MAPK scaffold and phosphatase activities and is sufficient to account for
66 on in ICL repair is dependent on its protein phosphatase activity and ability to be SUMOylated, yet i
69 e found an inverse relationship between root phosphatase activity and AM colonization in field-collec
70 l differentiation such as increased alkaline phosphatase activity and an elevated level of matrix met
72 esulting in significantly increased alkaline phosphatase activity and calcium deposition of encapsula
74 in MK migration due to the reduction in SHP1 phosphatase activity and consequent increase in the phos
75 trasting requirements for protein kinase and phosphatase activity and differential impact on CP-AMPAR
76 s from increased tissue-nonspecific alkaline phosphatase activity and diminished ATP availability cau
77 cleaved by calpain-2, which inactivates its phosphatase activity and generates stable breakdown prod
78 R306, of EYA1 are essential for its in vitro phosphatase activity and in vivo function during Drosoph
79 nstrate that PTPN1 mutations lead to reduced phosphatase activity and increased phosphorylation of JA
80 d in partial inhibition of its ATP-dependent phosphatase activity and inhibited subsequent phosphoryl
82 tation of allosteric sites that can regulate phosphatase activity and may enable the discovery of nov
83 P-activated signaling pathway controls SHP-1 phosphatase activity and may regulate numerous receptor
84 r, the p85alpha homodimer enhances the lipid phosphatase activity and membrane association of PTEN.
85 function mutations in PTEN that impair lipid phosphatase activity and membrane binding are oncogenic,
86 rotein levels and induced increased alkaline phosphatase activity and mineralization in osteoblast cu
87 rt1(DeltaOsx1) mice exhibited lower alkaline phosphatase activity and mineralization, as well as decr
89 competition, however, AM colonization, root phosphatase activity and N2 fixation increased in the N2
90 formance remain unclear: biomass allocation, phosphatase activity and phosphorus-use efficiency did n
92 show that FTY720-P enhances TNF-induced PP2A phosphatase activity and significantly represses TNF-ind
93 nt in polyP coincided with enhanced alkaline phosphatase activity and substitution of sulfolipids for
95 phate and tensin homolog through its protein phosphatase activity and that the increase in INPP4B is
96 mains of Pah1 are required for phosphatidate phosphatase activity and the in vivo function of the enz
97 tion based on the maintenance of the Ser/Thr phosphatase activity and their neuroprotection against t
98 only tyrosine phosphatase activity, has dual phosphatase activities, and both the N- and C-terminal d
99 ulation of organic acids, enhanced secretory phosphatase activity, and depletion of ATP in overexpres
100 ant effects on protein synthesis or alkaline phosphatase activity, and drove discrete changes in a pa
101 disrupted sebocyte cell membranes, alkaline phosphatase activity, and significantly reduced sebocyte
103 ponent analysis shows that dehydrogenase and phosphatase activities are the vital variables contribut
104 tection from proteolysis, and stimulation of phosphatase activity are linked to oligomerization of Sp
105 Moreover, the PST/TPM and the threonine phosphatase activity are not required for in vitro inter
106 we report inherited dysregulation of protein phosphatase activity as a cause of intellectual disabili
107 y interacted with PTP1B and suppressed PTP1B phosphatase activity as well as the association of PTP1B
108 9D) constructs, in vitro binding assays, and phosphatase activity assays, we demonstrate that phospho
110 PHLPP phosphatase network allows coordinated phosphatase activities at the site of T-cell receptor ac
111 ive estimates for the intracellular alkaline phosphatase activity at five different temperatures in d
113 ssion of OsHAD1 in rice resulted in enhanced phosphatase activity, biomass, and total and soluble P c
114 s no change in glycogen content or glucose 6-phosphatase activity but increased Slc2a2 glucose transp
115 of ethanol, caused no changes in BP or RVLM phosphatase activity but it produced significant increas
116 usually is attributed to myosin light chain phosphatase activity, but findings in non-VSM identified
121 c homology 2 domain-containing phosphatase 2 phosphatase activity by scavenging reactive oxygen speci
122 burgdorferi CheD significantly enhances CheX phosphatase activity by specifically interacting with th
124 greatly promote MSC proliferation, alkaline phosphatase activity, calcium deposition and total prote
125 defects in balancing cytoplasmic kinase and phosphatase activities, changing their activation thresh
126 BL) and enhanced the respiratory burst, acid phosphatase activity, chemotactic activity, and gene exp
128 inhibiting kinase activity while stimulating phosphatase activity, consistent with the selective inac
131 sponse to TNF, and this increased GADD34-PP1 phosphatase activity, dephosphorylating eukaryotic trans
134 ediated inductions of PAH1 and phosphatidate phosphatase activity do not correlate with the amount of
136 phosphorylated RyRs because of reduced local phosphatase activity enhance triggered activity in LQT2
137 or of STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhib
138 transduction results from sensor transmitter phosphatase activity for phospho-receiver dephosphorylat
139 itant with a significant increase in protein phosphatase activity for two colon cancer cell lines in
140 mong all the compounds screened for alkaline phosphatase activity, four compounds 10, 14, 18, and 22
143 tes, including bile acids transfer, alkaline phosphatase activity, gamma-glutamyl-transpeptidase acti
144 the N2 fixer with high N2 fixation and root phosphatase activity grew best on organic P, whereas the
145 , a GAS strain selectively deficient in CovS phosphatase activity had a distinct transcriptome relati
148 hich has been reported to have only tyrosine phosphatase activity, has dual phosphatase activities, a
149 we manipulated native loci to ablate hCDC14A phosphatase activity (hCDC14A(PD)) in untransformed hTER
150 Unexpectedly, we observed that inhibiting a phosphatase activity highly sensitive to OA caused an ab
151 he coronavirus macrodomain has ADP-ribose-1"-phosphatase activity; however, its function during infec
153 Chlamydomonas GPD2 showed both reductase and phosphatase activities in vitro and it can work as a bif
154 merize with wild-type PTEN and constrain its phosphatase activity in a dominant-negative manner.
156 nt hops induced estrogen responsive alkaline phosphatase activity in endometrial cancer cells, estrog
159 prelamin A-expressing VSMCs induced alkaline phosphatase activity in mesenchymal progenitor cells, an
161 ion of OC protein partially rescued alkaline phosphatase activity in periodontal ligament (PDL) cells
162 cant increases in BP and inhibition of local phosphatase activity in rats treated with OKA or fostrie
163 ly members, serving as a platform to control phosphatase activity in response to diverse inputs.
164 Under laboratory conditions, BvgS shifts to phosphatase activity in response to modulators, notably
165 ate, showing that BvgS shifts from kinase to phosphatase activity in response to this modulator via a
166 aining protein tyrosine phosphatase 2 (Shp2) phosphatase activity in the absence of extracellular sti
167 tion uncover a novel mechanism whereby lipid phosphatase activity in the nucleus can regulate mammali
168 ed on the inhibition of immobilized alkaline phosphatase activity, in the presence of the phosphate i
169 ulate actin cytoskeleton dynamics and myosin phosphatase activity, including focal adhesion kinase, p
170 dramatic increases in hydrolase EEAs (e.g., phosphatase activity increased >28-fold) supporting the
173 strain, indicating that both CovS kinase and phosphatase activities influence the CovR phosphorylatio
174 al RNA-binding NSP2 octamer with nucleotidyl phosphatase activity is central to viroplasm formation a
175 ining phosphatase 1 (SHP)-1, SHP-2, and SHIP phosphatase activity is dispensable for this function.
177 nd maintain 1 null allele, we show that PTEN phosphatase activity is required for preventing the emer
179 ow that PTEN requires both lipid and protein phosphatase activity, its extreme C-terminal PDZ binding
180 - 0.31 mumol min(-)(1) mg protein(-)(1)) and phosphatase activity (Km 27.38 +/- 3.1 mM and Vmax 0.077
181 h in vivo and in vitro, loss of EYA tyrosine phosphatase activity leads to defective assembly of gamm
183 confounders, such as inflammation, alkaline phosphatase activity, low serum albumin, renal function,
184 hanced differentiation indicated by alkaline phosphatase activity, mineral deposition, and transcript
185 entiation as indicated by increased alkaline phosphatase activity, mineralization, and up-regulation
187 These results indicate that neither Cps2B phosphatase activity nor Cps2D phosphorylation levels pe
188 ies of the bifunctional 5-InsP7 kinase/InsP8 phosphatase activities of full-length diphosphoinositol
192 , in vivo characterization of the kinase and phosphatase activities of TCS proteins is often limited
193 ere, we identified tumor inhibitory and RelA phosphatase activities of the protein phosphatase 2C (PP
194 , we show that the nuclease, polymerase, and phosphatase activities of yeast CPF are organized into t
195 nteraction with AtMIA40 is necessary for the phosphatase activity of AtSLP2 and is dependent on the f
196 at dimerization is important for controlling phosphatase activity of CacyBP/SIP and for regulating th
201 with our previous results that the tyrosine phosphatase activity of Eya is dispensable for normal Ey
204 86Ser) transgenic mice demonstrates that the phosphatase activity of FIG4 has an essential role in vi
206 we show is critical for the specific glucan phosphatase activity of LSF2 toward native Arabidopsis s
209 ular allosteric regulation mechanism for the phosphatase activity of PGAM5, in which the assembly of
215 ever, Hsp70 binding to PP5 stimulates higher phosphatase activity of PP5 than the binding of Hsp90.
216 PTEN mutant constructs, we show that protein phosphatase activity of PTEN targets PTK6, with efficien
217 tumors, functionally caused the loss of the phosphatase activity of PTPRD, and were associated with
218 vels increased mRNA, protein expression, and phosphatase activity of SHP-1, which remained elevated d
220 Tim50 was overexpressed, suggesting that the phosphatase activity of TbTim50 plays a role in regulati
222 oadly conserved mechanism that regulates the phosphatase activity of the largest family of bifunction
228 PHO13-overexpressing strain showed a higher phosphatase activity on xylulose-5-phosphate (X-5-P), su
229 in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of
230 enopus early embryonic extract revealed that phosphatase activity other than PP1 continuously suppres
231 15 (P = 0.0001), and calcification (alkaline phosphatase activity, P < 0.01; osteocalcin, P < 0.05).
232 ere, we use fission yeast to investigate how phosphatase activity participates in this interplay duri
233 GAS mutants lacking SP-PTP revealed that the phosphatase activity per se positively regulates growth,
234 hese data reinforce the hypothesis that CpxA phosphatase activity plays a critical role in controllin
236 hese requirements, namely segregation of the phosphatase activity predominantly onto the free form of
237 acdc55 mutation affecting Cdc55-PP2A protein phosphatase activity prevented Orm dephosphorylation and
238 sion of a mutated form of PTEN with enhanced phosphatase activity prevented the TGF-beta-induced coll
239 1 directly binds to STRIPAK and inhibits its phosphatase activity, protecting MST2 activation-loop ph
240 fferences we observed in voltage-sensing and phosphatase activity provide a starting point for future
241 with helix disruption decreasing the kinase/phosphatase activity ratio, as required to modulate the
242 ho85-Pho80 kinase complex, maximum Nem1-Spo7 phosphatase activity required Mg(2+) ions (8 mm) and Tri
243 Fig4 mutations predicted to inactivate FIG4 phosphatase activity rescue lysosome expansion phenotype
244 tracellular stores and increased calcineurin phosphatase activity, resulting in NFATc1 nuclear transl
248 weight, long bone length, and serum alkaline phosphatase activity, suggesting that tooth dysfunction
249 es a family of enzymes with 5'-kinase and 3'-phosphatase activities that function in nucleic acid rep
250 dystrophies to defective phosphoinositide 5-phosphatase activity that is becoming increasingly recog
251 rtantly, NFI phosphorylation is dependent on phosphatase activity that is enriched in GFAP/B-FABP+ve
253 a novel positive regulator of lipin 1beta PA phosphatase activity that is not achieved via altering i
255 use a significant reduction in phosphatidate phosphatase activity, the phosphorylation of Pah1p by pr
256 rovascular integrity by enabling VEC-related phosphatase activity, thereby preventing vascular leak d
257 e receptor kinase activity or enhancing CheC phosphatase activity, thereby regulating the levels of t
258 antly, S-nitrosylation of PTEN decreases its phosphatase activity, thus promoting cell survival.
259 pair factor possessing both 5'-kinase and 3'-phosphatase activities to modify ends of a DNA break pri
260 o the nucleus, where Eya1 uses its threonine phosphatase activity to control Myc phosphorylation/deph
261 horylation requires regulation of kinase and phosphatase activity to prevent aberrant signal transduc
266 addition, we find key differences in glucan phosphatase activity toward soluble and insoluble polygl
270 high basal autophagy, possess stronger basal phosphatase activity towards ULK1 and require ULK1 for s
271 ation, starvation also causes an increase in phosphatase activity towards ULK1, an mTORC1 substrate w
273 cherichia coli similarly exhibited increased phosphatase activity under conditions of high-oxygen gro
274 m substrate trapping complexes with impaired phosphatase activity via increased recruitment of TIPRL1
280 elate with phosphorus associations; however, phosphatase activity was most strongly down-regulated in
281 creased under these conditions, but alkaline phosphatase activity was not significantly altered.
283 vitro and in vivo data demonstrated that the phosphatase activity was required for the inactivation o
285 uced Smad 1/5/8 phosphorylation and alkaline phosphatase activity were both enhanced by the addition
286 A on cell proliferation, migration, and PP2A phosphatase activity were investigated using ovarian and
287 genes, among which genes involved in protein phosphatase activity were overrepresented, suggesting a
288 te that Hsp70 recruits PP5 and activates its phosphatase activity which suggests dual roles for PP5 t
289 is governed by dynamic changes in kinase and phosphatase activities, which are difficult to assess wi
291 ressor activity depends largely on its lipid phosphatase activity, which opposes PI3K/AKT activation.
292 tion with CD45 on the T cell, inhibiting its phosphatase activity, which resulted in up-regulation of
293 tial of UBASH3B is dependent on its tyrosine phosphatase activity, which targets CBL ubiquitin ligase
294 atus of actin, as was its eIF2alpha-directed phosphatase activity, while localised G-actin depletion
295 d osteoblast differentiation marker alkaline phosphatase activity, while miR-138 inhibitor and OC pro
296 mbinant TbTim50 possesses a dual specificity phosphatase activity with a greater affinity for protein
297 tations in these allosteric clusters altered phosphatase activity with changes in kcat/KM ranging fro
298 oint mutations in cps2B demonstrated reduced phosphatase activity with corresponding increases in lev
299 enable the discovery of novel modulators of phosphatase activity with much improved pharmacological
300 n and septum formation and FgCdc14 possesses phosphatase activity with specificity for a subset of Cd
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