ライフサイエンスコーパス: phospholipase A

1 is an acyl hydrolase, rather than a specific phospholipase A.

2 Trypanosoma brucei phospholipase A(1) (TbPLA(1)) is unique from previously

3 Phospholipase A(1) activities have been detected in most

4 2)delta stands out as having relatively high phospholipase A(1) activity.

5 idosis, which is caused by the inhibition of phospholipase A(1) activity.

6 e also demonstrated that sertraline inhibits phospholipase A(1) and phospholipase D, exhibits mixed e

7 by protect the lipids from being degraded by phospholipase A(1) rather than inhibiting the enzyme.

8 The lysophospholipase, phospholipase A(1), and phospholipase A(2) activities of

9 of the cobra venom (Naja naja naja) group IA phospholipase A 2 (GIA PLA 2) was carried out in the pre

10 Pig pancreatic IB phospholipase A 2 (PLA2) forms three distinguishable pre

11 At 1 year, an allograft biopsy showed phospholipase A 2 receptor-negative membranous nephropat

12 Among the phospholipases A 2 (PLA 2s) are the group VI Ca (2+)-ind

13 Adipose phospholipase A(2) (AdPLA or Group XVI PLA(2)) plays an

14 are responsible for this response: cytosolic phospholipase A(2) (cPLA(2)) and diacylglycerol lipase;

15 Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central molecule in NK

16 e present work, we have identified cytosolic phospholipase A(2) (cPLA(2)) as an effector molecule of

17 C), catalyzed by the activation of cytosolic phospholipase A(2) (cPLA(2)) in the PPT1-KO mouse brain,

18 lation by Ang II was attenuated by cytosolic phospholipase A(2) (cPLA(2)) inhibitor pyrrolidine-1 and

19 Cytosolic phospholipase A(2) (cPLA(2)) is a key enzyme in the gene

20 a cAMP-independent mechanism, i.e. cytosolic phospholipase A(2) (cPLA(2)) signalling.

21 5LO interacts with the membranous cytosolic phospholipase A(2) (cPLA(2)) to produce leukotriene B(4)

22 he receptor-mediated activation of cytosolic phospholipase A(2) (cPLA(2)) with isotetrandrine reduces

23 creasing cholesterol, activating cytoplasmic phospholipase A(2) (cPLA(2)), and triggering synapse dam

24 used RT-PCR to identify mRNAs for cytosolic phospholipase A(2) (cPLA(2)), COX-1, COX-2, 5-LOX, and 1

25 anes and increased activation of cytoplasmic phospholipase A(2) (cPLA(2)).

26 eta oligomers activated synaptic cytoplasmic phospholipase A(2) (cPLA(2)).

27 e reported that mice deficient for cytosolic phospholipase A(2) (cPLA(2)-KO) are protected against th

28 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) catalyzes release of a

29 Although group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) has been reported to b

30 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) initiates eicosanoid p

31 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) is regulated by phosph

32 at mediate activation of group IVA cytosolic phospholipase A(2) (cPLA(2)alpha), a regulatory enzyme t

33 y the interaction of C2 domains of cytosolic phospholipase A(2) (cPLA(2)alpha-C2) with a Langmuir mon

34 The cytosolic (group IV) phospholipase A(2) (cPLA(2)s) family contains six member

35 phage encoding a previously unknown secreted phospholipase A(2) (designated SlaA) has been implicated

36 Highly cationic mammalian group IIA phospholipase A(2) (gIIA PLA(2)) kills S. aureus at nano

37 ed the inhibition mode of group IIA secreted phospholipase A(2) (GIIA sPLA(2)) selective inhibitors a

38 Inhibitors of the Group IVA phospholipase A(2) (GIVA cPLA(2)) and GVIA iPLA(2) are u

39 ncreased activity of the group IV isoform of phospholipase A(2) (GIVA-PLA(2)).

40 ated whether deficiency of group V secretory phospholipase A(2) (GV sPLA(2)) protects from experiment

41 The Group VIA-2 Ca(2+)-independent phospholipase A(2) (GVIA-2 iPLA(2)) is composed of seven

42 In particular, the Group VIA phospholipase A(2) (GVIA-iPLA(2)) subfamily of enzymes f

43 ned the mechanism by which secretory group V phospholipase A(2) (gVPLA(2)) secreted from stimulated e

44 with targeted deletion of group X secretory phospholipase A(2) (GX KO).

45 ies in vitro indicate that group X secretory phospholipase A(2) (GX sPLA(2)) potently releases arachi

46 he X-ray structure of human group X secreted phospholipase A(2) (hGX), we carried out structure-based

47 f inhibition of group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)) by fluoroketone (FK) ligand

48 Group VI Ca(2)(+)-independent phospholipase A(2) (iPLA(2)) is a water-soluble enzyme t

49 d others have shown that calcium-independent phospholipase A(2) (iPLA(2)) is involved in epithelial o

50 uced an increase of both calcium-independent phospholipase A(2) (iPLA(2)) mRNA and iPLA(2) activity i

51 Calcium-independent phospholipase A(2) (iPLA(2)) plays a pivotal role in pho

52 sults in activation of a calcium-independent phospholipase A(2) (iPLA(2)), and this leads to arachido

53 LSS [an inhibitor of the calcium-independent phospholipase A(2) (iPLA(2))] and AACOCF(3) [an inhibito

54 molecular biologic manipulation of Group VIA phospholipase A(2) (iPLA(2)beta) activity in pancreatic

55 Group VIA phospholipase A(2) (iPLA(2)beta) hydrolyzes beta-cell me

56 The Group VIA phospholipase A(2) (iPLA(2)beta) hydrolyzes glycerophosp

57 Group VIA phospholipase A(2) (iPLA(2)beta) in pancreatic islet bet

58 Group VIA phospholipase A(2) (iPLA(2)beta) is expressed in phagocy

59 Whether group VIA phospholipase A(2) (iPLA(2)beta) is involved in vascular

60 We reported that Group VIA phospholipase A(2) (iPLA(2)beta) is required for this re

61 is by a pathway involving Ca(2+)-independent phospholipase A(2) (iPLA(2)beta)-mediated ceramide gener

62 INS-1 cell apoptosis by a Ca(2+)-independent phospholipase A(2) (iPLA(2)beta)-mediated mechanism that

63 Increased lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity is associated wi

64 e prognostic value of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associated with high-dens

65 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been shown to be asso

66 AF-AH), also known as lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inactivates potent lipid

67 rapladib, a selective lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inhibitor, on biomarkers

68 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phosph

69 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a proinflammatory enzy

70 Elevated lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) may be positively associa

71 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) plays important roles in

72 sayed for activity of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a marker of inflammation

73 Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an inflammatory enzyme e

74 ted risk for elevated lipoprotein-associated phospholipase A(2) (Lp-PLA(2)).

75 o examine the role of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)/PLA2G7) in human inflammat

76 mouse alveolar macrophages release lysosomal phospholipase A(2) (LPLA(2)) into the medium of cultured

77 ndosomal compartments requires a cytoplasmic phospholipase A(2) (PLA(2)) activity.

78 soPC in vitro indicating that the enzyme has phospholipase A(2) (PLA(2)) activity.

79 rapidly lyses the intoxicated cells via its phospholipase A(2) (PLA(2)) activity.

80 R inhibited GABAergic IPSCs through both the phospholipase A(2) (PLA(2)) and cAMP/protein kinase A (P

81 The GIVA phospholipase A(2) (PLA(2)) contains two domains: a calc

82 ntain motifs that are highly homologous to a phospholipase A(2) (PLA(2)) domain and nuclear localizat

83 erminal half of ExoU contains a patatin-like phospholipase A(2) (PLA(2)) domain that requires the hos

84 Phospholipase A(2) (PLA(2)) enzymes become activated by

85 or their function, the membrane insertion of phospholipase A(2) (PLA(2)) enzymes has not been studied

86 Phospholipase A(2) (PLA(2)) has long been proposed to be

87 Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 position

88 iously reported a role for group V secretory phospholipase A(2) (PLA(2)) in regulating phagocytosis o

89 An analysis of group IVA (GIVA) phospholipase A(2) (PLA(2)) inhibitor binding was conduc

90 PLA(2), or with LY311727, a global secretory phospholipase A(2) (PLA(2)) inhibitor, attenuated the ac

91 CGG (rCGG) repeats, among them several known phospholipase A(2) (PLA(2)) inhibitors.

92 acetylhydrolase (PAFAH) Ib, comprised of two phospholipase A(2) (PLA(2)) subunits, alpha1 and alpha2,

93 The phospholipase A(2) (PLA(2)) superfamily consists of 16 g

94 branes and reduced activation of cytoplasmic phospholipase A(2) (PLA(2)), consistent with the hypothe

95 Using a fluorogenic substrate for phospholipase A(2) (PLA(2)), we observed an increased va

96 Eicosanoids produced after phospholipase A(2) (PLA(2))-catalyzed release of arachid

97 udy, we show that 1,25(OH)(2)D(3) stimulates phospholipase A(2) (PLA(2))-dependent rapid release of p

98 Phospholipase A(2) (PLA(2))-derived arachidonic acid (AA

99 We found that, among the three phospholipase A(2) (PLA(2))-regulated arachidonic acid (

100 atty acid, probably arachidonic acid (AA) by phospholipase A(2) (PLA(2)).

101 an enzymatic product of autotaxin (ATX) and phospholipase A(2) (PLA(2))enzymes.

102 Recently, PEDF-R (TTS-2.2/independent phospholipase A(2) (PLA(2))zeta and mouse desnutrin/ATGL

103 Group IValpha phospholipase A(2) (PLA(2)IValpha) is a lipolytic enzyme

104 ytes, whereas expression of adipose-specific phospholipase A(2) (pla2g16) was unchanged.

105 This study used group 1B phospholipase A(2) (Pla2g1b)-deficient mice, which are r

106 Female mice lacking group IVA phospholipase A(2) (Pla2g4a(-/-)) have a smaller litter

107 Some isoforms of secretory phospholipase A(2) (sPLA(2)) distinguish between healthy

108 Although individual mammalian secreted phospholipase A(2) (sPLA(2)) enzymes exhibit unique tiss

109 Secretory phospholipase A(2) (sPLA(2)) enzymes, produced and secre

110 Recently, a secreted phospholipase A(2) (sPLA(2)) motif was identified in the

111 have previously shown that group V secretory phospholipase A(2) (sPLA(2)) regulates phagocytosis of z

112 Secretory phospholipase A(2) (sPLA(2)) represents a family of proa

113 The ability of secretory phospholipase A(2) (sPLA(2)) to hydrolyze cell membranes

114 Secretory phospholipase A(2) (sPLA(2)) type IIa, elevated in infla

115 Conversely, overexpression of GX secretory phospholipase A(2) (sPLA(2)), but not a catalytically in

116 ly resist the hydrolytic action of secretory phospholipase A(2) (sPLA(2)), they become susceptible du

117 ce by phagocytes and hydrolysis by secretory phospholipase A(2) (sPLA(2)).

118 them susceptible to hydrolysis by secretory phospholipase A(2) (sPLA(2)).

119 he endothelially expressed secretory group V phospholipase A(2) (sPLA(2)-V).

120 We have shown that group VIA phospholipase A(2) [calcium-independent phospholipase A(

121 ture, whereas the addition of surfactants or phospholipase A(2) activation increases the outer monola

122 The results suggest that cytosolic phospholipase A(2) activation triggered by the beta-gluc

123 dose-dependently inhibited platelet Nox2 and phospholipase A(2) activation, along with inhibition of

124 Upstream, MAPK-p38 mediates cytosolic phospholipase A(2) activation, which is required for PPA

125 e lysophospholipase, phospholipase A(1), and phospholipase A(2) activities of the full set of mammali

126 it both monoacylglycerol acyltransferase and phospholipase A(2) activities.

127 noacylglycerol acyltransferase and increased phospholipase A(2) activities.

128 operoxidase mass, and lipoprotein-associated phospholipase A(2) activity and association with CAD eve

129 of 22:6 FA in phospholipids suggests altered phospholipase A(2) activity and changes in membrane dyna

130 oubled) by the highest tertiles of secretory phospholipase A(2) activity and mass but less so for mye

131 associated with the inhibition of cytosolic phospholipase A(2) activity and the PI3K/ERK/NF-kappaB p

132 Kinetic characterization of bee venom phospholipase A(2) activity at bile salt+phospholipid ag

133 antly, PEDF binding stimulates the enzymatic phospholipase A(2) activity of PEDF-R.

134 Phospholipase A(2) activity plays key roles in generatin

135 high binding affinity for PEDF, has a potent phospholipase A(2) activity that liberates fatty acids,

136 r myeloperoxidase and lipoprotein-associated phospholipase A(2) activity.

137 and seem to be independent of its effect on phospholipase A(2) activity.

138 oth a monoacylglycerol acyltransferase and a phospholipase A(2) activity.

139 t is postulated that inhibition of cytosolic phospholipase A(2) alpha (cPLA(2)alpha) can reduce sever

140 arachidonic acid-generating enzyme cytosolic phospholipase A(2) alpha (cPLA(2)alpha) has been implica

141 Cytosolic phospholipase A(2) alpha (cPLA(2)alpha, type IVA phospho

142 associated augmentation of ERK1/2, cytosolic phospholipase A(2) alpha, and cysteinyl-leukotriene synt

143 Phosphorylation of ERK1/2 and cytosolic phospholipase A(2) alpha, known to enhance the release o

144 essary to generate hepoxilin A(3), including phospholipase A(2) and 12-lipoxygenase, potently interfe

145 Arachidonic acid is released by phospholipase A(2) and converted into hundreds of distin

146 Inhibitors of phospholipase A(2) and cytochrome P450 epoxygenase atten

147 at inhibition of the overexpressed secretory phospholipase A(2) and cytosolic phospholipase A(2) duri

148 of phospholipase A(2) isoenzymes, secretory phospholipase A(2) and cytosolic phospholipase A(2), are

149 MAPK-activated c-Src subsequent to cytosolic phospholipase A(2) and generation of AA metabolites via

150 for signaling cross talk between a secreted phospholipase A(2) and the BMP/transforming growth facto

151 Platelet phospholipase A(2) and thromboxane A(2) significantly de

152 n-activated protein kinase (MAPK), cytosolic phospholipase A(2) and urokinase type plasminogen activa

153 The Group IVA (GIVA) phospholipase A(2) associates with natural membranes in

154 functional inhibition of Ca(2+)-independent phospholipase A(2) beta (iPLA(2)beta or PLA2g6A), or dep

155 A supplementation on membrane incorporation, phospholipase A(2) catalyzed release, and eicosanoid pro

156 spholipase A(2)-alpha and group IIA secreted phospholipase A(2) contribute to arachidonate release fr

157 n the enzymatic activity of the patatin-like phospholipase A(2) domain localized to the N-terminal ha

158 d secretory phospholipase A(2) and cytosolic phospholipase A(2) during sepsis benefits the disease's

159 Phospholipase A(2) enzymes hydrolyze phospholipids to li

160 hospholipase, designated calcium-independent phospholipase A(2) gamma (iPLA(2)gamma), which possesses

161 rload caused overexpression and secretion of phospholipase A(2) group IIA (pla2g2a) from immune cells

162 Secreted phospholipase A(2) group X (sPLA(2)-X) has recently been

163 Phospholipase A(2) has been implicated to play a pivotal

164 te that antisense strategy against secretory phospholipase A(2) IIa and cytosolic phospholipase A(2)

165 s is mediated by the activation of cytosolic phospholipase A(2) in resident peritoneal macrophages, w

166 Results with highly specific and potent phospholipase A(2) inhibitors and with small interfering

167 Using the GIVA phospholipase A(2) irreversible inhibitor methyl-arachid

168 The mitochondrial Ca(2+)-independent phospholipase A(2) is activated during energy-dependent

169 Cytosolic phospholipase A(2) is activated during phagocytosis, rel

170 of arachidonate release, group IIA secreted phospholipase A(2) is induced (detected at the mRNA and

171 ent of sepsis by targeting multiple forms of phospholipase A(2) isoenzymes with DNA antisense oligome

172 The two major forms of phospholipase A(2) isoenzymes, secretory phospholipase A

173 cretory phospholipase A(2) IIa and cytosolic phospholipase A(2) IVa can inhibit their target protein

174 ipase A2 IIa and the other against cytosolic phospholipase A(2) IVa) (Group 4) increased the median s

175 oteins, the mitochondrial Ca(2+)-independent phospholipase A(2) may be an important factor governing

176 e membrane, we have shown that the action of phospholipase A(2) on acyl-based phospholipids triggers

177 one and oligomycin, but not by the cytosolic phospholipase A(2) or xanthine oxidase inhibitors.

178 PI3K/Btk pathway does not regulate cytosolic phospholipase A(2) phosphorylation but rather appears to

179 tofluorescence findings suggest that group V phospholipase A(2) plays a role in the phagocytosis of p

180 Sustained activity of the Ca(2+)-independent phospholipase A(2) promotes rupture of the outer mitocho

181 Autoantibodies to the M-type phospholipase A(2) receptor (PLA(2)R) are sensitive and

182 The phospholipase A(2) receptor (PLA(2)R) is the major targe

183 he reactive protein band detected the M-type phospholipase A(2) receptor (PLA(2)R).

184 opathy with fine granular co-localization of Phospholipase A(2) receptor and IgG evident on transplan

185 f idiopathic disease is associated with anti-Phospholipase A(2) receptor autoantibodies.

186 nd elevated circulating levels of serum anti-Phospholipase A(2) receptor autoantibody that declined o

187 membranous nephropathy with circulating anti-Phospholipase A(2) receptor autoantibody, which supports

188 This is a very early case of Phospholipase A(2) receptor-associated recurrent membran

189 holipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing cha

190 erated channels, and the calcium-independent phospholipase A(2) that activates these channels were re

191 poptosis because overexpression of PAFAH2 (a phospholipase A(2) that selectively hydrolyzes truncated

192 asured in bovine RPE was highly sensitive to phospholipase A(2) treatment, but the observed decline i

193 Their relationship to secretory phospholipase A(2) type IIA mass and activity, myelopero

194 acrophages have long been known to secrete a Phospholipase A(2) with an acidic pH optimum in response

195 t-activating factor (PAF) acetylhydrolase, a phospholipase A(2) with selectivity for acetyl residues

196 e four most abundant proteins (disintegrins, phospholipase A(2)'s, serine proteinases, and snake veno

197 Higher lipoprotein-associated phospholipase A(2)(Lp-PLA2) activity is associated with

198 Phospholipase A(2)(PLA(2)) enzymes are considered the pr

199 e encoding a secreted phospholipase (group V phospholipase A(2)).

200 PLA(2) that we named AdPLA (adipose-specific phospholipase A(2)).

201 d S. flexneri activate different subtypes of phospholipase A(2), a critical enzyme involved in the li

202 Group X (GX) phospholipase A(2), a member of a large group of secrete

203 role of the newly identified major adipocyte phospholipase A(2), AdPLA (encoded by Pla2g16, also call

204 PGLYRPs and antibacterial peptides (phospholipase A(2), alpha- and beta-defensins, and bacte

205 lipid classes suggests increased activity of phospholipase A(2), an enzyme that has been implicated i

206 tes LPA from CHO cells primed with bee venom phospholipase A(2), and ATX-mediated LPA production is e

207 endent phospholipase A(2), calcium-dependent phospholipase A(2), and phospholipase D activities, but

208 , secretory phospholipase A(2) and cytosolic phospholipase A(2), are overexpressed during sepsis.

209 released from the membrane by the action of phospholipase A(2), are potent lipid mediators of the in

210 RGM1 cells also express group XIIA secreted phospholipase A(2), but this enzyme is not regulated by

211 soforms of bradykinin-potentiating peptides, phospholipase A(2), C-type lectins, serine proteinases a

212 ation is known to induce calcium-independent phospholipase A(2), calcium-dependent phospholipase A(2)

213 ptosis is often accompanied by activation of phospholipase A(2), causing release of free fatty acids

214 ong up-regulation of expression of secretory phospholipase A(2), group IIA (sPLA(2)) was identified.

215 n of the gene encoding a calcium-independent phospholipase A(2), iPLA2-VIA, which also prevents cardi

216 reases the levels of mRNA encoding cytosolic phospholipase A(2), LTA(4) hydrolase, and 5-LO-activatin

217 ration and survival, activation of cytosolic phospholipase A(2), mast cell degranulation, and phagocy

218 l being activated by a downstream product of phospholipase A(2), relegating mechanosensitivity to the

219 cellular Ca(2+) release, protein kinase C or phospholipase A(2), suggesting a direct coupling between

220 the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus liberating arachidonic acid, wh

221 stimulated phosphoprotein, nitric oxide, and phospholipase A(2), were determined at baseline and afte

222 s suppress COX-2 expression while activating phospholipase A(2), which enhances AA levels by hydrolys

223 se effects are recapitulated with pancreatic phospholipase A(2), which hydrolyses the release of memb

224 anosporum ortholog, is a self-processing pro-phospholipase A(2), whose phospholipase activity increas

225 In contrast, the synapse damage induced by a phospholipase A(2)-activating peptide was independent of

226 th small interfering RNA show that cytosolic phospholipase A(2)-alpha and group IIA secreted phosphol

227 protein levels), and the action of cytosolic phospholipase A(2)-alpha is required for this induction.

228 nt prospective analysis identified secretory phospholipase A(2)-IIa (sPLA(2)IIa) as a coronary artery

229 PLOOH peroxidase nor hydrolase and that the phospholipase A(2)-like activity previously attributed t

230 f protein synthesis and priming for enhanced phospholipase A(2)-mediated eicosanoid production work t

231 sults with RGM1 cells and group IIA secreted phospholipase A(2)-transfected HEK293 cells show that th

232 ed effects on phospholipase C, and activates phospholipase A(2).

233 ies identify LPLA(2) as a high m.w.-secreted Phospholipase A(2).

234 evealed a gene with homology to patatin-like phospholipase A(2).

235 c exotoxin A, Mac protein, and streptococcal phospholipase A(2).

236 lcholine externally or by generating it with phospholipase A(2).

237 (AA) from cellular membranes by cytoplasmic phospholipase A(2)alpha (cPLA(2)alpha) and contributes t

238 p44/42(ERK1/2) or inactivation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha) completely inhibi

239 We have previously shown that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contributes to E.

240 he first direct evidence that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contributes to ty

241 In the vascular endothelium, group IV phospholipase A(2)alpha (cPLA(2)alpha) enzyme activity i

242 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the rate-limit

243 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the rate-limit

244 and specific activator of group IV cytosolic phospholipase A(2)alpha (cPLA(2)alpha) via interaction w

245 lso induced the phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), a key enzyme tha

246 ion of Smad and phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), a rate-limiting

247 esis proximal to the activation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), the initial rate

248 host signaling molecules including cytosolic phospholipase A(2)alpha (cPLA(2)alpha).

249 in concert with 5-lipoxygenase and cytosolic phospholipase A(2)alpha activation.

250 principal splice variant of human cytosolic phospholipase A(2)beta (cPLA(2)beta) (also known as Grou

251 Here we report that calcium-independent phospholipase A(2)beta (iPLA(2)beta) is required for hig

252 VIA phospholipase A(2) [calcium-independent phospholipase A(2)beta (iPLA(2)beta)] is important in re

253 trate that mice null for calcium-independent phospholipase A(2)gamma (iPLA(2)gamma(-/-)) are complete

254 Calcium-independent phospholipase A(2)gamma (iPLA(2)gamma) (PNPLA8) is the p

255 ein, we demonstrate that calcium-independent phospholipase A(2)gamma (iPLA(2)gamma) is a critical mec

256 Genetic ablation of calcium-independent phospholipase A(2)gamma (iPLA(2)gamma) results in profou

257 ling pathways, including calcium-independent phospholipase A(2)gamma (iPLA(2)gamma), and mitogen-acti

258 ent eicosanoid biosynthesis is controlled by phospholipase A(2)s (PLA(2)s), most notably cytosolic PL

259 Secretory phospholipase A(2)s (sPLA(2)) hydrolyze glycerophospholi

260 generated by one or more calcium-independent phospholipases A(2) (iPLA(2)s) participate in the regula

261 Phospholipases A(2) (PLA(2)) hydrolyze the sn-2 fatty ac

262 Phospholipases A(2) (PLA(2)s) catalyze hydrolysis of fat

263 The mechanisms by which secretory phospholipases A(2) (PLA(2)s) exert cellular effects are

264 The secreted phospholipases A(2) (sPLA(2)s) comprise a family of smal

265 A(2), a member of a large group of secreted phospholipases A(2) (sPLA(2)s), has recently been demons

266 s of the fungal/bacterial group XIV secreted phospholipases A(2) (sPLA(2)s).

267 (2+) flux and activation of Ca(2+)-dependent phospholipases A(2) that cycle polyunsaturated FA into p

268 The other eight secreted phospholipases A(2) were not detected in RGM1 cells at t

269 y show that cytosolic and group IIA secreted phospholipases A(2) work together to liberate arachidona

270 characterization lags far behind that of the phospholipases A(2), C and D.

271 eal epithelial (HCE) cells via the cytosolic phospholipase A(2alpha) (cPLA(2alpha)) pathway.

272 We describe mycobacterial phospholipase A activity (MPLA) and, using reverse genet

273 Both cytotoxicity and phospholipase A activity associated with RT0522 were red

274 emonstrate that recombinant RT0522 possesses phospholipase A activity that requires a eukaryotic host

275 tified from Rickettsia typhi with functional phospholipase A activity.

276 s of RT0522 also eliminates cytotoxicity and phospholipase A activity.

277 for phosphatidyl-based substrate binding and phospholipase A activity.

278 es an essential enzyme with thioesterase and phospholipase A activity.

279 The effects of the sphingolipids on the phospholipase A and cholesterol esterification reactions

280 ed with and without ATP, ATP inhibitors, and phospholipase-A and -C inhibitors.

281 ading frames that are predicted to contain a phospholipase A domain with sequence similarity to the t

282 f genes encoding 13-lipoxygenases (LOXs) and phospholipase A-Igamma3 (At1g51440), a plastid lipase wi

283 ure the DeltaG(o)(w,l) of the outer membrane phospholipase A into large unilamellar vesicles (LUVs) o

284 Outer membrane phospholipase A (OMPLA) is a unique, integral membrane e

285 Outer membrane phospholipase A (OMPLA) is a widely conserved transmembr

286 In Gram-negative bacteria, outer membrane phospholipase A (OmpLA) is involved in outer-membrane li

287 smembrane beta-barrel protein outer membrane phospholipase A (OMPLA) revealed an intermolecular hydro

288 tinized the unfolded state of outer-membrane phospholipase A (OmpLA) to provide a detailed view of it

289 cA gene product (PagP), OmpT, outer membrane phospholipase A (OmpLa), the fadl gene product (FadL), t

290 those parameters for E. coli outer membrane phospholipase A (OmpLA).

291 r interface of beta-barrel MP outer membrane phospholipase A (OMPLA).

292 er phosphodiesterases and three patatin-like phospholipases A on the transcriptome level.

293 hrome groups, are usually employed to screen phospholipase A (PLA) activities.

294 chniques, we discover that ACT has intrinsic phospholipase A (PLA) activity, and that such activity d

295 homologue of the Pseudomonas aeruginosa ExoU phospholipase A (PLA) secreted cytotoxin.

296 spholipases, including at least 15 different phospholipases A (PLA).

297 secreted by Legionella pneumophila, such as phospholipases A (PLAs) and glycerophospholipid:choleste

298 The patatin-related phospholipase A (pPLA) hydrolyzes membrane glycerolipids

299 d that the dominant mlaA* mutation activates phospholipase A, resulting in increased levels of lipopo

300 se (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003).