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1 hene with concomitant release of the desired phosphodiester.
2 irectly by the 5'-OH RNA end to form a 3',5'-phosphodiester.
3 1 incision at the relevant ribonucleotide 3'-phosphodiester.
4 o form a splice junction with a 2'-OH, 3',5'-phosphodiester.
5 uration and instead display the Man-P-GlcNAc phosphodiester.
6 covert the nicked DNA-adenylate to a sealed phosphodiester.
7 ly, coordinating to the Zn complexes) of the phosphodiester.
8 t synthetic route to beta-D-arabinofuranosyl phosphodiesters.
9 lly redundant hydrogen bonds to the terminal phosphodiester; a S37A-T80A double mutation reduced kina
10 e first direct evidence for the formation of phosphodiester adducts by B[a]PDE following reaction wit
11 smembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase ("uncoverin
12 e (GlcNAc-1-phosphotransferase) and GlcNAc-1-phosphodiester alpha-N-acetylglucosaminidase ("uncoverin
19 they both recognize AP sites and incise the phosphodiester backbone 5' to the lesion, yet they lack
21 ation reduces the amplitude of motion in the phosphodiester backbone and furanose ring of the same DN
22 asymmetric contacts between the A-duplex RNA phosphodiester backbone and the EF-loop in one coat prot
23 tion that engages a continuous region of the phosphodiester backbone and the hydrophobic faces of exp
24 and to reveal unexpected control of the DNA phosphodiester backbone by electrostatic interactions.
27 ntact the AMP adenine (Lys(290)), engage the phosphodiester backbone flanking the nick (Arg(218), Arg
28 groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); pe
29 DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the dama
30 f APE1, which is responsible for nicking the phosphodiester backbone in DNA on the 5' side of an apur
33 d through noncanonical pairings and that the phosphodiester backbone is not contacted by the RNA.
34 between cisplatin and the negatively charged phosphodiester backbone may play an important role in fa
36 ed dipole-enhanced hydrogen bond between the phosphodiester backbone of bound DNA and the N terminus
37 zyme accelerates cleavage or ligation of the phosphodiester backbone of RNA has been incompletely und
38 urface provides an extended scaffold for the phosphodiester backbone of the conserved catalytic core
40 ation reduces the amplitude of motion in the phosphodiester backbone of the same DNA, and our observa
44 interactions; and (b) the arrangement of the phosphodiester backbone to focus negative electrostatic
45 c-di-GMP structure and replacing the charged phosphodiester backbone with an isosteric nonhydrolyzabl
46 ive contacts between the protein and the DNA phosphodiester backbone, as well as a number of direct h
47 ntly alters the intrinsic flexibility of the phosphodiester backbone, favoring the A-form in duplex R
54 ted in the duplex by a slight opening in the phosphodiester backbone; all sugars retain a C2'-endo pu
55 used defined dsDNA fragments with a natural (phosphodiester) backbone and show that unmethylated CpG
56 toplasmic thioesterases into native, charged phosphodiester-backbone siRNAs, which induce robust RNAi
57 onomer in solution and that DNA ligands with phosphodiester backbones induce TLR9 dimerization in a s
62 ues in ONC that are proximal to the scissile phosphodiester bond (His10, Lys31, and His97) and uracil
64 pathway by catalyzing the hydrolysis of the phosphodiester bond 5 ' to a baseless sugar (apurinic or
65 function in nature is to cleave an internal phosphodiester bond and linearize concatemers during rol
66 -DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3' end linked to a tyrosyl
67 -DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3'-end linked to a tyrosyl
68 By enzymatically hydrolyzing the terminal phosphodiester bond at the 3'-ends of DNA breaks, tyrosy
70 plice-site selection and consists of a 2'-5' phosphodiester bond between a bulged adenosine and the 5
72 and DNA ligases catalyze the formation of a phosphodiester bond between the 5'-phosphate and 3'-hydr
73 alyzes regiospecific formation of a 5' to 3' phosphodiester bond between the 5'-triphosphate and the
74 This DNA break is linked to the protein by a phosphodiester bond between the active site tyrosine of
75 transient enzyme/DNA adduct is mediated by a phosphodiester bond between the active-site tyrosine and
76 ir enzyme for trapped Top1cc, hydrolyzes the phosphodiester bond between the DNA 3'-end and the Top1
77 ost possibly via a reaction that cleaves the phosphodiester bond between the tyrosine of the polymera
78 ly loads an NTP substrate at i+1 and forms a phosphodiester bond but cannot rapidly complete bond syn
79 ifications of U51 decrease RNase P-catalyzed phosphodiester bond cleavage 16- to 23-fold, as measured
81 eobase, ribose and backbone modifications on phosphodiester bond cleavage in collisionally activated
82 ins, has the potential to participate in the phosphodiester bond cleavage reaction by stabilizing the
84 The hairpin ribozyme catalyzes reversible phosphodiester bond cleavage through a mechanism that do
88 ational change, followed by relatively rapid phosphodiester bond formation (11 s(-1)) and then fast r
89 he transition state and reaction barrier for phosphodiester bond formation after the prechemistry sta
90 indicating that the more sensitive steps are phosphodiester bond formation and partitioning into inac
91 third Mg(2+) appeared during the process of phosphodiester bond formation and was located between th
92 l ligase couples the hydrolysis of NAD(+) to phosphodiester bond formation between an adjacent 3'OH a
94 hich is greater than the predicted values of phosphodiester bond formation both in solution and withi
95 hanistic coupling of the efficiency of early phosphodiester bond formation during productive TSS util
96 ng the nucleotide and metal bindings and the phosphodiester bond formation in a time perspective.
97 es during a "nonchemical" step that precedes phosphodiester bond formation in the enzymatic cycle of
98 s (DNAPs) require divalent metal cations for phosphodiester bond formation in the polymerase site and
99 ith rate constants of 75 and 20 s(-1); rapid phosphodiester bond formation occurs with a Keq of 2.2 a
101 kinetically, but several key steps following phosphodiester bond formation remain structurally unchar
102 ulse-chase experiments indicate that a rapid phosphodiester bond formation step is flanked by slow co
105 crease in the Trp fluorescence occurred when phosphodiester bond formation was permitted, and these r
110 repetition of the nucleotide addition cycle: phosphodiester bond formation, translocation and binding
111 in the entire primase active site needed for phosphodiester bond formation, while UL5 minimally contr
120 entify many deoxyribozymes that catalyze DNA phosphodiester bond hydrolysis and create 5'-phosphate a
121 l Type II restriction endonucleases catalyze phosphodiester bond hydrolysis within or close to their
123 vations, the enzyme's closed complex forms a phosphodiester bond in a highly efficient process >99.8%
125 The energy of ATP is used to form a new phosphodiester bond in DNA via a reaction mechanism that
127 pase D (PLD) catalyzes the hydrolysis of the phosphodiester bond in phospholipids and plays a critica
129 sidues affect the positioning of the cleaved phosphodiester bond in the active site without disruptio
130 RNA-dependent RNA polymerases occurs when a phosphodiester bond is formed between the first two nucl
134 XPF-ERCC1 has a preference for cleaving the phosphodiester bond positioned on the 3'-side of a T or
136 hich transcribing complexes, upon completing phosphodiester bond synthesis at register +5, enter one
139 tides, are the result of cleavage of the C-O phosphodiester bond through transfer of LEEs to the phos
142 10MD5 is also site-specific because only one phosphodiester bond within the DNA substrate is cleaved,
143 s the regioselective formation of a 5'-to-3' phosphodiester bond, a reaction for which there is no kn
144 Mg(2+) ions can drive the hydrolysis of each phosphodiester bond, and how conformational changes in b
145 addition of a single nucleotide via a normal phosphodiester bond, and since there is no identifiable
146 duplex DNA segment, nicking one strand at a phosphodiester bond, covalently attaching to the 3' end
154 des are removed by incising approximately 20 phosphodiester bonds 5' and 5 phosphodiester bonds 3' to
155 TFIIF stimulates formation of the first two phosphodiester bonds and dramatically stabilizes a short
156 p and multiple phosphate oxygen atoms in the phosphodiester bonds are exposed to replace the oleic ac
160 s RNA ligase (MthRnl) catalyzes formation of phosphodiester bonds between the 5'-phosphate and 3'-hyd
161 sterase 1 (Tdp1) catalyzes the hydrolysis of phosphodiester bonds between the DNA 3'-phosphate and ty
162 rotein folds that catalyze the hydrolysis of phosphodiester bonds have arisen independently in nature
163 In addition, the mixture of 2-5 and 3-5 phosphodiester bonds have emerged as a plausible structu
164 nd RNA polymerases catalyze the formation of phosphodiester bonds in a 5' to 3' direction, suggesting
167 s indicate that some endonucleases hydrolyze phosphodiester bonds in both strands simultaneously wher
169 al genetic polymer composed of vicinal 2',3'-phosphodiester bonds linking adjacent threofuranosyl nuc
170 uences, like Type I sites, but cut specified phosphodiester bonds near their sites, like Type IIS enz
171 These enzymes catalyze the hydrolysis of phosphodiester bonds via a mechanism involving two Mn(2+
172 two DNA segments together, by cleaving eight phosphodiester bonds within a single-DNA binding event.
173 and (32)P labeling demonstrated the lack of phosphodiester bonds, which typically occur in PG-polysa
178 dp1, provided it is attached to the DNA by a phosphodiester (but not a phosphorothioate) linkage.
180 nge of 17-35 muM, implying that the cycloSal phosphodiester-carrying amino acid could mimic the phosp
181 RNA motifs that catalyze the same reversible phosphodiester cleavage reaction, but each motif adopts
185 ails of the calcium inhibition mechanism for phosphodiester cleavage, an essential reaction in the me
188 vides new avenues to investigate the role of phosphodiester-containing lysosomal enzymes in the bioge
189 ing this region of the receptor in targeting phosphodiester-containing lysosomal enzymes to the lysos
191 e CD-MPR bound weakly or undetectably to the phosphodiester derivatives, but strongly to the phosphom
192 ion of an enzyme that can hydrolyze a cyclic phosphodiester directly to a vicinal diol and inorganic
193 y of strand joining whereby the 2',3'-cyclic phosphodiester end is hydrolyzed to a 3'-monophosphate,
194 intermediate (step 2) but is dispensable for phosphodiester formation at a preadenylylated nick (step
196 At pH 7.0, the overall charge (including the phosphodiester group charge) is found to be -3.96 +/- 0.
198 cine (EAL) domains, which hydrolyze a single phosphodiester group in c-di-GMP to produce 5'-phosphogu
199 ractions with the +1 and -1, but not the +2, phosphodiester group of the single-stranded DNA substrat
200 es with a positively charged lipid lacking a phosphodiester group reveal that this lipid modification
202 ns in EPLs and that the distance between the phosphodiester groups in the two leaflets of the DMPC an
205 methyltransferase 3a and methyl-5'-cytosine-phosphodiester-guanine-domain binding proteins, reduced
206 ycerol positions, and (3) elaboration of the phosphodiester headgroup using a 2-chloro-1,3,2-dioxapho
207 e configuration that suggests a mechanism of phosphodiester hydrolysis by a metal-activated water mol
208 the selection strategy deliberately avoided phosphodiester hydrolysis led to DNA-catalyzed ester and
214 Increasing the number of negatively charged phosphodiesters in the oligonucleotide increased the amo
215 entification and quantification of metal ion-phosphodiester interactions are essential for understand
219 to ribonucleoside monophosphate and cyclic X-phosphodiester, is identical to a DAK-encoded dihydroxya
220 ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have
221 linked to Thr and Ser residues in gp72 via a phosphodiester linkage (GlcNAcpalpha1-P-Thr/Ser) and tha
222 ps in c-di-GMP with a bridging sulfur in the phosphodiester linkage affords an analogue called endo-S
223 How pol II recognizes DNA template backbone (phosphodiester linkage and sugar) and whether it tolerat
224 osition of the pyrophosphate and the unusual phosphodiester linkage between the two terminal RNA resi
225 e suggest that the asymmetric recognition of phosphodiester linkage by modern nucleic acid enzymes li
226 lves to mature-sized tRNAs where the joining phosphodiester linkage contains the phosphate originally
227 clic dinucleotide (cGAMP) containing a 2'-5' phosphodiester linkage essential for optimal immune stim
229 compatibility of a triazole mimic of the DNA phosphodiester linkage in Escherichia coli has been eval
230 ecific nucleophilic substitution at a single phosphodiester linkage in the pentapyrimidine recognitio
231 l-transferase superfamily and hydrolyzes the phosphodiester linkage on the RNA strand of a DNA/RNA hy
234 lf becomes the junction phosphate of the new phosphodiester linkage, and (ii) a 3'-P ligation process
235 we propose a novel structure-a ribitol in a phosphodiester linkage-for the moiety on which TMEM5, B4
238 AMP containing a unique combination of mixed phosphodiester linkages (2'3'-cGAMP) is an endogenous se
239 osamine-1-phosphate units linked together by phosphodiester linkages [ --> 6)-alpha-D-ManNAc-(1 --> O
241 n generating site-specific oxygen-18-labeled phosphodiester linkages in oligonucleotides, such that c
243 his work, we systematically investigated how phosphodiester linkages of nucleic acids govern pol II t
244 was treated with cisplatin, but not when the phosphodiester linkages of T(pT)(8) were replaced with m
245 gments containing (2'-->5')-internucleotidic phosphodiester linkages or noteworthy nucleobase modific
246 nsferase (NT) superfamily and hydrolyzes the phosphodiester linkages that form the backbone of the RN
247 catalysts (deoxyribozymes) can hydrolyze DNA phosphodiester linkages, but DNA-catalyzed amide bond hy
248 messenger contains G(2',5')pA and A(3',5')pG phosphodiester linkages, designated c[G(2',5')pA(3',5')p
249 AMP in mammalian cells contains two distinct phosphodiester linkages, one between 2'-OH of GMP and 5'
256 ed as homo- or heterodimers or multimers via phosphodiester linkers that are stable in plasma, but cl
257 ffinity for lysosomal enzymes containing the phosphodiester Man-P-GlcNAc when in the context of a con
258 ontain solely phosphomonoesters (Man-6-P) or phosphodiesters (mannose 6-phosphate N-acetylglucosamine
259 nd that amides as non-ionic replacements for phosphodiesters may be useful modifications for optimiza
263 no acid carrying a cyclosaligenyl (cycloSal) phosphodiester moiety, into dipeptides to investigate th
266 f the sequence motifs of B-class and C-class phosphodiester ODNs to identify the sequence properties
268 oside monomers ("fluorosides") into DNA-like phosphodiester oligomers (oligodeoxyfluorosides or ODFs)
270 a mixture of porcine-derived single-stranded phosphodiester oligonucleotides (9-80-mer; average, 50-m
272 re containing zero, one, or two Man-P-GlcNAc phosphodiester or Man-6-P phosphomonoester residues was
274 ound to produce the corresponding unmodified phosphodiester (PDE) primer, which was then a suitable D
275 holds that synthesis of polynucleotide 3'-5' phosphodiesters proceeds via the attack of a 3'-OH on a
276 oups have been introduced as esterase-labile phosphodiester protecting groups that additionally are t
277 ts often yield ribozymes that generate 2'-5' phosphodiesters rather than conventional 3'-5' linkages.
278 riants, reveal the molecular basis for 2',5'-phosphodiester recognition and explain why the enzyme la
279 een attributed to diffusion-in-a-cone of the phosphodiester region, analogous to motion of a cylinder
280 e substrate at the positions of the scissile phosphodiesters result in abolition or inhibition of res
281 transitions required for intercalation of a phosphodiester-ribose backbone and suggest a possible co
284 ltanuM) is largely insensitive to changes in phosphodiester structure but strongly dependent on the a
285 at enables Escherichia coli to utilize alkyl phosphodiesters, such as diethyl phosphate, as the sole
286 r, we found that the number and placement of phosphodiesters surrounding a GTG sequence significantly
287 VLig-AMP revealed that the rate constant for phosphodiester synthesis (k(step3) = 25 s(-1)) exceeds t
294 ze the requisite chemistry, generating a new phosphodiester through attack of a terminal hydroxyl of
296 The hairpin ribozyme accelerates the rate of phosphodiester transfer reactions by at least 5 orders o
297 ribitol, and phosphoric acid, joined to form phosphodiester units that are found in the envelope of G
298 templates with triazole linkages in place of phosphodiesters, we have designed a strategy for chemica
299 ')pp(5')G end is converted to a 2',3'-cyclic phosphodiester, which is then attacked directly by the 5
300 H 14 are both large relative to reactions of phosphodiesters with good leaving groups, indicating tha
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