ライフサイエンスコーパス: phosphatidylinositol 4-phosphate

1 zes the synthesis of PIP2 by phosphorylating phosphatidylinositol 4 phosphate.

2 ndicate that the hBFIT2 StarD14 domain binds phosphatidylinositol 4-phosphate.

3 sphatidylinositol (4,5)-bisphosphate but not phosphatidylinositol 4-phosphate.

4 hate and ATP but greatly increased levels of phosphatidylinositol 4-phosphate.

5 ix other tested lipids including the similar phosphatidylinositol 4-phosphate.

6 eased apoptosis, and decreased production of phosphatidylinositol 4-phosphate.

7 p complex only in the additional presence of phosphatidylinositol-4-phosphate.

8 f EHD1 binds to phosphoinositides, including phosphatidylinositol-4-phosphate.

9 a selective reduction in the 32P-labeling of phosphatidylinositol-4-phosphate.

10 itol-4,5-biphosphate and a smaller amount of phosphatidylinositol-4-phosphate.

11 , altering the intracellular distribution of phosphatidylinositol-4-phosphate.

12 se11, phosphatidylinositol (3) phosphate and phosphatidylinositol (4) phosphate.

13 ns phosphatidylinositol transfer protein and phosphatidylinositol (4)-phosphate 5-kinase, as well as

14 Knockdown of the phosphatidylinositol 4-phosphate 5 (PIP5) kinases alpha

15 Here, we found that phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K

16 fy a truncated form of the murine type Ibeta phosphatidylinositol 4-phosphate 5-kinase (mPIP5K-Ibeta)

17 cently, ion channel activity and activity of phosphatidylinositol 4-phosphate 5-kinase (PI(4)P 5-K).

18 -derived endosomal compartment and activates phosphatidylinositol 4-phosphate 5-kinase (PIP 5-kinase)

19 intact myocardium, but not excised patches, phosphatidylinositol 4-phosphate 5-kinase (PIP5K) activi

20 dified Rho in its GTP-bound state stimulated phosphatidylinositol 4-phosphate 5-kinase (PIP5K) activi

21 Phosphatidylinositol 4-phosphate 5-kinase (PIP5K) cataly

22 Nexus (MORN) motif found in the lipid kinase-phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family

23 We investigated the role of type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) gamma

24 Phosphatidylinositol 4-phosphate 5-kinase (PIP5K) gamma

25 R), a prototypical 7TMR, beta-arrestins bind phosphatidylinositol 4-phosphate 5-kinase (PIP5K) Ialpha

26 n of phosphatidylinositol 4-phosphate by the phosphatidylinositol 4-phosphate 5-kinase (PIP5K) to gen

27 isoforms of the main PIP2-generating enzyme, phosphatidylinositol 4-phosphate 5-kinase (PIP5K), play

28 The regulation of phosphatidylinositol 4-phosphate 5-kinase (PIP5K), which

29 cruitment and activation of the lipid kinase phosphatidylinositol 4-phosphate 5-kinase (PIP5Kalpha).

30 Here, we describe a role for phosphatidylinositol 4-phosphate 5-kinase (PIPK) Igammai

31 sitol 4,5-biphosphate (PIP2), synthesized by phosphatidylinositol 4-phosphate 5-kinase (PIPKI) enzyme

32 Here, we show that type Igamma phosphatidylinositol 4-phosphate 5-kinase (PIPKIgamma) i

33 Neither IP3 levels nor phosphatidylinositol 4-phosphate 5-kinase activity chang

34 Additionally, phosphatidylinositol 4-phosphate 5-kinase activity in th

35 tidic acid, which potently stimulates type I phosphatidylinositol 4-phosphate 5-kinase activity, is g

36 Murine phosphatidylinositol 4-phosphate 5-kinase alpha (PI5KIal

37 lipid localization, as overexpression of the phosphatidylinositol 4-phosphate 5-kinase alpha [PtdIns(

38 Depletion of the human type I phosphatidylinositol 4-phosphate 5-kinase beta isoform (

39 dentified the short splice variant of type I phosphatidylinositol 4-phosphate 5-kinase gamma (PIP5KIg

40 e IIIbeta and PKC; the increased activity of phosphatidylinositol 4-phosphate 5-kinase gamma was also

41 Overexpression of the phosphatidylinositol 4-phosphate 5-kinase homolog MSS4 c

42 Here, we demonstrated a role for the phosphatidylinositol 4-phosphate 5-kinase Igamma (PIPKIg

43 se (PI3-K), as well as RhoA and its effector phosphatidylinositol 4-phosphate 5-kinase increase ENaC

44 ositol 4,5-biphosphate produced by activated phosphatidylinositol 4-phosphate 5-kinase may play a rol

45 on yeast zygotes and show by perturbation of phosphatidylinositol 4-phosphate 5-kinase that Mcp5 bind

46 dylinositol 4,5-bisphosphate (PIP2), and the phosphatidylinositol 4-phosphate 5-kinase type I (PIP5KI

47 Phosphatidylinositol 4-phosphate 5-kinase type I gamma (

48 generation in focal adhesions by the enzyme phosphatidylinositol 4-phosphate 5-kinase type Igamma ar

49 nds directly to Skittles (SKTL), a predicted phosphatidylinositol 4-phosphate 5-kinase, and genetic e

50 wn to be necessary for the export of Mss4, a phosphatidylinositol 4-phosphate 5-kinase, and required

51 gulation by K-Ras and PI3-K but not RhoA and phosphatidylinositol 4-phosphate 5-kinase.

52 atidylinositol 4-kinase and a soluble type I phosphatidylinositol 4-phosphate 5-kinase.

53 regulates not only phospholipase D but also phosphatidylinositol 4-phosphate 5-kinase.

54 Three related phosphatidylinositol 4-phosphate 5-kinases (PI(4)P 5-kin

55 How the biosynthesis of PtdIns(4,5)P2 by phosphatidylinositol 4-phosphate 5-kinases (PI4P 5-kinas

56 Here, we targeted two related phosphatidylinositol 4-phosphate 5-kinases (PI4P 5-kinas

57 rom plasma membrane-bound Arf GTPases to the phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) to g

58 rization and GLUT4 translocation, the type I phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) were

59 circuitry, is generated primarily by type I phosphatidylinositol 4-phosphate 5-kinases (PIPKIalpha,

60 This PtdIns(4,5)P(2) dependence makes type I phosphatidylinositol 4-phosphate 5-kinases (PIPKIs) lync

61 s PIP2 turnover by recruiting and activating phosphatidylinositol 4-phosphate 5-kinases alpha (PIP5Ka

62 The interaction of talin with phosphatidylinositol(4) phosphate 5 kinase type I gamma

63 Talin interacts with phosphatidylinositol-(4)-phosphate 5-kinase type Igamma,

64 producing PA, which is a known activator of phosphatidylinositol-4-phosphate 5 kinase, the enzyme re

65 emonstrated that Rac interacts with a type I phosphatidylinositol-4-phosphate 5-kinase (PIP 5-kinase)

66 tor and a newly discovered 47-kDa isoform of phosphatidylinositol-4-phosphate 5-kinase (PIP5K), a mem

67 mmunity) now suggest that Btk also activates phosphatidylinositol-4-phosphate 5-kinase (PIP5K), there

68 sm from an intergenic transcript between the phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) and

69 Type I phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) catal

70 Three isoforms of phosphatidylinositol-4-phosphate 5-kinase (PIP5KIalpha,

71 Here we report that type Igamma phosphatidylinositol-4-phosphate 5-kinase (PIPKIgamma) a

72 ve shown previously that the nuclear form of phosphatidylinositol-4-phosphate 5-kinase 1alpha (PIP5K)

73 Phosphatidylinositol-4-phosphate 5-kinase 1alpha (PIP5K1

74 and sequentially activated phospholipase D1, phosphatidylinositol-4-phosphate 5-kinase 1alpha, and NA

75 ns to PIP5K3 and COW1, which encode a type B phosphatidylinositol-4-phosphate 5-kinase 3 and a phosph

76 Overexpression of type Ialpha phosphatidylinositol-4-phosphate 5-kinase [PIP(5)Kalpha]

77 endent on the C-terminal catalytic domain of phosphatidylinositol-4-phosphate 5-kinase but did not re

78 lear poly(A) polymerase that associates with phosphatidylinositol-4-phosphate 5-kinase Ialpha (PIPKIa

79 equired activation of p38, PKC isoforms, and phosphatidylinositol-4-phosphate 5-kinase Ialpha, a majo

80 reasing PtdIns(4,5)P2 levels by coexpressing phosphatidylinositol-4-phosphate 5-kinase inhibited TRPV

81 e kinase type 1 gamma (PtdInsPKI gamma) is a phosphatidylinositol-4-phosphate 5-kinase that is expres

82 2) and is regulated by the associated Type I phosphatidylinositol-4-phosphate 5-kinase that synthesiz

83 ne enzyme responsible for PIP(2) production, phosphatidylinositol-4-phosphate 5-kinase type 1beta (PI

84 sphatidylinositol 4-kinase type II alpha and phosphatidylinositol-4-phosphate 5-kinase type I (PIP5KI

85 rough direct phosphorylation of FA-localized phosphatidylinositol-4-phosphate 5-kinase type-l gamma (

86 pon activation by Sema3E, Plexin-D1 recruits phosphatidylinositol-4-phosphate 5-kinase, and its enzym

87 I phosphoinositide 3-kinase, vps34p, and the phosphatidylinositol-4-phosphate 5-kinase, its3p, but do

88 We previously demonstrated that phosphatidylinositol-4-phosphate 5-kinase, one of the ef

89 Phosphatidylinositol-4-phosphate 5-kinase-alpha (PIP5Kal

90 ding the downstream effectors Rho kinase and phosphatidylinositol-4-phosphate 5-kinase.

91 hate kinase type I gamma, the major neuronal phosphatidylinositol-4-phosphate 5-kinase.

92 o with a phosphatidylinositol 4-kinase and a phosphatidylinositol-4-phosphate 5-kinase.

93 1, was previously shown to encode a putative phosphatidylinositol-4-phosphate 5-kinase.

94 sphosphate is mostly produced in the cell by phosphatidylinositol-4-phosphate 5-kinases (PIP5K) and h

95 Phosphatidylinositol-4-phosphate 5-kinases (PIP5K) synth

96 Phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks) util

97 ic protein tyrosine kinases, associates with phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks), the

98 cell migration, but the roles of the type I phosphatidylinositol-4-phosphate 5-kinases (PIPKIs), whi

99 ncreased PIP(2) by transient expression of a phosphatidylinositol-4-phosphate-5-kinase (hPIP5KIbeta)

100 Phosphatidylinositol-4-phosphate-5-kinase (PI4P5K) has b

101 Phosphatidylinositol-4-phosphate-5-kinase cannot be dete

102 hough the alpha, beta, and gamma isoforms of phosphatidylinositol-4-phosphate-5-kinase I (PIP5KI) all

103 The phosphatidylinositol-4-phosphate-5-kinase MSS4 was isola

104 pleckstrin homology and C2 domains binds to phosphatidylinositol 4-phosphate, a lipid precursor of P

105 sac1-22 strain showed an 8-fold increase in phosphatidylinositol 4-phosphate along with a decrease i

106 temperature range, another phosphoinositide, phosphatidylinositol 4-phosphate, also potentiated heat

107 charged lipids with a free phosphate group, phosphatidylinositol 4-phosphate and lyso-PA, had the sa

108 gion was found to bind the phosphoinositides phosphatidylinositol 4-phosphate and phosphatidylinosito

109 comparable activities toward the substrates phosphatidylinositol 4-phosphate and phosphatidylinosito

110 ue to severe mislocalization of the cellular phosphatidylinositol 4-phosphate and phosphatidylinosito

111 the unstimulated steady-state levels of both phosphatidylinositol 4-phosphate and PIP2 by a catalytic

112 Hence, Rab27a promotes high levels of PM phosphatidylinositol 4-phosphate and the localized produ

113 ate membranes displayed decreased binding to phosphatidylinositol-4-phosphate and other phosphoinosit

114 analysis reveals that RTCs contain the lipid phosphatidylinositol-4-phosphate and proteins involved i

115 7 binds phosphatidylinositol-3-phosphate and phosphatidylinositol-4-phosphate and that the basic surf

116 sitol 4,5-bisphosphate (PtdIns(4,5P)(2)) and phosphatidylinositol 4-phosphate, and both promoted synd

117 ort here that phosphatidylinositol (PtdIns), phosphatidylinositol-4-phosphate, and other phosphatidyl

118 ly phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate, are important channel

119 ositides are comparable with those seen with phosphatidylinositol 4-phosphate as the substrate.

120 phosphatidic acid, phosphatidylinositol, or phosphatidylinositol-4-phosphate as an acyl donor and ca

121 Herein, we identify phosphatidylinositol-4-phosphate as an essential compone

122 fragment of PLC-epsilon maximally hydrolyzed phosphatidylinositol 4-phosphate at a rate of approximat

123 ynthesis is thought to be phosphorylation of phosphatidylinositol 4-phosphate at the 5 position of th

124 yA-GFP was targeted to Golgi membranes via a phosphatidylinositol 4-phosphate-binding domain.

125 mology domain ORP4 are essential for binding phosphatidylinositol 4-phosphate but not sterols.

126 new PLD activity was partially stimulated by phosphatidylinositol 4-phosphate, but not by other phosp

127 int in the pathway is the phosphorylation of phosphatidylinositol 4-phosphate by the phosphatidylinos

128 e (CCV) enriched 70-kD protein that binds to phosphatidylinositol-4-phosphate, clathrin, and the gamm

129 osphates of PI(4,5)P2 and the 4-phosphate of phosphatidylinositol 4-phosphate, converting both compou

130 We measured dynamic changes of PI(4,5)P2, phosphatidylinositol 4-phosphate, diacylglycerol, inosit

131 ensitive [(32)P]phosphate incorporation into phosphatidylinositol 4-phosphate during Ca(2+)-induced p

132 and found that mainly phosphatidic acid and phosphatidylinositol-4-phosphate enhance association of

133 ds to stimulate PI4KA to create a permissive phosphatidylinositol 4-phosphate-enriched membrane micro

134 In contrast, phosphatidylinositol 4-phosphate generated by Pik1p loca

135 Here we show that the phosphatidylinositol-4-phosphate/GOLPH3/myosin 18A/F-act

136 since other anionic phospholipids including phosphatidylinositol 4-phosphate had no stimulatory effe

137 A substantial burst of phosphatidylinositol-4-phosphate immediately after buddi

138 The PH domain of ORP4L also binds phosphatidylinositol 4-phosphate in the Golgi apparatus.

139 Acute depletion of phosphatidylinositol 4-phosphate in the Golgi caused acc

140 olgi-localized, and it generates >50% of the phosphatidylinositol 4-phosphate in the Golgi.

141 I 4-phosphatase that specifically hydrolyzes phosphatidylinositol 4-phosphate in vitro.

142 es to visualize pools of PtdIns(4,5)P(2) and phosphatidylinositol 4-phosphate in yeast.

143 oreover, we demonstrate that accumulation of phosphatidylinositol-4-phosphate in sac1 mutants is insu

144 We propose that phosphatidylinositol-4-phosphate is an essential compone

145 ound specialized domains with high levels of phosphatidylinositol-4-phosphate kinase (PIPKI) and chro

146 Significantly, the Golgi phosphatidylinositol 4-phosphate level was altered in pa

147 ressing AT1 receptors revealed that PIP2 and phosphatidylinositol 4-phosphate levels are to be strong

148 Spatial and temporal control of phosphatidylinositol 4-phosphate levels through activati

149 ne, and phosphatidylinositol-3-phosphate and phosphatidylinositol-4-phosphate mark distinct endosomal

150 tently regulate its activation, we show that phosphatidylinositol (4)-phosphate (PI(4)P) and phosphat

151 phosphatidylinositol 3-phosphate (PI(3)P) or phosphatidylinositol 4-phosphate (PI(4)P) > phosphatidyl

152 Phosphatidylinositol 4-phosphate (PI(4)P) and cholestero

153 hosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 4-phosphate (PI(4)P) as regulators

154 Phosphatidylinositol 4-phosphate (PI(4)P) has been shown

155 hosphatidylinositol 4-kinase (PI4K)-mediated phosphatidylinositol 4-phosphate (PI(4)P) production has

156 phosphoinositide homeostasis by limiting PM phosphatidylinositol 4-phosphate (PI(4)P), the precursor

157 an also transport the signaling phospholipid phosphatidylinositol 4-phosphate (PI(4)P), which binds t

158 kinase (PI4KII) enzymes synthesize the lipid phosphatidylinositol 4-phosphate (PI(4)P), which has bee

159 udy, we found that Hh elevates production of phosphatidylinositol 4-phosphate (PI(4)P).

160 ing protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact site

161 h RabA4B through N-terminal domains and with phosphatidylinositol 4-phosphate (PI-4P) through a C-ter

162 logy (PH) domain of human Fapp1, which binds phosphatidylinositol-4-phosphate (PI(4)P) specifically,

163 sphatidylinositol-3,4-bisphosphate and d-myo-phosphatidylinositol-4-phosphate (PI(4)P), but much less

164 e upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).

165 generated by the canonical pathway in which phosphatidylinositol-4-phosphate (PI-4-P) is the interme

166 4, which is knocked-out in a gene encoding a phosphatidylinositol-4-phosphate (PI-4P) phosphatase, wa

167 s and that POL is catalytically activated by phosphatidylinositol (4) phosphate [PI(4)P] in vitro.

168 Phosphatidylinositol 4 phosphate [PI(4)P] is essential f

169 dylinositol 4,5-bisphosphate [PI(4,5)P2] and phosphatidylinositol 4-phosphate [PI(4)P] applied to the

170 Generation of phosphatidylinositol 4-phosphate [PI(4)P] from phosphati

171 arious endocytic compartments and identified phosphatidylinositol 4-phosphate [PI(4)P], phosphatidyli

172 PHOSH1 domains as indicators of PM and Golgi phosphatidylinositol 4-phosphate [PI(4)P], respectively.

173 RHD4 displayed a preference for phosphatidylinositol-4-phosphate [PI(4)P] in vitro, and

174 The phospholipid phosphatidylinositol-4-phosphate [PI(4)P], generated at

175 and, more weakly, with liposomes containing phosphatidylinositol-4-phosphate [PI(4)P].

176 Phosphatidylinositol 4 phosphate (PI4P) is highly enrich

177 overexpression increased PIP(2) and reduced phosphatidylinositol 4 phosphate (PI4P) levels.

178 CV replicons produced a dramatic increase in phosphatidylinositol 4-phosphate (PI4P) accumulation thr

179 d PI4KIIalpha, a lipid kinase that generates phosphatidylinositol 4-phosphate (PI4P) and binds GABARA

180 -kinase has been shown to generate a pool of phosphatidylinositol 4-phosphate (PI4P) at the plasma me

181 of cardiac hypertrophy that depends on Golgi phosphatidylinositol 4-phosphate (PI4P) hydrolysis by a

182 eracts with actin and regulates the level of phosphatidylinositol 4-phosphate (PI4P) in the membranes

183 on of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (PI4P) in this membrane

184 Phosphatidylinositol 4-phosphate (PI4P) is identified as

185 We show that phosphatidylinositol 4-phosphate (PI4P) is present in la

186 expression of mutant PSS1 enzymes decreased phosphatidylinositol 4-phosphate (PI4P) levels both in t

187 ing massive production and redistribution of phosphatidylinositol 4-phosphate (PI4P) lipid to the rep

188 Golgi-localized phosphatidylinositol 4-phosphate (PI4P) recruits protein

189 Phosphatidylinositol 4-phosphate (PI4P) regulates biosyn

190 Intriguingly, Golgi-associated phosphatidylinositol 4-phosphate (PI4P) works together w

191 one of four human PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but ess

192 ATPase activity, which remains dependent on phosphatidylinositol 4-phosphate (PI4P), a regulator of

193 brane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned

194 ane (PM) depends on levels of its precursor, phosphatidylinositol 4-phosphate (PI4P), synthesized pri

195 ses that require expansion and remodeling of phosphatidylinositol 4-phosphate (PI4P)-containing membr

196 4 of yeast integrates signaling by Cdc42 and phosphatidylinositol 4-phosphate (PI4P).

197 rescued by addition of exogenous inositol or phosphatidylinositol 4-phosphate (PI4P).

198 dependent on the levels of the phospholipid phosphatidylinositol-4 phosphate (PI4P).

199 a selective increase in an endosomal pool of phosphatidylinositol-4-phosphate (PI4P) and a perturbati

200 GOLPH3 is a phosphatidylinositol-4-phosphate (PI4P) effector that pl

201 LAT domain to phosphatidylserine and L-alpha-phosphatidylinositol-4-phosphate (PI4P) enriched in the

202 Phosphatidylinositol-4-phosphate (PI4P) is produced on b

203 branes over coat proteins, yielding uncoated phosphatidylinositol-4-phosphate (PI4P) lipid-enriched o

204 olved is unclear but requires recognition of phosphatidylinositol-4-phosphate (PI4P) within the Golgi

205 oinositide species, we also demonstrate that phosphatidylinositol-4-phosphate (PI4P), the product of

206 ly, EV71 infection induces the production of phosphatidylinositol-4-phosphate (PI4P).

207 phosphatidylinositol-3-phosphate (PI3P) and phosphatidylinositol-4-phosphate (PI4P).

208 ence of F(surf) because messages for cardiac phosphatidylinositol-4-phosphate (PIP) 5-kinases increas

209 Both phosphatidylinositol-4-phosphate (PIP) and PIP(2) were i

210 Phosphatidylinositol-4-phosphate (PIP) and PIP2 were an

211 extensive aggregation of vesicles containing phosphatidylinositol-4-phosphate (PIP) and, to a lesser

212 Phosphatidylinositol-4-phosphate (PIP) was a less effect

213 5 mol % phosphatidylinositol-4-phosphate (PIP) was enough to cau

214 human platelets promotes an increase in the phosphatidylinositol 4-phosphate (PtdIns 4-P) 5-kinase (

215 ab1p was initially proposed to function as a phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinase (

216 Here we show that type Igamma phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinase (

217 ng of its pleckstrin homology (PH) domain to phosphatidylinositol 4-phosphate (PtdIns(4)P) and a smal

218 domain targets it to the Golgi by binding to phosphatidylinositol 4-phosphate (PtdIns(4)P) in the Gol

219 undertaken to further define the effects of phosphatidylinositol 4-phosphate (PtdIns(4)P) metabolism

220 specific increase in the cellular levels of phosphatidylinositol 4-phosphate (PtdIns(4)P), accompani

221 in from Bem1p that has been reported to bind phosphatidylinositol 4-phosphate (PtdIns(4)P).

222 d phosphatase Sac1p regulates local pools of phosphatidylinositol-4-phosphate (PtdIns(4)P) at endopla

223 om yeast to humans, are uniquely enriched in phosphatidylinositol-4-phosphate (PtdIns(4)P), although

224 ositol-4,5-bisphosphate (PtdIns-4,5-P(2)) to phosphatidylinositol-4-phosphate (PtdIns-4-P).

225 Spn2 and Spn7 bind to phosphatidylinositol 4-phosphate [PtdIns(4)P] in vitro,

226 g membrane components, the phosphoinositides phosphatidylinositol 4-phosphate (PtdIns4P) and phosphat

227 ifferent acyl chains for both the substrates phosphatidylinositol 4-phosphate (PtdIns4P) and phosphat

228 e distribution, fate, and functional role of phosphatidylinositol 4-phosphate (PtdIns4P) during phago

229 One member, phosphatidylinositol 4-phosphate (PtdIns4P) has been loc

230 The phosphoinositide phosphatidylinositol 4-phosphate (PtdIns4P) is an essent

231 Phosphatidylinositol 4-phosphate (PtdIns4P) is an interm

232 PM depletion of either phosphatidylinositol 4-phosphate (PtdIns4P) or PtdIns(4,

233 At the trans-Golgi network (TGN), phosphatidylinositol 4-phosphate (PtdIns4P) plays import

234 se (PIP5K1) phosphorylates the head group of phosphatidylinositol 4-phosphate (PtdIns4P) to generate

235 tidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (PtdIns4P), a signaling

236 ze the conversion of phosphatidylinositol to phosphatidylinositol 4-phosphate (PtdIns4P).

237 usly showed that Rac interacts with a type I phosphatidylinositol-4-phosphate (PtdInsP) 5-kinase, ind

238 synapses formed as a result of depletion of phosphatidylinositol-4-phosphate rather than a build-up

239 These data indicate that phosphatidylinositol 4-phosphate, rather than mannosyl-d

240 t, in addition to a dramatic accumulation of phosphatidylinositol-4-phosphate, sac1 mutants also exhi

241 ne composition principally via regulation of phosphatidylinositol 4-phosphate signaling.

242 sterol-regulated antagonist of TGN/endosomal phosphatidylinositol-4-phosphate signaling.

243 ion of pleckstrin homology domains that bind phosphatidylinositol 4-phosphate strongly inhibited the

244 minal pleck-strin homology domain that binds phosphatidylinositol 4-phosphate suggesting that phospha

245 r data suggest that independent pathways for phosphatidylinositol 4-phosphate synthesis emerged durin

246 at mediates endosome motility independent of phosphatidylinositol 4-phosphate synthesis.

247 stranded RNA, and cellular lipids, including phosphatidylinositol 4-phosphate), the mutation in NS5A

248 These results explain why phosphatidylinositol-4-phosphate tightly controls Drs2p-

249 Phosphatidylinositol 4-phosphate was a weak activator an

250 We further found that phosphatidylinositol 4-phosphate, which contains a monoe

251 the Golgi apparatus by controlling levels of phosphatidylinositol 4-phosphate, which facilitates carg

252 terface results in a broader distribution of phosphatidylinositol 4-phosphate within the Golgi appara