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1 ic binding to acidic phospholipids including phosphoinositides.
2 macological targeting of membrane-associated phosphoinositides.
3 CB is tethered to the membrane via phosphoinositides.
4 ion of its headgroup produces seven distinct phosphoinositides.
7 oughput virtual screening (HTVS) study using phosphoinositide 3-kinase (both PI3Kgamma and PI3Kdelta)
9 rain neuroblasts (NBs) in Drosophila utilize Phosphoinositide 3-kinase (PI3-kinase) and DE-cadherin t
11 led that platelet DREAM positively regulates phosphoinositide 3-kinase (PI3K) activity during platele
13 evels of phosphorylated Akt, an indicator of phosphoinositide 3-kinase (PI3K) activity, and decreased
14 (PTEN), a tumor suppressor that counteracts phosphoinositide 3-kinase (PI3K) activity, is one of the
15 fication or ligand overexpression maintained phosphoinositide 3-kinase (PI3K) and MEK/ERK signaling e
16 )/LYN complexes, which allows recruitment of phosphoinositide 3-kinase (PI3K) and phosphorylation of
19 ficient of SHP2 binding (PDGFRalpha-F720) or phosphoinositide 3-kinase (PI3K) binding (PDGFRalpha-F73
21 120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the trea
24 to the functions of the ubiquitous class IA phosphoinositide 3-kinase (PI3K) isoforms, p110alpha and
25 but not by AG1478, indicating that Gi/o and phosphoinositide 3-kinase (PI3K) mediate the increase in
30 ubtype frequently harbors aberrations in the phosphoinositide 3-kinase (PI3K) pathway, raising the po
35 Ralpha), produced in tumour cells, activates phosphoinositide 3-kinase (PI3K) signalling by binding t
36 d mGluR I subsequently induces activation of phosphoinositide 3-kinase (PI3K) through phosphorylation
38 tic signaling by the pre-TCR/Notch effector, phosphoinositide 3-kinase (PI3K), and by inositol-trisph
39 of mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), and interferon regulat
40 ncover the role of Vps34, the sole class III phosphoinositide 3-kinase (PI3K), in megakaryocytes (MKs
42 inase 1 (PDK1) is a pivotal regulator in the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway t
43 bly, nearly all KRAS deficient cells exhibit phosphoinositide 3-kinase (PI3K)-dependent mitogen-activ
45 iphosphate at the plasma membrane to enhance phosphoinositide 3-kinase (PI3K)-dependent tumor cell in
46 red systolic contractility and activated the phosphoinositide 3-kinase (PI3K)-pathway in the heart.
48 tly contributes to activating the consequent phosphoinositide 3-kinase (PI3K)/Akt signaling pathway.
49 w that Ang1 induces ERG phosphorylation in a phosphoinositide 3-kinase (PI3K)/Akt-dependent manner, r
50 n the liver, a process mediated by the IL-23/phosphoinositide 3-kinase (PI3K)/mammalian target of rap
51 activities of bone morphogenetic protein and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)
54 rmacologic targeting of the gamma isoform of phosphoinositide 3-kinase (PI3Kgamma), highly expressed
57 subtype that showed increased sensitivity to phosphoinositide 3-kinase and fibroblast growth factor r
58 ifloxacin, an IKr blocker with no effects on phosphoinositide 3-kinase and INa-L prolonged APD acutel
64 n-of-function variants in the genes encoding phosphoinositide 3-kinase delta (PI3Kdelta) lead to accu
68 as independent of the regulatory function of phosphoinositide 3-kinase in mediating the metabolic act
69 cted findings cast doubt over the utility of phosphoinositide 3-kinase inhibition in acute respirator
70 to include time and INa-L in evaluating the phosphoinositide 3-kinase inhibition-derived proarrhythm
73 location biosensor for signaling through the phosphoinositide 3-kinase pathway, along with a cytosoli
74 either mitogen-activated protein kinases or phosphoinositide 3-kinase prevented the MP-induced endot
78 e findings further support engagement of the phosphoinositide 3-kinase-AKT signaling axis by H-Ras.
80 Here, we studied the function of class II phosphoinositide 3-kinase-C2alpha (PI3K-C2alpha) in rena
82 estin-1 to the plasma membrane, and promoted phosphoinositide 3-kinase-dependent activation of protei
84 enhances the glycine-activated current in a phosphoinositide 3-kinase-dependent manner, a positive f
85 tion of the 5' to 3' exonuclease EXO1 by the phosphoinositide 3-kinase-like kinases ATM (ataxia telan
86 ghly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family a
91 s/extracellular signal-regulated kinase 1/2, phosphoinositide 3-kinase/AKT and signal transducer and
92 ha (HIF-1alpha) stabilization, including the phosphoinositide 3-kinase/Akt pathway, Siah1, and Siah2,
95 of HCK reduced survival and attenuated BTK, phosphoinositide 3-kinase/AKT, and mitogen-activated pro
98 In this study, we tested whether the dual phosphoinositide 3-kinase/mechanistic target of rapamyci
99 resulted in dose-dependent inhibition of the phosphoinositide 3-kinase/mechanistic target of rapamyci
101 Furthermore, LMP1 activated and triggered phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pa
102 ion, and invasion of Huh-7 cells through the phosphoinositide 3-kinase/protein kinase B pathway and i
103 through the aberrant expression of the TYRO3/phosphoinositide 3-kinase/protein kinase B signal transd
104 everal signal transduction pathways, such as phosphoinositide 3-kinase/protein kinase B, which are cr
105 inflammatory molecules and the activation of phosphoinositide 3-kinases (PI3K) in a process that requ
106 e elucidation of the biological functions of phosphoinositide 3-kinases (PI3K) was realized years ago
113 implications for cancer treatments targeting phosphoinositide 3-kinases and Akt because they may impa
115 fy a kinase-independent function of class II phosphoinositide 3-OH kinase alpha (PI3K-C2alpha) acting
117 e expansion phenotypes, and mutations in the phosphoinositide (3) phosphate kinase Fab1 that performs
121 f activated AKT owing to the deregulation of phosphoinositide-3 kinase (PI3K) signaling, and depletio
124 lated GRP78 then bound to VPS34, a class III phosphoinositide-3 kinase, consequently preventing the s
125 3-RAF1 aberrantly activate both the MAPK and phosphoinositide-3 kinase/mammalian target of rapamycin
126 tracellular signal-regulated kinase/RSK1 and phosphoinositide-3 kinase/mTOR pathway, which synergizes
129 a fly-human cross-species comparison of the phosphoinositide-3-kinase (PI3K) interactome in a drosop
130 a clear degenerating axons slowly due to low phosphoinositide-3-kinase (PI3K) signalling and, subsequ
131 holipase C (PLC), protein kinase C (PKC) and phosphoinositide-3-kinase (PI3K), and subsequently to ph
134 lls from patients treated with idelalisib, a phosphoinositide-3-kinase delta inhibitor recently appro
135 adding idelalisib, a first-in-class targeted phosphoinositide-3-kinase delta inhibitor, to bendamusti
137 on of the essential NMD effector UPF1 by the phosphoinositide-3-kinase-like kinase (PIKK) SMG-1 is a
138 ve been proposed, such as activations of the phosphoinositide-3-kinase/Akt pathway and p38 mitogen-ac
139 ating mutations in PIK3CA, the gene encoding phosphoinositide-(3)-kinase alpha (PI3Kalpha), are frequ
140 allografts (Fib-MCs) demonstrated increased phosphoinositide-3kinase (PI3K) dependent activation of
141 erse membrane cargo by the tubby domain in a phosphoinositide 4,5-bisphosphate (PI(4,5)P2)-dependent
142 congenital muscular dystrophies to defective phosphoinositide 5-phosphatase activity that is becoming
145 ivity that phosphorylates the 3'-hydroxyl of phosphoinositides and a protein-kinase activity that inc
147 latelets have reduced intracellular pools of phosphoinositides and an 80% reduction in IP3 generation
153 ors to obtain complexes of ion channels with phosphoinositides and to use computational and experimen
155 demonstrate that phospholipids, specifically phosphoinositides, are important regulators of TRPV1 and
160 rates that VACV H7 displays a novel fold for phosphoinositide binding, which is essential for poxviru
161 pamycin-resistant mutants, we identify Pib2 (PhosphoInositide-Binding 2) as a master regulator of TOR
162 t P4-ATPase Drs2, ATP8A2 is not regulated by phosphoinositides but undergoes phosphorylation on the s
163 Although Ca(2+) is known to directly impact phosphoinositide clustering, little is known about the m
164 tecting' sensors that selectively report the phosphoinositide composition of clathrin-associated stru
165 s a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane.
166 senger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comprises a huge field of biology.
167 demonstrate the possibility that switchable phosphoinositide conformational states can serve as lipi
171 ol 4,5-biphosphate (PIP2) is a cell membrane phosphoinositide crucial for cell signaling and activati
175 of sphingolipids, which in turn activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and m
176 olipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and m
177 rturb multiple signalling pathways including phosphoinositide-dependent cytosolic calcium ([Ca(2+) ]i
179 and the phosphatidylinositol 3-kinase (PI3K)/phosphoinositide-dependent kinase 1 (PDK1) pathway.
182 5 min of training, in which phosphorylated 3-phosphoinositide-dependent kinase-1 (p-PDK1) is increase
184 n of PIK3CA-driven HNSCC is facilitated by 3-phosphoinositide-dependent protein kinase (PDK1) and enh
187 volves formation of a protein complex with 3-phosphoinositide-dependent protein kinase 1 (PDK1).
188 sis or transfection of active Akt1 or Pdpk1 (phosphoinositide-dependent protein kinase 1 ) augmented
189 ith alpha2M*, CS-GRP78 signaling activates 3-phosphoinositide-dependent protein kinase-1 (PDK1) to in
190 TIPE2 functioned as a local enhancer of phosphoinositide-dependent signaling and cytoskeleton re
192 comparison, CID spectra of {LGa2}(5+)-bound phosphoinositides generally resulted in fragment ions co
195 sed of kinases, GTPases, and lipids, such as phosphoinositides, helps to coordinate all of these proc
198 AR1 expression also enhanced agonist-induced phosphoinositide hydrolysis and endothelial barrier perm
201 keratinocytes depleted from WD repeat domain phosphoinositide interacting 1 or Unc-51 like autophagy
205 so caused a dramatic generalized decrease in phosphoinositide levels that was rescued by inositol sup
206 is gain-of-function activity shifts cellular phosphoinositide levels, hyperactivates the PI3K/Akt cel
207 Phosphatase and tensin homolog (PTEN) is a phosphoinositide lipid phosphatase and one of the most f
208 y of enzymes constituting a junction between phosphoinositide lipid signaling and the trans-membrane
209 cell-free system, we recently identified the phosphoinositide lipids (PIPs) phosphatidylinositol 3-ph
212 ne trafficking requires coordination between phosphoinositide lipids, Rab GTPases, and microtubule-ba
217 hosphocholine membranes doped with different phosphoinositides on silicon/silicon dioxide substrates
218 to nitrocellulose membranes immobilized with phosphoinositides or sulfatide, but not with cardiolipin
219 ng a new perspective on the function of this phosphoinositide phosphatase in health and development.
222 The biological relevance of most of these phosphoinositide phosphatases in acute myeloid leukemia
224 intensities obtained in positive ion-mode of phosphoinositide phosphates and phosphatidic acid bound
225 ons impaired phosphatase activity toward the phosphoinositide phosphatidylinositol (4,5)-bisphosphate
227 naling that functions to dephosphorylate the phosphoinositide phosphatidylinositol 3,4,5-trisphosphat
228 es the integral membrane protein ATP1A1, the phosphoinositide phosphatidylinositol-4,5-bisphosphate (
229 teracts with a plasma membrane (PM)-specific phosphoinositide, phosphatidylinositol-(4,5)-bisphosphat
230 i trigger a signaling cascade culminating in phosphoinositide-phospholipase C (PLC) activation, which
231 mobile G-actin pool in spines depends on the phosphoinositide PI(3,4,5)P3 and involves the actin mono
232 Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger al
233 functionally regulated by hydrolysis of the phosphoinositide PI(4,5)P2 and changes in the level of p
238 astating pediatric neuromuscular disorder of phosphoinositide (PIP) metabolism resulting from mutatio
243 s4P during phagocytosis and suggest that the phosphoinositide plays important roles during the matura
244 SopE and SopB target MYO6 to coordinate phosphoinositide production at invasion foci, facilitati
247 pids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of
248 tic variation affects expression of VAC14, a phosphoinositide-regulating protein, to influence suscep
250 n assembly factors Dia2 and N-WASP reside on phosphoinositide-rich membranes for longer periods to pe
251 ay transient, low-affinity interactions with phosphoinositide-rich membranes, whereas F-actin assembl
254 tion are currently known: (i) binding of the phosphoinositide second messenger PIP3, (ii) binding of
257 nally, in eukaryotes, the negatively charged phosphoinositides serve as key signals not only through
258 al point of convergence between Hedgehog and phosphoinositide signaling at cilia that maintains TZ fu
259 and PIP kinases serve as a proximal node in phosphoinositide signaling axis and how its interaction
260 des (e.g. mTORC1) dominates the landscape of phosphoinositide signaling axis in cancer research.
266 demonstrate that platelet PITPalpha-mediated phosphoinositide signaling is inconsequential for in viv
267 data suggest a general principle for how the phosphoinositide signaling landscape is physically bit m
270 and talin together control the adhesion and phosphoinositide signaling that regulates conversion to
271 that hijack the host actin cytoskeleton and phosphoinositide signaling to drive pathogen invasion.
272 microtubule and actin cytoskeletal dynamics, phosphoinositide signaling, clathrin-mediated endocytosi
276 w that FplA binds with high affinity to host phosphoinositide-signaling lipids, revealing a potential
277 to and from the plasma membrane, as well as phosphoinositide signalling and cholesterol homeostasis.
278 l(-) regulates the organization of the major phosphoinositide species PtdIns(4,5)P2 into microdomains
279 ain to properly bind lipids depending on the phosphoinositide species with a preference for phosphati
283 V120027 promotes the recruitment of TRPC3 or phosphoinositide-specific phospholipase C (PLCgamma) to
284 ng differentiation in the cellular levels of phosphoinositide-specific phospholipase Cbeta (PLCbeta)
285 , the pleckstrin homology domain of Cb binds phosphoinositides, specifically phosphatidylinositol 3-p
288 -bisphosphate (PtdIns(3,5)P2), whereas other phosphoinositides such as PtdIns(4,5)P2, which is enrich
290 odia typically harbor higher densities of 3' phosphoinositides than adjacent regions at the cell peri
292 mino acid residues and acidic lipids such as phosphoinositides that play a primary role in these inte
293 E complex formation and its interaction with phosphoinositides, the function of Syx's polybasic juxta
294 ct as a cellular sensor and controller of PM phosphoinositides, thereby influencing many PM processes
295 on the membrane phospholipids, including the phosphoinositides, to form the proinflammatory arachidon
296 Thus, the leukocyte polarizer is a dual-role phosphoinositide-transfer protein and represents a poten
297 ar3 silencing causes apoptosis, triggered by phosphoinositide trisphosphate depletion and decreased A
298 bition by muscarinic receptors that increase phosphoinositide turnover in neurons is enhanced in Kcnq
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