ライフサイエンスコーパス: phosphatidylserine

1 associate with anionic phospholipids such as phosphatidylserine.

2 stimuli, including the anionic phospholipid phosphatidylserine.

3 d apoptotic cells, possibly via externalized phosphatidylserine.

4 s, nor does it elicit the externalization of phosphatidylserine.

5 d the endosomal acidic phospholipids, mainly phosphatidylserine.

6 grin tension is coupled with the exposure of phosphatidylserine.

7 asts, with a strong substrate preference for phosphatidylserine.

8 ed mutant of C2Am (iC2Am) that does not bind phosphatidylserine.

9 ace of these two processes resides the lipid phosphatidylserine.

10 an interaction site with the head groups of phosphatidylserine, a known activator of PKCdelta.

11 at negatively charged phospholipids, such as phosphatidylserine, act as coupling factors enhancing th

12 bose) polymerase, and the externalization of phosphatidylserine after treatment of cells with IFN-gam

13 localization but does alter its affinity for phosphatidylserine, allowing it to recycle at the plasma

14 (PSR) was first identified as a receptor for phosphatidylserine, an 'eat-me' signal exposed by apopto

15 corporation of anionic phospholipids such as phosphatidylserine and an acidic pH.

16 We conclude that the roles of phosphatidylserine and ceramide in phagocytosis is based

17 tides antagonize the binding of factor Xa to phosphatidylserine and inhibit the enzymatic activity of

18 Depolarization-induced changes in phosphatidylserine and K-Ras plasma membrane organizatio

19 the selective binding of the PLAT domain to phosphatidylserine and L-alpha-phosphatidylinositol-4-ph

20 Phosphatidylserine and N,N-dimethyl phosphatidylethanola

21 nly observed upon binding onto monolayers of phosphatidylserine and not in the case of other anionic

22 ulin secretory granules (ISG) suggested that phosphatidylserine and other phospholipids, such as phos

23 ATP8A2 is a P4-ATPase that flips phosphatidylserine and phosphatidylethanolamine across c

24 The finding that CD300a recognizes phosphatidylserine and phosphatidylethanolamine, two ami

25 Phosphatidylinositol, phosphatidylserine and phosphatidylglycerol were minor g

26 that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-

27 rization induces nanoscale reorganization of phosphatidylserine and phosphatidylinositol 4,5-bisphosp

28 VP40 residues in the absence and presence of phosphatidylserine and phosphatidylinositol 4,5-bisphosp

29 fatty acids 12:0 and 14:0 were high, as were phosphatidylserine and phosphatidylinositol containing 1

30 receptor phospho-Tyr and two anionic lipids (phosphatidylserine and PIP2) to make PI3Kalpha competent

31 ion, granularity, mitochondrial content, and phosphatidylserine and protein receptor surface expressi

32 P4 ATPase flippases translocate primarily phosphatidylserine and, to a lesser extent, phosphatidyl

33 e stimulation, the concentration of many ISG phosphatidylserines and phosphatidylinositols increased;

34 ipid membranes (made of phosphatidylcholine, phosphatidylserine, and ceramide) and rat alveolar macro

35 drial membrane potential, externalization of phosphatidylserine, and DNA fragmentation, that ultimate

36 s based on ligand specificity, regulation by phosphatidylserine, and function.

37 ed MPs expressed VE-cadherin and superficial phosphatidylserine, and in a thrombin generation assay,

38 lysis, allosteric activation, stimulation by phosphatidylserine, and pharmacological inhibition by th

39 ted in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.

40 rations of negatively charged phospholipids, phosphatidylserine, and phosphatidylinositol in ISG were

41 0f (CLM-1) recognizes outer membrane-exposed phosphatidylserine, and regulates the phagocytosis of AC

42 Similarly, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin lipids did not ind

43 tly to PIP2, but not to phosphatidic acid or phosphatidylserine, and that sequential reduction of the

44 phosphatidylglycerol, phosphatidylinositol, phosphatidylserine, and triacylglycerides.

45 Disruption of phosphatidylcholine, phosphatidylserine, and/or phosphatidylethanolamine meta

46 verse correlation between the levels of anti-phosphatidylserine antibodies and plasma hemoglobin, sug

47 -not-eat-me" signal, but the binding of anti-phosphatidylserine antibodies mediates their phagocytosi

48 tion, such as docosahexaenoic acid (DHA) and phosphatidylserines, appear early and then fall dramatic

49 ith membrane-mimicking environment, DAG, and phosphatidylserine, as well as the affinities associated

50 C-STAMP)-dependent non-apoptotic exposure of phosphatidylserine at the surface of fusion-committed ce

51 aenorhabditis elegans PSR, mediates specific phosphatidylserine binding in vitro and clearance of apo

52 We describe here the validation of a phosphatidylserine-binding agent for detecting tumor cel

53 function normally provided by the C-terminal phosphatidylserine-binding KA1 domain (residues 1379-151

54 Mutations in the phosphatidylserine-binding motif, but not in its Fe(II)

55 ish and identified Cavin-2, a membrane-bound phosphatidylserine-binding protein and critical organize

56 ssays, this study demonstrates that PR3 is a phosphatidylserine-binding protein and this interaction

57 lentiviral vectors, we found that a soluble phosphatidylserine-binding protein, MFG-E8, enhances tra

58 ion also depended on extracellular annexins, phosphatidylserine-binding proteins, which, along with a

59 that can be replaced by other, heterologous phosphatidylserine-binding sequences.

60 Finally, saturating the phosphatidylserine-binding sites on HIV target cells did

61 Phosphatidylserine binds to an integral-membrane N-termi

62 for phosphatidylethanolamine synthesis from phosphatidylserine catalyzed by phosphatidylserine decar

63 sed membrane rigidity and externalization of phosphatidylserine, consistent with eryptosis (erythrocy

64 ein mesh able to form polyhedral lattices on phosphatidylserine-containing vesicles.

65 Phosphatidylserine decarboxylase (PSDs) play a central r

66 Etn in the mitochondrion is synthesized by a phosphatidylserine decarboxylase (TgPSD1mt) of the type

67 Phosphatidylserine decarboxylase 1 (Psd1p), an ancient e

68 he mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p).

69 In yeast, low levels of PE in the phosphatidylserine decarboxylase deletion mutant (psd1De

70 nthesis from phosphatidylserine catalyzed by phosphatidylserine decarboxylase enzymes (PSD) as a suit

71 In Caenorhabditis elegans, RNAi depletion of phosphatidylserine decarboxylase in dopaminergic neurons

72 Here, we demonstrate that the phosphatidylserine decarboxylase Psd1, located in the in

73 ndrial localization of a key pathway enzyme, phosphatidylserine decarboxylase Psd1, which generates p

74 Phosphatidylserine decarboxylase, which is embedded in t

75 ugh reduction of the levels of mitochondrial phosphatidylserine decarboxylase, which is involved in t

76 Phosphatidylserine decarboxylases (PSDs) are central enz

77 e C-terminal 33 residues resulted in reduced phosphatidylserine-dependent ATPase activity, phosphatid

78 phosphatidylserine, efficiently blocks these phosphatidylserine-dependent viral entry mechanisms.

79 Notably, "soluble" phosphatidylserine (dihexanoyl-phosphatidylserine) faile

80 the engulfment of erythrocytes with exposed phosphatidylserine directly modulated the phenotype of b

81 lipid composition, and plasma membrane (PM) phosphatidylserine distribution.

82 ock phagocytosis of dead cells by concealing phosphatidylserine, efficiently blocks these phosphatidy

83 Gag, but not PHPLCdelta1, to the dipalmitoyl-phosphatidylserine-enriched gel phase of these GUVs.

84 liquid phase, and the other appeared to be a phosphatidylserine-enriched gel phase.

85 ine-rich C-kinase substrate (MARCKS) bind to phosphatidylserine exposed on activated platelets and th

86 mechanism through which phagocytes recognize phosphatidylserine exposed on dead cells.

87 In particular, phosphatidylserine exposed on the external leaflet of th

88 ein S and Gas6 are involved in the uptake of phosphatidylserine-exposing apoptotic cells in macrophag

89 ts adherent to collagen are transformed into phosphatidylserine-exposing balloonlike structures with

90 We find that phosphatidylserine-exposing erythrocytes are reticulocyt

91 he mutant mice had an elevated percentage of phosphatidylserine-exposing mature erythrocytes in the p

92 ) T cells following phagocytosis of injured, phosphatidylserine-exposing oligodendroglial cells is ab

93 Spreading on fibrin was associated with phosphatidylserine exposure (procoagulant activity), and

94 Both phosphatidylserine exposure and caspase-3 activation wer

95 following ingestion of S. aureus, including phosphatidylserine exposure and mitochondrial membrane d

96 Next, we discuss the molecular mechanisms of phosphatidylserine exposure during necroptosis and its r

97 ochrome c release, caspase 3 activation, and phosphatidylserine exposure).

98 yclooxygenase-1 and integrin activation, and phosphatidylserine exposure, blood clotting simulations

99 ll death analysis by morphologic assessment, phosphatidylserine exposure, caspase cleavage and chemic

100 ne potential dissipation, membrane blebbing, phosphatidylserine exposure, DNA damage and chromatin co

101 sembled acanthocytes and displayed increased phosphatidylserine exposure, high intracellular calcium,

102 phage proinflammatory cytokine release after phosphatidylserine exposure.

103 ceptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic

104 te et al describe how under flow conditions, phosphatidylserine-expressing platelets modulate the lys

105 h flow cytometry and phenotyped according to phosphatidylserine expression (PS(+)/PS(-)), cellular or

106 iated with the initiation and propagation of phosphatidylserine externalization after axotomy.SIGNIFI

107 time-lapse imaging to study the dynamics of phosphatidylserine externalization immediately after axo

108 ucing drug, slowed the onset and velocity of phosphatidylserine externalization in wild-type axons si

109 The extension of phosphatidylserine externalization was slowed and delaye

110 /-) mice, levels of membrane cholesterol and phosphatidylserine externalization were increased, foste

111 embrane phospholipid polarity, manifested as phosphatidylserine externalization, which was significan

112 ly, "soluble" phosphatidylserine (dihexanoyl-phosphatidylserine) failed to stimulate C1P transfer.

113 hosphatidylserine-dependent ATPase activity, phosphatidylserine flippase activity, and neurite extens

114 however, assembled with CDC50A and displayed phosphatidylserine flippase activity.

115 erythrocytes from mice lacking the putative phosphatidylserine flippase ATP11C showed a lower rate o

116 n with its subunit CDC50A, and function as a phosphatidylserine flippase.

117 ) yeast Psd1p does not require its substrate phosphatidylserine for autocatalysis; and 3) contrary to

118 ) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the ce

119 y translocating phosphatidylethanolamine and phosphatidylserine from the outer leaflet to the cytosol

120 The interaction between phosphatidylserine, Gas6, and Axl was originally shown t

121 nity of recoverin for the negatively charged phosphatidylserine has been clearly shown to be governed

122 Envelope phosphatidylserine has previously been shown to be impor

123 s6, various molecules are known to recognize phosphatidylserine; however, the effects of these molecu

124 impaired Ca(2+)-dependent externalization of phosphatidylserine in activated platelets, suggesting th

125 ds phosphatidylinositol-4,5-bisphosphate and phosphatidylserine in different compositions.

126 The negative charge of phosphatidylserine in lipid bilayers of secretory vesicl

127 the level of the N-containing lipids PE and phosphatidylserine in root hairs decreased whereas the l

128 inding, whereas phosphatidylethanolamine and phosphatidylserine in the inner leaflet of asymmetric ve

129 cteristics of apoptosis, such as flipping of phosphatidylserine in the membrane as well as cell size

130 rovide insights into the role(s) of envelope phosphatidylserine in viral infection, which can be appl

131 membrane by electrostatic interactions with phosphatidylserine, in turn undergoes enhanced nanoclust

132 sitols increased; unsaturated fatty acids in phosphatidylserine increased; and most phosphatidylethan

133 This motif also mediates phosphatidylserine-induced oligomerization of PSR-1, sug

134 Blocking phosphatidylserine, inhibiting thrombin or blocking PAR1

135 Phosphatidylserine is a common constituent of all Ras na

136 As phosphatidylserine is a major component of microvesicles

137 Here we demonstrate that plasma membrane phosphatidylserine is critical for Ebola virus budding f

138 is exquisitely sensitive to plasma membrane phosphatidylserine levels.

139 ipid vesicles is promoted by the presence of phosphatidylserine lipids but inhibited by ceramide, in

140 led by externalization on the cell target of phosphatidylserine lipids, which activate receptors on m

141 Both the phosphatase and C2 domains bind phosphatidylserine lipids, which likely helps to positio

142 Direct binding of NM2s to phosphatidylserine-liposomes, but not to phosphatidylcho

143 We conclude that phosphatidylserine maintains the lateral segregation of

144 Next, the phosphatidylserine marker GFP::Lact-C2 was expressed in

145 aken together, these studies suggest that PM phosphatidylserine may be an important component of Ebol

146 ed and the possibility of ligand-independent phosphatidylserine-mediated binding is explored.

147 facilitate their entry, suggesting that the phosphatidylserine-mediated viral entry mechanism can be

148 pment of novel antiviral reagents that block phosphatidylserine-mediated viral entry.

149 amics simulations yielded a dynamic model of phosphatidylserine membrane recognition by Tim1 with ato

150 sease, to our knowledge, caused by disrupted phosphatidylserine metabolism.

151 highest affinity for ZENV; HSP70, TIM-1, and phosphatidylserine might also play active roles in zika

152 ic residues of MA and multiple PI(4,5)P2 and phosphatidylserine molecules.

153 as the extent of penetration of recoverin in phosphatidylserine monolayers was estimated by ellipsome

154 genesis inhibitor 1 (BAI1), which recognizes phosphatidylserine on apoptotic cells, and the intracell

155 eir ability to recognize the 'eat-me' signal phosphatidylserine on apoptotic cells.

156 ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells.

157 early IFN-I, and that surface expression of phosphatidylserine on infected RBCs might promote their

158 otic mimicry, many enveloped viruses display phosphatidylserine on the outer leaflet of their membran

159 r typical scavenger receptors that recognize phosphatidylserine on the surface of dead cells.

160 Moreover, the levels of phosphatidylserine on the surface of HIV-1 particles, wh

161 Activated platelets expose phosphatidylserine on their outer membrane leaflet and a

162 brane-derived microparticles (PMPs) exposing phosphatidylserine on their surface.

163 hich express immunomodulatory molecules like phosphatidylserine or TGF-beta1.

164 eric state that preferentially binds anionic phosphatidylserine over neutral phosphatidylcholine.

165 ) and phospholipids (FXa/phosphatidylcholine-phosphatidylserine [PCPS]) vs LD100 Escherichia coli We

166 e and phosphatidylethanolamine) and anionic (phosphatidylserine, phosphatidic acid, cardiolipin, and

167 the exosomes, including phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatid

168 he anionic phospholipids, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, and phosphatid

169 containing one or more acidic phospholipids (phosphatidylserine, phosphatidylinositol 4,5-diphosphate

170 In ISG phosphatidylserine, phosphatidylinositol, phosphatidylet

171 r, 71 sulfatides and 59 polar phospholipids (phosphatidylserines, phosphatidylinositols, lysophosphat

172 evident in protruding caps on the surface of phosphatidylserine-positive platelets.

173 from rafts to filopodia and ultimately onto phosphatidylserine-positive, highly procoagulant MPs.

174 Furthermore, Na,K-ATPase activity depends on phosphatidylserine (PS) and cholesterol, which stabilize

175 mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of plate

176 lated domains (ORDs) harbored either PI4P or phosphatidylserine (PS) and exchanged these lipids betwe

177 ype (WT) yeast normally restrict most of the phosphatidylserine (PS) and phosphatidylethanolamine (PE

178 The relative enrichments of phosphatidylserine (PS) and phosphatidylethanolamine (PE

179 andidiasis is dependent on the phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE

180 FF-1 fusogen after axotomy, and establishing phosphatidylserine (PS) and the PS receptor (PSR-1) as c

181 ir ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability t

182 Phosphatidylethanolamine (PE) and phosphatidylserine (PS) are ubiquitously expressed and m

183 duces vesiculation from membranes containing phosphatidylserine (PS) at concentrations of PS that are

184 s hsc-70 interaction with negatively charged phosphatidylserine (PS) at the endosomal limiting membra

185 sensor proteins (mNG-KRn), and the specific phosphatidylserine (PS) binding protein Evectin2.

186 Mutation of the phosphatidylserine (PS) binding sites of TIM-1 abolishes

187 mbin-stimulated platelets expose very little phosphatidylserine (PS) but express binding sites for fa

188 acidic region, preferentially interacts with phosphatidylserine (PS) compared with other phospholipid

189 -dependent platelet signaling with defective phosphatidylserine (PS) exposure and microparticle forma

190 but instead associated with reduced platelet phosphatidylserine (PS) exposure and procoagulant functi

191 In this issue of Blood, Mankelow et al link phosphatidylserine (PS) exposure in sickle erythrocytes

192 , MLKL-dependent calcium (Ca(2+)) influx and phosphatidylserine (PS) exposure on the outer leaflet of

193 shrinkage and cell membrane scrambling with phosphatidylserine (PS) exposure.

194 ral bioeffects triggered by nsPEF, including phosphatidylserine (PS) externalization, nanopore-conduc

195 kage and cell membrane scrambling leading to phosphatidylserine (PS) externalization.

196 silico analysis predicted that externalized phosphatidylserine (PS) in MPs may associate with and he

197 Phosphatidylserine (PS) is an abundant charged lipid tha

198 Phosphatidylserine (PS) is asymmetrically distributed be

199 he inner leaflet, long acyl-chain-containing phosphatidylserine (PS) is necessary for transbilayer co

200 we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert s

201 of enteroviral particles are packaged within phosphatidylserine (PS) lipid-enriched vesicles that are

202 Recognition of phosphatidylserine (PS) lipids exposed on the extracellu

203 ormation, the exposure of negatively charged phosphatidylserine (PS) on adherent leukocytes, and clot

204 Ms as soluble factors, or, in turn, opsonize phosphatidylserine (PS) on apoptotic cells (ACs) and ser

205 a vacuolar protein B (CvpB) binds PI(3)P and phosphatidylserine (PS) on CCVs and early endosomal comp

206 in part, by receptors that bind to exofacial phosphatidylserine (PS) on cells or cellular debris afte

207 observed during apoptosis is the exposure of phosphatidylserine (PS) on the outer plasma membrane.

208 We discovered that IFNgamma is captured by phosphatidylserine (PS) on the surface of viable cells b

209 TIM-4 expression by stressed hepatocellular phosphatidylserine (PS) presentation, peaking at 6 hours

210 Phosphatidylserine (PS) receptors contribute to two cruc

211 ily proteins were recently found to serve as phosphatidylserine (PS) receptors which promote infectio

212 We have found that the lipid phosphatidylserine (PS) regulates the assembly of Ebola

213 Mutations in thePTDSS1gene coding one of the phosphatidylserine (PS) synthase enzymes, PSS1, were des

214 Phosphatidylserine (PS) that is normally constrained to

215 that either gain or lose the ability to flip phosphatidylserine (PS) to determine that PS flip by Drs

216 cells by bridging cells with surface exposed phosphatidylserine (PS) to macrophage receptors, includi

217 membrane protein complex (EMC) has decreased phosphatidylserine (PS) transfer from the ER to mitochon

218 Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer leaflet of cancer

219 Phosphatidylserine (PS), an 'eat-me' signal for macropha

220 EnDi-modified phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) li

221 VSMC exosome composition and accumulation of phosphatidylserine (PS), annexin A6 and matrix metallopr

222 EnDi-modified phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylcholine (PC), and s

223 hatidic acid (PA), phosphoethanolamine (PE), phosphatidylserine (PS), phosphatidylglycerol (PG), phos

224 pecific eat-me signals, such as externalized phosphatidylserine (PS), that are recognized in a specif

225 establish that PlyCB interacts strongly with phosphatidylserine (PS), whereas its interaction with ot

226 of three peptides per vesicle, but only with phosphatidylserine (PS)-containing vesicles.

227 el process whereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are

228 eased the plasminogen signal associated with phosphatidylserine (PS)-exposing platelets.

229 Binding of coagulation factors to phosphatidylserine (PS)-exposing procoagulant-activated

230 complexes (SLMO2-TRIAP1 in humans) serve as phosphatidylserine (PS)-specific lipid transfer proteins

231 cell surface exposure of the membrane lipid phosphatidylserine (PS).

232 ibitory receptor TIM3 (hTIM3) and its ligand phosphatidylserine (PSF).

233 an occur with phosphatidylcholines (PCs) and phosphatidylserines (PSs), making them indistinguishable

234 membrane charges through negatively charged phosphatidylserines (PSs), which act to position the Cdc

235 s (PCs), phosphatidylethanolamine (PEs), and phosphatidylserines (PSs).

236 ndiline, a potent ASM inhibitor, reduces the phosphatidylserine (PtdSer) and cholesterol content of t

237 Phosphatidylserine (PtdSer) and phosphatidylinositol 4,5

238 o negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIn

239 luorescence imaging approaches revealed that phosphatidylserine (PtdSer) exposure on the outer leafle

240 Phosphatidylserine (PtdSer) receptors that are responsib

241 Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apo

242 ell immunoglobulin mucin protein 4 (TIM4), a phosphatidylserine (PtdSer)-binding receptor, mediates t

243 r TIM family members are recently identified phosphatidylserine (PtdSer)-mediated virus entry-enhanci

244 M family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhanci

245 The plasma membrane is uniquely enriched in phosphatidylserine (PtdSer).

246 nt of both its receptor and the phospholipid phosphatidylserine (PtdSer): Gas6 lacking its PtdSer-bin

247 The conserved phosphatidylserine receptor (PSR) was first identified a

248 The phosphatidylserine receptor BAI1 was expressed in human

249 KIM-1/TIM-1 is a phosphatidylserine receptor that is expressed on epithel

250 macrophages that express high levels of the phosphatidylserine receptor TIM-4 and CD169 (TIM-4hiCD16

251 lasmacytoid DCs (pDCs) that express the TIM1 phosphatidylserine receptor, a known viral- and exosomal

252 However, many phosphatidylserine receptors are also capable of recogni

253 icient eHAV uptake, which was facilitated by phosphatidylserine receptors on pDCs.

254 as a type of cue that induces signaling via phosphatidylserine receptors to promote fusion of myobla

255 ve confirmed that Axl/Gas6, as well as other phosphatidylserine receptors, facilitate entry of dengue

256 xperiments to produce an atomistic model for phosphatidylserine recognition by the immune receptor Ti

257 ic platelets mediate IL-10 secretion through phosphatidylserine recognition in platelet-monocyte aggr

258 isit the work on signaling downstream of the phosphatidylserine recognition receptor BAI1, and evalua

259 Phosphatidylserine recognition receptors are a highly di

260 We also propose the concept that phosphatidylserine recognition receptors could be viewed

261 Most of the phosphatidylserine recognition receptors dampen inflamma

262 Therefore, how phosphatidylserine recognition receptors mediate specifi

263 annexin V, underscoring the requirement for phosphatidylserine recognition.

264 In this study, we examined most human phosphatidylserine-recognizing molecules for their abili

265 s study, we examined most of the known human phosphatidylserine-recognizing molecules, including MFG-

266 results establish that PSR-1 is a conserved, phosphatidylserine-recognizing phagocyte receptor.

267 step in osteoclastogenesis is controlled by phosphatidylserine-regulated activity of several protein

268 binds to phosphatidylinositol phosphates and phosphatidylserine (restricted to the cell membrane inne

269 ce from the PM and impaired Ca(2+)-triggered phosphatidylserine scrambling.

270 ning PI(4,5)P2, cholesterol, and dipalmitoyl phosphatidylserine separated into two coexisting phases:

271 Phosphatidylserine spatial organization is also modified

272 By responding to voltage-induced changes in phosphatidylserine spatiotemporal dynamics, K-Ras nanocl

273 are similarly mediated through regulation of phosphatidylserine spatiotemporal dynamics.

274 trast, replacement with 1-palmitoyl-2-oleoyl-phosphatidylserine stimulated C1P transfer by ACD11 and

275 d provided strong discrimination against the phosphatidylserine substrate.

276 or of this lipid flippase, and specific to a phosphatidylserine substrate.

277 milar overall fold as phospholipase D (PLD), phosphatidylserine synthase (PSS) and tyrosyl-DNA phosph

278 the PAP-mediated regulation of CHO1-encoded phosphatidylserine synthase (PSS), which catalyzes the c

279 missense mutations in PTDSS1, which encodes phosphatidylserine synthase 1 (PSS1).

280 Phosphatidylserine synthesis was increased in intact fib

281 by acting as a bridging molecule that binds phosphatidylserine, the 'eat-me' signal on apoptotic cel

282 Interestingly, at high proportions of phosphatidylserine, the Kd values of all four proteins b

283 tional serum protein, Gas6, bridges envelope phosphatidylserine to a cell surface receptor, Axl.

284 itate viral entry by bridging viral envelope phosphatidylserine to Axl, a receptor tyrosine kinase ex

285 e enzyme responsible for remodeling of human phosphatidylserine to bacterial phosphatidylethanolamine

286 e 1 (Psd1p), an ancient enzyme that converts phosphatidylserine to phosphatidylethanolamine in the in

287 upport roles for P4 ATPases in translocating phosphatidylserine to the cytosolic leaflets of ISG and

288 of ceramide, and subsequent translocation of phosphatidylserine to the erythrocyte surface.

289 us fungi, and the asymmetric distribution of phosphatidylserine to the Spitzenkorper in A. nidulans.

290 mutagenesis, we found that ABCA1's PIP2 and phosphatidylserine translocase activities are independen

291 r drugs in cultured cell lines by monitoring phosphatidylserine translocation that occurs in early ap

292 We show that gzmB(+)Tc-mediated apoptosis (phosphatidylserine translocation, mitochondrial depolari

293 osphatidylcholine, phosphatidylethanolamine, phosphatidylserine, triacylglycerol, and cholesteryl est

294 simulations suggest that PR3 interacts with phosphatidylserine via a small number of amino acids, wh

295 duals, and end-product inhibition of PSS1 by phosphatidylserine was markedly reduced.

296 vation of the Gardos channel and exposure of phosphatidylserine were also inhibited, probably indirec

297 ecific binding of myristoylated recoverin to phosphatidylserine, whereas the extent of penetration of

298 Furthermore, we reveal that the phospholipid phosphatidylserine, which becomes exposed on the damaged

299 These antibodies recognize phosphatidylserine, which is exposed on the surface of a

300 Mutated MFG-E8, which binds viral envelope phosphatidylserine without bridging virus to cells, but,