1 r PtdIns(4,5)P2, by tagging the PH domain of phospholipase C delta 1 (PLC-delta 1) with the green flu

2 ition by the default PI(4,5)P2 lipid sensor, phospholipase C delta 1 pleckstrin homology domain (PLC

3                       The 2.4-A structure of phospholipase C delta 1 reveals a multidomain protein in

4 ies, which encodes phosphoinositide-specific phospholipase C delta 1 subunit, a key enzyme in phospho

5 raction of the pleckstrin homology domain of phospholipase C delta 1 with PtdIns(4,5)2 combined with

6 te [PI(4,5)P2] hydrolysis catalyzed by human phospholipase C-delta 1 (PLC-delta 1) in model membranes

7                          Here we report that phospholipase C-delta(1) accumulates in the nucleus at t

8 cell cycle-dependent compartmentalization of phospholipase C-delta(1) and support the idea that relat

9                                          The phospholipase C-delta(1) PH domain shows a 10-fold prefe

10   Like certain PH domains (such as that from phospholipase C-delta(1)), the Hrs-1 FYVE domain specifi

11 ion within the pleckstrin homology domain of phospholipase C-delta(1), which disables high affinity p

12 (-1)) than the pleckstrin homology domain of phospholipase C-delta (13 s(-1)).

13  X-ray crystal structure of the C2 domain of phospholipase-C-delta and phylogenetic analysis clarifie

14 rance of the PI(4,5)P2-specific PH domain PH-phospholipase C delta-EGFP at the PM after Ca(2+) ionoph

15  a knockout of the plc-4 gene, which encodes phospholipase C-delta in C. elegans, and demonstrated th

16 o structural information now available for a phospholipase C delta isozyme.

17 ogy (PH)-green fluorescent protein (GFP) and phospholipase C delta (PLC delta)-PH-GFP both first conc

18  marginally changed the dissociation rate of phospholipase C-delta, suggesting that additional electr