ライフサイエンスコーパス: phospholipase D

1 ost typically with Streptomyces chromofuscus phospholipase D.

2 ctivation of phosphoinositide hydrolysis and phospholipase D.

3 elial cells requires activation of host-cell phospholipase D.

4 ector of Ras is the lipid hydrolyzing enzyme phospholipase D.

5 n requires an intact copy of SPO14, encoding phospholipase D.

6 biosynthetic enzymes, N-acyltransferase and phospholipase D.

7 ving the interaction between aquaporin 3 and phospholipase D.

8 y accessible to its periplasmic, PC-specific phospholipase D.

9 tudy, we set out to test the hypotheses that phospholipase D 1 (PLD1) is an upstream regulator of mTO

10 Phospholipase D 1, a PA-generating enzyme that is an est

11 Inhibitors of phospholipase D (1-butanol and a dominant negative const

12 abolism of phosphatidic acid, the product of phospholipase D(2), and gangliosides, and point to a cen

13 Finally, genetic ablation of phospholipase D(2), which rescues the synaptic and behav

14 The kinetics of bombesin-induced phospholipase D activation and LPA production were simil

15 ontrast, neither transactivation of RhoA nor phospholipase D activation was detected in cells express

16 Phospholipase D activation was measured in primary cultu

17 of the small G-protein RhoA is required for phospholipase D activation.

18 from G(13) heterotrimers are responsible for phospholipase D activation.

19 ), calcium-dependent phospholipase A(2), and phospholipase D activities, but inhibition of these enzy

20 ease in AEA levels and N-acyltransferase and phospholipase D activities.

21 nd coat proteins as well as in regulation of phospholipase D activity and cytoskeleton modifications.

22 The effects of phospholipase D activity and its product phosphatidic ac

23 Both phospholipase D activity and vesicular trafficking were

24 nt phosphatidylcholine reveal a low level of phospholipase D activity associated with cortical vesicl

25 Recent studies have revealed that elevated phospholipase D activity generates survival signals in b

26 Increasing the phospholipase D activity in MCF7 cells also suppressed p

27 We report here that the elevated phospholipase D activity in the human breast cancer cell

28 monstrate that Gbetagamma directly regulates phospholipase D activity in vitro and suggest a novel me

29 Phospholipase D activity increased by 62% (p < 0.01).

30 In mammalian cells, phospholipase D activity is tightly regulated by diverse

31 However, blocking phospholipase D activity resulted in release of MV incap

32 Elevated phospholipase D activity suppressed association of prote

33 We demonstrate that ARF6 stimulates a sperm phospholipase D activity to produce phosphatidic acid an

34 inant Gbeta1gamma2 was also found to inhibit phospholipase D activity under basal and stimulated cond

35 otease, a hypothetical protein with putative phospholipase D activity, and a riboflavin specific deam

36 Syk phosphorylation, phospholipase D activity, and mitogen-activated protein

37 Phosphatidylcholine-phospholipase D activity, cell membrane cholesterol, and

38 ins, we have identified a novel inhibitor of phospholipase D activity, Gbetagamma subunits of heterot

39 prowazekii pld gene, encoding a protein with phospholipase D activity, has been associated with phago

40 , Sec14p-independent Golgi function requires phospholipase D activity.

41 bypass Sec14p mutations in its dependence on phospholipase D activity.

42 modulators of development such as CDC48A and phospholipase D alpha 1.

43 Second step assembly is modulated by phospholipase D and A2.

44 ll-molecule inhibitors, we demonstrated that phospholipase D and diacylglycerol lipase were required

45 Immunostaining studies revealed that NAPE-phospholipase D and fatty acid amide hydrolase are expre

46 rpretations concerning the possible roles of phospholipase D and its biologically active product phos

47 ovide mechanistic insights into the roles of phospholipase D and PIP kinases in the late stages of re

48 events the formation of phosphatidic acid by phospholipase D and specifically inhibits phospholipase

49 noleate depend on phospholipid hydrolysis by phospholipase D and subsequent generation of diacylglyce

50 ed distinct requirements for both Ca(2+) and phospholipase D and was highly correlated with killing o

51 ha, N-acyl-phosphatidylethanolamine-specific phospholipase D, and 12-lipoxygenase, as well as type I

52 of ABA signaling: 1-butanol, an inhibitor of phospholipase D, and abi1-1, a dominant negative mutant

53 protein kinase B and p38MAPK, activation of phospholipase D, and calcium fluxes were equivalent in w

54 pression of the OEA-synthesizing enzyme NAPE-phospholipase D, and decreased activity and expression o

55 cylethanolamine acid amidase, NAPE-selective phospholipase D, and protein tyrosine phosphatase non-re

56 Exogenous ATP activates phospholipase D, and we show here that ATP activates the

57 by extracellular signal-regulated kinase or phospholipase D, as exemplified by the lack of effect of

58 nd LEP localization in cells lacking Sma1, a phospholipase D-associated protein dispensable for initi

59 KY-18 DNA-binding protein (AtWRKY-18), and a phospholipase D (AtPLD-1) from Arabidopsis.

60 raction occurs through the amino terminus of phospholipase D, because Gbeta1gamma1 is unable to inhib

61 Infection of phospholipase D beta1 (PLDbeta1)-deficient plants by Pse

62 ospholipase D or after addition of bacterial phospholipase D, binding of PA to RdgBbeta was greater a

63 e PAs by activating diacylglycerol kinase or phospholipase D, both of which were elevated in the live

64 ble to inhibit an amino-terminally truncated phospholipase D construct, PLD1.d311, which like full-le

65 n consisting of the amino-terminal region of phospholipase D containing the phox/pleckstrin homology

66 least in part, by glutamate acting through a phospholipase D-coupled metabotropic glutamate receptor.

67 sponses elicited by Chlamydophila pneumoniae phospholipase D (CpPLD) in the pathogenesis of atheroscl

68 enic stimulation of mammalian cells led to a phospholipase D-dependent accumulation of cellular PA, w

69 The internalized BCR signals through a phospholipase-D-dependent pathway to recruit TLR9-contai

70 and molecular aspects of the involvement of phospholipase D-derived phosphatidic acid in regulated e

71 (14)C]Glc or UDP-[(14)C]GlcUA, we found that phospholipase D digestion of the Glc-labeled lipid yield

72 (GPI) anchor signal sequence followed by GPI-phospholipase D digestion, appending a trimeric coiled-c

73 t synthesized in vitro was also sensitive to phospholipase D digestion, suggesting that the same lipi

74 ization of a P. aeruginosa H3-T6SS-dependent phospholipase D effector, PldB, and its three tightly li

75 Here, we characterized LpdA, a phospholipase D effector, which was previously proposed

76 ver, treating activated human platelets with phospholipase D enhanced the rates of factor X activatio

77 Venoms of the sicariid spiders contain phospholipase D enzyme toxins that can cause severe derm

78 rown spiders in the genus Loxosceles contain phospholipase D enzyme toxins that can cause severe derm

79 Phospholipase D enzymes have long been proposed to play

80 ecreasing levels of diacylglycerol kinase or phospholipase D-enzymes that produce phosphatidic acid-r

81 t sertraline inhibits phospholipase A(1) and phospholipase D, exhibits mixed effects on phospholipase

82 ndicates greater architectural similarity to phospholipase-D family nucleases than to phospholipases.

83 la melanogaster Zucchini, is a member of the phospholipase-D family of phosphodiesterases, which incl

84 Phospholipase D from Streptomyces chromofuscus (sc-PLD)

85 oteins with basic-aromatic clusters, such as phospholipase D, GAP43, SCAMP2, and the N-methyl-d-aspar

86 Serum glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) activity is reduced over 75% i

87 he GPI-anchorage site by the activity of GPI-phospholipase D (GPI-PLD), because CR-1 shedding was sup

88 resence of phosphatidic acid, the product of phospholipase D, growth in soft agar and tumor formation

89 s in chlamydial cytotoxins, guaBA-add, and a phospholipase D homolog developed normally in cell cultu

90 uggest that the F13L protein, like its human phospholipase D homolog, regulates vesicle formation and

91 Phospholipase D, however, could not complement a vaccini

92 Additionally, a phospholipase D implicated in soluble N-ethyl-maleimide

93 imulation of the 5-HT(2C) receptor activates phospholipase D in addition to phospholipase C, the trad

94 hat Gcs1p/Age2p act downstream of Sec14p and phospholipase D in both Sec14p-dependent and Sec14p-inde

95 of extracellular signal-regulated kinase and phospholipase D in CaP cells.

96 t evidence has emerged indicating a role for phospholipase D in cell proliferation, membrane traffick

97 e C in COS-7 cells (EC(50) = 0.18 microM) or phospholipase D in chick primary cardiomyocytes, both me

98 us TRPC3 channel and identify a key role for phospholipase D in the generation of the slow excitatory

99 asma membrane, thus demonstrating a role for phospholipase D in the juxtanuclear translocation of PKC

100 To study the potential importance of phospholipase D in the oncogenic ability of Ras, we used

101 Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and

102 While using phospholipase D inhibitors (which block the conversion o

103 in regulated exocytosis, we used an array of phospholipase D inhibitors for ex vivo and in vitro trea

104 evidence that the plasma membrane localized phospholipase D, involved in the biosynthesis of PA, is

105 e investigated whether the signaling protein phospholipase D is implicated in leukocyte cell motility

106 of Pseudomonas aeruginosa, a eukaryotic-like phospholipase D, is a member of the type VI lipase effec

107 construct, PLD1.d311, which like full-length phospholipase D isoforms, requires phosphatidylinositol-

108 -type Arabidopsis (Arabidopsis thaliana) and phospholipase D knockout mutants pld zeta1, pld zeta2, a

109 t the N terminus and a unique, unanticipated phospholipase D-like (PLD) domain at the C terminus that

110 F) domain protein (CT153) and members of the phospholipase D-like (PLD) family, are related to protei

111 east in part, through the recently described phospholipase D-linked metabotropic Glu receptor to main

112 Phospholipase D-mediated hydrolysis of phosphatidylcholi

113 by phospholipase D and specifically inhibits phospholipase D-mediated vesicle formation, also inhibit

114 We suggest that a phospholipase D might cleave N-acyl-PS to generate N-acy

115 The mammalian Phospholipase D MitoPLD facilitates mitochondrial fusion

116 identifies a critical target of an emerging phospholipase D/mTOR survival pathway in the transformat

117 by N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and its degradation by fatty

118 by N-acylphosphatidylethanolamine-selective phospholipase D (NAPE-PLD) and its degradation by fatty

119 Recently, an N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) was identified as a candidate

120 N-Arachidonoyl phosphatidylethanolamine-phospholipase D (NAPE-PLD), glycerophosphodiesterase (GD

121 n of N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD), which catalyzes the producti

122 dylethanolamine (NAPE) through cleavage by a phospholipase D (NAPE-PLD).

123 s) in a single enzymatic step catalyzed by a phospholipase D (NAPE-PLD).

124 annabinoids (N-acyl phosphatidylethanolamine phospholipase D [NAPE-PLD] and diacylglycerol lipase alp

125 he PhoD protein of Bacillus subtilis and the phospholipase D of Streptomyces chromofuscus.

126 PA levels following activation of endogenous phospholipase D or after addition of bacterial phospholi

127 al signals lost by the suppression of either phospholipase D or mTOR.

128 acological inhibitors of phosphatidylcholine-phospholipase D (PC-PLD), butan-1-ol and C2 ceramide, pr

129 ression of catalytically inactive mutants of phospholipase D (PLD) 1 or 2 attenuated LPA-induced IL-1

130 at the membrane-associated signaling protein phospholipase D (PLD) accumulates abnormally in cilia of

131 assessing interleukin-8 (IL-8) secretion and phospholipase D (PLD) activation in human bronchial epit

132 Here we demonstrate that phospholipase D (PLD) activation is required to support

133 Moreover inhibition of phospholipase D (PLD) activity and inhibition of PLD1 an

134 that infection by influenza virus stimulates phospholipase D (PLD) activity and that PLD co-localizes

135 nvasive metastatic cell line that depends on phospholipase D (PLD) activity for survival when deprive

136 Phospholipase D (PLD) activity is elevated in response t

137 Phospholipase D (PLD) activity was required for high PA

138 re that elevated FAM83B expression increases Phospholipase D (PLD) activity, and that suppression of

139 ation of lymphocytes induces upregulation of phospholipase D (PLD) activity, but the biological signi

140 ted but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-buta

141 h levels of a mutant p53, has high levels of phospholipase D (PLD) activity, which provides a surviva

142 hat photoreceptors contain a light-dependent phospholipase D (PLD) activity.

143 KC) plays an important role in regulation of phospholipase D (PLD) activity.

144 ol 4,5-bisphosphate (PIP(2)) and in inducing phospholipase D (PLD) activity.

145 on of HUVECs with StxB transiently increased phospholipase D (PLD) activity.

146 thway involving the combined activities of a phospholipase D (PLD) and a phosphatidic acid (PA) phosp

147 scade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK).

148 yte (PMN) phagocytosis through inhibition of phospholipase D (PLD) and downstream events, including a

149 Phospholipase D (PLD) and heterotrimeric G-protein both

150 ncreased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1

151 We show here that phospholipase D (PLD) and its enzymatic reaction product

152 Phospholipase D (PLD) and its metabolite phosphatidic ac

153 Phospholipase D (PLD) and its product phosphatidic acid

154 Phospholipase D (PLD) and its product, phosphatidic acid

155 , and so is the overexpression of the enzyme phospholipase D (PLD) and its reaction product, phosphat

156 ) and MMP9, whereas the ED peptide activates phospholipase D (PLD) and MMP2, but not MMP9.

157 r, in situ and in real-time, the activity of phospholipase D (PLD) and phospholipase C (PLC) on plana

158 Activation of phospholipase D (PLD) and protein kinase C (PKC) as well

159 Phospholipase D (PLD) and protein phosphatase 2C (PP2C)

160 Phospholipase D (PLD) and small GTPases are vital to cel

161 icking, and secretion, are regulated by both phospholipase D (PLD) and the actin microfilament system

162 The signaling enzyme phospholipase D (PLD) and the lipid second messenger it

163 ory pathway for mTOR signaling that involves phospholipase D (PLD) and the lipid second messenger pho

164 n-coupled receptors can potentially activate phospholipase D (PLD) by a number of routes.

165 Phospholipase D (PLD) catalyzes the conversion of phosph

166 The membrane-active enzyme phospholipase D (PLD) catalyzes the hydrolysis of the ph

167 lts revealed that disruption of A. baumannii phospholipase D (PLD) caused a reduction in the organism

168 ther genes annotated as a helicase domain, a phospholipase D (PLD) domain, a DUF1998 domain and a gen

169 The product of phospholipase D (PLD) enzymatic action in cell membranes

170 of eukaryotic and prokaryotic members of the phospholipase D (PLD) enzyme family varies among chlamyd

171 or imaging sites of cellular PA synthesis by phospholipase D (PLD) enzymes is reported.

172 Phospholipase D (PLD) enzymes play a double vital role i

173 BceSIV and Bce14579I belong to the phospholipase D (PLD) family of endonucleases that are w

174 Recombinant phospholipase D (PLD) from Streptomyces chromofuscus (sc

175 phatidic acid generated by the activation of phospholipase D (PLD) functions as a second messenger an

176 Phospholipase D (PLD) generates a metabolite, phosphatid

177 Phospholipase D (PLD) generates lipid signals that coord

178 Phospholipase D (PLD) has also been implicated in signal

179 Phospholipase D (PLD) has been implicated in regulating

180 Phospholipase D (PLD) has been implicated in various pro

181 Phospholipase D (PLD) has been linked to the regulation

182 Phospholipase D (PLD) has been reported to generate surv

183 sphate metabolism, respectively, the role of phospholipase D (PLD) has so far remained elusive.

184 specifically releases proteins, including a phospholipase D (PLD) homolog, which facilitate membrane

185 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to

186 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to

187 Phospholipase D (PLD) hydrolyzes phosphatidylcholine to

188 Experiments were performed with phospholipase D (PLD) in a Ca(2+) dependent fashion.

189 Hyperactivation of phospholipase D (PLD) in certain tumor-derived cell line

190 To investigate the role of phospholipase D (PLD) in FcepsilonRI signaling, the wild

191 , we provide evidence for the involvement of phospholipase D (PLD) in LPA-mediated transactivation of

192 In this study, we investigated the role of phospholipase D (PLD) in mediating Arf6 function in cell

193 A recent report has implicated phospholipase D (PLD) in mTOR signaling.

194 Phospholipase D (PLD) is a key facilitator of multiple t

195 Phospholipase D (PLD) is a major plant phospholipase fam

196 Because phospholipase D (PLD) is linked to several signaling pat

197 gh its production of phosphatidic acid (PA), phospholipase D (PLD) is strongly involved in vesicular

198 The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed i

199 eviously that it can also signal through the phospholipase D (PLD) pathway in an ADP-ribosylation fac

200 Phospholipase D (PLD) plays a major role in the activati

201 Activation of phospholipase D (PLD) produces phosphatidic acid (PA), a

202 We show here that phospholipase D (PLD) production of the lipid phosphatid

203 Phospholipase D (PLD) proteins are enzymes that catalyze

204 Phospholipase D (PLD) regulates the polymorphonuclear le

205 Most types of plant phospholipase D (PLD) require Ca(2+) for activity, but h

206 Phospholipase D (PLD) signaling plays a critical role in

207 The phospholipase D (PLD) superfamily is a diverse group of

208 The Phospholipase D (PLD) superfamily is linked to neurologi

209 Tdp1 is a member of the phospholipase D (PLD) superfamily of enzymes and hydroly

210 Here, we identify an ancestral member of the phospholipase D (PLD) superfamily of lipid-modifying enz

211 Norepinephrine (NE) stimulates phospholipase D (PLD) through a Ras/MAPK pathway in rabb

212 s measurements suggested that sperm activate phospholipase D (PLD) to elevate phosphatidic acid (PA).

213 The A3 receptor signals via RhoA and phospholipase D (PLD) to induce cardioprotection.

214 hosphatidic acid (PA), which is generated by phospholipase D (PLD) via hydrolysis of phosphatidylchol

215 These data indicated that activation of phospholipase D (PLD) was required for activation of p38

216 Furthermore, ARF6 and its effector phospholipase D (PLD) were both required for bacteria-in

217 shown that alpha and beta-synucleins inhibit phospholipase D (PLD), an enzyme involved in lipid-media

218 Small molecule inhibitors of phospholipase D (PLD), an enzyme that produces phosphati

219 ARF6 also results in increased activation of phospholipase D (PLD), and inhibition of PLD activity al

220 the role of protein kinase C (PKC) isoforms, phospholipase D (PLD), and Rac in S1P-induced migration

221 bition or depletion of the mTORC1 regulator, phospholipase D (PLD), and recapitulated with the additi

222 itors of casein kinase II, NFkappaB, PLA(2), phospholipase D (PLD), cyclooxygenases, lipoxygenase, or

223 Three major metabolic pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and

224 PA > 300 nM or the enzyme that produces it, phospholipase D (PLD), downregulate EGFR expression.

225 In Saccharomyces cerevisiae, phospholipase D (PLD), encoded by the SPO14 gene, cataly

226 Phosphatidic acid, as synthesized by phospholipase D (PLD), enhances cancer cell survival.

227 embrane lipid phosphatidic acid, produced by phospholipase D (PLD), has been shown to take part in bo

228 tidic acid and the enzyme that generates it, phospholipase D (Pld), in this process.

229 hatidylinositol (4,5) bisphosphate-activated phospholipase D (PLD), is essential for meiosis and spor

230 feedback loop between the signaling protein phospholipase D (PLD), phosphatidic acid (PA), and a spe

231 The role of phospholipase D (PLD), phosphatidylinositol-specific pho

232 DNase II exhibits a similar overall fold as phospholipase D (PLD), phosphatidylserine synthase (PSS)

233 Four types of phospholipase D (PLD), PLD alpha, beta, gamma, and delta

234 Here, a plasmid-encoded phospholipase D (PLD), previously characterized as Yersi

235 ylation factor 6 (myr-ARF6), an activator of phospholipase D (PLD), to a model membrane were investig

236 Phospholipase D (PLD), which has been implicated in vesi

237 Rapid activation of phospholipase D (PLD), which hydrolyzes membrane lipids

238 reported evidence that alphaSyn can inhibit phospholipase D (PLD), which hydrolyzes phosphatidylchol

239 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylchol

240 ipase activity in breast cancers in vitro is phospholipase D (PLD), which is also involved in cell mi

241 Phospholipase D (PLD), which is commonly elevated in ren

242 PA is the metabolic product of phospholipase D (PLD), whose activity is elevated in a l

243 lves the presence of an enzymatically active phospholipase D (PLD), with the PLD2 isoform being more

244 ne lipid biosynthesis and the product of the phospholipase D (PLD)-catalyzed hydrolysis of phosphatid

245 ian target of rapamycin) signaling through a phospholipase D (PLD)-dependent increase in the concentr

246 assical PKCalpha and PKCbetaII induces their phospholipase D (PLD)-dependent internalization and tran

247 y, Han et al., 2011 clearly demonstrate that phospholipase D (PLD)-dependent production of membrane p

248 PAR1-activating peptide (PAR1-AP) requires a phospholipase D (PLD)-mediated phosphatidic acid (PA) si

249 ATC1 and Galpha(i) or Galpha(o)-PKCalpha-PLC-phospholipase D (PLD)-mTOR in a bell-shaped, dose-depend

250 g the synthesis of phosphatidic acid (PA) by phospholipase D (PLD).

251 ylcholine, suggesting that PTEN may regulate phospholipase D (PLD).

252 RNAs (miRs) mediated by the signaling enzyme phospholipase D (PLD).

253 hospecific phospholipase C (PtdCho-PLC), and phospholipase D (PLD).

254 s of mTOR, phosphatidylinositol 3-kinase and phospholipase D (PLD).

255 phatidic acid (PA), the metabolic product of phospholipase D (PLD).

256 recursor, N-acylphosphatidylethanolamine, by phospholipase D (PLD).

257 kinase-2 (PYK2), ERK pathway components, and phospholipase D (PLD).

258 for up to 6 h and mediated through RhoA and phospholipase D (PLD).

259 en primarily attributed to the activation of phospholipase D (PLD).

260 dy showed that cholinergic agonists activate phospholipase D (PLD).

261 ment whose formation is dependent on PKC and phospholipase D (PLD).

262 The rat mast cell line RBL-2H3 contains both phospholipase D (PLD)1 and PLD2.

263 2 tyrosine phosphorylation via activation of phospholipase D (PLD)2.

264 Mammalian phospholipases D (PLD), which catalyze the hydrolysis of

265 f Arabidopsis deficient in the most abundant phospholipase D, PLD alpha, were analyzed.

266 ating the activities and/or levels of either phospholipase D (PLD1 and PLD2) or diacylglycerol kinase

267 of the gene for a membrane lipid-hydrolyzing phospholipase D (PLDalpha1) in Arabidopsis enhanced seed

268 interact with the plasma membrane-associated phospholipase D (PLDdelta) to transduce the ROS hydrogen

269 Here, we show that the plasma membrane-bound phospholipase D, PLDdelta, is activated in response to H

270 that two Arabidopsis (Arabidopsis thaliana) phospholipase Ds (PLDs), PLDzeta1 and PLDzeta2, were inv

271 e shedding, ARF6-GTP-dependent activation of phospholipase D promotes the recruitment of the extracel

272 Transport defects via PA generated by phospholipase D require the activity of type I phosphati

273 pathways, involving the exocyst complex and phospholipase D, respectively.

274 g cells, but not to the extent found for the phospholipase D signal.

275 est a novel mechanism to negatively regulate phospholipase D signaling in vivo.

276 Blocking phospholipase D signals also led to reduced phosphorylat

277 small GTP-binding protein Rho and subsequent phospholipase D stimulation.

278 The HKD-containing Phospholipase D superfamily catalyzes the cleavage of th

279 n TDP belongs to a distinct class within the phospholipase D superfamily in spite of very low sequenc

280 hosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3'-phospho-D

281 we show that glaikit (gkt), a member of the phospholipase D superfamily, is essential for the format

282 tivated catalysis that applies to the entire phospholipase D superfamily.

283 with ClsA and ClsB, which all belong to the phospholipase D superfamily.

284 critical role for protein phosphatase 2A in phospholipase D survival signals, either SV40 small t-an

285 g N-acylphosphatidylethanolamine-hydrolyzing phospholipase D that generates anandamide.

286 F, MEK1 and ERK1/2; and, most interestingly, phospholipase D, thus yielding increases in phosphatidic

287 tioned in an additive manner with gonococcal phospholipase D to augment Akt kinase activity.

288 Multiple signaling pathways converge upon phospholipase D to modulate cellular actions, such as ce

289 The ability of phospholipase D to suppress protein phosphatase 2A ident

290 8690 using a combination of base hydrolysis, phospholipase D treatment, ESI-MS, and MS/MS to show tha

291 glycerol into PG and is catalyzed by ClsB, a phospholipase D-type cardiolipin synthase.

292 madillo-like repeats, and NAPE-PLD encodes a phospholipase D-type phosphodiesterase.

293 human 5-HT2C receptor isoform INI activates phospholipase D via the G13 heterotrimer G-protein.

294 cerol released by phospholipase C but not by phospholipase D was implicated as a substrate for 2-AG p

295 Using phospholipase D, we incorporated tritium into each analo

296 d lysophospholipase 1, phospholipase A2, and phospholipase D were significantly underexpressed, in br

297 n addition, increased expression of cellular phospholipase D, which has a similar phospholipase motif

298 expansion, blocked by acute perturbation of phospholipase D, which reflects both properties intrinsi

299 rturbed phospholipid synthesis by activating phospholipase D with sphingosine 1-phosphate (S1P) or in

300 aII, but not PKCbetaI, was found to activate phospholipase D within this time frame.