ライフサイエンスコーパス: phosphatidylinositol 4,5-bisphosphate

1 igh curvature strictly depends on binding to phosphatidylinositol 4,5-bisphosphate.

2 hosphatidic acid and boosts the synthesis of phosphatidylinositol 4,5-bisphosphate.

3 rn repeated for C2F domain interactions with phosphatidylinositol 4,5-bisphosphate.

4 2 phosphorylation and impaired metabolism of phosphatidylinositol 4,5-bisphosphate.

5 pids, capsaicin-induced activity depended on phosphatidylinositol 4,5-bisphosphate.

6 the membrane phospholipid signaling molecule phosphatidylinositol 4,5-bisphosphate.

7 lipase C, and it increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate.

8 t increases substantially in the presence of phosphatidylinositol 4,5-bisphosphate.

9 in, and treatment with neomycin to sequester phosphatidylinositol 4,5-bisphosphate.

10 ion of interactions between Kir6.2/SUR2A and phosphatidylinositol 4,5-bisphosphate.

11 dhesion of a pleckstrin homology domain with phosphatidylinositol 4,5-bisphosphate.

12 sence and presence of phosphatidylserine and phosphatidylinositol 4,5-bisphosphate.

13 converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate.

14 a specific structure upon binding its ligand phosphatidylinositol-(4,5)-bisphosphate.

15 Gag through interaction with an acidic lipid phosphatidylinositol-(4,5)-bisphosphate.

16 ced YAP nuclear accumulation via the FAK-Src-phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) si

17 h encodes the catalytic subunit alpha of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) fr

18 tivation of spleen tyrosine kinase (Syk) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K).

19 the list of genes encoding components of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AK

20 Phosphatidylinositol-4,5-bisphosphate 3-kinase 1A, activ

21 Akt/PKB, a key effector of phosphatidylinositol-4,5-bisphosphate 3-kinase 1A, was p

22 intact signaling through the Janus Kinase 2/phosphatidylinositol-4,5-bisphosphate 3-kinase pathway.

23 Itk(-/-)Btk(-/-) mast cells, and blockage of phosphatidylinositol-4,5-bisphosphate 3-kinase, Akt, or

24 breast cancer bearing an activating PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalyti

25 r receptor 2 (HER2; ERBB2) amplification and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalyti

26 e included an activating mutation in PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalyti

27 IAM1 to the membrane require the activity of phosphatidylinositol-4,5-bisphosphate 3-kinase.

28 ivation of canonical nuclear factor kappa B, phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt, and

29 The phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt/ mamm

30 Although phosphatidylinositol 4,5-bisphosphate, 3-phosphate, and

31 Postzygotic somatic mutations activating the phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)-pr

32 VEGFR2 interacts with phosphatidylinositol-4,5-bisphosphate-3-kinase and AKT t

33 We found VEGFR2 to activate phosphatidylinositol-4,5-bisphosphate-3-kinase and AKT,

34 regulates the sensitivity of the channels to phosphatidylinositol 4,5-bisphosphate, a phosphoinositid

35 Septin filaments and phosphatidylinositol-4,5-bisphosphate (also known as Ptd

36 r reorientation, while depleting the pool of phosphatidylinositol-4,5-bisphosphate, an activator of m

37 er by the presence of phospholipid vesicles, phosphatidylinositol 4,5-bisphosphate and Ca(2+), or by

38 iven by the plasma membrane phosphoinositide phosphatidylinositol 4,5-bisphosphate and cargo relieves

39 Phosphatidylinositol 4,5-bisphosphate and cholesterol en

40 NCX inactivation occurs in the absence of phosphatidylinositol 4,5-bisphosphate and is facilitated

41 kers for the anionic signaling phospholipids phosphatidylinositol 4,5-bisphosphate and phosphatidic a

42 this regard, phosphoinositides, particularly phosphatidylinositol 4,5-bisphosphate and phosphatidylin

43 shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5-bisphosphate and phosphatidylin

44 ortical granule exocytosis, the elevation of phosphatidylinositol 4,5-bisphosphate and the large, lat

45 ne and occurs following its interaction with phosphatidylinositol-(4,5)-bisphosphate and its subseque

46 branes containing the annexin binding lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylse

47 odomains, which are enriched in cholesterol, phosphatidylinositol 4,5-bisphosphate, and gangliosidic

48 e cation channel activated by cold, voltage, phosphatidylinositol 4,5-bisphosphate, and menthol.

49 d protein kinase, the signaling phospholipid phosphatidylinositol-(4, 5)-bisphosphate, and the c-Abl-

50 rate three regulatory components, myristate, phosphatidylinositol-(4,5)-bisphosphate, and RNA, to ens

51 sphate (PIP3) signaling and converts PIP3 to phosphatidylinositol (4,5)-bisphosphate at the plasma me

52 Phosphatidylinositol 4,5-bisphosphate binding of the car

53 otentiated by cold temperature involving the phosphatidylinositol 4,5-bisphosphate binding residue (L

54 ge-sensing domain, and about cold sensor and phosphatidylinositol 4,5-bisphosphate binding sites, whi

55 Phosphatidylinositol 4,5-bisphosphate binding to GEP100

56 ) input, including motifs for calmodulin and phosphatidylinositol 4,5-bisphosphate binding, protein k

57 The phosphatidylinositol 4,5-bisphosphate-binding capacity o

58 This FPR2 selective inhibitor adopts a phosphatidylinositol 4,5-bisphosphate-binding sequence i

59 ary to localize the -amine of Lys-170 in the phosphatidylinositol 4,5-bisphosphate-binding site.

60 Our results further indicate conserved phosphatidylinositol 4,5-bisphosphate-binding sites in t

61 rotein (GFP)-Myo1c mutants revealed that the phosphatidylinositol-4,5-bisphosphate-binding site is ne

62 e 5-kinase, and its enzymatic lipid product, phosphatidylinositol 4,5-bisphosphate, binds to the plec

63 osphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate but not phosphat

64 ale reorganization of phosphatidylserine and phosphatidylinositol 4,5-bisphosphate but not other anio

65 yoblast fusion depended on dynamin activity, phosphatidylinositol(4,5)bisphosphate content, and cell

66 We show that phosphatidylinositol 4,5-bisphosphate-dependent FGF2 oli

67 nventional secretory mechanism that involves phosphatidylinositol 4,5-bisphosphate-dependent insertio

68 Here, we show that phosphatidylinositol 4,5-bisphosphate-dependent membrane

69 leaflet of plasma membranes that may control phosphatidylinositol 4,5-bisphosphate-dependent membrane

70 ivates p75NTR to induce a Rac1-dependent and phosphatidylinositol 4,5-bisphosphate-dependent signalin

71 orrelating with the drug's ability to induce phosphatidylinositol 4,5-bisphosphate depletion after ag

72 nding to KCNQ2 channel, caused resistance to phosphatidylinositol 4,5-bisphosphate depletion, and inc

73 S4 movement and gate opening by mutations or phosphatidylinositol 4,5-bisphosphate depletion, we show

74 re due to the differences in plasma membrane phosphatidylinositol 4,5-bisphosphate depletion.

75 KAP79/150 action correlates with the PIP(2) (phosphatidylinositol 4,5-bisphosphate)-depletion mode of

76 Thus, although cholesterol and phosphatidylinositol 4,5-bisphosphate do not interact wi

77 move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enriched domains

78 PLC hydrolysis of phosphatidylinositol-(4,5)-bisphosphate generates inosit

79 intact F-actin architecture is required for phosphatidylinositol 4,5-bisphosphate homeostasis mediat

80 increases phospholipase C activity, causing phosphatidylinositol 4,5-bisphosphate hydrolysis and ino

81 r bradykinin-induced M-current inhibition or phosphatidylinositol 4,5-bisphosphate hydrolysis.

82 n activator of PKC) by inhibition of PIP(2) (phosphatidylinositol-4,5-bisphosphate) hydrolysis caused

83 ion displaces ciliary Inpp5e and accumulates phosphatidylinositol 4,5-bisphosphate in distal cilia.

84 in the surrounding membrane, including PIP2 (phosphatidylinositol-4,5-bisphosphate) in the inner leaf

85 , attached to KirBac1.1 tetramers, show that phosphatidylinositol-4,5-bisphosphate-induced closure in

86 mutation suppressed sensitivity of GSNL-1 to phosphatidylinositol 4,5-bisphosphate inhibition.

87 beta1 activity measured with the fluorescent phosphatidylinositol 4,5-bisphosphate/inositol 1,4,5-tri

88 phospholipase C (PLC) isozymes to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second me

89 Phospholipase C (PLC) enzymes convert phosphatidylinositol-4,5-bisphosphate into the second me

90 Phosphatidylinositol 4,5-bisphosphate is mostly produced

91 TEMs, either acylation of Gag or binding of phosphatidylinositol-(4,5)-bisphosphate is sufficient.

92 Specific binding of ENTH to phosphatidylinositol 4,5-bisphosphate leads to a substan

93 PIPKIgamma activity and, thereby, modulates phosphatidylinositol (4,5)-bisphosphate levels and adhes

94 Upon binding to the phosphatidylinositol 4,5-bisphosphate lipid, the wild-ty

95 rminal homology (ENTH) domain that acts as a phosphatidylinositol 4,5-bisphosphate-lipid-targeting an

96 its APC to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate lipids via lysine-

97 rings were initiated by a circular array of phosphatidylinositol(4,5)bisphosphate microdomains, and

98 red filaments on lipid monolayers containing phosphatidylinositol-4,5-bisphosphate, mimicking presenc

99 phatase activity toward the phosphoinositide phosphatidylinositol (4,5)-bisphosphate or altered the s

100 The phosphatidylinositol (4,5) bisphosphate (PI(4,5)P2) head

101 (3,4,5)-trisphosphate (PI(3,4,5)P3) to form phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2).

102 Eisosomes promote hydrolysis of phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) by fun

103 utative second messengers, change in pH, and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) depl

104 the effects of Ca(2+), calmodulin (CaM), and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) in e

105 phate-mediated Ca(2+) release by hydrolyzing phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) in t

106 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is a

107 es the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

108 to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and di

109 CAPS binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and SN

110 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) has be

111 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a m

112 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a n

113 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a v

114 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) reside

115 s recently found to bind to the phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a mar

116 study the direct interaction of Ca(2+) with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), the m

117 demonstrated to be secreted from cells in a phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-depend

118 nexin A2 (AnxA2), to induce the formation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-rich d

119 d by the presence of its biological product, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

120 Moreover, steady-state PM phosphatidylinositol 4,5-bisphosphate (PI[4,5]P2) levels

121 occur through interactions of proteins with phosphatidylinositol(4,5)-bisphosphate (PI(4,5)P2), whic

122 Regulated by phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2)-leve

123 virtue of its affinity to the phospholipid, phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)).

124 embrane protein ATP1A1, the phosphoinositide phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), and T

125 by bradykinin led to a moderate decrease in phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), but n

126 The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fu

127 on the ability of PI5P4Kalpha to synthesize phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] rath

128 Igamma) is a key enzyme in the generation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] and

129 metabolism, notably causing a deficiency of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)], a p

130 es the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)].

131 membrane Ca(2+)-ATPase isoform 2 (PMCA2) and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]; mor

132 holipase requiring the cellular host factors phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and ub

133 Protein kinase C (PKC) and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] are ob

134 Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is a m

135 Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an

136 In this study, we demonstrate that phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is ano

137 In other systems, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is kno

138 In neurons, loss of plasma membrane phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] leads

139 ipid-binding module in TMEM24 transports the phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] precur

140 Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regula

141 idylinositol 3-phosphate [PI(3)P] along with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] to sti

142 ubule cell survival through interaction with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], but p

143 Membrane phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], regul

144 itol 4-phosphate 5-kinase that Mcp5 binds to phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

145 t-SNARE-carrying vesicles in the absence of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

146 hoinositides, key signaling lipids including phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

147 rGag proteins to their lipid raft-associated phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] as

148 HIV-1 MA has a phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] bi

149 Previously, we observed that phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] is

150 Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] pl

151 Interaction with a PM phospholipid, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)], p

152 erminal myristoylated matrix (MA) domain and phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)].

153 ion is stimulated by physiological levels of phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2] and

154 binding to the plasma membrane phospholipid phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2].

155 sma membrane (PM)-specific phosphoinositide, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2].

156 Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)] play

157 NT-1, we found overaccumulation of endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] in cnt

158 Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is ess

159 the plasma membrane via specific binding to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

160 tep activation mechanism of FAK initiated by phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

161 gion, and a PM-specific acidic phospholipid, phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

162 d is dependent on the plasma membrane marker phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2].

163 is regulated by the lipid signaling molecule phosphatidylinositol 4,5 bisphosphate (PI4,5P(2)), and i

164 lyphosphoinositides (PPIs) and in particular phosphatidylinositol-(4,5)-bisphosphate (PI4,5P2), contr

165 In addition, we observed phosphatidylinositol-4,5-bisphosphate (PI4,5P(2)) accumu

166 Phosphatidylinositol (4,5)-bisphosphate (PIP(2)) is a ph

167 Phosphatidylinositol 4,5 bisphosphate (PIP(2)) is a key

168 nts for activity: a specific requirement for phosphatidylinositol 4,5-bisphosphate (PIP(2)) and a non

169 ted mechanisms, namely depletion of membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) and a ris

170 is mediated by its role in the generation of phosphatidylinositol 4,5-bisphosphate (PIP(2)) and in in

171 oform SGK1.1 interacts with phosphoinositide-phosphatidylinositol 4,5-bisphosphate (PIP(2)) and is di

172 th ezrin upon binding to the signaling lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) and to F-

173 For ezrin, phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding t

174 due to Rac2 were reversed in the presence of phosphatidylinositol 4,5-bisphosphate (PIP(2)) both in v

175 atalyze the hydrolysis of the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) into seco

176 Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is necess

177 of this work was to determine the effect of phosphatidylinositol 4,5-bisphosphate (PIP(2)) on the C2

178 and triggers local actin polymerization and phosphatidylinositol 4,5-bisphosphate (PIP(2)) productio

179 Our group previously reported that cytosolic phosphatidylinositol 4,5-bisphosphate (PIP(2)) stimulate

180 Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP(2)) to inosit

181 ates more strongly with liposomes containing phosphatidylinositol 4,5-bisphosphate (PIP(2)) when comp

182 In particular, phosphatidylinositol 4,5-bisphosphate (PIP(2)), a minor

183 to both Ca(2+) and the anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), but the

184 of the endogenous substrate of PLC isozymes, phosphatidylinositol 4,5-bisphosphate (PIP(2)), indicati

185 PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), leading

186 To account for the many functions of phosphatidylinositol 4,5-bisphosphate (PIP(2)), several

187 ucleotide exchange activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).

188 5-kinase (PI5K) with subsequent synthesis of phosphatidylinositol 4,5-bisphosphate (PIP(2)).

189 lated by the membrane signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)).

190 Phosphatidylinositol-(4,5)-bisphosphate (PIP(2)), the ma

191 including: (i) a myristoylation tag; (ii) a phosphatidylinositol-(4,5)-bisphosphate (PIP(2))-binding

192 The phospholipid phosphatidylinositol-4,5-bisphosphate (PIP(2)) anchors A

193 utyrate (PDBu), a PKC catalytic subunit, and phosphatidylinositol-4,5-bisphosphate (PIP(2)) and phosp

194 ds in DRG neurons and injection of exogenous phosphatidylinositol-4,5-bisphosphate (PIP(2)) fully rev

195 Although the phospholipid phosphatidylinositol-4,5-bisphosphate (PIP(2)) in the in

196 Intracellular phosphatidylinositol-4,5-bisphosphate (PIP(2)) shifted I

197 e capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although

198 e, and the most common polyphosphoinositide, phosphatidylinositol-4,5-bisphosphate (PIP(2)), is invol

199 mechanism involving diacylglycerol (DAG) or phosphatidylinositol-4,5-bisphosphate (PIP(2)).

200 specifically insulin secretion by generating phosphatidylinositol-4,5-bisphosphate (PIP(2)).

201 run down of mK(ATP) activity was reversed by phosphatidylinositol-4,5-bisphosphate (PIP(2)).

202 We addressed the role of phosphatidylinositol (4,5)-bisphosphate (PIP2) in the re

203 th its interaction with the second messenger phosphatidylinositol (4,5)-bisphosphate (PIP2).

204 Pases Rac1 and Cdc42 as well as by the lipid phosphatidylinositol (4,5)-bisphosphate (PIP2).

205 We previously reported that the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2 ) directly s

206 Previous work demonstrated that the lipid phosphatidylinositol 4,5-bisphosphate (PIP2 ) enabled th

207 Phosphatidylinositol 4,5-bisphosphate (PIP2) affects the

208 is conformational transition is dependent on phosphatidylinositol 4,5-bisphosphate (PIP2) and is rela

209 gnizes membrane phosphoinositides, including phosphatidylinositol 4,5-bisphosphate (PIP2) and phospha

210 a process that involves binding of ezrin to phosphatidylinositol 4,5-bisphosphate (PIP2) and phospho

211 arance and recovery correlated with synaptic phosphatidylinositol 4,5-bisphosphate (PIP2) and that al

212 lly investigated the close interplay between Phosphatidylinositol 4,5-bisphosphate (PIP2) and the F-a

213 Here, we identify phosphatidylinositol 4,5-bisphosphate (PIP2) as a critic

214 analyses of Rabphilin-3A C2B-SNAP25 and C2B-phosphatidylinositol 4,5-bisphosphate (PIP2) complexes,

215 evident at the level of Galphaq activation, phosphatidylinositol 4,5-bisphosphate (PIP2) depletion,

216 s TRPC4/5 channel activity is potentiated by phosphatidylinositol 4,5-bisphosphate (PIP2) depletion.

217 ve previously reported that the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) directly st

218 ducing (pronociceptive) receptors signal via phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis.

219 Here, we show that the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) is a potent

220 Plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2) is required

221 used an initial increase and a later fall in phosphatidylinositol 4,5-bisphosphate (PIP2) levels in t

222 hoinositides in vitro and colocalized with a phosphatidylinositol 4,5-bisphosphate (PIP2) marker in p

223 d it remains unclear how PLCzeta targets its phosphatidylinositol 4,5-bisphosphate (PIP2) membrane su

224 6R associated weakly but preferentially with phosphatidylinositol 4,5-bisphosphate (PIP2) through the

225 -beta) isozymes hydrolyze the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) to propagat

226 lserine, phosphatidic acid, cardiolipin, and phosphatidylinositol 4,5-bisphosphate (PIP2)) PLs contai

227 Cgamma, enzymes that deplete plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2), and these

228 on by SMIT-transported, myo-inositol-derived phosphatidylinositol 4,5-bisphosphate (PIP2), the mechan

229 diacylglycerols produced by PLC breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2), the mechan

230 e replenishment of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2), the source

231 permissive role in myogenesis and depends on phosphatidylinositol 4,5-bisphosphate (PIP2), underlies

232 the N termini in the presence and absence of phosphatidylinositol 4,5-bisphosphate (PIP2), we found t

233 , we show that CDO is contingent on membrane phosphatidylinositol 4,5-bisphosphate (PIP2), which is f

234 2/3 channel activity is augmented in vivo by phosphatidylinositol 4,5-bisphosphate (PIP2), which is g

235 Oxo-M inhibition is occluded by screening phosphatidylinositol 4,5-bisphosphate (PIP2)-negative ch

236 Phosphatidylinositol 4,5-bisphosphate (PIP2)-sensitive t

237 binding to the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2).

238 known regulator of Kv7 channels is the lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

239 the plasma membrane, it can be inhibited by phosphatidylinositol 4,5-bisphosphate (PIP2).

240 oupling in Kv7.1 channels requires the lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

241 and NBCn1-A by IRBIT and their regulation by phosphatidylinositol 4,5-bisphosphate (PIP2).

242 and depletion of the phospholipid messenger phosphatidylinositol 4,5-bisphosphate (PIP2).

243 with CCh resulted in a similar reduction in phosphatidylinositol 4,5-bisphosphate (PIP2).

244 cific interactions with the regulatory lipid phosphatidylinositol 4,5-bisphosphate (PIP2).

245 only in an 84-residue sequence that binds to phosphatidylinositol(4,5)bisphosphate (PIP2), the substr

246 ted by conformational changes in response to phosphatidylinositol-4,5-bisphosphate (PIP2) and cargo b

247 al understanding of how the signalling lipid phosphatidylinositol-4,5-bisphosphate (PIP2) and intrace

248 inositides, we investigated the influence of phosphatidylinositol-4,5-bisphosphate (PIP2) availabilit

249 f this linkage is the activation of ezrin by phosphatidylinositol-4,5-bisphosphate (PIP2) binding and

250 We found that phosphatidylinositol-4,5-bisphosphate (PIP2) or clotrima

251 Nerve functions require phosphatidylinositol-4,5-bisphosphate (PIP2) that binds

252 kinases phosphorylate the constitutive lipid phosphatidylinositol-4,5-bisphosphate (PIP2) to produce

253 the GIRK1 subunit in a manner that requires phosphatidylinositol-4,5-bisphosphate (PIP2), but is oth

254 1 C terminus (CT) binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphosphate (PIP2), but the ro

255 Phosphatidylinositol-4,5-bisphosphate (PIP2), one of the

256 rich C kinase substrate (MARCKS) and release phosphatidylinositol-4,5-bisphosphate (PIP2), thereby st

257 catalyze the final step in the synthesis of phosphatidylinositol-4,5-bisphosphate (PIP2), which in t

258 channels exhibit spontaneous activity via a phosphatidylinositol-4,5-bisphosphate (PIP2)-dependent g

259 ntial for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only dur

260 ellular phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate pools.

261 somes is accompanied by the disappearance of phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P(2)

262 6 (LRP5/6) and frizzled proteins, leading to phosphatidylinositol (4,5)bisphosphate (PtdIns(4,5)P(2))

263 hosphatidylinositol 3,4,5-trisphosphate into phosphatidylinositol 4,5-bisphosphate (PtdIns(3,4)P2).

264 interact with the plasma membrane containing phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2))

265 sphatidylinositol-5-phosphate (PtsIns5P) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)).

266 ,5-trisphosphate (Ins(1,4,5)P3) 3-kinase and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) 3-

267 Phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) ha

268 eins controlling the lateral organization of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) la

269 inase i5 (PIPKIgammai5), an enzyme producing phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), s

270 phosphorylation via a novel interaction with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-bi

271 n via its actin-binding motor domain and its phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-bi

272 A prototype sensor for phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P(2))-

273 TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) -m

274 he affinity of the polybasic lysine patch to phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2).

275 d myosin-Ic (myo1c) isoform binds tightly to phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)]

276 al cells is critically dependent on membrane phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)]

277 old or menthol evokes a decrease in cellular phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)]

278 Both phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)]

279 sphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] as

280 main enriched in the regulatory phospholipid phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] is

281 phoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P2].

282 The functions of the minor phospholipid phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] du

283 Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2),

284 Phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P(2)) is

285 ck, where the plasma membrane is enriched in phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P(2)).

286 ed in all LPS responses, but a single lipid (phosphatidylinositol-4,5-bisphosphate) regulates many LP

287 for promoting the spatially highly organized phosphatidylinositol-4,5-bisphosphate signaling program

288 producing physiologically active unsaturated phosphatidylinositol 4,5-bisphosphate species in the cel

289 e 1alpha (PIP5K), the enzyme responsible for phosphatidylinositol 4,5-bisphosphate synthesis, is modi

290 nase that mediates the rate-limiting step in phosphatidylinositol 4,5-bisphosphate synthesis.

291 Upon binding phosphatidylinositol 4,5-bisphosphate, the N-terminal he

292 ning cholesterol, phosphatidylserine, and/or phosphatidylinositol-4,5-bisphosphate, thus providing a

293 olipase C-beta (PLC-beta) isoforms hydrolyze phosphatidylinositol 4,5-bisphosphate to the second mess

294 In the presence of 2.5 mum phosphatidylinositol 4,5-bisphosphate, TRPV1 channels de

295 haq Therefore, XY-69 can replace radioactive phosphatidylinositol 4,5-bisphosphate used in convention

296 dynamins bind the plasma membrane-localized phosphatidylinositol-4,5-bisphosphate using the pleckstr

297 ain probe revealed that the regulatory lipid phosphatidylinositol 4,5-bisphosphate was enriched at si

298 Moreover, fusion occurred only when phosphatidylinositol 4,5-bisphosphate was included in th

299 arly in IS formation, in parallel to a local phosphatidylinositol (4,5)-bisphosphate wave, and requir

300 bicans IRS4 encodes a protein that regulates phosphatidylinositol-(4,5)-bisphosphate, which was shown