ライフサイエンスコーパス: phosphatidylinositol-5-phosphate

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1 sitides phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate.

2 In this study we identify Drosophila phosphatidylinositol 5-phosphate 4-kinase (dPIP4K) as a

3 n wild-type littermates, female mice lacking phosphatidylinositol 5-phosphate 4-kinase beta have incr

4 While adult male mice lacking phosphatidylinositol 5-phosphate 4-kinase beta have sign

5 These results indicate that phosphatidylinositol 5-phosphate 4-kinase beta plays a r

6 skeletal muscle and liver from mice lacking phosphatidylinositol 5-phosphate 4-kinase beta.

7 nases, we generated mice that do not express phosphatidylinositol 5-phosphate 4-kinase beta.

8 pe II phosphatidylinositol-phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) also inhibite

9 alpha-granule secretion involves the type II phosphatidylinositol 5-phosphate 4-kinase-dependent path

10 Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are

11 Phosphatidylinositol 5-phosphate 4-kinases convert phosp

12 Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) conve

13 w that mice with germline deletion of type 2 phosphatidylinositol-5-phosphate 4-kinase gamma (Pip4k2c

14 2 or decreased cellular PIP2 by knockdown of phosphatidylinositol-5-phosphate 4-kinase impaired apoA1

15 One of these, the lipid kinase phosphatidylinositol-5-phosphate 4-kinase, type II, alph

16 st cancers express high levels of the type 2 phosphatidylinositol-5-phosphate 4-kinases alpha and/or

17 tide phosphatases, PLIP has a preference for phosphatidylinositol 5-phosphate, a newly discovered pho

18 The mutant reduces catalytic activity toward phosphatidylinositol 5-phosphate by approximately 50-fol

19 )P(3)) >> phosphatidylinositol 3-phosphate > phosphatidylinositol 5-phosphate >> other phosphoinositi

20 involved in elevating the cellular level of phosphatidylinositol 5-phosphate in response to dehydrat

21 tase (PLIP) exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate

22 4-phosphate (PI(4)P), but much less by d-myo-phosphatidylinositol-5-phosphate (PI(5)P) or d-myo-phosp

23 Phosphatidylinositol-5-phosphate (PI-5-P) is a newly ide

24 inositol-4,5-bisphosphate (PI-4,5-P(2)) from phosphatidylinositol-5-phosphate (PI-5-P).

25 t al. (2014) identify the signaling molecule phosphatidylinositol 5-phosphate (PI5P) as an allosteric

26 the cellular content of its substrate lipid phosphatidylinositol 5-phosphate (PI5P), suggesting that

27 ve also is responsible for nearly all of the phosphatidylinositol-5-phosphate (PI5P) pool.

28 at ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P.

29 tdInsPs, including the rare PtdInsP species, phosphatidylinositol 5-phosphate (PtdIns(5)P).

30 scovered phosphatidylinositol monophosphate, phosphatidylinositol 5-phosphate (PtdIns-5-P), plays an

31 nositol-3,5-bisphosphate (PtdIns-3,5-P2) and phosphatidylinositol- 5-phosphate (PtdIns-5-P), have bee

32 on of ING2 with the nuclear phosphoinositide phosphatidylinositol-5-phosphate (PtdIns(5)P) regulates

33 atalyze the hydrolysis of PtdIns-4,5-P(2) to phosphatidylinositol-5-phosphate (PtdIns-5-P).

34 ,5-bisphosphate and, directly or indirectly, phosphatidylinositol-5-phosphate [PtdIns(5)P].

35 The role of cellular phosphatidylinositol 5-phosphate (PtdIns5P), as a signal

36 Phosphatidylinositol-5-phosphate (PtdIns5P) 4-kinase bet

37 alpha (PIP4K2A) regulates cellular levels of phosphatidylinositol-5-phosphate (PtsIns5P) and phosphat

38 atidylinositol 5-phosphate 4-kinases convert phosphatidylinositol 5-phosphate to phosphatidylinositol

39 sitol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol

40 atase in complex with a surrogate substrate, phosphatidylinositol 5-phosphate, which sheds light on t

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