ライフサイエンスコーパス: phosphinic acid

1 f the GABA(B) agonist, 3-aminopropyl-(methyl)phosphinic acid.

2 dary phosphine, and finally oxidation to the phosphinic acid.

3 ficient method for the synthesis of glycosyl phosphinic acids (21) from the corresponding C-phosphona

4 competitive antagonist 3-aminopropyl(methyl)phosphinic acid (3-APMPA) induced fluorescence changes i

5 l)ethyl]amino-2-hydroxypropyl](phenylme thyl)phosphinic acid] (a GABA(B) antagonist)-sensitive respon

6 el and practical approach to monosubstituted phosphinic acid (alkylphosphonous acid) derivatives from

7 When evaluated in vivo, the methyl phosphinic acid analogue (4b) produced a bone anabolic r

8 hylene glutaric acid ester provided the aryl phosphinic acid analogue of p-aminobenzoyl glutamic acid

9 protecting groups, provided the target aryl phosphinic acid analogues of folic acid and related anti

10 r concentrations, both 3-aminopropyl(methyl)-phosphinic acid and GABA directly activated the A, G, S,

11 thesis of suitably protected p-aminophenyl H-phosphinic acids and esters from the corresponding para-

12 pon previous routes for the preparation of H-phosphinic acids and other organophosphorus compounds.

13 Monosubstituted phosphinic acids are usually obtained in better than 90%

14 agonists, such as baclofen or 3-aminopropyl phosphinic acid, are presented.

15 A novel series of phosphinic acid based inhibitors of the neuropeptidase N

16 III)) cations with bis(2,4,4-trimethylpentyl)phosphinic acid, bis(2,4,4-trimethylpentyl)monothiophosp

17 ophenyl)-methyl]amino]propyl](diethoxymethyl)phosphinic acid blocked ACh-induced reduction in the evo

18 ic approaches, not only to prepare allylic H-phosphinic acids but also their esters via one-pot tande

19 Previously inaccessible phosphinic acids can be prepared in a single step from c

20 ne, and tetrahydrothiophene derivatives with phosphinic acid catalysis.

21 ly affected by 3-amino-propyl(diethoxymethyl)phosphinic acid (CGP 35348; 1 mM).

22 yl)ethyl]amino- 2-(S)-hydroxypropyl-P-benzyl-phosphinic acid (CGP 55845A, 1 microM).

23 ich was used in two approaches to the target phosphinic acid containing pseudopeptide.

24 ious PIII species derived from p-aminophenyl phosphinic acid derivatives is significantly reduced com

25 H-phosphinic acids derived from N-Cbz vinyl glycine esters

26 competitive antagonist 3-aminopropyl(methyl)-phosphinic acid did not block the resting conductance, t

27 Racemization experiments show that phosphinic acid does not promote SN1 reactivity.

28 ogenation to yield an alpha,beta-unsaturated phosphinic acid ester, following which conjugate additio

29 on of these suitably protected p-aminophenyl phosphinic acid esters with a 6-(bromomethyl)pteridine o

30 nd the same suitably protected p-aminophenyl phosphinic acid esters, followed by removal of protectin

31 Phenyl phosphinic acid has been the catalyst of choice to study

32 ning carbon-phosphorus bonds (phosphonic and phosphinic acids) have found widespread use in medicine

33 ted vinyl glycine led to the corresponding H-phosphinic acid in excellent yield.

34 lysin was prepared for comparison to a known phosphinic acid inhibitor, providing the first compariso

35 (K(i) = 41 nM) was comparable to that of the phosphinic acid (K(i) = 10 nM) even though the silanedio

36 ic acid and its analog 3-aminopropyl-(methyl)phosphinic acid mainly depended on residues Tyr102, Val1

37 sed drug design, we have discovered that the phosphinic acid moiety (P(O)(OH)R) behaves as an isoster

38 Simultaneously, the oxo group of phosphinic acid operates as a base abstracting the nucle

39 ons corroborate a reaction pathway where the phosphinic acid operates as a bifunctional catalyst in t

40 on, generated in situ from either the free H-phosphinic acid or ester, to a 2-methylene glutaric acid

41 raalkyl orthosilicate, to provide the free H-phosphinic acid or the corresponding ester, respectively

42 Perfluoroalkyl phosphinic acids (PFPIAs) are perfluoroalkyl acids (PFAA

43 In this mechanism, the acidic proton of the phosphinic acid protonates the hydroxyl group, enhancing

44 cyclopent-1-ene, led to a rearranged allylic phosphinic acid rather than the desired homoallylic deri

45 r antagonist (3-aminopropyl)(diethoxymethyl) phosphinic acid shifted PPD to PPF, indicating that pres

46 The non-nucleophilic H-phosphinic acid was converted to a nucleophilic P(III) s