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1 cloning and was found to encode a Sac1p-like phosphoinositide phosphatase.
2 mechanism uncovered INP53, a gene encoding a phosphoinositide phosphatase.
3 II secreted Salmonella effector protein with phosphoinositide phosphatase activity and a distinct GTP
5 ty protein phosphatase and also possesses D3-phosphoinositide phosphatase activity on phosphatidylino
6 re, we show that SopB/SigD, an effector with phosphoinositide phosphatase activity, has anti-apoptoti
7 c1 proteins individually defective in either phosphoinositide phosphatase activity, or in recycling o
10 , we addressed the reverse process driven by phosphoinositide phosphatases and uncovered a key negati
11 ng enzymes, including phospholipase C (PLC), phosphoinositide phosphatase, and diacylglycerol (DAG) k
12 enzymes involved in PIP metabolism--Sac1p, a phosphoinositide phosphatase, and Vps34p and Pik1p, a PI
13 al that the main domains of VSPs and related phosphoinositide phosphatases are intrinsically modular
14 have previously identified synaptojanin 2, a phosphoinositide phosphatase, as an effector of Rac1.
15 (mtm), a Drosophila melanogaster MTM1/MTMR2 phosphoinositide phosphatase, as necessary and sufficien
16 ase (PLIP), which defines a new subfamily of phosphoinositide phosphatases clearly distinct from PTEN
17 Salmonella recruited ARNO via Arf6 and the phosphoinositide phosphatase effector SopB-induced PIP3
20 tested the hypothesis that synaptojanin 1, a phosphoinositide phosphatase implicated in the endocytos
21 ng a new perspective on the function of this phosphoinositide phosphatase in health and development.
23 The biological relevance of most of these phosphoinositide phosphatases in acute myeloid leukemia
24 family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically ina
25 ddition to recombinant versions of the Sac1p phosphoinositide-phosphatase indicated that PI(4)P was r
27 ns that lack expression of synaptojanin 1, a phosphoinositide phosphatase involved in clathrin-coated
30 hosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein co
33 egatively targeting the tumor suppressor and phosphoinositide phosphatase PTEN (phosphatase and tensi
34 gand found within the C-terminal tail of the phosphoinositide phosphatase PTEN revealed two discrete
35 we describe a defect in expression of the D3 phosphoinositide phosphatase, PTEN, in Jurkat and JTAg T
38 functions between Sac1p and other homologous phosphoinositide phosphatases, sac1(ts) mutant cells lac
41 and gene ablation in mice suggested that two phosphoinositide phosphatases, SH2 domain-containing ino
43 s required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key reg
44 philin also binds the GTPase dynamin and the phosphoinositide phosphatase synaptojanin and is thought
45 ially suppressed by removing one copy of the phosphoinositide phosphatase synaptojanin, suggesting a
46 g diameters, we show that the major synaptic phosphoinositide phosphatase, synaptojanin 1 (Synj1), ac
51 EN suppresses tumor formation by acting as a phosphoinositide phosphatase to limit signaling by phosp
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