ライフサイエンスコーパス: phosphatidylinositol 3-phosphate

1 functional and that binding is specific for phosphatidylinositol 3-phosphate.

2 n binds with high specificity and avidity to phosphatidylinositol 3-phosphate.

3 Vps15 and stimulates increased production of phosphatidylinositol 3-phosphate.

4 imulated the activity of PI3K as measured by phosphatidylinositol 3-phosphate.

5 m-1 to abolish its weak, specific binding to phosphatidylinositol 3-phosphate.

6 domain that has recently been shown to bind phosphatidylinositol 3-phosphate.

7 multiple negative charges such as citrate or phosphatidylinositol 3-phosphate.

8 holipid bilayer can abet specific binding to phosphatidylinositol 3-phosphate.

9 strates phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate.

10 tein known (in any context) to interact with phosphatidylinositol 3-phosphate.

11 gets 3-position phosphoinositides, including phosphatidylinositol 3-phosphate.

12 required an intact FYVE domain, which binds phosphatidylinositol 3-phosphate.

13 CP1 is an ER-resident molecule that binds to phosphatidylinositol 3-phosphate.

14 ts FYVE (Fab1p, YOTB, Vac1p, EEA1) domain to phosphatidylinositol 3-phosphate.

15 ty was determined by measuring production of phosphatidylinositol-3-phosphate.

16 s involved in autophagy initiation, and bind phosphatidylinositol-3-phosphate.

17 tidylinositols such as phosphatidylinositol, phosphatidylinositol 3-phosphate, 4-phosphate, 5-phospha

18 lization and degradation requires binding to phosphatidylinositol 3-phosphate 5-kinase (PIKfyve), a l

19 The activated Akt acted through phosphatidylinositol 3-phosphate 5-kinase and Rab11 to f

20 The Fab1 protein is a phosphatidylinositol 3-phosphate 5-kinase involved in ye

21 We had previously shown that Fab1 phosphatidylinositol 3-phosphate 5-kinase is also requir

22 e (PtdIns(3,5)P2) is synthesized by a single phosphatidylinositol 3-phosphate 5-kinase, Fab1.

23 te 5-kinase, its3p, but does not require the phosphatidylinositol-3-phosphate 5-kinase, fab1p.

24 Leucettine L41 modestly inhibited phosphatidylinositol-3-phosphate 5-kinase, FYVE domain-c

25 I PI3K Vps34, while PI(3,5)P(2) requires the phosphatidylinositol-3-phosphate-5-kinase PIKFYVE.

26 he lack of Vps34p resulted in the absence of phosphatidylinositol 3-phosphate, a lipid required for S

27 14/PI3KIII complex in regard to synthesis of phosphatidylinositol 3-phosphate, a process that is link

28 Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide syn

29 responsible for inducing the accumulation of phosphatidylinositol-3-phosphate, a regulator of both NO

30 eases in the potential products of 5PTase11, phosphatidylinositol (3) phosphate and phosphatidylinosi

31 in a diminishment of localized generation of phosphatidylinositol 3-phosphate and blockade of both en

32 These findings define the generation of phosphatidylinositol 3-phosphate and EEA1 recruitment as

33 t MTMR7 dephosphorylated the D-3 position of phosphatidylinositol 3-phosphate and inositol 1,3-bispho

34 ms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuro

35 tion, the central region mediated binding to phosphatidylinositol 3-phosphate and other phosphoinosit

36 sphorylated phosphatidylinositols (including phosphatidylinositol 3-phosphate and phosphatidylinosito

37 direct measurement of increases in cellular phosphatidylinositol 3-phosphate and phosphatidylinosito

38 PIKfyve binds to phosphatidylinositol 3-phosphate and synthesizes phospha

39 ity through a functional interaction between phosphatidylinositol 3-phosphate and the Phox homology (

40 is the result of interactions of Vps27 with phosphatidylinositol 3-phosphate and ubiquitin.

41 zinc finger domain, which specifically binds phosphatidylinositol(3)-phosphate and is conserved in se

42 ins a phox homology domain predicted to bind phosphatidylinositol-3-phosphate and a C-terminal coiled

43 5-biphosphate marks the plasma membrane, and phosphatidylinositol-3-phosphate and phosphatidylinosito

44 in, an enzyme specifically dephosphorylating phosphatidylinositol-3-phosphate and phosphatidylinosito

45 Our data demonstrate that H7 binds phosphatidylinositol-3-phosphate and phosphatidylinosito

46 of phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3-phosphate, and phosphatidic acid

47 represents a bifunctional protein with both phosphatidylinositol 3-phosphate- and arabinogalactan pr

48 linositol (3,5)-bisphosphate and decrease in phosphatidylinositol 3-phosphate] and up-regulation of m

49 mmediate autophagic response, accompanied by phosphatidylinositol-3-phosphate appearance at the ER me

50 By metabolic labeling, we here identify phosphatidylinositol 3-phosphate as the sole in vivo pro

51 kinase (also known as Vps34) and its product phosphatidylinositol-3-phosphate, as well as on the lipi

52 This defect reduces the phosphatidylinositol 3-phosphate binding affinity of Cb,

53 studies therefore indicate that low affinity phosphatidylinositol 3-phosphate binding by the C-termin

54 docytic pathway and the number of accessible phosphatidylinositol 3-phosphate binding sites they cont

55 The phosphatidylinositol 3-phosphate binding, FYVE domain-co

56 ntains only 12 genes predicted to encode for phosphatidylinositol 3-phosphate binding, FYVE domain-co

57 ATG18 is a phosphatidylinositol-3-phosphate binding protein essenti

58 TyA-GFP to endosome membranes by fusion to a phosphatidylinositol 3-phosphate-binding domain induced

59 n phosphatidylinositol 3-kinase activity and phosphatidylinositol 3-phosphate-binding effectors.

60 ws how anionic ligands can interact with the phosphatidylinositol 3-phosphate-binding site.

61 a synthetic interaction via competition for phosphatidylinositol 3-phosphate-binding sites with endo

62 nuclear receptor-like fingers, LIM domains, phosphatidylinositol-3-phosphate-binding domains and His

63 We also identify FYVE1, a phosphatidylinositol-3-phosphate-binding protein recruit

64 Phosphatidylinositol 3-phosphate binds to a pocket forme

65 es is blocked by inhibition of fatty acid or phosphatidylinositol-3-phosphate biosynthesis, and the f

66 gnaling and membrane-trafficking proteins to phosphatidylinositol 3-phosphate-containing endosomes, e

67 In addition to establishing phosphatidylinositol-3-phosphate deficiency as a contrib

68 horylation of Thr-252 in vitro by the enzyme phosphatidylinositol 3-phosphate-dependent kinase-1 or m

69 Phosphatidylinositol 3-phosphate directs the endosomal l

70 tely after budding coincides with a burst of phosphatidylinositol-3-phosphate, distinct from any late

71 quired for Transport) pathway, including the phosphatidylinositol-3-phosphate effector Hrs and Tsg101

72 of a sorting nexin (SNX) dimer that binds to phosphatidylinositol 3-phosphate-enriched endosomal memb

73 he phox (PX) domain of Snx 17 interacts with phosphatidylinositol-3-phosphate for membrane associatio

74 by accumulation of the MTMR substrate lipid phosphatidylinositol 3-phosphate generated from the type

75 3,4,5-trisphosphate (PtdIns-(3,4,5)P(3)) >> phosphatidylinositol 3-phosphate > phosphatidylinositol

76 To begin to address the function of phosphatidylinositol 3-phosphate in skeletal muscle, we

77 65Q mutant, which has decreased affinity for phosphatidylinositol 3-phosphate in vitro, fails to targ

78 ard the vacuole of structures labeled by the phosphatidylinositol 3-phosphate indicator YFP-2xFYVE.

79 Here we show that phosphatidylinositol-3-phosphate is selectively deficien

80 inositides, Tiam1 selectively interacts with phosphatidylinositol 3-phosphate (K(D) approximately 5-1

81 ng MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol

82 Phosphatidylinositol 3-phosphate kinase activity was als

83 Phosphatidylinositol 3-phosphate kinase and Akt activiti

84 tivities were also induced by C5b-9, and the phosphatidylinositol 3-phosphate kinase inhibitor LY2940

85 Here, we report on the role of the class II phosphatidylinositol 3-phosphate kinase PIK3C2A in S. fl

86 rsed with LY294002 or wortmannin, suggesting phosphatidylinositol-3-phosphate kinase (PI3K) dependenc

87 however, diploids exhibit resistance to the phosphatidylinositol-3-phosphate kinase inhibitor wortma

88 evels, thereby restricting activation of the phosphatidylinositol-3-phosphate kinase pathway and prom

89 Inhibition of phosphatidylinositol-3-phosphate kinase, an upstream act

90 KO and Mtm1 p.R69C mice have similar muscle phosphatidylinositol 3-phosphate levels.

91 f2 deficiency led to increased intracellular phosphatidylinositol-3 phosphate levels and diminished A

92 , a chimeric protein that specifically binds phosphatidylinositol 3-phosphate, localizes to the trypa

93 uires the activity of Vps34, suggesting that phosphatidylinositol(3)phosphate may be essential for th

94 ncreasingly clarified, the normal role(s) of phosphatidylinositol 3-phosphate metabolism in muscle de

95 NX2 protein as did the overexpression of the phosphatidylinositol 3-phosphate phosphatase, confirming

96 n of dominant-negative PI3K (DN-p85alpha) or phosphatidylinositol 3-phosphate-phosphatase, PTEN, also

97 ot phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3-phosphate, phosphatidylinositol,

98 sitide-3-phosphatases, which dephosphorylate phosphatidylinositol 3-phosphate (PI(3)P) and bisphospha

99 Autophagosome formation is known to require phosphatidylinositol 3-phosphate (PI(3)P) and occurs nea

100 Phosphatidylinositol 3-phosphate (PI(3)P) and phosphatid

101 dentified the phosphoinositide lipids (PIPs) phosphatidylinositol 3-phosphate (PI(3)P) and phosphatid

102 e report here that the stepwise formation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatid

103 , has an N-terminal PX domain which binds to phosphatidylinositol 3-phosphate (PI(3)P) and to HOPS an

104 nner that depended on its FYVE domain and on phosphatidylinositol 3-phosphate (PI(3)P) biosynthesis.

105 ically dephosphorylate at the D3 position of phosphatidylinositol 3-phosphate (PI(3)P) in PI(3)P and

106 3, with a relative potency of PI(3,4,5)P3 >> phosphatidylinositol 3-phosphate (PI(3)P) or phosphatidy

107 phoinositide 3-kinase Vps34, suggesting that phosphatidylinositol 3-phosphate (PI(3)P) plays a role i

108 Phosphatidylinositol 3-phosphate (PI(3)P) plays an impor

109 Mtm-mediated turnover of endosomal phosphatidylinositol 3-phosphate (PI(3)P) pools generate

110 Invaginations are stabilized by phosphatidylinositol 3-phosphate (PI(3)P) produced by th

111 a MTM pseudophosphatase Sbf coordinates both phosphatidylinositol 3-phosphate (PI(3)P) turnover and R

112 Most FYVE domains bind specifically to phosphatidylinositol 3-phosphate (PI(3)P), a lipid that

113 bularin utilizes the lipid second messenger, phosphatidylinositol 3-phosphate (PI(3)P), as a physiolo

114 YFP-2xFYVE, recognizing phosphatidylinositol 3-phosphate (PI(3)P), showed two pa

115 p7p/Vps19p, associates with Pep12p and binds phosphatidylinositol 3-phosphate (PI(3)P), the product o

116 Phosphatidylinositol 3-phosphate (PI(3)P), the product o

117 along microtubules, tethered to vesicles via phosphatidylinositol 3-phosphate (PI(3)P), the signature

118 t RME-8 associates with early endosomes in a phosphatidylinositol 3-phosphate (PI(3)P)-dependent fash

119 A recent study reported that phosphatidylinositol-3-phosphate (PI(3)P) concentrated i

120 cilitates export by recognition of the lipid phosphatidylinositol-3-phosphate (PI(3)P) in the ER, pri

121 5-trisphosphate were below detection limits, phosphatidylinositol-3-phosphate (PI(3)P) levels in rod

122 tively, along with a PX domain that binds to phosphatidylinositol-3-phosphate (PI(3)P), which is gene

123 lcholine/phosphatidylinositol monophosphate (phosphatidylinositol-3-phosphate (PI-3P), -4-phosphate (

124 These findings indicate that phosphatidylinositol-3-phosphate (PI[3]P) is required fo

125 s nanomolar affinity for bilayers containing phosphatidylinositol-3-phosphate (PI[3]P).

126 curved membranes, but not flat ones, can use phosphatidylinositol 3-phosphate [PI(3)P] along with pho

127 the HOPS complex), and 2 phosphoinositides, phosphatidylinositol 3-phosphate [PI(3)P] and phosphatid

128 ases that dephosphorylate the 3' position of phosphatidylinositol 3-phosphate [PI(3)P] and PI(3,5)P(2

129 d its recruitment to the endosome depends on phosphatidylinositol 3-phosphate [PI(3)P] and the Rab5 G

130 Binding of the lipid phosphatidylinositol 3-phosphate [PI(3)P] is a critical

131 We found that yeast mutants lacking the phosphatidylinositol 3-phosphate [PI(3)P] kinase Vps34 o

132 The lipid second messenger phosphatidylinositol 3-phosphate [PI(3)P] plays a crucia

133 d phosphatidylinositol 4-phosphate [PI(4)P], phosphatidylinositol 3-phosphate [PI(3)P], and the lipid

134 ity of PX domains bind with high affinity to phosphatidylinositol 3-phosphate [PI(3)P], whereas the m

135 tophagy pathways, which are characterized by phosphatidylinositol 3-phosphate [PI(3)P]-positive membr

136 he KCa3.1 channel also specifically requires phosphatidylinositol-3 phosphate [PI(3)P] for channel ac

137 is due to the HT signal binding to the lipid phosphatidylinositol-3-phosphate [PI(3)P] in the parasit

138 The synthesis and recognition of the lipid phosphatidylinositol 3-phosphate, PI(3)P, is essential f

139 of downstream target proteins: Raf kinases, phosphatidylinositol-3 phosphate (PI3) kinase, and Ral-s

140 activates several kinase cascades, including phosphatidylinositol 3-phosphate (PI3K)/Akt, a signaling

141 erminal PX domain of Vam7 binds to the lipid phosphatidylinositol 3-phosphate (PI3P) and the tetherin

142 of retromer to endosomes requires the lipid phosphatidylinositol 3-phosphate (PI3P) as well as Rab5

143 Filimonenko et al. provide evidence that the phosphatidylinositol 3-phosphate (PI3P) binding protein,

144 PI(3,5)P2 is generated from phosphatidylinositol 3-phosphate (PI3P) by the lipid kin

145 the process, specifically for Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition.

146 nramp4 Our results indicate that AtPH1 binds phosphatidylinositol 3-phosphate (PI3P) in vivo and acts

147 Phosphatidylinositol 3-phosphate (PI3P) is a key ligand

148 y negative regulatory role in autophagy of a phosphatidylinositol 3-phosphate (PI3P) phosphatase Jump

149 Phosphatidylinositol 3-phosphate (PI3P), a membrane traf

150 ysosomes, the existence of cyclical waves of phosphatidylinositol 3-phosphate (PI3P), a membrane traf

151 o bind with high affinity and specificity to phosphatidylinositol 3-phosphate (PI3P), a phosphoinosit

152 w that Vps13 binds phospholipids, especially phosphatidylinositol 3-phosphate (PI3P), via its SHR_BD

153 zing the paramagnetic restraints obtained in phosphatidylinositol 3-phosphate (PI3P)-enriched micelle

154 AnkB associates with phosphatidylinositol 3-phosphate (PI3P)-positive organel

155 e fusion) and has Phox homology, providing a phosphatidylinositol 3-phosphate (PI3P)-specific membran

156 of Cb binds phosphoinositides, specifically phosphatidylinositol 3-phosphate (PI3P).

157 ergosterol (ERG), diacylglycerol (DAG), and phosphatidylinositol 3-phosphate (PI3P).

158 cs that are highly specialized with abundant phosphatidylinositol 3-phosphate (PI3P).

159 itol 3-kinase (VPS34) specifically increases phosphatidylinositol 3-phosphate (PI3P).

160 s, presumably by preventing the formation of phosphatidylinositol 3-phosphate (PI3P).

161 atidylinositol 3-kinase Vps34, and the lipid phosphatidylinositol 3-phosphate (PI3P).

162 We have previously shown phosphatidylinositol-3-phosphate (PI3P) accumulation in

163 selectively binds the membrane phospholipid phosphatidylinositol-3-phosphate (PI3P) and is important

164 r viral replication and for binding of H7 to phosphatidylinositol-3-phosphate (PI3P) and phosphatidyl

165 s stimulated by p40(phox) and its binding to phosphatidylinositol-3-phosphate (PI3P), a phosphoinosit

166 otal syntheses of phosphatidylinositol (PI), phosphatidylinositol-3-phosphate (PI3P), phosphatidylino

167 R motifs enable binding to the phospholipid, phosphatidylinositol-3-phosphate (PI3P).

168 of the kinase, as well as its lipid product phosphatidylinositol-3-phosphate (PI3P).

169 Cdt functioned both as a DNase and a phosphatidylinositol 3-phosphate (PIP(3)) phosphatase, a

170 dylinositol 3'-kinase (PI 3-kinase) produces phosphatidylinositol 3'-phosphates, plays a critical rol

171 In the presence of phosphatidylinositol 3-phosphate, polymerization is both

172 , distinct from any later encounter with the phosphatidylinositol-3-phosphate pool in early endosomes

173 fferent vesicle maturation stages shows that phosphatidylinositol 3-phosphate production precedes fus

174 which, when expressed alone, interacts with phosphatidylinositol 3-phosphate (PtdIns (3)P).

175 Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a signa

176 tions with both the dynactin subunit p62 and phosphatidylinositol 3-phosphate (PtdIns(3)P) lipids gen

177 We provide evidence that Phosphatidylinositol 3-Phosphate (PtdIns(3)P) regulates

178 autophagy by endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns(3)P) synthesis.

179 Tollip preferentially binds phosphatidylinositol 3-phosphate (PtdIns(3)P) via its C2

180 re, we examined the relationship between the phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding ab

181 n membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing

182 s, we found that the p40(phox) PX domain has phosphatidylinositol 3-phosphate (PtdIns(3)P)-dependent

183 nserved cell renewal process that depends on phosphatidylinositol 3-phosphate (PtdIns(3)P).

184 ia a phox homology (PX) domain that binds to phosphatidylinositol 3-phosphate (PtdIns(3)P).

185 ruited to endosomes through interaction with phosphatidylinositol 3-phosphate (PtdIns(3)P).

186 FYVE domain that interacts specifically with phosphatidylinositol 3-phosphate (PtdIns-3-P) and a Rab5

187 at certain PX domains specifically recognize phosphatidylinositol 3-phosphate (PtdIns-3-P) and drive

188 and have been shown to bind specifically to phosphatidylinositol 3-phosphate (PtdIns-3-P).

189 TECPR1 binds to the Atg12-Atg5 conjugate and phosphatidylinositol 3-phosphate (PtdIns[3]P) to promote

190 ruited to endosomal membranes via binding to phosphatidylinositol 3-phosphate (PtdIns[3]P).

191 singly, the regulatory early endosomal lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) persists o

192 w metabolically stabilized (ms) analogues of phosphatidylinositol-3-phosphate (PtdIns(3)P) were synth

193 Similarly, the role of phosphatidylinositol-3-phosphate (PtdIns-3-P) as an intr

194 Phosphatidylinositol-3-phosphate (PtdIns-3-P) is conside

195 motifs can bind phospholipids, specifically phosphatidylinositol-3-phosphate (PtdIns-3-P).

196 omyces cerevisiae FAB1 gene encodes the sole phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinase r

197 ossess catalytic activity, dephosphorylating phosphatidylinositol 3-phosphate [PtdIns(3)P] and phosph

198 membrane, and it favors membrane composed of phosphatidylinositol 3-phosphate [PtdIns(3)P] and phosph

199 2A expression was required for production of phosphatidylinositol 3-phosphate [PtdIns(3)P] at the pla

200 LtpD471-626 bound directly to phosphatidylinositol 3-phosphate [PtdIns(3)P] in vitro a

201 d signaling proteins to membranes containing phosphatidylinositol 3-phosphate [PtdIns(3)P] is mediate

202 Vps34 lipid kinase complex, which generates phosphatidylinositol 3-phosphate [PtdIns(3)P] on the for

203 ylinositol 3-kinase) complex and its product phosphatidylinositol 3-phosphate [PtdIns(3)P] play key r

204 Phagosome maturation requires phosphatidylinositol 3-phosphate [PtdIns(3)P], yet how P

205 ins a zinc-binding FYVE finger that may bind phosphatidylinositol 3-phosphate [PtdIns(3)P].

206 P3], accompanied by small quantities of [32P]phosphatidylinositol 3-phosphate [PtdIns(3)P].

207 The lipid kinase Fab1 converts phosphatidylinositol-3-phosphate [PtdIns(3)P] to PtdIns(

208 MTMR3 decreased PRR-induced phosphatidylinositol 3-phosphate (PtdIns3P) and autophag

209 ide (PI) 3-phosphatases that dephosphorylate phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3

210 ide (PI) 3-phosphatases that dephosphorylate phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3

211 g and by amino acid-stimulated production of phosphatidylinositol 3-phosphate (PtdIns3P) by the lipid

212 In contrast, phosphatidylinositol 3-phosphate (PtdIns3P) levels were

213 linositols (PIs) demonstrates that it is the phosphatidylinositol 3-phosphate (PtdIns3P) or its metab

214 ynthesis depends upon both the generation of phosphatidylinositol 3-phosphate (PtdIns3P), which is se

215 ABH binds with high affinity to phosphatidylinositol-3-phosphate (PtdIns3P) and cleaves

216 Specific recognition of phosphatidylinositol 3-phosphate [PtdIns3P] by the FYVE

217 Recognition of phosphatidylinositol 3-phosphate (Ptdlns(3)P) is crucial

218 Phosphatidylinositol 3-phosphate regulates membrane traf

219 everal vacuolar membrane constituents: HOPS, phosphatidylinositol 3-phosphate, SNAREs, and acidic pho

220 19 PX domains bind the early endosomal lipid phosphatidylinositol 3-phosphate, SNX14 shows no membran

221 lusion that the p40(phox) PX domain binds to phosphatidylinositol 3-phosphate specifically in vitro a

222 ulates Akt activation via a cellular pool of phosphatidylinositol 3-phosphate that is distinct from t

223 Here we identify a lysosomal pool of phosphatidylinositol 3-phosphate that, when depleted by

224 Remarkably, these kinases can convert phosphatidylinositol 3-phosphate to phosphatidylinositol

225 Conversely, SNAREs and actin regulate phosphatidylinositol 3-phosphate vertex enrichment.

226 7 and the endosomally enriched lipid species phosphatidylinositol 3-phosphate via the FYVE domain (Fa

227 cells, whereas levels of the PtdIns(4)P and phosphatidylinositol-3-phosphate were unchanged.

228 ion of the p40(phox) PX domain is induced by phosphatidylinositol 3-phosphate, whereas that of the p4

229 he PX domain of p40(phox) specifically binds phosphatidylinositol 3-phosphate, whereas the PX domain

230 psinogen activation causes a 75% decrease in phosphatidylinositol 3-phosphate, which is implicated in

231 of macrophages Slamf1 induces production of phosphatidylinositol 3-phosphate, which positively regul