ライフサイエンスコーパス: phosphodiester backbone

1 ve charge that oligonucleotides carry on the phosphodiester backbone.

2 d is not influenced by the continuity of the phosphodiester backbone.

3 ino acids at these positions may contact the phosphodiester backbone.

4 l difference is the result of changes in the phosphodiester backbone.

5 is allow the enzyme to translocate along the phosphodiester backbone.

6 d to make 12 symmetrical contacts to the DNA phosphodiester backbone.

7 he RNA bases and has little influence on the phosphodiester backbone.

8 to the nonbridging phosphate oxygens in the phosphodiester backbone.

9 RNA body primarily through contacts with the phosphodiester backbone.

10 m was sufficient for optimal cleavage of the phosphodiester backbone.

11 s necessary to perform hydrolysis of the DNA phosphodiester backbone.

12 rostatically stabilized interaction with the phosphodiester backbone.

13 t with tDNA bases, while Arg362 contacts the phosphodiester backbone.

14 polycation, neutralizing the highly negative phosphodiester backbone.

15 recognize damaged DNA as well as cleave the phosphodiester backbone.

16 governs the conformational properties of the phosphodiester backbone.

17 lting break, and the rejoining of the broken phosphodiester backbone.

18 is possibly important for DNA binding at the phosphodiester backbone.

19 feature of DNA helicases that move along DNA phosphodiester backbones.

20 mes catalyze site-specific cleavage of their phosphodiester backbones.

21 ccelerate site-specific cleavage/ligation of phosphodiester backbones.

22 d platinum G-G diadducts and cleaves the DNA phosphodiester backbone 5' to a lesion.

23 izing intermediary abasic sites cleaving the phosphodiester backbone 5' to the abasic site.

24 ir of this common DNA lesion by incising the phosphodiester backbone 5' to the damage site.

25 pair enzyme for abasic sites and incises the phosphodiester backbone 5' to the lesion to initiate a c

26 they both recognize AP sites and incise the phosphodiester backbone 5' to the lesion, yet they lack

27 An adjustment in the position of the phosphodiester backbone 5'-phosphate enables 8-oxoG to a

28 out from the minor groove and loops over the phosphodiester backbone, adds a substantial negative ent

29 ted in the duplex by a slight opening in the phosphodiester backbone; all sugars retain a C2'-endo pu

30 , an initial enzyme binding primarily to the phosphodiester backbone and a base dependent isomerizati

31 ation reduces the amplitude of motion in the phosphodiester backbone and furanose ring of the same DN

32 lane reflecting interactions between the DNA phosphodiester backbone and positively charged arginine

33 wobble pair distorts the conformation of the phosphodiester backbone and presents the functional grou

34 etween them, involving torsion angles of the phosphodiester backbone and the arrangements of stacked

35 asymmetric contacts between the A-duplex RNA phosphodiester backbone and the EF-loop in one coat prot

36 tion that engages a continuous region of the phosphodiester backbone and the hydrophobic faces of exp

37 IHF contacts the DNA exclusively via the phosphodiester backbone and the minor groove and relies

38 used defined dsDNA fragments with a natural (phosphodiester) backbone and show that unmethylated CpG

39 rporated into model oligomers with a natural phosphodiester backbone, and enzymatic degradation was m

40 olyamide molecules alter the geometry of the phosphodiester backbone, and the water molecules mediati

41 of two invariant interfacial contacts to the phosphodiester backbone, and two semi-conserved base-spe

42 on, but some changes in the positions of the phosphodiester backbone are present compared to a C+ x G

43 rly show that portions of the anticodon loop phosphodiester backbone are protected from cleavage only

44 ive contacts between the protein and the DNA phosphodiester backbone, as well as a number of direct h

45 ning complementary sequences and cleaves the phosphodiester backbone at a specific site measured from

46 g that integrase requires flexibility of the phosphodiester backbone at the 3'-P site.

47 removal of the damaged base, incision of the phosphodiester backbone at the abasic sugar residue, inc

48 metrical, characterized by a reversal of the phosphodiester backbone at the UC step (hydrogen bond C1

49 displays a weak preference for cleaving the phosphodiester backbone between 5'-GC dinucleotides.

50 a P-site-bound tRNA(Met) with a break in the phosphodiester backbone between positions 56 and 57 in t

51 tack of a tyrosine hydroxyl group on the DNA phosphodiester backbone bond during the step of DNA clea

52 d to substitution of the negatively-charged, phosphodiester backbone by a nonionic, internucleoside l

53 hat asymmetric neutralization of the anionic phosphodiester backbone by basic histone proteins could

54 and to reveal unexpected control of the DNA phosphodiester backbone by electrostatic interactions.

55 Substitution of the 2',5'-phosphodiester backbone by phosphorothioate linkages giv

56 cative of small changes in base stacking and phosphodiester backbone conformation.

57 e changes in base vibrational ring modes and phosphodiester backbone conformation.

58 crossed a turn rather than running along the phosphodiester backbone contour.

59 ity imparted by these sugar modifications in phosphodiester backbones correlated with the size of the

60 modified oligonucleotides that possessed the phosphodiester backbone demonstrated excellent resistanc

61 Conserved patterns of phosphodiester backbone dihedral distortions during flip

62 hosphoramidate DNA backbone differs from the phosphodiester backbone due to the N3'-H moiety having o

63 results in the protection of regions of the phosphodiester backbone expected for tertiary folding of

64 ntly alters the intrinsic flexibility of the phosphodiester backbone, favoring the A-form in duplex R

65 ntact the AMP adenine (Lys(290)), engage the phosphodiester backbone flanking the nick (Arg(218), Arg

66 groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); pe

67 he P4-P6 RNA induces formation of a specific phosphodiester-backbone geometry that is required for CY

68 DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the dama

69 tion, by introducing symmetrical cuts in the phosphodiester backbone in a Mg2+ dependent reaction.

70 f APE1, which is responsible for nicking the phosphodiester backbone in DNA on the 5' side of an apur

71 The dynamics of the phosphodiester backbone in the [5'-GCGC-3'] 2 moiety of

72 semi-synthetic tRNA contained a break in the phosphodiester backbone in the D loop and was an efficie

73 structures reveal a subtle distortion to the phosphodiester backbone in the dimer-containing sequence

74 onomer in solution and that DNA ligands with phosphodiester backbones induce TLR9 dimerization in a s

75 on-template single strand bases, leaving the phosphodiester backbone intact, did not interfere with b

76 Phosphodiester backbone interactions between the protosp

77 e base interactions together with additional phosphodiester-backbone interactions along one face of t

78 25 mM KCl, indicating a strong dependence on phosphodiester-backbone interactions.

79 ch or hole in the protein, thus bringing the phosphodiester backbone into close proximity with the ac

80 Electrostatic interactions with the RNA phosphodiester backbone involve protein side chains that

81 d through noncanonical pairings and that the phosphodiester backbone is not contacted by the RNA.

82 demonstrates that the anomeric effect in the phosphodiester backbone is significantly more complex th

83 By analyzing the conformation of the phosphodiester backbones, it is possible to understand f

84 at divalent metal ion coordination along the phosphodiester backbone may play a role in the inhibitor

85 between cisplatin and the negatively charged phosphodiester backbone may play an important role in fa

86 nces that originate from displacement of the phosphodiester backbone near the effector binding pocket

87 Thus, a continuous phosphodiester backbone negative charge is not essential

88 e site are stacked in an A-form pattern, the phosphodiester backbone next to the cleavage site on the

89 n of structural transitions of the sugar and phosphodiester backbone observed during computational st

90 ly active homodimeric enzyme each cleave the phosphodiester backbone of a cruciform within the lifeti

91 ed dipole-enhanced hydrogen bond between the phosphodiester backbone of bound DNA and the N terminus

92 Here we report the effects of modifying the phosphodiester backbone of d(ATGACT) with phosphorothioa

93 BD binds d9 by a mechanism that perturbs the phosphodiester backbone of d9.

94 yme uracil DNA glycosylase (UDG) pinches the phosphodiester backbone of damaged DNA using the hydroxy

95 DNA ligases join breaks in the phosphodiester backbone of DNA molecules and are used in

96 te unwinding from discontinuities within the phosphodiester backbone of DNA.

97 catalyze the joining of strand breaks in the phosphodiester backbone of duplex DNA and play essential

98 ic ones, such as Lys-Trp-Lys, can incise the phosphodiester backbone of duplex DNA at an AP site via

99 ase isolated from vaccinia virus cleaves the phosphodiester backbone of duplex DNA at the sequence 5'

100 a specific three-dimensional geometry of the phosphodiester backbone of group I introns.

101 Hydroxyl radicals (.OH) can cleave the phosphodiester backbone of nucleic acids and are valuabl

102 The anomeric effect in the phosphodiester backbone of nucleic acids is a stereoelec

103 Amides are remarkably good mimics of the phosphodiester backbone of RNA and can be prepared using

104 Amides are remarkably good mimics of the phosphodiester backbone of RNA and can be prepared using

105 zyme accelerates cleavage or ligation of the phosphodiester backbone of RNA has been incompletely und

106 urface provides an extended scaffold for the phosphodiester backbone of the conserved catalytic core

107 Functionalization of the sugar/phosphodiester backbone of the GS, which is in direct co

108 domains of repressor which interact with the phosphodiester backbone of the operator site.

109 cures the duplex by binding the 7-nucleotide phosphodiester backbone of the overhang-containing stran

110 ation reduces the amplitude of motion in the phosphodiester backbone of the same DNA, and our observa

111 he N-terminal helix of NC interacts with the phosphodiester backbone of the SL2 RNA stem mainly via e

112 At one site, Mg(H(2)O)(6)(2+) ligates the phosphodiester backbone of the trinucleotide bulge in th

113 Because EF-Tu is known to contact only the phosphodiester backbone of tRNA, the observed specificit

114 y enriched MPOs) or (ii) alternating R(P) MP/phosphodiester backbone oligonucleotides, depending on t

115 We have examined the effects of the phosphodiester backbone on the reactions of cisplatin wi

116 part due to additional contacts made to the phosphodiester backbone outside the 8 bp target via the

117 described as a three-step process involving phosphodiester backbone pinching, base extrusion through

118 the sugar pucker 5' to the flipped base, and phosphodiester backbone rearrangement.

119 site-specific self-cleavage of the viral RNA phosphodiester backbone requires both divalent cations a

120 Neutralization of the phosphodiester backbone resulted in a DNA-footprinting p

121 toplasmic thioesterases into native, charged phosphodiester-backbone siRNAs, which induce robust RNAi

122 ommodates the 7G with less distortion of the phosphodiester backbone than would be required for an N9

123 The structure has a kink in the phosphodiester backbone that causes a sharp turn in the

124 ed pseudosugar induces a conformation on the phosphodiester backbone that corresponds to that of a di

125 The molecular properties of the phosphodiester backbone that made it the evolutionary ch

126 interactions; and (b) the arrangement of the phosphodiester backbone to focus negative electrostatic

127 ir X(6).T(17), accompanied by a shift in the phosphodiester backbone torsion angle beta P5'-O5'-C5'-C

128 The phosphodiester backbone twists at the lesion site, accou

129 A substrate containing a single break in the phosphodiester backbone was joined by DNA ligase.

130 When the phosphodiester backbone was replaced by a phosphorothioa

131 isorder is observed at several places in the phosphodiester backbone, which results from a simple cra

132 c-di-GMP structure and replacing the charged phosphodiester backbone with an isosteric nonhydrolyzabl

133 We report that replacement of the phosphodiester backbone with cationic phosphoramidate li