ライフサイエンスコーパス: phosphoramide

1 and stereoselectivity of various classes of phosphoramides.

2 the presence of catalytic amounts of chiral phosphoramides.

3 subjected to aldolization in the presence of phosphoramides, and the intrinsic selectivity of these e

4 N-triflylphosphoramide produces hydrazonium-phosphoramide anion complexes.

5 All of the phosphoramides are saturated with silicon tetrachloride

6 A new phosphoramide based on a 2,2'-bispyrrolidine skeleton ha

7 anistic pathways involving either one or two phosphoramides bound to a siliconium ion organizational

8 o hydrolase activity toward phosphodiesters, phosphoramides, carboxyl esters, or sulfoesters.

9 Chiral phosphoramide catalyzed-enantioselective aldol addition

10 In all cases, the phosphoramide-catalyzed aldol addition of E-trichlorosil

11 Phosphoramide-catalyzed aldol additions lacked substrate

12 The mechanism of the phosphoramide-catalyzed enantioselective aldol additions

13 d to DCP vapor, the conversion of FLA into a phosphoramide causes a rapid and intense fluorescence in

14 A thorough examination of a range of phosphoramides has established empirical structure-activ

15 the reaction was found to likely involve two phosphoramides in both the rate and stereochemistry dete

16 bination of silicon tetrachloride and chiral phosphoramides is a competent catalyst for highly select

17 sight that more than one Lewis basic moiety (phosphoramide) is involved in the rate- and stereochemis

18 by binding of a strongly Lewis basic chiral phosphoramide, leading to in situ formation of a chiral

19 The reaction is catalyzed by a BINAM-based phosphoramide Lewis base catalyst which assists in the h

20 bination of silicon tetrachloride and chiral phosphoramide Lewis bases.

21 Different chiral phosphoramide moieties were connected by tethers of meth

22 The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500x selective cyto

23 4-HC generates two active metabolites, phosphoramide mustard (PM) and acrolein.

24 iques were used to study the partitioning of phosphoramide mustard (PM) and its aziridinium ions amon

25 amide (4-HDC), a progenitor of acrolein, and phosphoramide mustard (PM).

26 ed to provide a pathway for expulsion of the phosphoramide mustard alkylating agent.

27 Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. col

28 t is metabolized by cytochrome P450 to yield phosphoramide mustard and acrolein, which alkylate DNA a

29 CPA undergoes metabolic activation to phosphoramide mustard and nornitrogen mustard (NOR) whic

30 y bound intermediates of mechlorethamine and phosphoramide mustard assumed thermodynamically stable c

31 ts in the highest quartile of o-carboxyethyl-phosphoramide mustard exposure had a 5.9-fold higher ris

32 ontrol compounds 5 and 15, which lack in the phosphoramide mustard group.

33 Mechlorethamine and phosphoramide mustard induced intrastrand crosslinks bet

34 ter than 1) and/or excellent cytotoxicity of phosphoramide mustard released.

35 diamidates have been designed as prodrugs of phosphoramide mustard requiring bioreductive activation.

36 eduction by DTD followed by expulsion of the phosphoramide mustard substituent from the hydroquinone.

37 amide and 4-hydroperoxyifosfamide but not to phosphoramide mustard, ifosfamide mustard, melphalan, or

38 ere cross-resistant to other OAPs but not to phosphoramide mustard, ifosfamide mustard, melphalan, or

39 rticularly for the metabolite o-carboxyethyl-phosphoramide mustard, whose area under the curve varied

40 base-catalyzed beta-elimination of cytotoxic phosphoramide mustard.

41 ntracellular concentrations of the cytotoxic phosphoramide mustard.

42 resulted in rapid expulsion of the cytotoxic phosphoramide mustard.

43 s treated with melphalan, mechlorethamine or phosphoramide mustard.

44 icancer prodrugs that liberate the cytotoxic phosphoramide mustards (PM, IPM, and tetrakis-PM) via be

45 unds were more potent than the corresponding phosphoramide mustards against V-79 Chinese hamster lung

46 t all these compounds spontaneously liberate phosphoramide mustards with half-lives in the range of 0

47 ulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility a

48 of SiCl4 and the catalytic action of chiral phosphoramide (R,R)-5, silyl ketene imines undergo extre

49 o date with the silicon tetrachloride-chiral phosphoramide system.

50 rosilanes to benzaldehyde promoted by chiral phosphoramides to give the enantioenriched homoallylic a

51 lyltrichlorosilane promoted by the bidentate phosphoramides was found to be highly dependent on the t

52 nantioselective allylation, bidentate chiral phosphoramides were developed.

53 , biotin-HDAAMP (adenosine 5'-(6-aminohexyl) phosphoramide; where HDA is 1,6-hexanediamine), is chemi