ライフサイエンスコーパス: phosphate group

1 aining neutral nucleotides with a methylated phosphate group.

2 l group, and the presence or absence of a 5'-phosphate group.

3 two specific orientations of the bridging 3'-phosphate group.

4 ater proton is transferred to the downstream phosphate group.

5 interactions depends on the structure of the phosphate group.

6 n downstream modifications to the lipid A 4'-phosphate group.

7 galactosamine (GalN) residue linked to its 1-phosphate group.

8 also anchored to the PLP via H-bonds to its phosphate group.

9 independent of the structure of the cofactor phosphate group.

10 m a contact ion pair with the nearby anionic phosphate group.

11 tem, the Na(+) ions are localized around the phosphate group.

12 xtra OH capable of forming a H-bond with the phosphate group.

13 roxyl group but not with RNA possessing a 3'-phosphate group.

14 n water molecules mainly associated with the phosphate group.

15 t provides a binding motif for the dianionic phosphate group.

16 ER intermediates containing a 5'-deoxyribose phosphate group.

17 )-methylated guanine system and at least one phosphate group.

18 and length of the acyl chains and the single-phosphate group.

19 ting a role for the negatively charged extra phosphate group.

20 apparent disagreement with regard to the +2 phosphate group.

21 water molecule binds to the charge-carrying phosphate group.

22 endowed with a similar capacity to bind a 5'-phosphate group.

23 ate for deletion or neutralization of the +2 phosphate group.

24 ites have similar affinity for the inorganic phosphate group.

25 n excess of up to three positive charges per phosphate group.

26 pKa of the oxygen nucleophile attacking the phosphate group.

27 ed in receptor activation interacts with the phosphate groups.

28 tatic/hydrogen bond contacts with quadruplex phosphate groups.

29 blets or triplets according to the number of phosphate groups.

30 reventing complete neutralization of the RNA phosphate groups.

31 ar valence angles and in the geometry of the phosphate groups.

32 in native DNA substrates containing scissile phosphate groups.

33 site as deduced from frequency shifts of the phosphate groups.

34 salt bridges with acidic residues and lipid phosphate groups.

35 nt headgroup orientation for the interacting phosphate groups.

36 f long chains of covalently linked inorganic phosphate groups.

37 hydrated by interactions with additional RNA phosphate groups.

38 d to lysines that directly interact with DNA phosphate groups.

39 for species containing increased numbers of phosphate groups.

40 y charged amino acids and negatively charged phosphate groups.

41 the accessibility of bulky PIs with multiple phosphate groups.

42 amples contain uncapped RNAs with exposed 5' phosphate groups.

43 with B[a]PDE adducted (either on the base or phosphate group) 2'-deoxynucleotides of guanine, adenine

44 activation that (1) directly contact the 5'-phosphate group, (2) participate in a hydrophobic cluste

45 fferent between magnesium citrate and sodium phosphate groups (790 HU +/- 216 vs 978 HU +/- 160; P <.

46 ond is specific to the presence of a primary phosphate group, acts only through the intracellular mem

47 e the cationic Arg residues drag the anionic phosphate groups along as they insert into the hydrophob

48 The cluster extends from the backbone phosphate groups along the mouth of the groove and links

49 duce translocation, EF-G*GDP in complex with phosphate group analogs BeF3(-) and AlF4(-) promotes the

50 3% (95% CI, 64.0% to 74.2%) in the tedizolid phosphate group and 71.9% (95% CI, 66.8% to 76.7%) in th

51 % to 83.7%) of 332 patients in the tedizolid phosphate group and 79.4% (95% CI, 74.7% to 83.6%) of 33

52 5% (95% CI, 81.3% to 89.1%) in the tedizolid phosphate group and 86.0% (95% CI, 81.8% to 89.5%) in th

53 n which D(2)S interacts with both a backbone phosphate group and a neutral nucleobase through hydroge

54 gh electrostatic interactions with the A2662 phosphate group and H-bond networks are key features of

55 27 of 708) of colonic segments in the sodium phosphate group and in 88.1% (608 of 690) in the magnesi

56 n of an oxoanion functional group, usually a phosphate group and less commonly a sulfate group, leads

57 l interactions between the covalently linked phosphate group and Lys-82 of the trans beta-chain.

58 ate by a distinct kinase to create a docking phosphate group and scaffold protein-mediated protein co

59 consistent with titration of the cofactor's phosphate group and support a model in which the major d

60 he two terminal oxygen atoms of the catalyst phosphate group and the hydrogen atoms at N and C2 of th

61 d, where one binding site interacts with the phosphate group and the other interacts with the dye.

62 e strongly dependent on the chirality at the phosphate group and the position of the methyl-group(s)

63 re, we show that DUSP11 modulates the 5' end phosphate group and/or steady-state level of several hos

64 ntains polar residues that interact with the phosphate groups and an aromatic patch that appears sele

65 s a disaccharide headgroup with two negative phosphate groups and at least four acyl chains.

66 lar nucleotides increased with the number of phosphate groups and ATP was the most effective cellular

67 d shed new light into coordinated motions of phosphate groups and bases in free B-DNA in solution.

68 can be grouped on the basis of the number of phosphate groups and basic residues in each peptide.

69 the interaction of anion exchanger with the phosphate groups and eluted at the pH of 7.5.

70 was clearly shown to ensure the existence of phosphate groups and nitrogen-containing ring structures

71 charged lysine and arginine residues and DNA phosphate groups and other binding sites in the minor an

72 ting that activation requires three adjacent phosphate groups and that other positions on the inosito

73 c IP(3), the relative roles of the different phosphate groups and the adenosine motif have not been e

74 The phosphate groups and the carbon and oxygen atoms of the

75 he ATP-enzyme interactions occur between the phosphate groups and the P-loop.

76 n interesting interactions between the RNA's phosphate groups and the Pi electrons of the peptide bon

77 effectively neutralize the charge of the DNA phosphate groups and the resulting influence on the DNA

78 the binding sites of the purine base, the 5'-phosphate group, and pyrophosphate.

79 gs showed absorption bands characteristic of phosphate groups, and EDX showed that the Ca/P ratios we

80 accumulation of lipid A species lacking both phosphate groups, and introduction of RlLpxQ generates p

81 arginine residues and the negatively charged phosphate groups, and thus the resulting charge neutrali

82 our oxygen-16 atoms attached to the terminal phosphate group are substituted with oxygen-18 [gamma((1

83 ve to the guanidinium group spacing when the phosphate groups are near close packing.

84 However, peptides with one or two phosphate groups are not separated from peptides with mu

85 ind in a common pre-insertion site where the phosphate groups are not yet positioned over the active

86 ative b and y ions which preserve the labile phosphate groups are observed in the negative ion mode,

87 Molecular subcomponents such as phosphate groups are often passed between biomolecules d

88 However, recent work has shown that up to 4 phosphate groups are present in human cMyBP-C.

89 N' are A or U and where the Palpha or Pbeta phosphate groups are replaced by boranophosphate, denote

90 ween the primary amine of 5-HT and the lipid phosphate group as the most important interaction.

91 '-OMe substituent and the vicinal 5'- and 3'-phosphate group, as seen in the X-ray crystal structure

92 cifically interacts with the phospho-Thr-231 phosphate group, as well as a long, disulfide-constraine

93 LpiR1 binds the phosphate group at a conserved site and is stabilized by

94 Removal of the phosphate group at T29 by an incoming phosphatase releas

95 , generated by annealing P oligo (carrying a phosphate group at the 5' end) and T oligo (carrying a T

96 hosphoethanolamine (P-Etn) instead of a free phosphate group at the C-1 position of the lipid A backb

97 The 5'-phosphate group at the nick is essential for loading, su

98 t it is the RepD covalently linked to the 5'-phosphate group at the nick that loads the helicase onto

99 trand joining in DNA substrates containing a phosphate group at the scissile position.

100 Intriguingly, PGH binds to NadA with its phosphate group at the site where the carboxylate groups

101 ysine side-chain NH3(+) amino groups and DNA phosphate groups at the molecular interface of the HoxD9

102 thetic marbox in vitro was enhanced when the phosphate group between positions 12 and 13 was eliminat

103 ons of the amino acid at position 89 and the phosphate group between positions 12 and 13.

104 ith phosphate mimic and three compounds with phosphate groups binding to BRCT to understand promiscuo

105 tiating nucleophilic attack on the ATP gamma-phosphate group by abstracting the proton from the 3'-hy

106 ostatic repulsion between negatively charged phosphate groups by counterion recruitment.

107 uctures of CDK2 bound to ADP showing how the phosphate groups can be coordinated by either one or two

108 peptide fragmentation and the loss of labile phosphate groups complicate identification of the site o

109 Investigation of another phosphate group containing compound, C1, suggested that

110 Phosphate groups contribute to solution charge by adding

111 f Tyr83 suggests that the negatively charged phosphate group could enhance the binding of positively

112 ps (CPe) and anionic iPC lipids nonethylated phosphate groups (CP) were synthesized.

113 Neutral iPC lipids with ethylated phosphate groups (CPe) and anionic iPC lipids nonethylat

114 PEP) to the re side of C1(A5P), with the PEP phosphate group deprotonated, has the lowest energy barr

115 f biotin, providing strong evidence that the phosphate group, derived from decomposition of carboxyph

116 dylinositol-4,5-bisphosphate that have three phosphate groups did not support TRPA1 activation.

117 g that the replacement of the hydrolyzable 5-phosphate group does not compromise the binding.

118 es provides a picture of the movement of the phosphate group during initial binding and subsequent ca

119 phate moiety of ImmHP is dianionic, and this phosphate group exists in two different conformations wi

120 ansfer from the 2'-hydroxyl to the departing phosphate group facilitates cleavage.

121 lashes with the 5'-G*) and the less bulky 5'-phosphate group forms a H-bond to HN-Pt (indicating that

122 transferase that in vivo transfers a ribitol phosphate group from a CDP -ribitol present in muscles t

123 ymes catalyses the transfer of a substituted phosphate group from a CDP-linked donor to an alcohol ac

124 ytic mechanism that irreversibly removes the phosphate group from a phosphorylated threonine via beta

125 drogelation resulted from the removal of the phosphate group from a tyrosine phosphate residue.

126 atase that processively cleaves the terminal phosphate group from the polyphosphate chain, until inor

127 omicron mutants that fail to remove a single phosphate group from their LPS were displaced from the m

128 The phosphatase laforin removes phosphate groups from glycogen during biosynthetic activ

129 xperimental conditions to follow the flow of phosphate groups from histidine kinases to the cognate r

130 e activity and the ability of CpxR to accept phosphate groups from other donors.

131 g Coulombic interactions with two contiguous phosphate groups from the DNA backbone while the lipophi

132 alkaline phosphatase (TNSALP), which removes phosphate groups from various substrates.

133 In both ALSE and RPE, the phosphate group hydrogen bonds not only with the conserv

134 sine has a direct role independent of the 2'-phosphate group in contributing toward the potency of ad

135 (31)P NMR reveals an orientation of the phosphate group in DOBMP that differs significantly from

136 f P148 (dephoso-P148) showed that the single phosphate group in P148 was responsible for the profound

137 e chain of K219, which coordinates the alpha-phosphate group in previous ground state structures, is

138 This model explains how the presence of a phosphate group in the activation loop determines the po

139 mide group as a nonhydrolyzable mimic of the phosphate group in the cognate Ub/Ubl-AMP adenylate inte

140 ions that are chelated by a common bridging phosphate group in the form Mg((a))(2+)-(O1P-P-O2P)-Mg((

141 as consistent with a tetrahedral Zn bound to phosphate groups in a monodentate inner-sphere surface c

142 However, the roles of the two lipid A phosphate groups in bacterial virulence and immunogenici

143 The proportions of sulfonic acid and phosphate groups in both the self-supported disk and mem

144 at a conservative modification of one of the phosphate groups in c-di-GMP with a bridging sulfur in t

145 , including regarding the behavior of facing phosphate groups in complementary dinucleotides, and the

146 iling of mRNA cleavage products retaining 5' phosphate groups in mouse embryonic stem cells (mESCs).

147 il and investigated the selective binding to phosphate groups in solution.

148 nd PI(4,5)P(2) the charges of the individual phosphate groups in the molecule differ, they are equal

149 t attract sulfate anions, as a simulation of phosphate groups in the product BPG.

150 The +2 phosphate group interacts directly with an active site h

151 activity of this inhibitor by converting the phosphate group into a less charged phosphate prodrug.

152 beta-methylene and extension of the terminal phosphate group into gamma-esters of UTP analogues.

153 In particular, the 5 phosphate group is a recognition element for L4 and is c

154 ctroscopy demonstrated that the undecaprenyl phosphate group is attached to the anomeric carbon of th

155 g(2+) and 5'-PO4 DNA, wherein the product 5' phosphate group is displaced by the NTP gamma phosphate

156 rform surprisingly well, indicating that the phosphate group is not essential.

157 he effect on beta-hairpin structure when the phosphate group is positioned to interact with a tryptop

158 a model in which the IBE provided by the 5'-phosphate group is used to allow interactions both near

159 d phosphoehthanolamine (pEtN) at the lipid A phosphate groups, is often induced in response to specif

160 hate (polyP) is composed of linear chains of phosphate groups linked by high-energy phosphoanhydride

161 Carbohydrate moieties or phosphate groups linked to Hs11S were not detected.

162 Tides, monophosphorylated acyclovir with the phosphate group masked by lipophilic groups to allow eff

163 latively high degree of solvation around the phosphate groups may contribute to the preservation of t

164 the Mn(II) ions are bound to histidines and phosphate groups, mostly from fructose-1,6-bisphosphate

165 idence that the negative charge of the A2662 phosphate group must be retained for uncompromised activ

166 for multiple residues in the molecule, some phosphate groups must be embedded in the hydrophobic par

167 Ser10 forms a direct hydrogen bond with a phosphate group near the active site and is involved in

168 mycin P inside the cap domain positioned the phosphate group next to a Mg(2+) ion present at the junc

169 t substrate, beta-alanine, and show that the phosphate group of AMP serves as an anchor for the bindi

170 cts with non-bridging oxygen atoms from each phosphate group of ATP and three water molecules than oc

171 same binding site for the 3'- and 2'-ribose phosphate group of CoA and NADP(+), respectively, but a

172 diester bond through transfer of LEEs to the phosphate group of DNA oligomers from the nucleobases.

173 The influence of the negatively charged 5'-phosphate group of FMN quinone on E1 could result in a m

174 vealed that the downstream strand and its 5'-phosphate group of gapped DNA interact intensely with th

175 ntation, anchored by hydrogen bonding to the phosphate group of lipids in a manner analogous to chole

176 demonstrates a new mode of binding of the 2'-phosphate group of NADP via a water-mediated contact wit

177 no acid residues responsible for binding the phosphate group of NADP(+) were identified.

178 uired for the recognition and binding of the phosphate group of nucleotides.

179 The intrinsic binding energies of the 5'-phosphate group of orotidine 5'-monophosphate for the mu

180 by the formation of salt bridges between the phosphate group of PEP and the side chains of Lys(340) a

181 s of Crb2 serine-548 and lysine-619 with the phosphate group of phospho-H2A (gamma-H2A) are critical

182 as well as modeling studies reveal that the phosphate group of pTyr99 imposes extensive steric clash

183 Instead, the phosphate group of S10 seems to form a persistent intram

184 favorable intramolecular interactions of the phosphate group of Ser-133 with the charged groups of an

185 eristic of B[a]PDE adduct formation with the phosphate group of the 2'-deoxynucleotide.

186 alpha-/beta-tubulins and interacts with the phosphate group of the alpha-tubulin-bound GTP.

187 e profoundly depends on the structure of the phosphate group of the ATP cofactor.

188 ucleotide-binding sites and depends upon the phosphate group of the bound cofactor.

189 mplex is independent of the structure of the phosphate group of the cofactor bound to the helicase.

190 ase become sensitive to the structure of the phosphate group of the cofactor.

191 f the ammine ligands of cisplatin and the 5' phosphate group of the DNA backbone is responsible for t

192 The phosphate group of the inhibitor attached to the hydroxy

193 sting a similar mode of interaction with the phosphate group of the ligand.

194 tionally contains GMPs bound to the terminal phosphate group of the MPTs (bis-MGD).

195 c transition depends on the structure of the phosphate group of the nucleotide.

196 leic acid, depending on the structure of the phosphate group of the present nucleotide cofactor and p

197 thermautotrophicus, we find the "remote" 5'-phosphate group of the substrate activates the enzyme 2.

198 pocket that specifically accommodates the D4 phosphate group of the substrate.

199 phosphate ion binds in the same site as the phosphate group of the substrate/product, 2-phospho-D-gl

200 ormation results in the rotation of the beta-phosphate group of UDP away from the cleaved GalNAc moie

201 The phosphate groups of AMP/ATP lie in a groove on the surfa

202 the P-loop, that normally interacts with the phosphate groups of ATP but is folded over a substructur

203 catalyzed by NS4B indicate that the terminal phosphate groups of ATP, GTP, and GDP are removed to pro

204 eas the coordination of Co(2+) ions with the phosphate groups of DNA and nucleotides statically quenc

205 of a complex between the negatively charged phosphate groups of DNA and the positively charged headg

206 tic IR absorption bands of all the bases and phosphate groups of DNA.

207 This counters the notion that the phosphate groups of GTP are fully deprotonated at the st

208 determine the roles of the 1-, 3-, 5-, and 6-phosphate groups of inositol 1,3,4,5,6-pentakisphosphate

209 tral aminoarabinose moiety onto the negative phosphate groups of lipid A, reducing the surface charge

210 acids, arginine (Arg) and lysine (Lys), with phosphate groups of phospholipid heads using quantum mec

211 The dimetal complexes bind specifically the phosphate groups of phospholipids and add an excess of u

212 Oxygen atoms at phosphate groups of phosphopeptide are not exchanged.

213 y ion-pairing between the negatively charged phosphate groups of ssDNA on the surface of the SWCNT an

214 neo-IP(6)) and delta = 6.48 ppm (equatorial phosphate groups of the 2-equatorial/4-axial conformer o

215 NMR signals at delta = 6.67 ppm (equatorial phosphate groups of the 4-equatorial/2-axial conformer o

216 ethyl (DMNPE), located on the four terminal phosphate groups of the duplex RNA.

217 probes could be directly labeled to the free phosphate groups of the hybridized PNA/DNA heteroduplexe

218 a4 helix and its vicinity mainly contact the phosphate groups of the iteron.

219 its transport to the bacterial surface, the phosphate groups of the lipid A anchor of Escherichia co

220 ntial magnesium ion is observed bridging the phosphate groups of the products.

221 The two phosphate groups of this 10-membered ring are contribute

222 (CID) tends to result in loss of the labile phosphate group, often at the expense of sequence fragme

223 s between the protonated amine of K7 and the phosphate group on S10, further enhancing the dynamic co

224 purified protein appeared to carry a single phosphate group on serine 150.

225 trast to these findings, P148, with a single phosphate group on serine 16, was found to inhibit calci

226 The phosphate group on the 1,2,9,9a-tetrahydrocyclopropa[c]b

227 cruits PP1c for the removal of an inhibitory phosphate group on the alpha subunit of elongation initi

228 emplated primer extension and relies on a 5'-phosphate group on the distal gap strand end to confer a

229 we have determined that the presence of the phosphate group on the Kdo residue is necessary for seco

230 3'-hydroxyl on one side of the gap, and a 5'-phosphate group on the other, for the polymerase and lig

231 r transfer to protein, (ii) the ethanolamine phosphate group on the third mannose residue of the GPI

232 In the structure of pY53-actin, the phosphate group on Tyr-53 makes hydrogen-bonding interac

233 gand molecules that specifically bind to the phosphate groups on any phosphoproteins.

234 nteractions between the Tat peptides and the phosphate groups on both sides of the lipid bilayer, the

235 and 18O1 labeling for counting the number of phosphate groups on peptides is also demonstrated.

236 Peptidyl phosphates, phosphate groups on phosphopeptides, are converted to ph

237 A novel method is reported to modify the phosphate groups on phosphoserine peptides to the corres

238 of the Rev1 BRCT domain is not to recognize phosphate groups on protein binding partners or on DNA.

239 d a Zn(II)-dipicolylamine complex that binds phosphate groups on proteins.

240 lized by divalent cation cross-links between phosphate groups on the core oligosaccharide regions.

241 inding affinity correlate with the number of phosphate groups on the inositol ring, with phosphate po

242 ptides, or by the loss of negatively charged phosphate groups on the LPS molecule, this information i

243 istics of these conformations is the exposed phosphate groups on the periphery, which possibly could

244 rmed in modern biochemistry (but without the phosphate groups on the sugars).

245 Modeling a phosphate group onto the side-chain hydroxyl oxygen of T

246 better than the polymer containing either a phosphate group or a sulfonic acid group in terms of (i)

247 lar dynamics indicate that introduction of a phosphate group or phosphomimetic at position 26 diminis

248 Wild-type alphas1-casein has 6 to 8 phosphate groups (P) while the internally deleted form 6

249 e measured for phospholipids with an exposed phosphate group: phosphatidic acid, ceramide-1-phosphate

250 2 (a metal coordinating ligand) and the oxoG phosphate group (PO4) interfere with the hydrogen bondin

251 in the gamma subunit, with their respective phosphate groups positioned near function-impairing muta

252 tion, near 1100 cm(-1), from the nonbridging phosphate groups, probes the effect of Mg(2+)-hydrate in

253 The conclusion that the IBE of the 5'-phosphate group provides stabilization to both the E(c).

254 d scission is then facilitated by a backbone phosphate group proximal to the alkylated base.

255 and Ser87 could be the key residues for the phosphate group recognition.

256 Binding of calcium cations to the lipid phosphate group reduces ordering of the water molecules.

257 The actual impact of adding and removing phosphate group(s) is 3-fold: changes in the local/globa

258 Removal of both phosphate groups severely attenuated the mutants when ad

259 As a result, the 4-phosphate group shows a significantly lower charge at pH

260 ensive hydrogen bonding with water and lipid phosphate groups (snorkeling) and by partial unfolding.

261 d by other macromolecules containing diverse phosphate groups, such as phospholipids and phosphorylat

262 acyl chains (16 and 18 carbons) and a single phosphate group that is partially modified by galactosam

263 c mitochondria with four acyl chains and two phosphate groups that have been implicated in numerous f

264 icial binding peak) or two oxygen atoms from phosphate groups (the most internal peak).

265 e predicted importance of the -2, -1, and +1 phosphate groups, there was an apparent disagreement wit

266 surface is covered by phospholipids, having phosphate groups, therefore lipoproteins are enriched by

267 to double-stranded nucleic acids via the 5' phosphate group these fluorophores stack onto the ends o

268 ith all the base pairs of DNA (A-T; G-C) and phosphate group through hydrogen bond (H-bond) interacti

269 gnaling requires hydrolysis of inositol ring phosphate groups through the actions of PtdIns(3,4,5)P3

270 nucleotide salvage pathway by transferring a phosphate group to a thymidine molecule.

271 ecting the sulfonate anion and a substrate's phosphate group to form the branched propargyl addition

272 We demonstrated that P1 Doc added a single phosphate group to the essential translation elongation

273 The kinase LpxT, for example, adds a phosphate group to the lipid A moiety of some Gram-negat

274 Through the covalent addition of phosphate groups to certain amino-acids, the interaction

275 ain lacking acetyl-phosphate that can donate phosphate groups to OmpR.

276 t-translational modifications (PTMs) such as phosphate groups underlie a majority of human diseases.

277 igands that imitate either a phosphoryl or a phosphate group was 357 at the end of 2016.

278 , the oxygen-to-sulfur substitution in a DNA phosphate group was found to enhance the mobility of the

279 n amino acid residue (valine or lysine) or a phosphate group was introduced on the thiazolium side ch

280 ted peptides, very little loss of the labile phosphate groups was observed.

281 residue (either an additional Kdo sugar or a phosphate group) was also found to be critical for secon

282 which was covalently attached at a specific phosphate group, was scanned consecutively through the D

283 ral methylphosphonate groups for anionic DNA phosphate groups weakened nonspecific DNA binding affini

284 r or oleyl-type ether chain and (32)P in the phosphate group were synthesized.

285 The vibrational and rotational modes of phosphate groups were analyzed with Raman microscopy.

286 When phosphate groups were globally reduced using nonspecific

287 n = number of phosphates) with at least four phosphate groups were highly effective (polyP4 approxima

288 ant for IP binding to IPK1, and the 1- and 3-phosphate groups were more important for IPK1 activation

289 The 5- and 6-phosphate groups were the most important for IP binding

290 the compounds, although charged at the alpha-phosphate group, were taken up by the cells and released

291 uction in the gas-phase basicity (GB) of the phosphate group when bound to {LGa2}(5+)/{LIn2}(5+) comp

292 ed LCD (determined previously), and with the phosphate group when the serine is phosphorylated.

293 explained by high polar surface areas (e.g. phosphate groups), whereas mOat3 prefers hydrogen bond a

294 re located in the major groove near multiple phosphate groups, whereas site 2 is adjacent to N7 of G6

295 ncy of CpG (the dinucleotide CG, linked by a phosphate group), which is underrepresented in most smal

296 ere directly labeled to the free 5'-terminal phosphate groups, which were activated by EDC and imidaz

297 features combine negative charges of the two phosphate groups with four hydrophobic fatty acid residu

298 s of the polycation mainly interact with DNA phosphate groups, with polycation intrusion into the maj

299 to the binding and orientation of the bound phosphate group within the ligand-binding pocket.

300 ed to measure the distance between amine and phosphate groups within cell wall fragments of Bacillus