ライフサイエンスコーパス: phospho

1 serted in 1-myristoyl-2-hydroxy-sn-glycero-3-phospho-1'-rac-glycerol (LMPG, anionic) than in 1-lauroy

2 romosome 10 (PTEN) induces activation of the phospho-5' adenosine monophosphate-activated protein kin

3 Furthermore, unlike mPDE, phospho-ablated mPDE-T309A protein exhibited impaired ce

4 ization of a flexible helix that bridges the phospho-acceptor site to the rigid PNT domain.

5 able the optimal localization of its dynamic phospho-acceptor T38 at the kinase active site to enable

6 3 with the HER2/HER3 complex facilitates its phospho-activation and transcriptional upregulation, whi

7 Further study indicated that phospho-activation of BMK1 by MEK5D enhanced the resista

8 onstrated that SRC MEK5 cascade promotes the phospho-activation of BMK1 in response to CIBM.

9 f TRIB2 induces drug resistance by promoting phospho-AKT (at Ser473) via its COP1 domain.

10 ly killed 3 of 4 TCL lines with constitutive phospho-AKT (pAKT) vs 0 of 7 lines lacking pAKT (P = .02

11 eins X-linked inhibitor of apoptosis (XIAP), phospho-Akt (pAkt), and phospho-BAD.

12 PD results showed inhibition of phospho-AKT (S473) in CLL tumor cells following a single

13 BCL cells with tonic BCR signaling decreased phospho-AKT and phospho-FOXO1 levels and triggered FOXO1

14 t Notch2HCS mutant splenocytes had increased phospho-Akt and phospho-Jun N-terminal kinase, and gene

15 Moreover, phospho-Akt levels are increased in most clinical specim

16 bitor co-treatment in patients with elevated phospho-Akt levels to therapeutically combat the heterog

17 tissues of IGF2 levels with phospho-ERK and phospho-AKT levels.

18 EGFR and cMet and inhibited phospho-ERK and phospho-AKT more potently than the combination of single

19 or autocrine VEGF signaling had no effect on phospho-AKT or phospho-ERK1/2 levels, indicating that VE

20 e monophosphate-activated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways

21 ravenous dofetide infusion, and the level of phospho-Akt was determined.

22 upregulates PTEN, results in a reduction of phospho-AKT.

23 rvival and associations with PIK3CA mRNA and phospho-AKT1 by gene expression and protein data, respec

24 ess in response to DSS with higher levels of phospho-AMPK and lower levels of phosphorylation of mamm

25 These fractions, rich in phospho- and sphingolipids, were strongly antiproliferat

26 tes of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which

27 of apoptosis (XIAP), phospho-Akt (pAkt), and phospho-BAD.

28 Conversely, the PIH1D1 phospho-binding domain PIH-N is required for association

29 These phospho-blocking and -mimicking mutations impact both th

30 In contrast, phospho-blocking mutations at one cluster of sites incre

31 o-extracellular signal-regulated kinase 1/2, phospho-c-Jun N-terminal kinase, and phospho-cJun, as we

32 of temporal and spatial expression of c-Jun, phospho-c-Jun, and Etv5/ERM in wild type and ERK1/2 defi

33 r growth; and it decreased the expression of phospho-c-Met and HO-1 and reduced blood vessel density

34 onditioning, as well as spine morphology and phospho-CaMKIIbeta in the striatum.

35 his suggests that the localized targeting of phospho-Cas within adhesions by CRL5(SOCS6) and concurre

36 sion assembly occurs against opposition from phospho-Cas.

37 xpression of cyclins A, E, and D1, activated phospho-CDK2, and phospho-S477/T479 AKT.

38 se 1/2, phospho-c-Jun N-terminal kinase, and phospho-cJun, as well as decreased activator protein 1 (

39 inished protein levels of LIMK-1, cofilin-1, phospho-cofilin-1, and beta-actin in the whole brain lys

40 The developed strategy enriches phospho- content from biological samples like phosvitin

41 d that hyperglycemia promoted phospho-p65 or phospho-CREB and CBP bindings and RNA polymerase II recr

42 ngation complexes are isolated with specific phospho-CTD antibodies from chromatin solubilized by mic

43 k-in mice of both sexes bearing a GFP-tagged phospho-dead S193A allele on a null background (Atoh1(S1

44 Analyses with phospho-defective and phospho-mimetic mutants of FoxM1b

45 Surprisingly, the phospho-defective STIM1-Y361F mutant formed puncta but f

46 ss the biological significance, we generated phospho-deficient [Su(H)(S269A)] and phospho-mimetic [Su

47 Here we report that phospho-deficient dam1-3A mutants show stabilized kineto

48 found that thick filaments from the cMyBP-C phospho-deficient hearts had highly ordered cross-bridge

49 ll hairpin ribonucleic acid or expression of phospho-deficient LDHA Y10F sensitized the cancer cells

50 orylation at NEK3 Thr-165 by expression of a phospho-deficient mutant (NEK3-T165V) resulted in increa

51 deficiency as well as overexpression of the phospho-deficient Pg-mutant S665A abrogated both cAMP-me

52 ion, we generated Eprs knock-in mice bearing phospho-deficient Ser999-to-Ala (S999A) and phospho-mime

53 deubiquitylation of Csr2 correlates with its phospho-dependent association with 14-3-3 proteins and i

54 nmodified or phosphorylated, and visualize a phospho-dependent MCM element likely important for Cdc45

55 nificantly reduced postischemic induction of phospho-Drp1, 3-nitrotyrosine, cleaved caspase-3, and LC

56 F-2K S500D display relatively high levels of phospho-eEF-2 under basal conditions.

57 Moreover, endogenous phospho-Elmo and ITSN1 co-localize with GPR124 at lamell

58 Interaction screening revealed that phospho-EPRS binds SLC27A1 (that is, fatty acid transpor

59 lation in benign tissues of IGF2 levels with phospho-ERK and phospho-AKT levels.

60 osphorylation of EGFR and cMet and inhibited phospho-ERK and phospho-AKT more potently than the combi

61 High levels of phospho-ERK were detected in vitro in cells overexpressi

62 ing as measured by decreased phospho-VEGFR2, phospho-ERK1/2 and phospho-p38-MAPK levels.

63 ic layer of the growth plate, with decreased phospho-Erk1/2 immunoreactivity and impaired hypertrophi

64 This was associated with decreased phospho-ERK1/2 immunoreactivity in the hypertrophic chon

65 GF signaling had no effect on phospho-AKT or phospho-ERK1/2 levels, indicating that VEGF mediates cel

66 tribute to propionate-mediated regulation of phospho-ERK1/2 MAP kinase signaling in FFA2-expressing 2

67 NIN, SMAD2/3, phospho-STAT3, P65, FOXO1, and phospho-ERK1/2) of key pathways commonly affected in NSC

68 Additionally, phospho-ETS1 expression was increased in cholangiocytes

69 nflammatory effects, increased inhibition of phospho-extracellular signal-regulated kinase 1/2, incre

70 OE knockdown resulted in decreased levels of phospho-extracellular signal-regulated kinase 1/2, phosp

71 2 domain-containing phosphatase [p-SHP2] and phospho-extracellular signal-regulated kinase [p-ERK]) i

72 K, abnormally high levels of phospho-Src and phospho-FAK accumulate at focal adhesions, positively re

73 ls with HSP70 inhibitors decreased levels of phospho-FAK along with impaired migration, invasion, and

74 of signaling molecules was analyzed by using phospho flow cytometry, immunoblotting, or co-immunoprec

75 ed biobanking, xenografting, and multiplexed phospho-flow (PF) cytometric profiling to study drug res

76 se and Syk activities were assessed by using phospho-flow analysis.

77 We utilized intracellular phospho-flow cytometry to investigate the relationship b

78 MUCL1 silencing abrogated phospho-focal adhesion kinase (FAK), Jun NH2-terminal ki

79 onic BCR signaling decreased phospho-AKT and phospho-FOXO1 levels and triggered FOXO1-driven gene exp

80 emperature-dependent behavior within anionic phospho-Fries rearrangements (apFr) of P(O)(OFc)n(EAr)3-

81 Consistently, phospho-GRIP1 and CDK9 are not detected at GR transrepre

82 ivalis lipopolysaccharide (LPS) and cytosine-phospho-guanine (CpG) oligodeoxynucleotides for 48 h.

83 staining for covalent topo I-DNA complexes, phospho-H2AX and Rad51 suggests that topotecan-induced D

84 sporin A resulted in nuclear accumulation of phospho-HDAC1 and was neuroprotective.

85 The SC-QDP: 1) identified pAKT and pERK phospho-heterogeneity and insensitivity in individual le

86 ansferase dUTP nick end labeling (TUNEL) and phospho-histone H3 (PH3) staining to assess apoptosis an

87 The ACCT group had more phospho-histone H3+ (a marker of mitosis) cardiomyocytes

88 nd lacked the proliferation markers Ki67 and phospho-histone H3.

89 A phospho-HSJ1 specific antibody confirmed phosphorylation

90 ced GLUT4 membrane translocation and reduced phospho-IRS-1(S302) through AMPKalpha-S6 Kinase.

91 lexes, producing distinct GRE-specific GRIP1 phospho-isoforms.

92 P activation involves its recruitment to the phospho-ITIM motif of the inhibitory receptor FcgammaRII

93 nt splenocytes had increased phospho-Akt and phospho-Jun N-terminal kinase, and gene expression analy

94 d higher CHK2 phosphorylation but much lower phospho-KAP1 relative to DSB inducers.

95 of PRMT5 on cellular signalling by the Human Phospho-Kinase Array and chromatin immunoprecipitation-P

96 Using a phospho-kinase screening array, we discovered that WA in

97 Assessment of the phospho-kinome showed decreased phosphorylation of pathw

98 In the presence of 2-phospho-L-ascorbic acid, miRNAs were quantitatively dete

99 er, full-length GST-mu1A did not bind to the phospho-L-selectin tail or phospho-mimetic S364D L-selec

100 (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) 3:1 mol/mole and at neutral pH,

101 results show that 1,2-dioleoyl-sn-glycero-3-[phospho-L-serine] (DOPS) small unilamellar vesicles (SUV

102 pressed recombinant AtABHD11 hydrolyzed lyso(phospho)lipid and monoacylglycerol.

103 M-HPLC considerably advances assessments of (phospho)lipophilicity for drug discovery and for environ

104 t bind Sld3 or Sld3 mutants that cannot bind phospho-MCM or Cdc45 do not support replication.

105 vanadate were needed to cause an increase in phospho-Met in GNPTAB(-/-) cells.

106 de treatment of parental HeLa cells elevated phospho-Met levels whereas antioxidant treatment of GNPT

107 idant treatment of GNPTAB(-/-) cells reduced phospho-Met levels.

108 phospho-deficient Ser999-to-Ala (S999A) and phospho-mimetic (S999D) mutations.

109 nerated phospho-deficient [Su(H)(S269A)] and phospho-mimetic [Su(H)(S269D)] variants: the latter disp

110 2 transgenic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS20

111 rays, whereas the filaments from the cMyBP-C phospho-mimetic hearts showed a strong tendency toward d

112 Analyses with phospho-defective and phospho-mimetic mutants of FoxM1b identified a critical

113 M that are targets of DNA-PKcs and show that phospho-mimetic mutations at these residues significantl

114 Using small molecule inhibitors, phospho-mimetic proteins, tamoxifen-sensitive and tamoxi

115 Furthermore a mutant DD with the phospho-mimetic residue Asp at this position is impaired

116 Consistently, a phospho-mimetic S321D RIPK1 mutation limits TNF-induced

117 d not bind to the phospho-L-selectin tail or phospho-mimetic S364D L-selectin tail.

118 The phospho-mimetic S437D mutation stabilizes Acn and promot

119 ably, re-expression of either wild type or a phospho-mimetic stathmin mutant (4E) made defective in t

120 Similarly, phospho-mimetic substitutions in the DHBV CTD did not bl

121 phospho-null S637A-Drp1 but not its inactive phospho-mimic mutant (S637D-Drp1), restored mitochondria

122 tion with the microsomal fraction, whereas a phospho-mimic mutant, TH1-S31E, was distributed througho

123 Moreover, the SLCO2A1 phospho-mimic p.A396E showed loss of transporter functio

124 Phospho-mimic Rad54 (Rad54-S572E), in contrast, promotes

125 Although expression of phospho-mimic Rad54 is beneficial for HR, it causes Rad5

126 Lin28a to TRBP in vitro is also enhanced by phospho-mimic TRBP.

127 Furthermore, cells expressing a phospho-mimicking Atf1 mutant display enhanced stress re

128 also observed that, in cells expressing the phospho-mimicking Atf1 mutant, the presence of Sty1 was

129 A phospho-mimicking Cdc20 mutant restores nocodazole-induc

130 We constructed five phospho-mimicking mutants (S256E, S261E, S264E, T269E, a

131 oscopy indicated that wild-type AQP2 and the phospho-mimicking mutants had similar overall structure

132 ersed by administering a small FOXO1-derived phospho-mimicking peptide inhibitor in vitro and in mice

133 Increased phospho-MLKL staining in liver biopsies from patients wi

134 The enriched phospho- moieties are analyzed by matrix-assisted laser

135 ed by its interaction domains and compatible phospho-motifs and provide insight into how MAPK-substra

136 horylation of mammalian target of rapamycin (phospho-mTOR).

137 ct analogues are nanomolar inhibitors of Mtb phospho-MurNAc-pentapeptide translocase, the enzyme resp

138 Using lithium and an AID-S38 phospho mutant, we compared the role of pS38 in AID acti

139 Phospho-mutant analysis shows that Aurora contributes to

140 ke behavior, an effect not observed in S831A phospho-mutant mice.

141 In addition, several phospho-mutations dramatically reduced the biosynthetic

142 data suggest that apical Rok first increases phospho-Myosin, followed by Pkn-mediated Myosin downregu

143 eviously unappreciated and exemplifies how a phospho-network is precisely controlled in different cel

144 stration rapidly normalized the abundance of phospho-NKCC2 in SORLA-deficient mice, and a functional

145 istration in mice augmented the abundance of phospho-NKCC2, and treatment of isolated TAL with cyclos

146 he cellular distribution of an overexpressed phospho-null mutant, TH1-S31A, was restricted to the som

147 mitophagy, and reconstitution of WT-Drp1 or phospho-null S637A-Drp1 but not its inactive phospho-mim

148 signaling in vivo, increasing the levels of phospho (P)-SMAD1 and decreasing P-SMAD3.

149 In the current study, we found that phospho-p21-activated kinase-1 (Pak1) and Pak1 expressio

150 this was associated with elevated levels of phospho-p38 consistent with decreased pro-survival AKT s

151 essed higher levels of the IL-1 receptor and phospho-p38 mitogen-activated protein kinase.

152 decreased phospho-VEGFR2, phospho-ERK1/2 and phospho-p38-MAPK levels.

153 pectively, were used to specifically capture phospho-p53(15) and phospho-p53(392) antigens, followed

154 chemical responses and the concentrations of phospho-p53(15) and phospho-p53(392) were obtained in th

155 magnetic Fe3O4 nanoparticles functionalized phospho-p53(15) capture antibody (MP-p53(15)c-Ab) and ph

156 to specifically capture phospho-p53(15) and phospho-p53(392) antigens, followed by immunorecognition

157 53(15) capture antibody (MP-p53(15)c-Ab) and phospho-p53(392) capture antibody (MP-p53(392)c-Ab), res

158 nd the concentrations of phospho-p53(15) and phospho-p53(392) were obtained in the range of 0.1-20 ng

159 assays confirmed that hyperglycemia promoted phospho-p65 or phospho-CREB and CBP bindings and RNA pol

160 Increased glomerular endothelial phospho-p65 staining in patients with AAV indicated that

161 related with crescent formation, and nuclear phospho-p65 staining showed NF-kappaB activation within

162 Further, we observed that phospho-Pak1 and Pak1 levels are high in UV-B-exposed ha

163 sphorylated peptides versus serine/threonine phospho-peptides and readily dephosphorylates a classic

164 ECD depletion increased the levels of both phospho-PERK (p-PERK) and p-eIF2alpha, and these effects

165 Analysis of phospho-PKA levels showed lower cytoplasmic levels in ST

166 s in terms of functional signatures such as (phospho)protein and transcription factor (TF) activities

167 d TGFbeta and resulted in a dysregulation of phospho-protein expression in HaCaT cells.

168 Bcl3 exists as phospho-protein in many cancer cells.

169 ARPP-16 (cAMP-regulated phospho-protein of molecular weight 16 kDa) is one of se

170 phosphatase domain related to the eukaryotic phospho-protein phosphatase (PPP) family.

171 otif is substantially enriched in the human (phospho)proteome, allowing us to predict hundreds of put

172 Here, we combine phospho-proteome profiling and proximity-dependent bioti

173 es present in humans, plants have a tyrosine phospho-proteome that rivals human cells.

174 A comprehensive (phospho)proteomic analysis revealed that Meis1 increased

175 utational strategy for integrating parallel (phospho)proteomic and mRNA sequencing data across 12 TCG

176 enome-wide miRNA screen with patient-derived phospho-proteomic signatures of the KRas downstream path

177 The NMR structure of the SUMO-2.phospho-RAP80 complex reveals that the molecular basis f

178 n and reduced response of the CDK4/6 target, phospho-Rb (pRb), to CDK4/6 inhibitors.

179 Importantly, the more complete phospho-Rb inhibition and cyclin D1 suppression by LY300

180 suppressors capable of reversing the p27/myc/phospho-Rb protein signature.

181 1a (-/-) Ezh2 (-/-) mice have high levels of phospho-Rb, indicating that loss of Cdkn1a enables progr

182 nteracts with the polymerase subunit PB2 and phospho-regulates NP oligomerization and RNP assembly du

183 Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the ba

184 nd properties of MIND show how it integrates phospho-regulatory inputs for kinetochore assembly and d

185 These phospho-regulon tools thus open up the possibility to en

186 These two phospho-residues, together with E341, form an extensive

187 Phospho-RhoA was localised in actin nodules with PKA typ

188 s of rhodopsin spectra show that regenerated phospho-rhodopsin has the same molecular photosensitivit

189 IL-7 treatment increased levels of phospho-ribosomal protein S6 in HIV-specific CD8 T cells

190 ndividuals, and decreased phosphorylation of phospho-ribosomal protein S6 was also observed, a findin

191 d rabies virus, catalyzes the transfer of 5'-phospho-RNA (pRNA) from 5'-triphospho-RNA (pppRNA) to GD

192 breaks were measured using anti-gamma-H2A.X (phospho S139) immunohistochemistry.

193 dentified Eps15 as an interacting partner of phospho-S227-Rab11-FIP2 (pS227-FIP2).

194 Total aquaporin 2 (AQP2) and phospho-S256-AQP2 (pAQP2) protein expression in the inne

195 ns A, E, and D1, activated phospho-CDK2, and phospho-S477/T479 AKT.

196 in-dependent kinase 9 (CDK9) recruitment and phospho-Ser 2 carboxy-terminal domain (CTD) RNA polymera

197 find that BRD4 independently regulates CDK9/phospho-Ser 2 CTD RNA Pol II recruitment to the IRF3-dep

198 BRD4 is required for stable CDK9 binding, phospho-Ser 2 RNA Pol II formation, and histone acetyltr

199 factors Fos/phospho-Ser(32) Fos, FosB, Fra1/phospho-Ser(265) Fra1, which was inhibited through suppr

200 ation of oncogenic transcription factors Fos/phospho-Ser(32) Fos, FosB, Fra1/phospho-Ser(265) Fra1, w

201 Moreover, Tsc1 deletion failed to stimulate phospho-Ser-302 or other putative S6K sites within IRS1,

202 s to insert stoichiometric and site-specific phospho-Ser/Thr(s) in the C-terminal tail of PTEN.

203 In vitro, Arc overexpression downregulates phospho-Ser10-histone H3 without modifying extracellular

204 of transcription, where it colocalizes with phospho-Ser10-histone H3, an important component of nucl

205 ctivation mechanism in parallel with the PKA-phospho-Ser133 CREB axis.

206 cancer cells, with a significant increase in phospho(Ser139) histone H2AX (gamma-H2AX) levels and foc

207 y automated, time-resolved quantification of phospho-SER139-H2AX (gammaH2AX) and 53BP1 foci, two fact

208 We focus on Rtt103, a protein that binds phospho-Ser2 and phospho-Thr4 marks and facilitates tran

209 specific "readers." Whereas phospho-Ser5 and phospho-Ser2 marks are ubiquitous, phospho-Thr4 is repor

210 or SRSF3, and increased binding of total and phospho-Ser2 RNA polymerase II specifically at the intro

211 s of Rtt103 in complex with phospho-Thr4- or phospho-Ser2-bearing CTD peptides.

212 n a manner analogous to its interaction with phospho-Ser2-modified CTD.

213 These results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CRE

214 Phospho-Ser271 CREB showed facilitated interaction with

215 Using phospho-Ser321 as a marker, we show that the transient p

216 Together, these studies suggest that phospho-Ser46-ARPP-16 acts to basally control PP2A in st

217 f the CTD engage specific "readers." Whereas phospho-Ser5 and phospho-Ser2 marks are ubiquitous, phos

218 Consistently, Oct-4 upon induction by phospho-Ser64-Skp2-mediated proteasomal degradation of N

219 me maintenance protein 7 (MCM7) knockdown in phospho Ser807/811-retinoblastoma protein (p-Rb) defect

220 motif slightly enhances specific binding of phospho-SF1 to its cognate U2AF(65) protein partner.

221 with mPDE/S20A/T240A/4A displayed decreased phospho-signal intensities in immunoblotting with anti-p

222 sed mRNA levels of Ifng and higher levels of phospho-signal transducer and activator of transcription

223 ties, to compete for control of their native phospho-signaling, thus hampering the cytoskeletal proce

224 n in mice with chronic disruption of nephrin phospho-signaling.

225 It was demonstrated that HisKA-Rec and the phospho-signalling between SagS and BfiS contribute to t

226 um Caulobacter crescentus uses two-component phospho-signalling to regulate spatially distinct cell c

227 generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyo

228 Among the phospho-site hits were known LRRK2 sites as well as two

229 ere found to genetically interact with rad55 phospho-site mutants.

230 A tandem approach of phospho-site mutation and treatment with CK2 specific in

231 able of dephosphorylating Tau at AD specific phospho-sites is protein phosphatase 2 A (PP2A).

232 e hits were known LRRK2 sites as well as two phospho-sites on human Rab10 and Rab12.

233 116 phospho-sites were identified as up-regulated and 45 dow

234 of human hepatocyte origin and activation of phospho-SMAD1/5 and ID1 downstream signaling molecules.

235 The status of phospho-SMAD1/5 and the expression of inhibitor of DNA b

236 miR-542-5p increased nuclear phospho-SMAD2/3 and suppressed expression of SMAD7, SMUR

237 ase in TGF-beta1 activation and induction of phospho-Smad2/3 in contrast with human nonfibrotic lungs

238 or all attenuated mechanical stretch-induced phospho-Smad2/3 in fibrotic lung strips.

239 In contrast, measurable active TGF-beta1 and phospho-Smad2/3 were not induced by mechanical stress in

240 nt stores with subsequent increase in tissue phospho-Smad2/3.

241 bese mice activates SMAD3 signaling, causing phospho-SMAD3 to bind to the miR-140 locus and inhibit m

242 Phospho-specific antibodies to four of these sites estab

243 AKT-mTOR pathway function was assessed using phospho-specific antibodies with patient lymphoblasts an

244 Using phospho-specific antibodies, we show that olaratumab att

245 e of residues, as detected by a set of novel phospho-specific antibodies.

246 ids the conventional paradigm of requiring a phospho-specific antibody for detection and could be a p

247 Using a new phospho-specific antibody, we show that YY1 phosphorylat

248 Here, we develop a phospho-specific antibody-based biosensor to detect acti

249 f this phosphorylation in vivo, we generated phospho-specific antiserum to Orco(S289) and show that p

250 Cellular imaging using a phospho-specific p-T153/Y155 antibody showed that phosph

251 supported by next-generation sequencing and phospho-specific-antibody array analysis.

252 annot bind to FAK, abnormally high levels of phospho-Src and phospho-FAK accumulate at focal adhesion

253 Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic st

254 gene A (CagA) and CagA-signaling molecules (phospho-Src homology-2 domain-containing phosphatase [p-

255 Moreover, binding of phospho-SRC1 to RORgammat displaced bound Foxp3, leading

256 Furthermore, phospho-SRC1-mediated recruitment of CARM1 induced promi

257 he expression levels of iNOS, CX3CR1, CD206, phospho-STAT1 and phospho-STAT3 proteins in the skin of

258 zation increased the expressions of iNOS and phospho-STAT1 in the IMQ-treated skin, but it decreased

259 d a trend toward increased phospho-Stat5 and phospho-Stat1 was noted.

260 enic Sp-regulated genes, including STAT3 and phospho-STAT3 (pSTAT3), and GSH attenuated these respons

261 Single ATP injection increased expression of phospho-STAT3 and GAP43, two markers of regenerative act

262 e ATP injections sustained the activation of phospho-STAT3 and GAP43, which may account for the marke

263 ative activity in sensory neurons, including phospho-STAT3 and GAP43.

264 IL-9 production correlates with increases in phospho-STAT3 levels within the cell, as well as the pro

265 ls of iNOS, CX3CR1, CD206, phospho-STAT1 and phospho-STAT3 proteins in the skin of B6 mice, and the e

266 ut it decreased the expressions of CD206 and phospho-STAT3 proteins in the skin of Flg (ft) mice, sug

267 ast tumors lead to a significant increase of phospho-STAT3(+) cancer cells and a decrease in the spat

268 ect classic readouts (beta-CATENIN, SMAD2/3, phospho-STAT3, P65, FOXO1, and phospho-ERK1/2) of key pa

269 ofiling identified FED-mediated reduction in phospho-STAT5 (pSTAT5) levels as a predictive biomarker

270 were increased, and a trend toward increased phospho-Stat5 and phospho-Stat1 was noted.

271 at the leading edge of cells, and that both phospho-STIM1 and ORAI1 co-localize with cortactin (CTTN

272 omotion of membrane ruffling by showing that phospho-STIM1 localizes at the leading edge of cells, an

273 te for energy production and biosynthesis of phospho-sugars, nucleobases, peptidoglycan and some amin

274 osphorylation of STIM1 at Y361 is a critical phospho-switch enabling recruitment of Orai1 into STIM1

275 nd PP2A-mediated dephosphorylation provide a phospho-switch that regulates the cellular activity of A

276 hospho-Thr75-DARPP-32, phospho-T308-Akt, and phospho-T202/Y204-ERK.

277 substrates including phospho-Thr75-DARPP-32, phospho-T308-Akt, and phospho-T202/Y204-ERK.

278 so accumulated in association with decreased phospho-T58 (pT58) levels.

279 1 has a striking conformation preference for phospho-T58 of Myc.

280 Following blast TBI, phospho-Tau (pTau) levels were unchanged in ApoE3 mice,

281 e adeno-associated virus (AAV)-vectored anti-phospho-tau antibody PHF1 to P301S tau transgenic mice r

282 esence of hyperphosphorylated tau [both AT8 (phospho-tau Ser202 and Thr205) and CP13 (pSer202) immuno

283 bnormal proteins, including beta-amyloid and phospho-Tau.

284 ydrogen bonds involving either the oxygen on phospho-Thr4 and the hydroxyl on Ser2, or the phosphate

285 tural data reveal that Rtt103 interacts with phospho-Thr4 in a manner analogous to its interaction wi

286 Here, we identify a role for phospho-Thr4 in transcription termination at noncoding s

287 -Ser5 and phospho-Ser2 marks are ubiquitous, phospho-Thr4 is reported to only impact specific genes.

288 tt103, a protein that binds phospho-Ser2 and phospho-Thr4 marks and facilitates transcription termina

289 ed on NMR analysis of Rtt103 in complex with phospho-Thr4- or phospho-Ser2-bearing CTD peptides.

290 ion of a subset of PP2A substrates including phospho-Thr75-DARPP-32, phospho-T308-Akt, and phospho-T2

291 Further, phospho-TRBP recapitulates BDNF-induced neuronal dendrit

292 petition or "theft" mechanism that enables a phospho-triggered swap of protein partners by Raf Kinase

293 Synergy requires receptor phospho-Tyr and two anionic lipids (phosphatidylserine a

294 LPS stimulation raised the binding of phospho-UBC9 but not the unphosphorylated counterpart, t

295 Hence, phospho-UBC9 may promote NF-kappaB signaling by regulati

296 homolog 4, alpha-smooth muscle actin, CD31, phospho-vascular endothelial growth factor receptor 2, a

297 F-induced signaling as measured by decreased phospho-VEGFR2, phospho-ERK1/2 and phospho-p38-MAPK leve

298 markers, alphaSM actin, SM22alpha, calponin, phospho-vimentin, and Slug.

299 One of these phosphorylations (phospho-Y341) is required for C-Raf dimerization, and th

300 We found that Shh stimulation increases phospho-ZBP1 levels in the growth cone.