ライフサイエンスコーパス: phosphatidic acid

1 age sensor regulation by the signaling lipid phosphatidic acid.

2 ds phosphatidylinositol 4,5-bisphosphate and phosphatidic acid.

3 d controlled, we characterize two effects of phosphatidic acid.

4 oss of function and, as expected, accumulate phosphatidic acid.

5 wn to be lipid-binding proteins specific for phosphatidic acid.

6 competing with the endogenous mTOR activator phosphatidic acid.

7 kinase that phosphorylates diacylglycerol to phosphatidic acid.

8 receptor gamma (PPARgamma) inhibitor cyclic phosphatidic acid.

9 talyzes the formation of diacylglycerol from phosphatidic acid.

10 Here we show that Epac1 binds directly to phosphatidic acid.

11 shes translocation, also prevents binding to phosphatidic acid.

12 veral APLs, including phosphatidylserine and phosphatidic acid.

13 in fibronectin and the membrane phospholipid phosphatidic acid.

14 hatidylcholine to the lipid second messenger phosphatidic acid.

15 ions between a cluster of basic residues and phosphatidic acid.

16 osphatidylglycerol, and cardiolipin, but not phosphatidic acid.

17 n of the pleiotropic lipid second messenger, phosphatidic acid.

18 through MGDG SYNTHASE1 (MGD1) activation by phosphatidic acid.

19 diacylglycerol that can be phosphorylated to phosphatidic acid.

20 Diacylglycerol kinase (DGK) converts DG into phosphatidic acid.

21 ne to generate an important signaling lipid, phosphatidic acid.

22 apping protein (CP) by the signalling lipid, phosphatidic acid.

23 anslocates to ER-PM junctions via binding to phosphatidic acid.

24 Cyclic phosphatidic acid (1-acyl-2,3-cyclic-glycerophosphate, C

25 18:1, alkylglycerophosphate 18:1, and cyclic phosphatidic acid 18:1, all with a monounsaturated C18 h

26 GAC PH domain also binds to phosphatidic acid, a lipid mediator associated with micr

27 -, di-, and triphosphorylated inositides), a phosphatidic acid, a phosphatidylcholine, a phosphatidyl

28 is required for the downstream production of phosphatidic acid, a promoter of several Ras signaling p

29 Intracellular phosphatidic acid accounts for a nearly 50 mV shift in t

30 We hypothesize this to be a result of phosphatidic acid accumulation in the chloroplast outer

31 uter leaflet of the outer envelope membrane, phosphatidic acid accumulation is not observed, likely b

32 ged lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidic acid acid (POPA), in supported lipid bilaye

33 The product of PLD, phosphatidic acid, activates the enhancer in a rapamycin

34 cial for TRE biogenesis is the generation of phosphatidic acid, an essential lipid component of TRE t

35 Ubiquitination hinders Dvl binding to phosphatidic acid, an interaction necessary for efficien

36 a sperm phospholipase D activity to produce phosphatidic acid and boosts the synthesis of phosphatid

37 headgroup of phosphatidylcholine to produce phosphatidic acid and choline.

38 ) hydrolyzes phosphatidylcholine to generate phosphatidic acid and choline.

39 which hydrolyzes phosphatidylcholine to form phosphatidic acid and choline.

40 plicating a variety of other lipids, such as phosphatidic acid and diacylglycerol, and their metaboli

41 of long chain CoAs and de novo generation of phosphatidic acid and diacylglycerol.

42 parent cells were significantly enriched in phosphatidic acid and N-acylphosphatidylethanolamine.

43 d triglycerides but presented high levels of phosphatidic acid and normal levels of phosphatidylinosi

44 this process in vitro and found that mainly phosphatidic acid and phosphatidylinositol-4-phosphate e

45 ly with a number of phospholipids, including phosphatidic acid and phosphoinositol(3,4,5)P3, phosphoi

46 ast membranes and specific interactions with phosphatidic acid and phosphorylated forms of phosphatid

47 tein is able to bind to liposomes containing phosphatidic acid and protect the liposomes from fusing

48 which in turn decreases phosphatidylcholine, phosphatidic acid and signaling through the MAPK and PI3

49 de, and phosphatidylethanolamine inhibit and phosphatidic acid and sphingomyelin enhance SPCA1a activ

50 served in obesity (e.g. free fatty acids and phosphatidic acid) and plastics exposure (monophthalate

51 nces were observed for phosphatidylinositol, phosphatidic acid, and bis(monoacylglycero)phosphate spe

52 sting of palmitoylsphingomyelin, dimyristoyl phosphatidic acid, and cholesterol in three different pr

53 ctions of its enzymatic product of reaction, phosphatidic acid, and its unique shape-binding role on

54 -bilayer-forming lipids such as cardiolipin, phosphatidic acid, and phosphatidylethanolamine (PE) are

55 ylserine, phosphatidylglycerol, cardiolipin, phosphatidic acid, and phosphorylated derivatives of pho

56 6K1 preferentially bound to the phospholipid phosphatidic acid, and this binding was required for IP6

57 s cardiolipin, phosphatidylethanolamine, and phosphatidic acid are present in the yeast bc(1) complex

58 Phosphatidic acid, as synthesized by phospholipase D (PL

59 pport the conclusion that a specific pool of phosphatidic acid, associated with lipid droplet formati

60 ifferent ionic strengths, and for dioctanoyl phosphatidic acid at different pH values.

61 1 led to its activation and the synthesis of phosphatidic acid at sites of neurite growth.

62 favors Opi1p interaction with both Scs2p and phosphatidic acid at the endoplasmic reticulum (ER) memb

63 With distinct phosphatidic acid binding abilities and PI transfer prot

64 We further studied phosphatidic acid binding by MAM7 using site-directed mu

65 nd mutated peptides in which the core of the phosphatidic acid binding domain was disrupted.

66 However, the significance of phosphatidic acid binding for the function of TGD2 in vi

67 Mutating residues implicated in phosphatidic acid binding revealed a possible role in Ba

68 Finally, we showed that fibronectin and phosphatidic acid binding to MAM7 are not mutually exclu

69 Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity),

70 us identified diacylglycerol kinase-mediated phosphatidic acid biosynthesis and production of phospha

71 ion-mode of phosphoinositide phosphates and phosphatidic acid bound to {LGa2}(5+) were between 2.5-

72 We also found that a lipid second messenger, phosphatidic acid, bound PTPD2 in vitro and enhanced its

73 wild type, including increased abundance of phosphatidic acids but reduced abundance of diglycerides

74 and potently disrupts liposomes composed of phosphatidic acid by forming pores.

75 Furthermore, depletion of phosphatidic acid by inhibition of phospholipase D1 prev

76 Apart from this function, exogenous phosphatidic acid by itself (300 pM) increases GTP bindi

77 rometry (LC-MS) to show that accumulation of phosphatidic acid by means other than cdsA mutations als

78 n response to nutrients is the generation of phosphatidic acid by PLD.

79 hanolamine) and anionic (phosphatidylserine, phosphatidic acid, cardiolipin, and phosphatidylinositol

80 -noise ratio (S/N) but showed high levels of phosphatidic acid caused by the loss of the headgroup in

81 ospholipids with an exposed phosphate group: phosphatidic acid, ceramide-1-phosphate, and dihydrocera

82 , phosphatidylserines, phosphatidylglycerol, phosphatidic acids, ceramide phosphates, sterol lipids,

83 We suggest that increased levels of phosphatidic acid change the physical properties of the

84 a distinct architecture, specifically binds phosphatidic acid commonly present within the inner leaf

85 phatidylserine, sphingosine 1-phosphate, and phosphatidic acid, could not elicit the potent chemotact

86 We also found that phosphatidic acid enhances Fes activity in MDA-MB-231 ce

87 ental evidence for the mitotic regulation of phosphatidic acid flux and suggest that the regulatory n

88 n for blood-brain barrier targeting and with phosphatidic acid for Abeta binding.

89 Last, we confirm the relative importance of phosphatidic acid for this pro-survival effect as phosph

90 acyl-ACP to acyl-phosphate on the pathway to phosphatidic acid formation.

91 interaction is required for the transfer of phosphatidic acid from the ER to the mitochondria for ca

92 Phosphatidic acid generated by the activation of phospho

93 id (GroP bearing C12:0, C16:0, or C16:1), or phosphatidic acid (GroP bearing either C16:0 + C12:0 or

94 hain, the sn-3 hydrophilic phosphocholine or phosphatidic acid group, and the polar sn-2 tail are abs

95 Phospholipase D (PLD) and its product, phosphatidic acid, have been established as mediators of

96 Phosphatidylethanolamine and phosphatidic acid, however, did not have a significant e

97 act with the negatively charged phospholipid phosphatidic acid immobilized on solid substrates or in

98 produce phosphatidic acid-reveal a role for phosphatidic acid in Bazooka embryonic epithelial activi

99 ospholipase D (PLD), an enzyme that produces phosphatidic acid in cells, also attenuated the ERBB2 ph

100 Overall our results highlight a new role for phosphatidic acid in endocytic recycling and provide new

101 Indeed, the presence of phosphatidic acid in liposomes enhances the ability of s

102 f the involvement of phospholipase D-derived phosphatidic acid in regulated exocytosis, we used an ar

103 o acyl chain discrimination among species of phosphatidic acid in the activation of the phosphorylati

104 lipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of

105 he inner membrane and its C terminus binding phosphatidic acid in the outer membrane.

106 TP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia

107 acted specifically with liposomes containing phosphatidic acid in vitro.

108 into the chloroplast, and was found to bind phosphatidic acid in vitro.

109 which CP activity is negatively regulated by phosphatidic acid in vivo.

110 (DGK), which phosphorylates DAG to generate phosphatidic acid, in the regulation of pigmentation.

111 ized membrane lipid species and normal-chain phosphatidic acids indicated that stress-induced ox-lipi

112 n (with fibronectin) and protein-lipid (with phosphatidic acid) interactions with the host cell membr

113 Phosphatidic acid interacts with Lsi6, a silicon transpo

114 which encodes a phospholipase that catalyzes phosphatidic acid into lysophosphatidic acid and free fa

115 Phosphatidic acid is a putative second messenger implica

116 Activation of PIP5K by phosphatidic acid is also acyl chain-dependent.

117 demonstrate that PLD-dependent generation of phosphatidic acid is critical for Rac1/IQGAP1 signal tra

118 Phosphatidic acid is generated from the cleavage of phos

119 ase D (PLD)-dependent production of membrane phosphatidic acid is required for invasion.

120 Phosphatidic acid is typically synthesized in a three-st

121 PLD2 overexpression-->PLD2/Fes association-->phosphatidic acid-led activation of Fes kinase-->granulo

122 AT6 increased both lysophosphatidic acid and phosphatidic acid levels in cells.

123 AGPAT2 modulated the levels of phosphatidic acid, lysophosphatidic acid, phosphatidylin

124 omains and the possibility that its product, phosphatidic acid, may regulate signal transduction and

125 may be required to provide a ready supply of phosphatidic acid necessary for the feed-forward amplifi

126 at both the substrate (LPA) and the product (phosphatidic acid) of the LPA acyltransferase reaction a

127 hroism and electron microscopy, we show that phosphatidic acid, oleic acid, and the phthalate metabol

128 tudy uncovers and investigates the effect of phosphatidic acid on Kv channel gating.

129 of phospholipase D activity and its product phosphatidic acid on the Ca(2+) sensitivity and rate of

130 ycerides and found that 1-palmitoyl-2-oleoyl-phosphatidic acid or 1-palmitoyl-2-oleoyl-phosphatidylgl

131 pid IV(A), whereas glycerophospholipids like phosphatidic acid or phosphatidylglycerol phosphate are

132 tivity is elevated with PLD2 overexpression, phosphatidic acid or phosphatidylinositol bisphosphate.

133 zeta binds significantly to PIP2, but not to phosphatidic acid or phosphatidylserine, and that sequen

134 ipids with phosphate headgroups, namely C1P, phosphatidic acid or their lyso-derivatives, remains unc

135 However, in the presence of phosphatidic acid, or of cardiolipin, interaction is det

136 horylating substrates lysophosphatidic acid, phosphatidic acid, or sphingosine-1-phosphate but surpri

137 While the precursors for phosphatidic acid (PA) (long-chain fatty acyl-CoAs and l

138 in phagocytosis, which is the production of phosphatidic acid (PA) and activation of phosphatidylino

139 her plants often induces rapid production of phosphatidic acid (PA) and changes in lipid profiles, bu

140 chemical assay for lipin 1 using mixtures of phosphatidic acid (PA) and phosphatidylethanolamine that

141 nteracts with the lysosomal signaling lipids phosphatidic acid (PA) and phosphatidylinositol(3,5)bisp

142 Phosphatidic acid (PA) and phytosphingosine 1-phosphate

143 Phosphatidic acid (PA) and phytosphingosine-1-phosphate

144 Phosphatidic acid (PA) and the conserved integral ER mem

145 Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated acyl chains of

146 ane surface to resemble apoptotic bodies and phosphatidic acid (PA) at the inner layer as a strategy

147 of lipins 1 and 2 and shown that di-anionic phosphatidic acid (PA) augments their activity and lipid

148 rprisingly, however, nanobilayers containing phosphatidic acid (PA) bound substantially more of two o

149 se, besides PI, RdgBbeta binds and transfers phosphatidic acid (PA) but hardly binds phosphatidylchol

150 f mTOR signalling involving the synthesis of phosphatidic acid (PA) by phospholipase D (PLD).

151 pressing AvrBsT accumulated higher levels of phosphatidic acid (PA) compared to leaves infected with

152 One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD

153 Phosphatidic acid (PA) has emerged as a class of cellula

154 Phospholipase D (PLD) and its metabolite phosphatidic acid (PA) have been implicated in the regul

155 rizzled receptor and the plasma membrane via phosphatidic acid (PA) in a mechanism proposed to be pH-

156 Here we analyzed a potential role of phosphatidic acid (PA) in biogenesis of mitochondrial pr

157 In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HG

158 NDGD1 binds to phosphatidic acid (PA) in membranes and mediates PA-depe

159 ture dendritic cells have elevated levels of phosphatidic acid (PA) in their plasma membrane.

160 nd -4-phosphate, and phosphatidylglycerol to phosphatidic acid (PA) in vitro.

161 Phosphatidic acid (PA) interacts with the FK506-binding

162 Phosphatidic acid (PA) is a central precursor for membra

163 Phosphatidic acid (PA) is a class of lipid messengers in

164 Phosphatidic acid (PA) is a critical mediator of mitogen

165 Phosphatidic acid (PA) is a critical metabolite at the h

166 Phosphatidic acid (PA) is a lipid second messenger locat

167 Phosphatidic acid (PA) is a pleiotropic lipid second mes

168 Phosphatidic acid (PA) is a potent lipid secondary messe

169 Phosphatidic acid (PA) is postulated to have both struct

170 Phosphatidic acid (PA) is the simplest phospholipid natu

171 restored by treatment with the PLD product, phosphatidic acid (PA) or adenoviral PLD1 expression in

172 Phosphatidic acid (PA) or Nuclear Receptors (NR) PPARalp

173 tor of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that cat

174 dition of a short-chain DAG or a short-chain phosphatidic acid (PA) restores the ABA response of NPC4

175 or Opi1 preferentially binds to C16 over C18 phosphatidic acid (PA) species: thus, C16-chain containi

176 ome precursors and we show that HS1BP3 binds phosphatidic acid (PA) through its PX domain.

177 plant defensin NsD7 targets the phospholipid phosphatidic acid (PA) to form oligomeric complexes that

178 glyceride synthesis and dephosphorylation of phosphatidic acid (PA) to generate diacylglycerol.

179 PLD produces phosphatidic acid (PA), a bioactive lipid involved in mu

180 A critical factor regulating mTOR is phosphatidic acid (PA), a central metabolite of membrane

181 This reliance of S6K on phosphatidic acid (PA), a curvature-inducing phospholipi

182 Activation of phospholipase D (PLD) produces phosphatidic acid (PA), a lipid messenger implicated in

183 Phosphatidic acid (PA), a second messenger typically der

184 the signaling protein phospholipase D (PLD), phosphatidic acid (PA), and a specific set of microRNAs

185 and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biol

186 tidylinositol (PI), phosphatidylserine (PS), phosphatidic acid (PA), cardiolipin (CL), ergosterol (ER

187 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the

188 ance between DAG and its downstream product, phosphatidic acid (PA), is essential for controlling mic

189 ular content of lysophosphatidic acid (LPA), phosphatidic acid (PA), or diacylglycerol (DAG), respect

190 to m/z of 1000, including lyso-phospholipid, phosphatidic acid (PA), phosphoethanolamine (PE), phosph

191 Through its production of phosphatidic acid (PA), phospholipase D (PLD) is strongl

192 D (PLD) and its enzymatic reaction product, phosphatidic acid (PA), regulate cell adhesion of immune

193 pha), which phosphorylates diacylglycerol to phosphatidic acid (PA), was required for RCP to be mobil

194 by lipid-derived second messengers, such as phosphatidic acid (PA), we sought to determine if dimini

195 We compare the negatively charged phosphatidic acid (PA), which at physiological pH and sa

196 n resistance in liver by activating PKC, and phosphatidic acid (PA), which inhibits insulin action in

197 estigated the regulation of TREK channels by phosphatidic acid (PA), which is generated by phospholip

198 g in the LD phospholipid monolayer and binds phosphatidic acid (PA).

199 )-dependent increase in the concentration of phosphatidic acid (PA).

200 rm activate phospholipase D (PLD) to elevate phosphatidic acid (PA).

201 pathways including the dephosphorylation of phosphatidic acid (PA).

202 glycerol (DAG) as a substrate and generating phosphatidic acid (PA).

203 s in response to the signaling phospholipid, phosphatidic acid (PA).

204 ial fusion by generating the signaling lipid phosphatidic acid (PA).

205 ts substrate to produce the signalling lipid phosphatidic acid (PA).

206 CTP-dependent phosphorylation of DAG to form phosphatidic acid (PA).

207 pecific lipids in CME, in particular that of phosphatidic acid (PA).

208 ts, and root hairs had an increased level of phosphatidic acid (PA).

209 4 has been shown to bind to the phospholipid phosphatidic acid (PA).

210 spholipase D (PLD) and its reaction product, phosphatidic acid (PA).

211 lates with an accumulation of its substrate, phosphatidic acid (PA).

212 tulated with the addition of the PLD product phosphatidic acid (PA).

213 cerols (PG), phosphatidylethanolamines (PE), phosphatidic acids (PA), and fatty acids.

214 the lipase (and signals through its product, phosphatidic acid [PA]) and another that involves protei

215 id metabolites, fatty acids, amino acids and phosphatidic acid (PAs), phosphatidylglycerol (PGs), gly

216 molecular species with oxidized acyl chains, phosphatidic acids (PAs)), tri- and tetra-galactosyldiac

217 sed of phospholipids phosphatidylcholine and phosphatidic acid (PC/PA) or phosphatidylcholine and pho

218 e found that LPIN1, which encodes lipin-1, a phosphatidic acid phosphatase (PAP) controlling the rate

219 Lipin 2 is a phosphatidic acid phosphatase (PAP) responsible for the

220 ene transcription and, as a Mg(2+)-dependent phosphatidic acid phosphatase (PAP), is a key enzyme in

221 telet-derived growth factor (PDGF)-beta, and phosphatidic acid phosphatase 2b (PPAP2B).

222 Lipin-1 is a Mg(2+)-dependent phosphatidic acid phosphatase involved in the de novo sy

223 lope-enriched activator of the ER-associated phosphatidic acid phosphatase lipin that promotes synthe

224 We show that inactivation of Ned1, the phosphatidic acid phosphatase of the lipin family, by CD

225 Mon1-Ccz1 is absent on vacuoles lacking the phosphatidic acid phosphatase Pah1, which also lack Ypt7

226 PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integ

227 controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase.

228 Lipins 1, 2, and 3 are Mg(2+)-dependent phosphatidic acid phosphatases and catalyze the penultim

229 e family encodes a class of Mg(2+)-dependent phosphatidic acid phosphatases involved in the de novo s

230 Lipins are phosphatidic acid phosphatases with a pivotal role in re

231 each line has an individual pattern of DAG, phosphatidic acid, phosphatidylcholine, and triacylglyce

232 Twenty-eight different lipid species (phosphatidic acids, phosphatidylethanolamines, phosphati

233 We identified phosphatidic acid, phosphatidylglycerol, and glycerol ph

234 MGDG) content in ads2 mutants were lower and phosphatidic acid, phosphatidylinositol, phosphatidyleth

235 The anionic phospholipids, phosphatidic acid, phosphatidylserine, phosphatidylglyce

236 We previously showed that the disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH) activity in Ara

237 actors and at the endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme (PAP-1) to cat

238 a protein that exhibits dual functions as a phosphatidic acid phosphohydrolase enzyme in the triglyc

239 pathway independent of protein kinase C and phosphatidic acid phosphohydrolase-1 hydrolase signaling

240 The nonspecific actions of BEL on phosphatidic acid phosphohydrolase-1, p47(phox) phosphor

241 We previously reported that disruption of PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 (PAH1) and PAH2 stim

242 n Arabidopsis thaliana, two Mg(2+)-dependent phosphatidic acid phosphohydrolases called PAH1 and PAH2

243 We show that cytosolic phosphatidic acid phospholipase A1 (PAPLA1) interacts wi

244 le for lipins as determinants of levels of a phosphatidic acid pool that influences Pparg expression.

245 acid by an acyl CoA substrate to produce the phosphatidic acid precursor of polar glycerolipids and t

246 Cellular levels of phosphatidic acid, precursor to all membrane phospholipi

247 , PstB2p, and Pbi1p that ligate to Scs2p and phosphatidic acid present in the donor membrane, forming

248 The membrane lipid phosphatidic acid, produced by phospholipase D (PLD), ha

249 Chemical inhibition of phosphatidic acid production by PLD increased the penetr

250 embrane of the chloroplast, while TGD4 binds phosphatidic acid (PtdOH) and resides in the outer chlor

251 Similarly, phosphatidic acid (PtdOH), generated from diacylglycerol

252 otein when fused to DsRED specifically binds phosphatidic acid (PtdOH).

253 own that the C-terminal domain of TGD2 binds phosphatidic acid (PtdOH).

254 t DGKalpha is required for the generation of phosphatidic acid required for tubular recycling endosom

255 Exogenously added phosphatidic acid rescued the PLD-inhibition phenotype,

256 DAG kinases (DGKs) convert DAG into phosphatidic acid, resulting in termination of DAG signa

257 that enables DEP domain-mediated binding to phosphatidic acid, resulting in the tethering of Epac1 a

258 eraction of CP with phospholipids, including phosphatidic acid, results in uncapping of filament ends

259 nase or phospholipase D-enzymes that produce phosphatidic acid-reveal a role for phosphatidic acid in

260 which phosphorylates diacylglycerol to yield phosphatidic acid, selectively dissociates Rac1 by stimu

261 ellular trafficking, lipid biosynthesis, and phosphatidic acid signaling pathway.

262 ntrols the switch between diacylglycerol and phosphatidic acid signaling pathways.

263 imaged, including phosphatidylethanolamines, phosphatidic acids, sterols, and gossypol, indicating th

264 nalysis, and determined that fully saturated phosphatidic acids such as 1,2-distearoyl-PA (18:0/18:0-

265 d intermediates such as free fatty acids and phosphatidic acid, suggesting a buffer function of TAG a

266 hatidic acid for this pro-survival effect as phosphatidic acid supplementation fully restores MAPK si

267 yoelii has an incomplete apicoplast-targeted phosphatidic acid synthesis pathway that is essential fo

268 s are being utilized for apicoplast-targeted phosphatidic acid synthesis, the phospholipid precursor.

269 - and cytosol/endoplasmic reticulum-targeted phosphatidic acid synthesis.

270 ese data reveal a signaling pathway by which phosphatidic acid synthesized via the glycerol-3-phospha

271 e-zeta (DGKzeta), which metabolizes DAG into phosphatidic acid, terminating DAG-mediated Ras signalin

272 cerophospholipids (phosphatidylethanolamine, phosphatidic acid) than to any other sphingolipid.

273 cyltransferase pathway for the biogenesis of phosphatidic acid that begins with the acylation of sn-g

274 pho-cofilin-dependent balanced production of phosphatidic acid that is required for optimal Listeria

275 volving PTPD2 and the lipid second messenger phosphatidic acid that promotes ERBB2 function.

276 en the mitochondrial fission GTPase Drp1 and phosphatidic acid that restrains Drp1 activity and shift

277 we report an itch-inducing molecule, cyclic phosphatidic acid, that activates TRPV1 and whose prurit

278 hospholipase D (PLD) generates a metabolite, phosphatidic acid, that facilitates association between

279 marked increase of diacylglycerol (DAG) and phosphatidic acid, the precursors for TAG, in the mutant

280 nmask a cross-talk between the metabolism of phosphatidic acid, the product of phospholipase D(2), an

281 types were associated with reduced levels of phosphatidic acid, the product of PLD activity and were

282 LD inhibitors and siRNA knockdowns establish phosphatidic acid, the product of the PLD reaction, as a

283 ing pathways by converting diacylglycerol to phosphatidic acid, thereby downregulating signaling by t

284 1,2,3 complex, which is proposed to transfer phosphatidic acid through the inner envelope membrane, T

285 with 1-butanol, which diverts production of phosphatidic acid to a phosphatidylalcohol, caused simil

286 , which is responsible for the conversion of phosphatidic acid to CDP-diacylglycerol in phospholipid

287 ve feedback loop in which DGKalpha generates phosphatidic acid to drive its own recruitment to TRE vi

288 d by 1-butanol, which subverts production of phosphatidic acid to the biologically inert phosphatidyl

289 ck the conversion of glycerophospholipids to phosphatidic acid) to deplete cellular TRE, we observed

290 ged phospholipids (e.g., bilayers containing phosphatidic acid together with sphingomyelins, phosphat

291 zation in selective binding of lipin1beta to phosphatidic acid, using blot overlay assays and model b

292 st that interfering with the CDP-DG route of phosphatidic acid utilization rewires cellular metabolis

293 phate, phosphatidylinositol 3-phosphate, and phosphatidic acid was nearly identical in all phagosomes

294 nse to fungal infection an overexpression of phosphatidic acids was discovered.

295 protein Syndapin2 associate selectively with phosphatidic acid, we propose a positive feedback loop i

296 ed oils whereas phosphatidylethanolamine and phosphatidic acid were less abundant.

297 elf regulated by phospholipids, specifically phosphatidic acid, whereby 300 nM 1,2-dioleoyl-sn-glycer

298 and the BAR-domain protein syndapin2 bind to phosphatidic acid, which we identify as a novel lipid co

299 of PLD-induced cell invasion is mediated by phosphatidic acid, Wiscott-Aldrich Syndrome protein, gro

300 Species of phosphatidic acid with two unsaturated acyl chains are m