ライフサイエンスコーパス: phosphonic acid

1 P ((+/-)3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid)].

2 (+/-)-3-[2-carboxypiperazine-4-yl]-propyl-1-phosphonic acid.

3 t (RS)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid.

4 azide linker between a carboxylic acid and a phosphonic acid.

5 achieved by linking a 2-aminothiazole with a phosphonic acid.

6 -1,2,3,4-tetrahydroquin oxalin-5-yl)-methyl]-phosphonic acid.

7 ntrast to the higher pK(a) values typical of phosphonic acids.

8 cleavage of the products to the parent amino phosphonic acids.

9 azapurine derivatives or deprotected to free phosphonic acids.

10 alogues, phosphonothioic acids compared with phosphonic acids.

11 ydrogen in the alpha-methylene groups of the phosphonic acid 1, 3-BPG analogs markedly improves their

12 N(6)-benzyl-adenosine-5'-O-[(phosphonomethyl)phosphonic acid] (10g, PSB-12379, Ki 9.03 nM).

13 ives, i.e., two monoesters (13 and 14), four phosphonic acids (15-18), and one cyclic phosphonate (23

14 (153)Sm-ethylenediamine tetramethylene phosphonic acid ((153)Sm-EDTMP) therapy for osteosarcoma

15 )SrCl, (153)Sm-ethylenediaminetetramethylene phosphonic acid ((153)Sm-EDTMP), (179m)SnCl, and (166)Ho

16 The resulting benzimidazole phosphonic acid, 16, inhibited human FBPase (IC50 = 90 n

17 with a novel Mn complex, fac-[MnBr(4,4'-bis(phosphonic acid)-2,2'-bipyridine)(CO)3 ] (MnP), immobili

18 Optimization of the diamide prodrugs of phosphonic acid 2a (MB05032) led to the identification o

19 A synthesis of the benzothiazepine phosphonic acid 3, employing both enzymatic and transiti

20 er(OBn)TrpNH2 (3), and alpha-hydroxyfarnesyl phosphonic acid (4).

21 No conversion of monoester 4c to phosphonic acid 4a was observed in rats after intravenou

22 -4-(2-fluorophenyl)but-3- yny l]amino]methyl]phosphonic acid (56), an arylacetylene amino phosphonate

23 of [1, 1-difluoro-1-(2-naphthalenyl)-methyl]phosphonic acid (6) complexed within the catalytic site

24 w [(bpHc)Ru(L)2] (bpH2cH = 2,2'-bipyridine-6-phosphonic acid-6'-carboxylic acid, L = 4-picoline or is

25 ifluoro-1-[2-(4-hydroxynaphthalenyl)] methyl]phosphonic acid (8), could potentially replace a water m

26 1,4,8,11-tetraazacyclotetradecane-1-(methane phosphonic acid)-8-(methane carboxylic acid) (CB-TE1A1P)

27 Both phosphonic acids ( 9, 12, or 13) and their disodium salt

28 s of CPP (3-(2-carboxypiperazin4-yl)propyl-l-phosphonic acid), a competitive NMDA receptor antagonist

29 surements of the binding affinity of leucine phosphonic acid, a transition state analogue, and leucin

30 ivudine (3TC), and cytarabine as well as the phosphonic acid adefovir were shown to cleave following

31 [(+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid], alone (n = 14) or combined with AMPA r

32 -1,2,3,4-tetrahydro-qu inoxalin-5-yl)-methyl]phosphonic acid), an antagonist with relative NR1/NR2A s

33 The enantiomeric phosphonic acid analogs of Leu and hPhe, which correspon

34 ibutable to the deviated orientations of its phosphonic acid and 3-pentyl groups in the NA active sit

35 of 3-((R)-2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid and CNQX or by uncaging IP3.

36 sitivity of the rho1 GABACR to 3-aminopropyl-phosphonic acid and its analog 3-aminopropyl-(methyl)pho

37 digit nanomolar affinities were exhibited by phosphonic acid and malonyl-containing diacidic phosphor

38 The phosphonic acid and sulfuric acid analogs of OVS are als

39 A direct approach to important alpha-amino phosphonic acids and its derivatives has been developed

40 enerate trialkylphosphine oxide and oleic or phosphonic acid anhydride products.

41 -, monoanhydride with (dichloromethylene)bis[phosphonic acid] (AR-C69931MX) as a neutral antagonist.

42 activity relationships of a small library of phosphonic acid arginine mimetics that probe the S1 pock

43 e report the discovery of a series of purine phosphonic acids as AMP mimics targeting the AMP site of

44 ty of microorganisms have the ability to use phosphonic acids as sole sources of phosphorus.

45 ally diverse compounds (benzoic, diketo, and phosphonic acids, as well as a bisamidine and a bisamine

46 h began by replacing the 5'-phosphate with a phosphonic acid attached to C8 of the adenine base via a

47 ric films enabled by polarizable pi-electron phosphonic acid building blocks and ultrathin ZrO(2) lay

48 e diamides that convert to the corresponding phosphonic acid by sequential action of an esterase and

49 (+/-)-3-(2-carboxypiperazin-4-yl)-propyl -1-phosphonic acid caused a dose-dependent attenuation of S

50 enylethyl)amino-2-(S) hydroxypropyl-p-benzyl-phosphonic acid (CGP 55845A), but not by the A(1)R antag

51 the alternative cadmium precursors, cadmium-phosphonic acid complexes.

52 receptor 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) high-affinity binding site is modi

53 t d(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP) on the extinction of conditioned f

54 agonist 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) or the AMPA receptor antagonist 1,

55 tagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) prevents modification of the recep

56 tor antagonist 3-(2-carboxypiperazin-4-yl)-1-phosphonic acid (CPP) reduces NMDA-mediated neurotoxicit

57 l-3[(+/-)-2-carboxypiperazine-4-yl]-propyl-1-phosphonic acid (CPP) to determine whether the alteratio

58 ist ((+)-3-2-(carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP)) treatment also increased the R1 a

59 st (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), administered in a dose that block

60 ist [(+/-)-2-carboxypiperazin-4-yl] propyl-1-phosphonic acid (CPP), were performed on sections from C

61 st (+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP).

62 agonist 3-[2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP; 5 microM) elevated the threshold f

63 er) and 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP; NMDA receptor blocker) greatly dim

64 (3-((+/-)-2- carboxypiperazin-4-yl)propyl-1-phosphonic acid, CPP) systemically either before examini

65 iethoxyphosphoryl)phenyl substituent (or the phosphonic acid derivative).

66 iazofurin (24) with the difluoromethylenebis(phosphonic acid) derivative gave the phosphonate 25 whic

67 an effective sequence for the preparation of phosphonic acid derivatives of the diamondoids diamantan

68 es, providing beta-stereogenic alpha-hydroxy phosphonic acid derivatives.

69 e formation of P-stereogenic cyclohexadienyl-phosphonic acid derivatives.

70 etraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid (DOTMP) and were a subset of patients en

71 s (EC50 = 19-89 nM) than their corresponding phosphonic acids (EC50 = 50-343 nM) in protection of cel

72 oride, (153)Sm-ethylenediaminetetramethylene phosphonic acid (EDTMP), and (223)Ra-dichloride.

73 ), and 153Sm-ethylene diamine tetramethylene phosphonic acid (EDTMP), have been used to treat bone pa

74 Phosphonic acids encompass a common yet chemically diver

75 metric behavior indicates that the porphyrin-phosphonic acids form robust, electrically well-behaved

76 es have been synthesized with bipyridine and phosphonic acid functional groups.

77 The derivatization of the phosphonic acid functionality of FPMPs with a diamyl asp

78 Replacement of the phosphonic acid group by either a carboxylic acid or a t

79 synthetic approaches for introduction of the phosphonic acid group include derivatization of a bromoa

80 nt of the carboxylic acid functionality by a phosphonic acid group which delivered the most potent mo

81 Synthetic molecules bearing phosphonic acid groups can be readily attached to oxide

82 he routes enable (1) incorporation of masked phosphonic acid groups in precursors for use in the rati

83 The MOF contains free phosphonic acid groups, shows high humidity stability, a

84 emistry associated with deprotonation of the phosphonic acid groups.

85 h contains an outer coordination sphere with phosphonic acid groups.

86 (2) derivatization of porphyrins with masked phosphonic acid groups.

87 anine ammonia lyase inhibitor 2-aminoindan-2-phosphonic acid, guaiacol and veratrole levels were redu

88 st, 3-((R)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, had no effect on the depolarizations at

89 ly used anchors such as carboxylic acids and phosphonic acids have limited stability in aqueous envir

90 acid, boronic acid, 2-oxoaldehyde, and ethyl phosphonic acid hydrogen bond-acceptor analogues were in

91 ddition of a small amount of stearic acid or phosphonic acid, immediate partial dissolution of ZnO na

92 ons with 4,4'-biphenyl and 4,4'-terphenylbis(phosphonic acid) in DMSO or DMSO-ethanol mixtures produc

93 of UMP-morpholidate with fluoromethylenebis(phosphonic acid)) in D2O at pH 10 are indeed readily dis

94 tly discovered potent and selective thiazole phosphonic acid inhibitors of fructose 1,6-bisphosphatas

95 rst and second generation aryldifluoromethyl-phosphonic acid inhibitors.

96 yl thiophene) containing chain-end thiols or phosphonic acids is crystallized to yield nanowires with

97 Thus the reaction with phosphonic acids is not just surface-limited, but can co

98 l)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid) is a dAMP (2'-deoxyadenosine monophosph

99 nions of phosphonothioic acids compared with phosphonic acids, it was found that, with some exception

100 ied with a self-assembled monolayer (SAM) of phosphonic acid ITO linkers with a dangling carboxylate

101 In this regard, this novel phosphonic acid methodology provides a new high-yielding

102 The phosphonic acid methyl ester monosodium salt 11 did not

103 the glycerol backbone and phosphonoinositol, phosphonic acid, methyl phosphonate, phosphatidic acid,

104 ium methoxide afforded disodium salts of the phosphonic acid moiety.

105 titution of the distal carboxylic acid for a phosphonic acid moiety.

106 a monolayer of t-butyl carbazole-substituted phosphonic acid molecules and subsequent p-doping.

107 By comparison, phosphonic acid molecules are found to adsorb electrosta

108 hat a perfectly ordered layer of monodentate phosphonic acid molecules is chemically grafted at room

109 The phosphonic acid mono alkyl esters are accessible by the

110 Treatment of nonstabilized beta-hydroxy phosphonic acid mono methyl esters with diisopropyl carb

111 analogous lariat ether carboxylic acids and phosphonic acid monoethyl esters.

112 ndergo ring opening was exploited to prepare phosphonic acid monomethyl esters in high yield by trans

113 The beta-hydroxy phosphonic acid monomethyl esters were dehydrated with d

114 resistance using a covalent attachment of a phosphonic acid motif to a peptidomimetic inhibitor scaf

115 imethyl methyl phosphonate (DMMP) and methyl phosphonic acid (MPA) exhibit the reduced mobility value

116 The complex Tb-3,6,9-tris(methylene phosphonic acid n-butyl ester)-3,6,9,15-tetraazabicyclo[

117 -1,2,3,4-tetrahydroquinoxalin- 5-yl)-methyl]-phosphonic acid (NVP-AAM077) and the NR2B-receptor-antag

118 -1,2,3,4-tetrahydroquino xalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) at rat recombinant N-methyl

119 o-1,2,3,4-tetrahydroquinoxalin-5 -yl)-methyl-phosphonic acid (NVP-AAM077), contains a unique combinat

120 ntration of glyphosate and AMPA (aminomethyl phosphonic acid, one of its major degradation products)

121 Phosphonic acid (PA) thyroid hormone receptor (TR) agoni

122 veys the literature on TCO modification with phosphonic acids (PAs), which has increasingly been used

123 luble protein receptors for pinacolyl methyl phosphonic acid (PMPA), the predominant hydrolytic produ

124 Farnesyl phosphonic acids potentiate the upregulation of these pr

125 s NRRL B-16338, were identified as potential phosphonic acid producers by screening for the gene enco

126 Titrations of G6P itself and the free phosphonic acids provides second pKa values of 6.5 (1, b

127 combination with the monomethylation of the phosphonic acid, renders DHP a Trojan horse type antibio

128 ogue of 2-(3-pyridyl)-1-hydroxyethylidenebis(phosphonic acid) (risedronic acid, 2), an osteoporosis d

129 st 3-((RS)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid ((RS)-CPP), and completely blocked by th

130 ohol could not react with the resulting zinc phosphonic acid salt, it could force the newly formed zi

131 n contrast (comparable to that obtained from phosphonic acid SAMs deposited from solution).

132 ontact printing to pattern pentafluorobenzyl phosphonic acid self-assembled monolayers (SAMs) on indi

133 o-1,2,3,4-tetrahydroquino xalin-5-yl)-methyl-phosphonic acid-sensitive (NVP-AAM077-sensitive) (NR2A-c

134 saccharide sucrose or industrially important phosphonic acid species slow dramatically the hydration

135 chalcogenides deoxygenate the oleic acid or phosphonic acid surfactant to generate trialkylphosphine

136 Oseltamivir phosphonic acid (tamiphosphor, 3a), its monoethyl ester

137 For selected porphyrin-phosphonic acids, the electrochemical characteristics ha

138 Like most phosphonic acids, the recently discovered potent and sel

139 koxide layer, which reacts with solutions of phosphonic acids to attach monolayer films of phosphonat

140 vity using the hydroxy-2-naphthalenyl methyl phosphonic acid tris acetoxymethyl ester (HNMPA-(AM)(3))

141 dical reactivity took place depending on the phosphonic acid used.

142 roM 3-((D)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid was applied during the preconditioning i

143 tors of this enzyme, a series of benzoic and phosphonic acids was designed and synthesized.

144 ,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid, was identified as a potent NMDA antagon

145 ADP (AOPCP, adenosine-5'-O-[(phosphonomethyl)phosphonic acid]) was used as a lead structure, and deri

146 The phosphonic acids were backflush-desorbed onto a polymeri

147 s of phosphonothioic acids and corresponding phosphonic acids were synthesized and their inhibitory p

148 us protecting groups, the four alpha-hydroxy phosphonic acids were tested for their ability to serve

149 D-3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid, which binds to NR2A/B with very high af

150 ization of the resulting [(alkyloxy)carbonyl]phosphonic acids with 2 equiv of sodium methoxide afford