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1 ay, which results in decreased expression of phosphatase and tensin homologue.
2 vation of miR-21 expression, which inhibited phosphatase and tensin homologue and enhanced AKT signal
3 of MEF cells by decreasing the expression of phosphatase and tensin homologue deleted from chromosome
4 ts effect through glutathionylation of PTEN (phosphatase and tensin homologue deleted from chromosome
12 esses the expression of the tumor suppressor phosphatase and tensin homologue deleted from chromosome
14 r the phosphatidylinositol phosphatase PTEN (phosphatase and tensin homologue deleted in chromosome t
16 gation regarding the interaction between the phosphatase and tensin homologue deleted on chromosome 1
18 sis, potential functions of tumor suppressor phosphatase and tensin homologue deleted on chromosome 1
21 IL-1beta and RANTES mRNA and phosphorylated phosphatase and tensin homologue deleted on chromosome 1
22 We now show a role for the tumor suppressor phosphatase and tensin homologue deleted on chromosome 1
23 Mutational inactivation or deletion of the phosphatase and tensin homologue deleted on chromosome 1
26 we have examined the role of the inositol 3-phosphatase and tensin homologue deleted on chromosome 1
27 inversely associated with expression of the phosphatase and tensin homologue deleted on chromosome 1
29 ations in the tumor suppressor protein PTEN (phosphatase and tensin homologue deleted on chromosome 1
31 ding Tep1p, a homolog of the mammalian PTEN (phosphatase and tensin homologue deleted on chromosome 1
32 ion is increased in cells deficient of PTEN (phosphatase and tensin homologue deleted on chromosome 1
35 1 integrin induces a significant increase in phosphatase and tensin homologue deleted on chromosome 1
36 nced cancers suppressor (MMAC; also known as phosphatase and tensin homologue deleted on chromosome 1
37 overexpression of the tumor suppressor gene phosphatase and tensin homologue deleted on chromosome 1
39 e putative tumor suppressor gene PTEN/MMAC1 (phosphatase and tensin homologue deleted on chromosome 1
41 ects are downstream of apo(a) attenuation of phosphatase and tensin homologue deleted on chromosome 1
42 creased activity of c-Abl kinase and loss of phosphatase and tensin homologue deleted on chromosome 1
43 we examined the role of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 1
45 cell polarization and migration, whereas the phosphatase and tensin homologue deleted on chromosome 1
49 ition of tumorigenesis without affecting the phosphatase and tensin homologue deleted on chromosome 1
50 PDK1 phosphorylation or activity, changes in phosphatase and tensin homologue deleted on chromosome 1
52 f PI3-kinase (PI3K) and the tumor suppressor phosphatase and tensin homologue deleted on chromosome 1
53 nockdown of the tumor suppressor phosphatase Phosphatase and tensin homologue deleted on chromosome 1
54 unction mutations in the catalytic domain of phosphatase and tensin homologue deleted on chromosome 1
55 y caused by deletion of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 1
62 779, an mTOR inhibitor, arrested growth of a phosphatase and tensin homologue deleted on chromosome 1
63 y growth response-1 transcription factor and phosphatase and tensin homologue deleted on chromosome 1
64 s seems to be dependent upon the presence of phosphatase and tensin homologue deleted on chromosome 1
65 apoptosis, phosphorylation, and activity of phosphatase and tensin homologue deleted on chromosome 1
67 , also called AKT) and reduced expression of phosphatase and tensin homologue deleted on chromosome 1
69 e recently shown in MCF-7 cells that nuclear phosphatase and tensin homologue deleted on chromosome 1
70 (H1792 and H1838), whereas it inhibited the phosphatase and tensin homologue deleted on chromosome 1
74 tecting mutations in tumor DNAs, each of the phosphatase and tensin homologue deleted on chromosome t
75 g fibroblast cell line derivative (VC8), and phosphatase and tensin homologue deleted on chromosome t
84 fibromas, a cutaneous manifestation of PTEN (phosphatase and tensin homologue) hamartoma-tumor syndro
87 identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dep
88 Ventral mesencephalic tissue from dopamine phosphatase and tensin homologue knock-out or control an
89 and inactivation (phosphorylation) of PTEN (phosphatase and tensin homologue) mediate the transactiv
90 or gene mutated in multiple advanced cancers/phosphatase and tensin homologue (MMAC/PTEN) has been sh
91 mployed mutated in multiple advanced cancers/phosphatase and tensin homologue (MMAC/PTEN), a natural
92 duced mutated in multiple advanced cancers 1/phosphatase and tensin homologue (MMAC1/PTEN) and suppre
95 p16INK4A (deleted in 15 of 33 patients), or phosphatase and tensin homologue (mutated in 15 of 41 pa
96 ppress the growth of tumors established from phosphatase and tensin homologue-null human cancer cells
97 ating mutations in the tumor suppressor gene phosphatase and tensin homologue on chromosome 10 (PTEN)
99 o insulin, caused by altered IRS-1 and PTEN (phosphatase and tensin homologue on chromosome 10) activ
100 protein levels of the tumor suppressor PTEN (phosphatase and tensin homologue on chromosome ten) were
101 other PI3K inhibitor, wortmannin, as well as phosphatase and tensin homologue or dominant-negative Ak
102 ssible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol tr
103 n replicative DNA synthesis or expression of phosphatase and tensin homologue, phosphoinositide-depen
104 essor and phosphoinositide phosphatase PTEN (phosphatase and tensin homologue) promotes axon regrowth
105 teractions released suppression of PTEN (the phosphatase and tensin homologue protein) and inhibited
106 (mTORC1) are known downstream targets of the phosphatase and tensin homologue protein, and their acti
107 nner associated with increased expression of phosphatase and tensin homologue (PTEN) and diminished p
108 tate cancer are loss of the tumor-suppressor phosphatase and tensin homologue (PTEN) and overexpressi
110 or overexpression of the lipid phosphatases phosphatase and tensin homologue (PTEN) and Src homology
111 nhibition of insulin-like growth factor, and phosphatase and tensin homologue (PTEN) deficiency.
115 diates the degradation and downregulation of phosphatase and tensin homologue (PTEN) in multiple cell
120 more PI3K pathway components, most commonly phosphatase and tensin homologue (PTEN) loss (by IHC) (3
122 is induced by AKT activation resulting from phosphatase and tensin homologue (PTEN) loss and EGFR-de
126 roblast growth factor receptor 3 (FGFR3) and phosphatase and tensin homologue (PTEN) signalling pathw
128 tudies support the role for mutations in the phosphatase and tensin homologue (PTEN) tumor suppressor
129 re characterized by a marked increase of the phosphatase and tensin homologue (PTEN) tumour suppresso
131 ble model of loss of function of the protein phosphatase and tensin homologue (PTEN), a phosphatase c
133 K-Akt-mammalian target of rapamycin pathway, phosphatase and tensin homologue (PTEN), and PHLPP.
134 FR), human epidermal growth factor 2 (HER2), phosphatase and tensin homologue (PTEN), and PI3K cataly
135 ells by deletion of the negative regulators, phosphatase and tensin homologue (PTEN), and tuberous sc
136 due to inactivation of the tumor suppressor phosphatase and tensin homologue (PTEN), correlates with
137 Glioblastomas frequently have loss of the phosphatase and tensin homologue (PTEN), leading to the
138 asked if loss of the PI3K pathway regulator, phosphatase and tensin homologue (Pten), which has been
139 cellularly and at the immunologic synapse by phosphatase and tensin homologue (PTEN), which increased
140 f its negative transcriptional regulation on phosphatase and tensin homologue (PTEN), which led to ac
142 urrent copy gains and losses, including both phosphatase and tensin homologue (PTEN)-dependent and PT
143 nectin via beta-catenin/LEF-1 signaling in a phosphatase and tensin homologue (PTEN)-dependent manner
148 exposure to wortmannin, and by expression of phosphatase and tensin homologue tumor suppressor (PTEN)
150 n of the tumor suppressor lipid phosphatase, phosphatase and tensin homologue, which is commonly lost
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