ライフサイエンスコーパス: phosphoglycerate

1 w concentrations (10 microM) of activator (3-phosphoglycerate).

2 and glycerate to enter central metabolism at phosphoglycerate.

3 the phosphotransferase reaction regenerating phosphoglycerate.

4 ed by G6P but is inhibited by both PEP and 3-phosphoglycerate.

5 ubisCO continues to fix CO2 and synthesize 3-phosphoglycerate.

6 s substrate 3-phosphoglycerate and product 2-phosphoglycerate.

7 ast types have the capacity to photoreduce 3-phosphoglycerate.

8 orms the unstable organoarsenical 1-arseno-3-phosphoglycerate (1As3PGA).

9 e, 3-phosphoglycerate (3-PG), and product, 2-phosphoglycerate (2-PG).

10 ns in the enolase-catalyzed dehydration of 2-phosphoglycerate (2-PGA).

11 sphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP.

12 phospho-transfer reaction between ATP and 3-phosphoglycerate (3-PG) that is thought to require a hin

13 ing intracellular levels of its substrate, 3-phosphoglycerate (3-PG), and product, 2-phosphoglycerate

14 When 3-phosphoglycerate (3-PGA), the putative physiological act

15 regulators such as inorganic phosphate and 3-phosphoglycerate (3-PGA).

16 d an enzyme, P52L, that was insensitive to 3-phosphoglycerate (3-PGA).

17 here it rapidly dissociates into As(V) and 3-phosphoglycerate (3PGA), creating a novel pathway of ars

18 ilar hinge closure but contain, instead of 3-phosphoglycerate, a single phosphate molecule bound in t

19 similar and the active site contains both 3-phosphoglycerate and 2-phosphoglycerate at equal occupan

20 cer cells and contributes to regulation of 3-phosphoglycerate and 2-phosphoglycerate levels, promotin

21 e quantification of the individual isomers 2-phosphoglycerate and 3-phosphoglycerate, as well as gluc

22 atalyzes phosphoryl transfer between 1,3-bis-phosphoglycerate and ADP to form 3-phosphoglycerate and

23 en 1,3-bisphosphoglycerate and ADP to form 3-phosphoglycerate and ATP in the presence of magnesium.

24 n 1,3-bis-phosphoglycerate and ADP to form 3-phosphoglycerate and ATP.

25 ling intracellular levels of its substrate 3-phosphoglycerate and product 2-phosphoglycerate.

26 L subunit had a high apparent affinity for 3-phosphoglycerate and substrates suggesting a leading rol

27 the structure of this iPGM complexed with 2-phosphoglycerate and two Mn(2+) ions at 1.7-A resolution

28 f the model leading to the accumulation of 3-phosphoglycerate and/or pyruvate.

29 PGMs) catalyze the isomerization of 2- and 3-phosphoglycerates and are essential for glucose metaboli

30 NADPH, 3-phosphoglycerate, and ATP were competitive inhibitors, a

31 ation of internal ribulose-1,5-bisphosphate, phosphoglycerate, and Ci pools when grown under comparab

32 ramatic changes in their responses to AMP, 3-phosphoglycerate, and pyruvate but not to NADPH and isoc

33 AMP, 3-phosphoglycerate, and pyruvate represent a class of regu

34 onversion efficiency through generation of 3-phosphoglycerate; and (iv) a larger contribution of amin

35 ductase, a glycerate kinase that generates 2-phosphoglycerate as product, and two hexaric acid transp

36 individual isomers 2-phosphoglycerate and 3-phosphoglycerate, as well as glucose-6-phosphate and fru

37 site contains both 3-phosphoglycerate and 2-phosphoglycerate at equal occupancies (50%).

38 (Lm iPGAM) crystallised with the substrate 3-phosphoglycerate at high and low cobalt concentrations h

39 sphonate group occupying part of the 1,3-bis-phosphoglycerate binding site.

40 M1 at least in part by promoting substrate 3-phosphoglycerate binding.

41 al low apparent affinity for the activator 3-phosphoglycerate, but it was atypically defective in the

42 lso formed by the TCA cycle, is converted to phosphoglycerate by a reaction sequence that is reversed

43 d the apparent affinity for the activator, 3-phosphoglycerate, by 3090- and 54-fold, respectively.

44 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escher

45 e catalytic activity of Escherichia coli D-3-phosphoglycerate dehydrogenase (PGDH) by binding to its

46 Phosphoglycerate dehydrogenase (PGDH) catalyzes the firs

47 Escherichia coli 3-phosphoglycerate dehydrogenase (PGDH) catalyzes the firs

48 An active conformation of phosphoglycerate dehydrogenase (PGDH) from Escherichia c

49 D-3-Phosphoglycerate dehydrogenase (PGDH) from Escherichia c

50 D-3-Phosphoglycerate dehydrogenase (PGDH) from Mycobacterium

51 ructural homology with the ASB domain of d-3-phosphoglycerate dehydrogenase (PGDH) from Mycobacterium

52 ric hybrid tetramers of Escherichia coli d-3-phosphoglycerate dehydrogenase (PGDH) have been made by

53 topped-flow analysis of Escherichia coli d-3-phosphoglycerate dehydrogenase (PGDH) reveals that the p

54 ol coefficient for the branch point enzyme 3-phosphoglycerate dehydrogenase (PGDH).

55 ding for the first enzyme of this pathway, 3-phosphoglycerate dehydrogenase (PGDH).

56 ulatory and substrate binding domains of D-3-phosphoglycerate dehydrogenase (PGDH, EC 1.1.1.95) from

57 nately regulate expression of genes encoding phosphoglycerate dehydrogenase (PHGDH) and five downstre

58 Enzymes of the SSP, such as phosphoglycerate dehydrogenase (PHGDH) and phosphoserine

59 Among the genes identified, phosphoglycerate dehydrogenase (PHGDH) is in a genomic r

60 Phosphoglycerate dehydrogenase (PHGDH) is the metabolic

61 BA, but not GH, caused a 2-fold increase in phosphoglycerate dehydrogenase (PHGDH) protein expressio

62 mes of the de novo serine synthesis pathway (phosphoglycerate dehydrogenase (PHGDH), phosphoserine am

63 uman cancers often exhibit overexpression of phosphoglycerate dehydrogenase (PHGDH), the metabolic en

64 The gene encoding the enzyme 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes

65 d into serine and glycine metabolism through phosphoglycerate dehydrogenase (PHGDH).

66 d-3-Phosphoglycerate dehydrogenase (Phgdh; EC 1.1.1.95) is t

67 xtracts of M. maripaludis were shown to have phosphoglycerate dehydrogenase and phosphoserine aminotr

68 The inhibition of Escherichia coli d-3-phosphoglycerate dehydrogenase by l-serine is positively

69 resents a second structural motif of the D-3-phosphoglycerate dehydrogenase family, one that contains

70 The binding of L-serine to phosphoglycerate dehydrogenase from E. coli displays ele

71 d-3-Phosphoglycerate dehydrogenase from Escherichia coli con

72 d-3-Phosphoglycerate dehydrogenase from Escherichia coli is

73 D-3-Phosphoglycerate dehydrogenase from Escherichia coli is

74 The heterologously expressed and purified phosphoglycerate dehydrogenase from M. maripaludis had e

75 D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberc

76 The crystal structure of D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberc

77 structure of Mycobacterium tuberculosis d-3-phosphoglycerate dehydrogenase has been solved with boun

78 10 interacted with the chloroplastic protein phosphoglycerate dehydrogenase in a yeast (Saccharomyces

79 3-Phosphoglycerate dehydrogenase is an exclusively astrocy

80 of residues in the regulatory domains of D-3-phosphoglycerate dehydrogenase provide the first direct

81 The crystal structure of d-3-phosphoglycerate dehydrogenase reveals a limited number

82 The first D-3-phosphoglycerate dehydrogenase structure to be determine

83 sphate pathway (PPP), while 2-PG activates 3-phosphoglycerate dehydrogenase to provide feedback contr

84 Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase undergoes significant inh

85 topped flow analysis of Escherichia coli D-3-phosphoglycerate dehydrogenase was performed by followin

86 e structure of a truncated form of human d-3-phosphoglycerate dehydrogenase with cofactor and a subst

87 In Escherichia colid-3-phosphoglycerate dehydrogenase, the amino acid sequences

88 n part to the genomic copy number gain for 3-phosphoglycerate dehydrogenase, the enzyme that controls

89 Consistently, inhibition of phosphoglycerate dehydrogenase, the first enzyme of the

90 and mice with targeted deletion of Srr or 3-Phosphoglycerate dehydrogenase, we demonstrate predomina

91 same fold; (iii) the C-terminal domain of 3-phosphoglycerate dehydrogenase, which binds serine and i

92 te of the ACT-domain of the Escherichia coli phosphoglycerate dehydrogenase.

93 etate methyltransferase deficiency and for 3-phosphoglycerated dehydrogenase deficiency appear promis

94 e, we present a detailed characterization of phosphoglycerate dehydrogenases (PGDHs) as components of

95 with the ASB domain like that in type 1 D-3-phosphoglycerate dehydrogenases (PGDHs).

96 Phosphoglycerate dehydrogenases exist in at least three

97 version of 3-phosphoglyceroyl phosphate to 3-phosphoglycerate, exhibited inositol auxotrophy.

98 reaction removing the phosphate from 2- or 3-phosphoglycerate, generating an enzyme-bound phosphoseri

99 PGK) converts 1,3-bisphosphoglycerate into 3-phosphoglycerate in glycolysis but also participates in

100 ses catalyze the interconversion of 2- and 3-phosphoglycerate in the glycolytic and gluconeogenic pat

101 3, which are primarily known for oxidizing 3-phosphoglycerate in the main serine biosynthesis pathway

102 the other hand, sensitivity to citrate and 3-phosphoglycerate inhibition was lost, indicating an impo

103 P-Glc and inorganic phosphate), activator (3-phosphoglycerate), inhibitor (inorganic phosphate), or o

104 Glycolytic interconversion of phosphoglycerate isomers is catalysed in numerous pathog

105 dehyde phosphate dehydrogenase (GAPDH) and 3-phosphoglycerate kinase (3-PGK) are enriched in synaptic

106 eviously, we identified that the chloroplast phosphoglycerate kinase (chl-PGK) from Nicotiana bentham

107 ng intermediates of the N-terminal domain of phosphoglycerate kinase (N-PGK) and a number of conserva

108 he chemically denatured N-terminal domain of phosphoglycerate kinase (N-PGK) has been determined by p

109 Phosphoglycerate kinase (PGK) catalyzes a reversible pho

110 The glycolytic enzyme phosphoglycerate kinase (PGK) catalyzes phosphoryl trans

111 Phosphoglycerate kinase (PGK) catalyzes the reversible p

112 In plants, phosphoglycerate kinase (PGK) converts 1,3-bisphosphogly

113 On a dataset of eukaryotic proteins from the phosphoglycerate kinase (PGK) family, interdomain site c

114 the stability and folding relaxation rate of phosphoglycerate kinase (PGK) Forster resonance energy t

115 Previous studies of the N-domain of phosphoglycerate kinase (PGK) from Bacillus stearothermo

116 anidinium-denatured state of the N-domain of phosphoglycerate kinase (PGK) has been characterized usi

117 dues 1-174) of Bacillus stearothermophilus 3-phosphoglycerate kinase (PGK) has been investigated usin

118 ion state analogue (TSA) complexes formed by phosphoglycerate kinase (PGK) have been used to test the

119 y and folding rate of a mutant of the enzyme phosphoglycerate kinase (PGK) inside bone tissue cells a

120 The pneumococcal glycolytic enzyme phosphoglycerate kinase (PGK) is both secreted and bound

121 Escherichia coli phosphoglycerate kinase (PGK) is resistant to proteolyti

122 Incorporation of these fragments upstream of phosphoglycerate kinase (PGK) or cytomegalovirus promote

123 rexpression of PDGFB using a relatively weak phosphoglycerate kinase (PGK) promoter completely avoide

124 Cs transduced by a vector that used a murine phosphoglycerate kinase (PGK) promoter led to a complete

125 cetyl-CoA carboxylase (ACCase) and plastid 3-phosphoglycerate kinase (PGK) to study grass evolution.

126 stigation of the interaction of the enzyme 3-phosphoglycerate kinase (PGK) with aryl and alkyl bispho

127 compaction of the already unfolded state of phosphoglycerate kinase (PGK) with decreasing denaturant

128 Phosphoglycerate kinase (PGK), a downstream protein of h

129 The nubian mutant disrupts phosphoglycerate kinase (PGK), an enzyme required for AT

130 We have used phosphoglycerate kinase (PGK), an enzyme that forms its

131 for inhibiting Trypanosoma brucei glycosomal phosphoglycerate kinase (PGK), glyceraldehyde-3-phosphat

132 Phosphoglycerate kinase (PGK), present on the surface of

133 en developed for a two-domain protein, yeast phosphoglycerate kinase (PGK), using Forster resonance e

134 d results for a hinge-bending enzyme, namely phosphoglycerate kinase (PGK), which support and extend

135 factor HIF-1, glucose transporter (GLUT)-1, phosphoglycerate kinase (PGK)-1, and vascular endothelia

136 xpressing the GAL4/VP16 fusion protein (Ad/3-phosphoglycerate kinase (PGK)-GV16) was dose-dependent a

137 ng investigation of the impact of a retained phosphoglycerate kinase (PGK)-neo cassette located betwe

138 mediate state of the large two-domain enzyme phosphoglycerate kinase (PGK).

139 analog diphosphates are phosphorylated by 3-phosphoglycerate kinase (PGK).

140 f proline 204 in the 'hinge' region of yeast phosphoglycerate kinase (PGK).

141 tructure, function, and folding landscape of phosphoglycerate kinase (PGK).

142 ng landscape of a FRET-labeled enzyme, yeast phosphoglycerate kinase (PGK-FRET).

143 e redox features of the Calvin-Benson enzyme phosphoglycerate kinase (PGK1) from the eukaryotic green

144 on nucleosomes present in the human X-linked phosphoglycerate kinase (PGK1) gene.

145 n the transcriptionally active human p53 and phosphoglycerate kinase (pgk1) genes in vivo.

146 dehyde-3-phosphate dehydrogenase (Gap1); and phosphoglycerate kinase (Pgk1).

147 e was confirmed by expressing the glycosomal phosphoglycerate kinase (PGKC) in the Deltappdk/Deltapep

148 xins 1 and 6), and metabolic proteins (e.g., phosphoglycerate kinase 1 (PGK 1), alpha enolase, aldola

149 Since other Hif target genes such phosphoglycerate kinase 1 (Pgk) were Hif-1alpha dependen

150 Phosphoglycerate kinase 1 (PGK1) catalyzes the reversibl

151 The promoter for the phosphoglycerate kinase 1 (PGK1) gene contains an initia

152 8 phosphorylation, leading to ARD1-dependent phosphoglycerate kinase 1 (PGK1) K388 acetylation and su

153 cible in vivo photofootprinting of the human phosphoglycerate kinase 1 (PGK1) promoter, as well as pr

154 Of note, expressions of Phosphoglycerate Kinase 1 (PGK1), Hexokinase 2 (HK2), an

155 ssion and secretion of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1).

156 V600E induce mitochondrial translocation of phosphoglycerate kinase 1 (PGK1); this is mediated by ER

157 ay genes, glucose transporter 1-4 (Glut1-4), phosphoglycerate kinase 1 and Glucokinase but not of pro

158 Elevated levels of phosphoglycerate kinase 1 in the serum were also signifi

159 Among these candidates, phosphoglycerate kinase 1 was associated with survival i

160 endothelial growth factor (VEGF), Glut1, and phosphoglycerate kinase 1, increased in the Cited2(-/-)

161 Phosphoglycerate kinase 2 (PGK2) is a germ cell-specific

162 ontaining the known, translationally delayed phosphoglycerate kinase 2 (Pgk2) is initially transcribe

163 Both features contrast with the phosphoglycerate kinase 2 retroposon, which is believed

164 1 mutant exhibited very low but measurable 3-phosphoglycerate kinase activity compared to the wild-ty

165 triphosphate inhibited recombinant T. brucei phosphoglycerate kinase activity in vitro with an IC50 o

166 s illustrated using the N-terminal domain of phosphoglycerate kinase and a synthetic reagent containi

167 ump-induced refolding of two proteins, yeast phosphoglycerate kinase and a ubiquitin mutant.

168 e (glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase and fructose bisphosphate aldola

169 ed to probe the ATP binding sites of yeast 3-phosphoglycerate kinase and glycerol kinase from Candida

170 ubation with bulk ATP or by operation of the phosphoglycerate kinase and pyruvate kinase reactions to

171 teomics and stimulation analyses, identified phosphoglycerate kinase as a stimulatory factor for neut

172 ilibrium dynamics of the native state, using phosphoglycerate kinase as model protein.

173 Using yeast phosphoglycerate kinase as model, here we identify the f

174 Apomyoglobin denaturant unfolding and phosphoglycerate kinase cold denaturation are discussed

175 ompare the folding kinetics of a fluorescent phosphoglycerate kinase construct in 30 mammalian cells

176 sonance energy transfer (FRET) probe-labeled phosphoglycerate kinase construct in two human cell line

177 The two protein domains of phosphoglycerate kinase correspond to two dynamic units,

178 mine whether this was caused by the retained phosphoglycerate kinase I gene promoter (PGK-neo) casset

179 itro, even though translational diffusion of phosphoglycerate kinase in the cell is slow compared to

180 gen, we propose that plasmin ligands such as phosphoglycerate kinase induce a conformational change i

181 Decrease in the expression of 3-phosphoglycerate kinase led to a corresponding decrease

182 reductase, UDP-glucose pyrophosphorylase and phosphoglycerate kinase play a role in heat-stress-media

183 hemical shift and hydrogen exchange rates as phosphoglycerate kinase progresses through its catalytic

184 ice that overexpress CXCL14 under control of phosphoglycerate kinase promoter.

185 he control of a strong internal constitutive phosphoglycerate kinase promoter.

186 Inhibition studies of 3-phosphoglycerate kinase show a dramatic decrease in isom

187 primary spermatocytes to provide a source of phosphoglycerate kinase that is critical to normal motil

188 ed that protein disulfide isomerase-like and phosphoglycerate kinase were required for optimal SCMV r

189 e mesoscopic level, including the pig muscle phosphoglycerate kinase with 416 residues.

190 acetyl-CoA carboxylase) and Pgk-1 (plastid 3-phosphoglycerate kinase) genes to determine phylogenetic

191 the stability of the cytoplasmic enzyme PGK (phosphoglycerate kinase) increases in cells, the stabili

192 s in lentiviral vectors (cytomegalovirus and phosphoglycerate kinase) revealed that suppression of vi

193 We studied the role of 3-phosphoglycerate kinase, a glycolytic enzyme, in the met

194 gene expression compared with MLV, MSV LTR, phosphoglycerate kinase, and CMV promoters in T-cell lin

195 e, glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, and enolase were elevated.

196 tion of lactate dehydrogenase A, aldolase-A, phosphoglycerate kinase, and enolase-1 genes.

197 f HIF-1alpha target genes, such as for VEGF, phosphoglycerate kinase, and glucose transporter-1.

198 Therefore, roles of creatine kinase, 3-phosphoglycerate kinase, and pyruvate kinase were evalua

199 on, which mapped to pgk, the gene encoding 3-phosphoglycerate kinase, failed to suppress a resD mutat

200 cular-dynamics (MD) simulation of a protein, phosphoglycerate kinase, from which we calculate small-a

201 atments were identified as adenylate kinase, phosphoglycerate kinase, glyceraldehyde-3-phosphate dehy

202 For the N-terminal domain of phosphoglycerate kinase, hen egg-white lysozyme and BPTI

203 id, 1,3-BPG,3 and evaluated their binding to phosphoglycerate kinase, PGK (EC 2.7.2.3).

204 nactivation center XIST and the ATRX, ATP7A, phosphoglycerate kinase, POU3F4, and choroideremia genes

205 ly reported more closely resemble those of 3-phosphoglycerate kinase, suggesting the surprising resul

206 sphates were selectively phosphorylated by 3-phosphoglycerate kinase, whereas, D-deoxynucleoside anal

207 HPRTminigene, under the control of the mouse phosphoglycerate kinase-1 gene promoter, was stably expr

208 Here, we used a ubiquitously active phosphoglycerate kinase-1 promoter to drive the expressi

209 led shRNA upon removal of a floxed reporter (phosphoglycerate kinase-driven enhanced green fluorescen

210 n sites around exon 7 of the Gbe1 gene and a phosphoglycerate kinase-Neomycin cassette within intron

211 and promoter region of the IRBP gene with a phosphoglycerate kinase-promoted neomycin-resistant gene

212 G binding site and in the hinge regions of 3-phosphoglycerate kinase.

213 ting glycolysis, especially by inhibition of phosphoglycerate kinase.

214 n of 1,3-bisphosphoglycerate, a substrate of phosphoglycerate kinase.

215 and the glycolytic phosphotransfer enzyme, 3-phosphoglycerate kinase.

216 xokinase is functionally open like that of 3-phosphoglycerate kinase.

217 ons of suramin in its free form and bound to phosphoglycerate kinases from T. brucei and S. cerevisae

218 es to regulation of 3-phosphoglycerate and 2-phosphoglycerate levels, promoting cancer cell prolifera

219 rprisingly, each dimer is comprised of one 3-phosphoglycerate.MgADP.PGK ternary complex and one Pi.Mg

220 osphonates bind in a manner similar to the 3-phosphoglycerate molecule identified crystallographicall

221 The more active was C16-phosphoglycerate-MurNAc-(L-Ala-D-Glu)-GlcNAc, which also

222 cture of Escherichia coli cofactor-dependent phosphoglycerate mutase (dPGM), complexed with the poten

223 (TroR), and the essential glycolytic enzyme phosphoglycerate mutase (Gpm).

224 ween the 2, 3-diphosphoglycerate-independent phosphoglycerate mutase (iPGM) from Bacillus stearotherm

225 of Leishmania mexicana cofactor-independent phosphoglycerate mutase (Lm iPGAM) crystallised with the

226 double labelled (15N,13C) monomeric, 23.7 kD phosphoglycerate mutase (PGAM) from Schizosaccharomyces

227 Here we report the interaction of Pak with phosphoglycerate mutase (PGAM)-B, an enzyme of the glyco

228 the phosphorylation of the glycolytic enzyme phosphoglycerate mutase (PGAM1) in PKM2-expressing cells

229 atase activity located within its C-terminal phosphoglycerate mutase (PGM) homology domain and key fo

230 the ecdysone phosphate phosphatase (EPPase) phosphoglycerate mutase (PGM) homology domain, the first

231 Bacillus stearothermophilus phosphoglycerate mutase (PGM), which interconverts 2- an

232 fibroblasts identified the glycolytic enzyme phosphoglycerate mutase (PGM).

233 Phosphoglycerate mutase 1 (PGAM1) functions in glycolysi

234 recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic bio

235 We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated

236 rs, covalently labeled the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), resulting in enzyme i

237 nts an additional acute mechanism underlying phosphoglycerate mutase 1 upregulation.

238 yaluronan synthase 2) and Bevacizumab/PGAM1 (Phosphoglycerate mutase 1) are interactions found in thi

239 nd filamin-C), glycolytic enzymes (aldolase, phosphoglycerate mutase 2, beta enolase and glycogen pho

240 0 MPa) provoked a significant degradation of phosphoglycerate mutase 2, glycogen phosphorylase muscle

241 to extend Drosophila lifespan, and identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this

242 Phosphoglycerate mutase 5 (PGAM5) is an atypical mitocho

243 activation of the mitochondrial phosphatase phosphoglycerate mutase 5 (PGAM5).

244 lysis and recombinant enzymes showed typical phosphoglycerate mutase activities in both the glycolyti

245 New allergenic candidates, phosphoglycerate mutase and phosphoglucomutase, were ide

246 rtially associated with the axoneme, whereas phosphoglycerate mutase and pyruvate kinase primarily re

247 otide ubiquinone oxidoreductase chain 2, and phosphoglycerate mutase B], ion regulation (members of s

248 The C-terminal phosphoglycerate mutase domain of PGAM5 shares homology

249 Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a

250 ere, we present evidence that members of the phosphoglycerate mutase family 5 (PGAM5) proteins are in

251 her found that the mitochondrial phosphatase phosphoglycerate mutase family member 5 (PGAM5), a putat

252 ice deficient for the mitochondrial protein, phosphoglycerate mutase family member 5 (PGAM5), display

253 alytic domains found in other members of the phosphoglycerate mutase family, including a conserved hi

254 is report we have identified a member of the phosphoglycerate mutase family, PGAM5, as a novel substr

255 present at the active site of the monomeric phosphoglycerate mutase from the fission yeast Schizosac

256 rystal structure of Saccharomyces cerevisiae phosphoglycerate mutase has been determined.

257 new crystal form of Saccharomyces cerevisiae phosphoglycerate mutase has been solved and refined to 2

258 a typical nucleotide binding fold, although phosphoglycerate mutase has no physiological requirement

259 des, unlike vertebrates, utilize independent phosphoglycerate mutase in glycolytic and gluconeogenic

260 ogenase (GPDH), calcium-binding protein, and phosphoglycerate mutase were also identified.

261 mer-specific autophosphorylation of NME1 and phosphoglycerate mutase were used with immunoblotting an

262 lycolysis (glucose-6-phosphate isomerase and phosphoglycerate mutase), in trehalose-6-P metabolism (t

263 Five of these (phosphoglycerate mutase, alcohol dehydrogenase, thioredo

264 etal transport system, the glycolytic enzyme phosphoglycerate mutase, and TroR.

265 three steps of the lower half of glycolysis (phosphoglycerate mutase, enolase, and pyruvate kinase).

266 lis, Treponema pallidum, the gene encoding 3-phosphoglycerate mutase, gpm, is part of a six-gene oper

267 Here, we reveal that the glycolytic enzyme phosphoglycerate mutase-1 (PGAM1) is negatively regulate

268 lism by overexpressing the glycolytic enzyme phosphoglycerate mutase-1 severely impaired the ability

269 The phosphoglycerate mutase-like domain of Sts-1 (Sts-1(PGM)

270 has been predicted to have only independent phosphoglycerate mutase.

271 with similarities to the catalytic motif of phosphoglycerate mutase.

272 veals that it has homology to members of the phosphoglycerate mutase/acid phosphatase (PGM/AcP) famil

273 s similar to the group of cofactor-dependent phosphoglycerate mutase/bisphosphoglycerate mutase enzym

274 ilarity to 2, 3-diphosphoglycerate-dependent phosphoglycerate mutases (dPGM).

275 Phosphoglycerate mutases (PGMs) catalyze the isomerizati

276 Phosphoglycerate mutases catalyze the interconversion of

277 cloned and produced recombinant, independent phosphoglycerate mutases from C. elegans and the human-p

278 nzyme is neither activated by the effector 3-phosphoglycerate nor inhibited by P(i).

279 NAD+, and arsenate until 50% conversion to 3-phosphoglycerate occurred.

280 31P resonances of enzyme-bound substrates 2-phosphoglycerate (PGA) and phosphoenolpyruvate (PEP) wer

281 nt of the 2,3-diphosphoglycerate-independent phosphoglycerate (PGA) mutases [iPGMs].

282 dihydroxyacetone phosphate, a decrease in 3-phosphoglycerate, phosphoenolpyruvate, and pyruvate, and

283 ation mass spectral analysis of the stable 3-phosphoglycerate product detected an extent of 1.4 +/- 0

284 er the apparent affinity for the activator 3-phosphoglycerate, showing two types of apparent roles fo

285 ) from Bacillus stearothermophilus and its 3-phosphoglycerate substrate has recently been solved, and

286 We have focused on the glucosyl-3-phosphoglycerate synthase (GpgS), a "retaining" enzyme,

287 taining shell protein that may weakly bind 3-phosphoglycerate, the product of CO2 fixation.

288 , a glycolytic-cycle enzyme that catalyzes 2-phosphoglycerate to form phosphoenolpyruvate, which is a

289 played a shift in effector preference from 3-phosphoglycerate to fructose-6 phosphate or fructose-1,6

290 y is controlled by the ratio of activator, 3-phosphoglycerate to inhibitor, P(i).

291 , the data revealed no significant flux from phosphoglycerate to Ser and Gly but showed formation of

292 fic chloroplast transporters could provide 3-phosphoglycerate to the cytosol.

293 e for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway.

294 In addition, the binding of substrate (3-phosphoglycerate) to wild-type, E93D and R120,121Q enzym

295 In the presence of phosphate, 3-phosphoglycerate was a mixed inhibitor with respect to b

296 olites, pyruvate, phosphoenolpyruvate, and 2-phosphoglycerate were elevated in cortical cells after t

297 glycan cortex, but adenine nucleotides and 3-phosphoglycerate were not.

298 olytic pathway can bypass the formation of 3-phosphoglycerate, which is a precursor for serine biosyn

299 GAPDH catalyzes the formation of 1-arseno-3-phosphoglycerate, which is then extruded out of the cell

300 Lm iPGAM co-crystallised with the product 2-phosphoglycerate yields the same structure.