ライフサイエンスコーパス: phosphonate

1 charged ligands (e.g., oleate and octadecyl phosphonate).

2 and benzyl bromide to produce diethylbenzyl phosphonate.

3 otent inhibitor in the series, L-rhamnose 1C-phosphonate.

4 (alkylamino) ester, or an (alkylamino)methyl phosphonate.

5 oxymethyl) (E)-4-hydroxy-3-methyl-but-2-enyl phosphonate.

6 oxymethyl) (E)-4-hydroxy-3-methyl-but-2-enyl phosphonate.

7 are more potent inhibitors than monoanionic phosphonates.

8 hesis of other types of 3'-fluoro nucleoside phosphonates.

9 of alpha,beta-unsaturated aldehydes and acyl phosphonates.

10 ich is required for the biosynthesis of most phosphonates.

11 n of phosphazenes and fluorinated acetylenic phosphonates.

12 chieved in high yield from the corresponding phosphonates.

13 ines to produce aromatic phosphonium ions or phosphonates.

14 ford tetrasubstituted alpha-amino-beta-nitro-phosphonates.

15 ed in the clinic, representative spirocyclic phosphonate 18a(-) features improved selectivity for the

16 nomethyl phosphonate [AMP](2-), 1-aminoethyl phosphonate [1AEP](2-), 2-aminoethyl phosphonate [2AEP](

17 2,3-triazolyl or substituted 1,2,3-triazolyl phosphonate-2'-deoxyribonucleotide internucleotide linka

18 noethyl phosphonate [1AEP](2-), 2-aminoethyl phosphonate [2AEP](2-), aminopropyl phosphonate [APP](2-

19 hydrogenation of (S)-alpha-amino-beta-nitro-phosphonate 2d gives enantiopure (S)-alpha,beta-diaminop

20 openta[b]-pyrrole-2-phosphine oxides 4a and -phosphonates 4b,c are generated by the addition of cycli

21 ented C-P bond cleavage reaction of ribose-1-phosphonate-5-phosphate to methane and ribose-1,2-cyclic

22 An epimeric mixture of H-phosphonates 5R and 5S has been synthesized in three ste

23 is to characterize the effects of FTY720 (S)-phosphonate, a novel analog of FTY720-phosphate, on vari

24 propyl phosphonate [APP](2-), and aminobutyl phosphonate [ABP](2-).

25 osphonate scaffold, alpha-carboxy nucleoside phosphonate (alpha-CNP), was designed that is recognized

26 Alpha-carboxynucleoside phosphonates (alpha-CNPs) are novel viral DNA polymerase

27 se (RT) inhibitors, alpha-carboxy nucleoside phosphonates (alpha-CNPs).

28 report for the first time the development of phosphonate amidines and sulfonate amidines as isosteres

29 This includes aminomethyl phosphonate [AMP](2-), 1-aminoethyl phosphonate [1AEP](2

30 bited by alternative substrates (aminomethyl phosphonate [AMPA] and N-methyl glyphosate [NMG]), which

31 taAla(P) would be generated from Ser(P), the phosphonate analog of Ser, by phosphorylation and subseq

32 radiation-induced gene dysregulation by the phosphonate analog, fTyS (0.1 and 1 mg/kg i.p., 2x/wk) a

33 iastereomeric cis- and trans-monocyclic enol-phosphonate analogs to Cyclophostin and Cyclipostins wer

34 An acetyl-protected phosphonate analogue of UDP-D-apiose was synthesized and

35 he first series of a new class of nucleoside phosphonate analogues is described.

36 the alpha position of carbocyclic nucleoside phosphonate analogues leads to a novel class of potent H

37 own sugar nucleotide substrates and selected phosphonate analogues.

38 5'-Phosphonate and 5'-phosphate analogues of AMP containing

39 By introducing POC groups on both the phosphonate and alpha-carboxylate, we synthesized Tris-P

40 hesis of a 3'-fluoro-3'-deoxytetrose adenine phosphonate and can be expanded toward the synthesis of

41 e, which results in surface stabilization of phosphonate and carboxylate derivatives of Ru(II)-polypy

42 Finally, the iminosugar phosphonate and its elongated phosphate analogue were ac

43 perfluoroalkyl ionomer materials containing phosphonate and phosphinate moieties substituted for the

44 the biosynthesis of MPn from 2-hydroxyethyl phosphonate and the bacterial C-P lyase complex is known

45 esents the most porous crystalline zirconium phosphonate and the only porous MOF material reported to

46 However, 1 is highly polar containing a phosphonate and two carboxylates, severely limiting its

47 heteroatom (N or O) in alpha-position to the phosphonate and using the resultant OH and NH(2) groups

48 Both H-phosphonates and diaryl phosphine oxides are suitable co

49 We report the synthesis of a series of phosphonates and ketosephosphonates possessing an L-rham

50 coupling and iodocyclization to give cyclic phosphonates and other cyclization reactions to give pi-

51 el methodology proceeds with a wide range of phosphonates and phosphoramidates under mild conditions

52 ng alkenyl halides, sulfides, triflates, and phosphonates and provides a mild and practical alternati

53 The hydroxyl groups of the phosphonates and pyrrole -NH protons are further engaged

54 he largest void volume recorded in zirconium phosphonates and SZ-3 represents the most porous crystal

55 yridin-4-yl)ethoxy)amino)-2,2-dimethylpropyl)phosphonate) and its N(+)-O(-) oxide activated version 3

56 o form surface bound n-alkylammonium oleate, phosphonate, and carbamate ion pairs that bind with grea

57 Molecules bearing phosphonamidate, phosphonate, and phosphinate moieties were synthesized.

58 with diverse substituents on the amine, the phosphonate, and the allene moieties.

59 re particularly useful in the preparation of phosphonate- and phosphinoxide-functionalized molecules.

60 Acyclic nucleoside phosphonates (ANPs) are inhibitors of HG(X)PRT and arres

61 Here, newly synthesized acyclic nucleoside phosphonates (ANPs) have been shown to be competitive in

62 Acyclic nucleoside phosphonates (ANPs) that contain a 6-oxopurine base are

63 tigates the adsorption and desorption of the phosphonate antiscalant nitrilotris(methylenephosphonic

64 inoethyl phosphonate [2AEP](2-), aminopropyl phosphonate [APP](2-), and aminobutyl phosphonate [ABP](

65 ls, whereas the alcohol of HMBPP and alkenyl phosphonates are directly recognized.

66 These BZN-phosphonates are highly adsorbed onto alum, which signif

67 Substantial quantities of phosphonates are produced worldwide for industrial proce

68 The beta-borylated phosphonates are readily converted to chiral beta- and g

69 The detection of xylose cyclic phosphonate as the turnover product reveals significant

70 negative bacteria have the capability to use phosphonates as a nutritional source of phosphorus under

71 d to allow bacteria to utilize environmental phosphonates as a source of carbon and phosphorus.

72 sed nucleosides, nucleotides, and nucleoside phosphonates as potential antiviral or anticancer agents

73 In light of the importance of amides and phosphonates as synthetic intermediates, we envision tha

74 e end of follow-up, 17.5%) followed by alkyl phosphonate-associated pol-gene (7.4%), immune-associate

75 The aza-acyclic nucleoside phosphonates (aza-ANPs) are good inhibitors of Plasmodiu

76 The pendant phosphonate base mediates O-O bond formation via intramo

77 e mechanism of proton diffusion within a new phosphonate-based metal-organic framework (MOF) material

78 e chains were introduced via stereoselective phosphonate-based olefinations.

79 oxyphosphonates and aminophosphonates and to phosphonates bearing a quaternary carbon stereocenter.

80 Collectively, our analyses show that phosphonate biosynthesis is both diverse and relatively

81 Based on the presence of this gene, phosphonate biosynthesis is common in microbes, with ~5%

82 arby genes, suggesting that the diversity of phosphonate biosynthetic pathways can be predicted by ex

83 used this approach to estimate the range of phosphonate biosynthetic pathways in nature, revealing d

84 pM), is shared by the vast majority of known phosphonate biosynthetic pathways.

85 , PCMOF10 is water stable owing to strong Mg phosphonate bonding.

86 structural basis for understanding microbial phosphonate breakdown.

87 ifluoroacetate, diethyl (bromodifluoromethyl)phosphonate, [(bromodifluoromethyl)sulfonyl]benzene, and

88 X and Y into 9-mer oligonucleotides using H-phosphonates building blocks 5R and 5S, respectively.

89 e, through dienamine formation, and the acyl phosphonate by hydrogen-bonding.

90 e rhodium-catalyzed hydroboration of allylic phosphonates by pinacolborane affords chiral tertiary bo

91 n the P horizontal lineO groups in the tetra-phosphonate calix[4]pyrrole cavitands are conformational

92 y constants than the previously reported bis-phosphonate calix[4]pyrrole counterparts in the complexa

93 The tetra-phosphonate calix[4]pyrroles exhibited larger affinity c

94 of the different classes of solids based on phosphonates, carboxylates and other linkers.

95 e, combining the features of single-site bis-phosphonate catalysts and fast bimolecular bis-carboxyla

96 ndings are relevant for the potential use of phosphonate cavitands as synthetic receptors for the det

97 tional assignment of three diasteromeric bis-phosphonate cavitands based on an aryl extended calix[4]

98 vers (MCs) functionalized by a film of tetra-phosphonate cavitands were employed to screen as guests

99 uced oxidation state P compounds include the phosphonates, characterized by C-P bonds, which bear up

100 Furthermore, a zero-dimensional zirconium phosphonate cluster acting as secondary building unit ha

101 ilt by previously unknown isolated zirconium phosphonate clusters and exhibit combined high porosity

102 , SnS nanocrystals are capped with a cadmium-phosphonate complex.

103 ix families of cobalt-lanthanide mixed-metal phosphonate complexes are reported in this Article.

104 stabilized by adsorbed metal carboxylate or phosphonate complexes or by ion pairs.

105 ationic calcium surface sites to form Ca(2+)-phosphonate complexes.

106 potential active sites that probably couple phosphonate compounds to ATP and subsequently hydrolyse

107 Among these phosphonate compounds, the dehydration derivative 7a tha

108 imited supply, some bacteria are able to use phosphonate compounds, which require specialized enzymat

109 s (H1N1, H3N2, H5N1, and H7N9), although the phosphonate congener 6a is unexpectedly less active than

110 Phosphonates constitute a class of natural products that

111 ion bridging group, which can bind a second phosphonate containing species from solution to establis

112 of new somatostatin analogues modified with phosphonate-containing cross-bridged chelators for evalu

113 h strains were subsequently shown to produce phosphonate-containing exopolysaccharides (EPS), also kn

114 In this study, we immobilized a unique phosphonate-containing ligand onto mesoporous silica par

115 new paradigm for the in vivo construction of phosphonate-containing natural products that can be expl

116 were compared to those obtained for the bis-phosphonate counterparts.

117 9-deazapurines, leading to new deazapurine-8-phosphonate derivatives, which can be further modified a

118 can be exploited for the preparation of new phosphonate derivatives.

119 n measurements, the MLCT excited state(s) of phosphonate derivatized [Ru(bpy)2((4,4'-(OH)2PO)2bpy)](2

120 In this procedure, solution deposited, phosphonate derivatized metal complexes on metal oxide s

121 Phosphonate-derivatized catalysts and molecular assembli

122 n this Communication, covalently anchoring a phosphonate-derivatized complex, Fe(tebppmcn)Cl2 (1), to

123 hesis has been applied to the preparation of phosphonate-derivatized oligoproline assemblies containi

124 n nanocrystalline TiO2 functionalized with a phosphonate-derivatized Ru(II) polypyridyl chromophore.

125 port enhanced surface binding stability of a phosphonate-derivatized water oxidation catalyst over a

126 Wittig-Horner reaction of a chiral phosphonate derived from (S)-lactic acid and ring-closin

127 Previous studies on ligands equipped with phosphonate diester and ether H-bond acceptors were inco

128 e absolute value of EM for an intramolecular phosphonate diester H-bond is about 4 times lower than t

129 1 for the ether ligands, and KEM > 1 for the phosphonate diester ligands.

130 Acceleration of H-phosphonate diester oxidation with iodine accompanied by

131 ries but similar H-bond strengths (amide and phosphonate diester), there is little correlation betwee

132 c activity was inhibited by an electrophilic phosphonate diester, consistent with a nucleophilic cata

133 ether-phenol interactions were compared with phosphonate diester-phenol interactions in a closely rel

134 uated several alkoxyalkyl acyclic nucleoside phosphonate diesters and identified octadecyloxyethyl be

135 configuration at the phosphorus center of H-phosphonate diesters and oxazaphospholidine oxides.

136 interactions with the enzyme and why neutral phosphonate diesters are more potent inhibitors than mon

137 nfigurations of phosphorothioate diesters, H-phosphonate diesters, and oxazaphospholidine oxides were

138 itrogen, protonated forms of dimethyl methyl phosphonate (DMMP) and methyl phosphonic acid (MPA) exhi

139 arbon monoxide, ethanol, and dimethyl methyl phosphonate (DMMP) are significantly higher than those u

140 ly detected three compounds, dimethyl methyl phosphonate (DMMP), cyclotrimethylene trinitramine (RDX)

141 FTY720 (S)-phosphonate does not induce beta-arrestin recruitment, s

142 mpared 177Lu-ethylene diamine tetramethylene phosphonate (EDTMP) with 153Sm-EDTMP for painful skeleta

143 double hydroxides, metal(iv) phosphates and phosphonates, especially zirconium, and zeolites.

144 ctively) despite the polar and acidic barium phosphonate ester backbone.

145 Chemical warfare agents containing phosphonate ester bonds are among the most toxic chemica

146 type associative displacement of the polymer phosphonate ester by a monomer as the rate-determining s

147 tic resolution of a 1:1 mixture of activated phosphonate ester diastereoisomers.

148 The use of phosphonate esters as linkers for the construction of MO

149 Intraperitoneal administration of FTY720 (S)-phosphonate every other day for 1 week in normal or bleo

150 organic frameworks (MOFs) based on zirconium phosphonates exhibit superior chemical stability suitabl

151 Using the known affinity of phosphonates for bone minerals in a model system, two fa

152 tly shown to be superior to standard (99m)Tc-phosphonates for diagnosis and (153)Sm-ethylenediaminete

153 role in the biosynthesis of the antimalarial phosphonate FR-900098.

154 r-protective S1P analogs, FTY720, (S)-FTY720-phosphonate (fTyS), and SEW-2871, identified significant

155 troduced between the pyrimidine ring and the phosphonate function.

156 Fluorescent molecular probes based on phosphonate-functionalized porphyrin derivatives have be

157 rivatives, as well as (E)-beta-aryl-(enamido)phosphonates, giving ee values in excess of 99%, the hig

158 able in aqueous environments, in contrast to phosphonates grafted on silicon oxides.

159 e-1,4-diols and naphtha-1,4-diones bearing a phosphonate group at the 2-position and various (het)ary

160 These novel compounds contain a second phosphonate group attached to the ANP scaffold.

161 phate oxygen of dNTPs and two oxygens of the phosphonate group of the alpha-CNP chelate Mg(2+), mimic

162 After introduction of the phosphonate group through classical reactions, the new i

163 the glyphosate binds to gamma-alumina via a phosphonate group, bridging the mineral surface and Zn.

164 ng the carboxylate group in peramivir with a phosphonate group, phosphono-peramivir (6a), the dehydra

165 an included water molecule and the linker's phosphonate group.

166 esis of an indenopyrazole scaffold bearing a phosphonate group.

167 ter-filled channels lined with free hydrogen phosphonate groups and gives a very low activation energ

168 n of hydrogen bonds between GLY carboxyl and phosphonate groups and protonated oxygen functions in hu

169 ere is evidence for a role for surface-bound phosphonate groups as proton acceptors.

170 tors resulting from the installation of four phosphonate groups at the upper rim of a calix[4]pyrrole

171 A is a bipyridine ligand functionalized with phosphonate groups for surface attachment to TiO2.

172 to a TiO(2) surface through carboxylate and phosphonate groups is demonstrated to be an effective me

173 In these complexes, the phosphonate groups provide redox-potential leveling thro

174 r anchors a robust backbone and has hydrogen phosphonate groups that interact with the lattice water

175 r, azide, tertiary amines, alkyne, vinyl, or phosphonate groups were obtained in moderate to excellen

176 cting the N(9) atom of guanine to one of the phosphonate groups.

177 tetraethyl (2,3-dihydroxy-1,4-phenylene)bis(phosphonate) (H2 -DPC), has been used to prepare a serie

178 route to a 3'-fluoro-3'-deoxytetrose adenine phosphonate has been developed.

179 egard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substitu

180 large number of biologically important amino phosphonates have been synthesized, isolated (37 example

181 Phosphonates have emerged as an alternative for function

182 ructure confirmed the phosphorylation by the phosphonate head group of the active site serine, it als

183 IDA approach is demonstrated on sensing of a phosphonate herbicide glyphosate and other biologically

184 Phosphonate hydrolases have evolved to allow bacteria to

185 Oxidation of 30 to sulfone 31 and phosphonate hydrolysis completed the synthesis of 3 in 1

186 he (R)-BINOL Fc phosphate gave Fc-rearranged phosphonate in 91% de.

187 methyl methylphosphonate, diisopropyl methyl phosphonate in positive polarity and carbon dioxide, sul

188 ates into the corresponding gamma-keto allyl phosphonates in 70-93% yields is described herein.

189 tic strategy for "stable isotope labeling of phosphonates in extract" (SILPE) that facilitates their

190 anes, leading to the corresponding propargyl phosphonates in good to excellent yields.

191 g a palladium or nickel catalyst giving aryl phosphonates in good to excellent yields.

192 c and cyclic amines to the alpha-position of phosphonates in one step.

193 rapid access to cyclic tertiary alpha-amino phosphonates in one-pot procedure under additive-free mi

194 c purification and that produces the dimer H-phosphonates in up to 44% yield in less than three days

195 tforward access to valuable mixed alkyl aryl phosphonates in very good yields and near perfect select

196 classes of phosphorus-containing compounds, phosphonates, in particular.

197 ide substrate sequences to develop selective phosphonate inhibitors with the structure Ac-peptidyl(P)

198 as 20 for four metal(IV) pillared phosphate phosphonate inorganic organic hybrid ion exchange materi

199 phosphonylation and (ii) carbanion-mediated phosphonate intramolecular cyclization (denoted CPIC) wa

200 FTY720 (S)-phosphonate is a promising barrier-promoting agent that

201 Synthesis of amino phosphonates is more important owing to their significan

202 with H2(17)O to yield a mixture of cyclic H-phosphonates labeled with (17)O and (18)O.

203 ound with N ligand as eta(2) bound motifs or phosphonate ligand as a monodentate, as well as on tetra

204 The N and phosphonate ligand-functionalized MMSNs hold promise as

205 stituted with a C(3)-symmetric tris(hydrogen phosphonate) ligand in a proton conducting metal-organic

206 evalonate, the alcohol of HMBPP, and alkenyl phosphonates-likely stimulate differently.

207 gomers tethered to graphene through covalent phosphonate linkages.

208 FTY720 (S)-phosphonate maintains endothelial sphingosine 1-phosphat

209 o GlgEI-V279S complexed with alpha-maltose-C-phosphonate (MCP), a non-hydrolyzable substrate analogue

210 We used the phosphonate methyltransferase DhpI involved in dehydroph

211 el approach in vaccine adjuvant design using phosphonate modification to afford adsorption of small m

212 Using the phosphonate moiety as an efficient trans-directing group

213 The phosphonate moiety in both phosphonoglycans was shown to

214 Here, we show that the conversion of the phosphonate moiety into acyloxymethyl and alkoxycarbonyl

215 Additionally, the phosphonate moiety represents a source of inorganic phos

216 rotease inhibitor (PI) with a unique diethyl-phosphonate moiety.

217 Attaching the phosphonated molecular catalyst [Re(I)Br(bpy)(CO)3](0) t

218 e polymer films are similar to those for the phosphonated molecular catalyst on metal oxide electrode

219 ommon in nature, suggesting that the role of phosphonate molecules in the biosphere may be more impor

220 An enigmatic pool of dissolved phosphonate molecules, with phosphorus in the +3 oxidati

221 Phosphonates, molecules containing direct carbon-phospho

222 The phosphonate monoalkyl esters (6b, 6c, 7b, 7c, 8b, and 8c

223 The phosphonate monoalkyl esters are stable in buffer soluti

224 uous members of this superfamily, namely the phosphonate monoester hydrolases from Burkholderia caryo

225 aphosphonate (CALF-25), which contains a new phosphonate monoester ligand, was synthesized through a

226 Recovery efficiencies for methyl phosphonate (MPA), nerve agent degradate, and ethylhydro

227 unreactive carbon-phosphorus bond in methyl phosphonate (MPn), but the biological or terrestrial sou

228 ophos biosynthesis to methylate a variety of phosphonate natural products in crude spent medium with

229 dinal FLARE studies in mice demonstrate that phosphonated near-infrared fluorophores remain stable in

230 inct surface charges, were synthesized using phosphonate (neutral), ammonium (cationic), and carboxyl

231 Nucleoside phosphonates (NP) are good inhibitors of EcXGPRT and EcH

232 y-2'-fluoro- and 3'-C-ethynyl L-threose 3'-O-phosphonate nucleosides.

233 The development of phosphate and phosphonate nucleotide prodrugs has led to important dru

234 described that involves the coupling of 3'-H-phosphonates of protected dinucleoside phosphates and or

235 A arms via solution-phase syntheses, using H-phosphonates of protected dinucleoside phosphates.

236 tack of the terminal oxygen from the dialkyl phosphonate on the silicon atom in bromotrimethylsilane.

237 is and (153)Sm-ethylenediaminetetramethylene phosphonate or (89)SrCl2 for therapy.

238 tron donor, the dyad linked to Pt-TiO2 via a phosphonate or carboxylate attachment shows excellent li

239 a series of pyrrolo[1,2-a]quinolines bearing phosphonate or phosphine oxide moieties is presented.

240 TP binding through a carboxylate oxygen, two phosphonate oxygens, and base-pairing with the template.

241 The developed dual function phosphonated p1TAM-D probe provides a unique tool for in

242 Perfluoroalkyl phosphonates (PFPAs) and perfluoroalkyl phosphinates (PF

243 l phosphate esters (PAPs) and perfluoroalkyl phosphonates (PFPAs).

244 minophosphonates at the CH3O group to induce phosphonate-phosphinate rearrangements.

245 , boronates, germanes, stannanes, pivalates, phosphonates, phthalimides, and tosylates from the corre

246 FTY720 (S)-phosphonate potently increases human pulmonary endotheli

247 r to examine the occurrence and abundance of phosphonate-producing organisms.

248 e than 50 y ago, the extent and diversity of phosphonate production in nature remains poorly characte

249 , which ultimately leads to decomposition to phosphonate products.

250 ic activation of alkynylphosphine oxides and phosphonates provides a novel approach to the synthesis

251 Reduction of the functionalized phosphonates provides access to novel primary and second

252 ynamic kinetic resolution of alpha-aryl acyl phosphonates, providing beta-stereogenic alpha-hydroxy p

253 This mild lithiated phosphonate reagent allows the synthesis of functionaliz

254 ric hydroxymethylphosphonamidates (phosphate-phosphonate rearrangement).

255 The isolated tetra-phosphonate receptors display either three (iooo) or fou

256 ed asymmetric transfer hydrogenation of acyl phosphonates: reduction proceeded from the opposite face

257 he details of how this machinery catabolizes phosphonates remain unknown.

258 port that phosphinates as well as monomethyl phosphonates represent excellent isosters, when introduc

259 In contrast to analogous tetra-phosphonate resorcin[4]arene cavitands, the 14-membered

260 at chemical group at the gamma-carbon of the phosphonate ring strongly impacts the inhibitory efficie

261 etics were carried out in combination with a phosphonated Ru(II) tris(bipyridine) dye (RuP) in homoge

262 poxidase HppE converts (S)-2-hydroxypropyl-1-phosphonate (S-HPP) to the antibiotic fosfomycin [(1R,2S

263 esent the first well-defined degradable poly(phosphonate)s with adjustable UCST.

264 ts that these seven-membered monocyclic enol-phosphonates should provide useful leads for the develop

265 acute lung injury in mice, while FTY720 (S)-phosphonate significantly decreases lung leak and inflam

266 This commercially available phosphonate smoothly reacts with a fluoride ion to liber

267 of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H b

268 d approximately 90% loading efficiency using phosphonate surface chemistry.

269 It was attached to the TiO2 shell by phosphonate-surface oxide binding.

270 We illustrate its utility by purifying a phosphonate that led to the identification of the fosfaz

271 nd obtain single crystals of three zirconium phosphonates that are suitable for structural analysis.

272 valuable, densely functionalized fluorinated phosphonates that takes advantage of (i) a Clostridial e

273 sed nucleosides, nucleotides, and nucleoside phosphonates, their stereoisomers, and their close analo

274 phates arising from 1,4-addition followed by phosphonate to phosphate rearrangement.

275 ) TLR7 agonists are chemically modified with phosphonates to allow adsorption onto aluminum hydroxide

276 echanism of the addition of nitroalkanes and phosphonates to benzaldehyde catalyzed by a chiral phosp

277 nthesized N-terminally biotinylated peptidyl phosphonates to identify the PR3 in complex biological s

278 ins that are essential for the conversion of phosphonates to phosphate and that the proteins encoded

279 d ketones, esters, sulfones, sulfoxides, and phosphonates to yield the corresponding adducts in good

280 Gene transcripts encoding phosphonate transport and hydrolysis proteins are upregu

281 ive nucleases, phosphotriesterases, putative phosphonate transporters and outer membrane proteins.

282 re it is shown that the recently synthesized phosphonated trityl radical possesses long relaxation ti

283 the synthesis of a deuterated derivative of phosphonated trityl radical, pTAM.

284 criptional regulator that may be involved in phosphonate utilization, and STM3846 encodes a retron re

285 ynthesis route to alpha-L-threose nucleoside phosphonates via 2-O and 3-O selectively protected L-thr

286 A spirocyclic phosphonate was identified as the optimal ring system fo

287 ly selective catalytic hydrogenation of acyl phosphonates was utilized in the dynamic kinetic resolut

288 nd improved gene silencing ability of borane phosphonates, we have focused our research on the relati

289 itionally, orthophosphate, pyrophosphate and phosphonates were also detected.

290 through classical reactions, the new indole phosphonates were found to undergo the desired condensat

291 e reduced, and 3-azabicyclo[3.1.0]hexan-1-yl phosphonates were obtained.

292 3-Azabicyclo[3.1.0]hex-2-en-1-yl phosphonates were prepared in a five-step reaction route

293 lly hindered aldehydes, (alpha-fluoroallenyl)phosphonates were the solely isolated products.

294 The unsaturated phosphonates were utilized as Hauser acceptors successfu

295 ex catalyses C-P bond cleavage of many alkyl phosphonates when the environmental concentration of pho

296 Instead, DeltaAla(P) is hydrolyzed to acetyl phosphonate, which is converted to Ala(P) by a second py

297 Our initial strategy was to cover the phosphonate with hydrophobic moieties such as pivaloylox

298 f the intermediate (3,3-dibromodifluoroallyl)phosphonate with potassium tert-butoxide gave rise to th

299 llows the direct oxygen-arylation of dialkyl phosphonates with diaryliodonium salts.

300 thesis of four l-2'-deoxy-threose nucleoside phosphonates with the natural nucleobases adenine, thymi

301 r-catalyzed electrophilic amination of alpha-phosphonate zincates with O-acyl hydroxylamines.