ライフサイエンスコーパス: phosphatidylinositol 4-kinase

1 the clone contains the STT4 gene, encoding a phosphatidylinositol 4-kinase.

2 drophobic residues that specifically contact phosphatidylinositol 4-kinase.

3 from fission yeast (Ncs1), which activates a phosphatidylinositol 4-kinase.

4 he transcription factor MYB99 and a putative phosphatidylinositol 4-kinase.

5 ed the Las17-binding protein Lsb6, a type II phosphatidylinositol 4-kinase.

6 y serve as regulators of certain isoforms of phosphatidylinositol 4-kinase.

7 with the N terminus of Pik1, a 1066-residue phosphatidylinositol 4-kinase.

8 which is associated with the recruitment of phosphatidylinositol 4-kinase 2A.

9 st, blockade of lipid kinases, in particular phosphatidylinositol-4-kinase, abolished recovery, as di

10 PITP did not enhance the initial rate of phosphatidylinositol 4-kinase activity but did increase

11 xpression of PI4KIIalpha increased the basal phosphatidylinositol 4-kinase activity of each membrane

12 pstB1 mutant exhibits a defect in Stt4p-type phosphatidylinositol 4-kinase activity, and direct gene

13 overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase activity, on biosynthetic

14 tments, a corresponding increase in cellular phosphatidylinositol 4-kinase activity.

15 the vacuolar surface, and associated with a phosphatidylinositol-4 kinase activity.

16 of a plant phosphatidylinositol 3-kinase and phosphatidylinositol 4-kinase, an observation that sugge

17 ow that PKCmu forms a complex in vivo with a phosphatidylinositol 4-kinase and a phosphatidylinositol

18 tial action of a lysosome-associated type II phosphatidylinositol 4-kinase and a soluble type I phosp

19 pervillin, MAGuK, three heat shock proteins, phosphatidylinositol 4-kinase and receptor protein tyros

20 By pharmacologically blocking phosphatidylinositol-4-kinase and PIPKI or disrupting th

21 Phosphatidylinositol 4-kinases are most abundant in the

22 7A interacts with EFR3 homolog B to regulate phosphatidylinositol 4-kinase at the plasma membrane.

23 Phosphatidylinositol 4-kinase beta (PI4KB) is one of fou

24 y showed a similar distribution of NCS-1 and phosphatidylinositol 4-kinase beta (PI4Kbeta).

25 man oligosaccharyltransferase complex, and a phosphatidylinositol 4-kinase beta adaptor hijacked by v

26 Supporting this idea, inhibition of phosphatidylinositol 4-kinase, but not the RhoA effector

27 The activity of phosphatidylinositol 4-kinase class III beta (PI4KIIIbet

28 s by concentrations of wortmannin that block phosphatidylinositol 4-kinase completely blocked calcium

29 c1 homology domain, in complex with Vps74, a phosphatidylinositol 4-kinase effector and the orthologu

30 e unique inhibitor sensitivities of type-III phosphatidylinositol 4-kinase enzymes (PI4Ks).

31 onserved role for Gga proteins in regulating phosphatidylinositol 4-kinase function at the TGN.

32 The Stt4 phosphatidylinositol 4-kinase has been shown to generate

33 ammalian cells express two type II isoforms, phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha) and

34 Phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha) is p

35 rectly correlated with increased activity of phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), a l

36 Phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), a m

37 oinositide kinase activity is contributed by phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha).

38 Phosphatidylinositol 4-kinase III alpha (PI4KA) is an es

39 cluding oxysterol binding protein (OSBP) and phosphatidylinositol 4-kinase III beta (PI4KB).

40 eviously shown to interact with and modulate phosphatidylinositol 4-kinase III-beta (PI4KIIIbeta) act

41 ation was dependent on mouse cyclophilin and phosphatidylinositol-4 kinase III alpha (PI4KIIIalpha) a

42 tes the activity of a cellular lipid kinase, phosphatidylinositol 4-kinase IIIalpha (PI4KA).

43 plicated independently from microRNA-122 and phosphatidylinositol 4-kinase IIIalpha and beta (PI4KIII

44 d RhoA signaling and defective expression of phosphatidylinositol 4-kinase IIIalpha represent biochem

45 g the synthesis of PIP(2) via stimulation of phosphatidylinositol 4-kinase IIIalpha.

46 ties of NS5A, including its interaction with phosphatidylinositol-4 kinase IIIalpha and induction of

47 eb, which was not linked to an inhibition of phosphatidylinositol-4 kinase IIIalpha.

48 ized to the Golgi complex, and both regulate phosphatidylinositol 4-kinase IIIbeta (PI(4)Kbeta).

49 teroviruses, enterovirus 71 (EV71) relies on phosphatidylinositol 4-kinase IIIbeta (PI4KB) for genome

50 The lipid kinase phosphatidylinositol 4-kinase IIIbeta (PI4KB) is an esse

51 Phosphatidylinositol 4-kinase IIIbeta (PI4KB) is indispe

52 to enviroxime-like compounds, which target a phosphatidylinositol 4-kinase IIIbeta (PI4KIIIbeta)-depe

53 iated by an up-regulated interaction between phosphatidylinositol 4-kinase IIIbeta and PKC; the incre

54 Phosphatidylinositol 4-kinase IIIbeta is a cellular lipi

55 rotein of enterovirus 71 recruits an enzyme, phosphatidylinositol 4-kinase IIIbeta, by interacting wi

56 found to be through an enhanced activity of phosphatidylinositol 4-kinase IIIbeta, which was mediate

57 GBF1, promoting preferential recruitment of phosphatidylinositol-4-kinase IIIbeta (PI4KIIIbeta) to m

58 Enzymatic and immunochemical assays show a phosphatidylinositol 4-kinase in novel and specific comp

59 venger polylysine, and the inhibition by the phosphatidylinositol 4-kinase inhibitor wortmannin corre

60 However, because phosphatidylinositol 4-kinase is an integral chromaffin

61 st, the sole essential target of Frq1 is the phosphatidylinositol 4-kinase isoform, Pik1; both FRQ1 a

62 he EF-hand superfamily and regulates a yeast phosphatidylinositol 4-kinase isoform.

63 Mammalian type II phosphatidylinositol 4-kinases may regulate WASp protein

64 Depletion of PIP(2) by inhibition of phosphatidylinositol 4-kinase or sequestration by aminog

65 Inhibition of phosphatidylinositol 4-kinases or enzymatic removal of p

66 he size (55 kDa) and other properties of the phosphatidylinositol 4-kinase (PI 4-K) (stimulated by no

67 n contrast, expression of the NCS-1 effector phosphatidylinositol 4-kinase (PI 4-kinase) inhibited in

68 fwd is shown to encode a phosphatidylinositol 4-kinase (PI 4-kinase), a member of

69 sent genetic and biochemical evidence that a phosphatidylinositol 4-kinase (PI 4-kinase), STT4, is a

70 Phosphatidylinositol 4-kinases (PI 4-kinases) catalyze t

71 ulation, RabA4B recruits the closely related phosphatidylinositol 4-kinase (PI4K) PI4Kbeta1 and PI4Kb

72 Mammalian cells express two classes of phosphatidylinositol 4-kinase (PI4K), designated as Type

73 vated TRPM8 channels in excised patches in a phosphatidylinositol 4-kinase (PI4K)-dependent manner.

74 Because phosphatidylinositol 4-kinase (PI4K)-mediated phosphatid

75 Phosphatidylinositol 4-kinases (PI4K) catalyze the first

76 centration (3 mum), suggesting that type III phosphatidylinositol-4-kinase (PI4K) activity is require

77 vestigated via inhibition of the activity of phosphatidylinositol-4-kinase (PI4K).

78 red for HCV replication, including class III phosphatidylinositol 4-kinases (PI4KA and PI4KB), carbam

79 The type II phosphatidylinositol 4-kinase (PI4KII) enzymes synthesiz

80 malian cells express two isoforms of type II phosphatidylinositol 4-kinase: PI4KIIalpha and PI4KIIbet

81 olated mutations in CG10260, which encodes a phosphatidylinositol 4-kinase (PI4KIIIalpha), and found

82 Type III phosphatidylinositol 4-kinase (PI4KIIIbeta) is an essent

83 Phosphatidylinositol 4-kinases (PI4Ks) and small guanosi

84 Two phosphatidylinositol 4-kinases (PI4Ks) have been localiz

85 We found that distinct phosphatidylinositol 4-kinases (PI4Ks) play important ro

86 he biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phos

87 ly different compounds that inhibit type III phosphatidylinositol 4-kinases (PI4Ks).

88 ecreased by inhibition or down-regulation of phosphatidylinositol 4-kinases (PI4Ks).

89 l N-myristoylated EF-hand protein, activates phosphatidylinositol 4-kinase Pik1.

90 Phosphatidylinositol 4-kinase, Pik1, is essential for vi

91 We identify two motifs in the yeast phosphatidylinositol 4-kinase, Pik1, which are required

92 D8 ubiquitin-like protein (rub1Delta), and a phosphatidylinositol 4-kinase (pik1Delta).

93 In Saccharomyces cerevisiae, the phosphatidylinositol 4-kinase, Pik1p generates a distinc

94 Phosphatidylinositol 4-kinases play essential roles in c

95 e conclude that frequenin, and by inference, phosphatidylinositol 4-kinase, plays an important and se

96 and complexes of CD63 (a TM4SF protein) with phosphatidylinositol 4-kinase (PtdIns 4-K) may indeed lo

97 Phosphatidylinositol 4-kinases (PtdIns 4-kinases or PI4K

98 ed a considerably higher level of associated phosphatidylinositol-4-kinase (PtdIns 4-kinase) activity

99 hich encodes a conserved PM scaffold for the phosphatidylinositol-4 kinase Stt4, build CRs that can s

100 Here we show that Pik1, a phosphatidylinositol 4-kinase that localizes primarily t

101 We now describe a novel class of phosphatidylinositol 4-kinases that probably corresponds

102 ence (RNAi) of PI4KIIalpha, a Golgi resident phosphatidylinositol 4 kinase, to determine whether PI(4

103 Defects in the phosphatidylinositol 4-kinase-TTC7A-EFR3 homolog B pathw

104 s the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 alpha (PI4KIIalpha)

105 small interfering RNA library, we identified phosphatidylinositol 4-kinase type II alpha and phosphat

106 Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a

107 his hypothesis by analyzing the targeting of phosphatidylinositol-4-kinase type II alpha (PI4KIIalpha

108 Phosphatidylinositol-4-kinase type II alpha (PI4KIIalpha

109 tein sorting complex subunits; clathrin; and phosphatidylinositol-4-kinase type II alpha (PI4KIIalpha

110 eficiencies affected the targeting of LAMP1, phosphatidylinositol-4-kinase type II alpha, and VAMP7-T

111 t with and are regulated by the lipid kinase phosphatidylinositol-4-kinase type IIalpha (PI4KIIalpha)

112 A protein enriched in this fraction was phosphatidylinositol-4-kinase type IIalpha (PI4KIIalpha)

113 Phosphatidylinositol 4-kinase was found to co-immunoprec

114 f the alpha(3)beta(1)-CD151Cys8 complex with phosphatidylinositol 4-kinase was not affected.

115 trongest temporal change is seen at a SNP in phosphatidylinositol 4-kinase, which is involved in a pa

116 The novel phosphatidylinositol 4-kinases, which are widely express

117 Inhibiting phosphatidylinositol 4 kinases with wortmannin decreased