ライフサイエンスコーパス: phosphoribosyl

1 ic acid mononucleotide (NAMN) and PPi from 5-phosphoribosyl 1-pyrophosphate (PRPP) and nicotinic acid

2 de, carbon dioxide, and pyrophosphate from 5-phosphoribosyl 1-pyrophosphate (PRPP) and quinolinic aci

3 d only slightly, whereas those for alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP) are lower by appro

4 ide (NAMN) from nicotinic acid and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP).

5 otide (NAMN) from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP).

6 yrophosphate from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP).

7 ibosyl transferases (ATP-PRT) join ATP and 5-phosphoribosyl-1 pyrophosphate (PRPP) in the first react

8 by the addition of 25 microM GMP, whereas 5-phosphoribosyl-1-diphosphate (PRibPP) at 50-250 microM c

9 GMP and 5-phosphoribosyl-1-diphosphate provided complete protectio

10 This is likely because of depletion of 5-phosphoribosyl-1-pyrophosphate (consumed in the hypoxant

11 ribosyltransferases (PRTases) with alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP) binding to the enz

12 Adenine and alpha-d-5-phosphoribosyl-1-pyrophosphate (PRPP) have K(m) values o

13 ibosyl transferase (ATP-PRT) joins ATP and 5-phosphoribosyl-1-pyrophosphate (PRPP) in a highly regula

14 hosphoribosylation of adenine from alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP) to form AMP and PP

15 ransfer of ribose 5-phosphate from alpha-d-5-phosphoribosyl-1-pyrophosphate (PRPP) to the N1 nitrogen

16 osphate (OMP) from orotic acid and alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP).

17 onophophate (OMP) from orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP).

18 guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (PRPP).

19 PP i) from nicotinamide (NAM) and alpha- d-5-phosphoribosyl-1-pyrophosphate (PRPP).

20 tinate mononucleotide from quinolinate and 5-phosphoribosyl-1-pyrophosphate (PRPP).

21 s: the ribose-phosphate pyrophosphokinase (5-phosphoribosyl-1-pyrophosphate synthetase; PRPP syntheta

22 of a ribosyl phosphate group from alpha-D-5-phosphoribosyl-1-pyrophosphate to the N1 nitrogen of ura

23 ssion decreased the intracellular level of 5-phosphoribosyl-1-pyrophosphate, a product of the pentose

24 d sensitivity to the allosteric activator, 5-phosphoribosyl-1-pyrophosphate, and a loss of UTP inhibi

25 TP, and decreased allosteric activation by 5-phosphoribosyl-1-pyrophosphate, functional changes that

26 se reaction) and subsequent slowing of the 5-phosphoribosyl-1-pyrophosphate-dependent orotate phospho

27 ne diphosphate, 2,3 diphosphoglycerate and 5-phosphoribosyl-1-pyrophosphate.

28 sion patterns of the single gene encoding 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole

29 The chimera has a single site that binds phosphoribosyl 5'-pyrophosphate (PRPP) with a dissociati

30 The enzyme N(1)-(5'-phosphoribosyl) adenosine-5'-monophosphate cyclohydrolas

31 ation by inclusion of the substrate N(1)-(5'-phosphoribosyl)adenosine 5'-monophosphate; (PR-AMP), whi

32 N1-(5'-Phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase

33 clearly identify the AMP as binding in the 5-phosphoribosyl-alpha-1-pyrophosphate (PRPP)-binding site

34 Phosphoribosyl amine (PRA) is an intermediate in purine

35 Phosphoribosyl amine (PRA) is the first intermediate in

36 has shown that the first common metabolite, phosphoribosyl amine (PRA), can be generated in the abse

37 s indicate that the cellular accumulation of phosphoribosyl anthranilate can result in nonenzymatic P

38 The N-1-(5'-phosphoribosyl)-ATP transferase (ATP-PRTase) encoded by

39 The N-1-(5'-phosphoribosyl)-ATP transferase catalyzes the first step

40 The crystal structures of the N-1-(5'-phosphoribosyl)-ATP transferase from Mycobacterium tuber

41 quence relationship to the phage T4 dCTPase, phosphoribosyl-ATP pyrophosphatase HisE, NTP pyrophospha

42 Numerous contacts are made both to the phosphoribosyl backbone and to the ordered bases.

43 hypoxanthine (Hx) and guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (P

44 sphoribosyltransferases that do not form the phosphoribosyl-enzyme intermediate predicted by classic

45 osynthesis and lead to the generation of pro-phosphoribosyl formimino-5-aminoimidazole-4-carboxamide

46 talyzes the Amadori rearrangement of N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide

47 Interactions between the enzyme and the phosphoribosyl group anchor the pyrimidine within the ac

48 nes that encode an enzyme that transfers the phosphoribosyl group of nicotinate mononucleotide (NaMN)

49 Compared to k(cat), phosphoribosyl group transfer is rapid in both the forwa

50 thin the active site, helping to explain the phosphoribosyl group's remarkably large contribution to

51 Thus, the effective concentration of the 5'-phosphoribosyl group, in stabilizing the transition stat

52 We observe that the dual-substrate phosphoribosyl isomerase A or priA gene, at which these

53 et-tRNAMet was almost entirely due to the 2'-phosphoribosyl modification at nucleotide G64, since rem

54 d by their removal from solvent water, the 1-phosphoribosyl moiety of OMP was replaced with 1-substit

55 tent with the observed binding energy of the phosphoribosyl part of the substrate; and (vi) the presu

56 thetase, carbamoyl phosphate synthetase, and phosphoribosyl pyrophosphate (PRPP) amidotransferase, gu

57 These mutations result in a loss of phosphoribosyl pyrophosphate (PRPP) synthetase 1 activit

58 y the reaction of 4-hydroxybenzoic acid with phosphoribosyl pyrophosphate (PRPP) to form 4-(beta-d-ri

59 d pyrophosphate from nicotinic acid (NA) and phosphoribosyl pyrophosphate (PRPP).

60 ntified in tryptophan synthase and glutamine phosphoribosyl pyrophosphate amidotransferase and are li

61 PRA is normally synthesized by phosphoribosyl pyrophosphate amidotransferase, a high-tu

62 De novo synthesis of purines and cellular phosphoribosyl pyrophosphate content also were moderatel

63 complex that contains ribosomal protein S1, phosphoribosyl pyrophosphate synthase, RNase R, and YfbG

64 identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1),

65 Repression of phosphoribosyl pyrophosphate synthetase 1, a target of t

66 of adenosine and inosine, and regulation of phosphoribosyl pyrophosphate synthetase by adenosine dip

67 Phosphoribosyl pyrophosphate synthetase-1 (PRPS1) is a k

68 sensitive to activation (which depends upon phosphoribosyl pyrophosphate).

69 longer activated by the allosteric effector phosphoribosyl pyrophosphate, although evidence indicate

70 threonine dehydratase (IlvA), threonine, and phosphoribosyl pyrophosphate.

71 sugar pentoses utilization and biogenesis of phosphoribosyl pyrophosphate.

72 ude SmpB, ribosomal protein S1, RNase R, and phosphoribosyl pyrophosphate.

73 AS was able to generate PRA from ammonia and phosphoribosyl pyrophosphate.

74 timated Kis of 25.4 microM against alpha-D-5-phosphoribosyl-pyrophosphate (PRPP) in converting hypoxa

75 We find that a single rate-limiting enzyme, phosphoribosyl-pyrophosphate synthetase 2 (PRPS2), promo

76 d step in the process is the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate to

77 of NAMN formation, indicating that on-enzyme phosphoribosyl transfer chemistry is rate-determining.

78 In contrast, D137N showed slower phosphoribosyl transfer chemistry, although guanine (300

79 a burst in product formation indicating that phosphoribosyl transfer proceeds rapidly relative to som

80 etic mechanism for OPRTase, in which a rapid phosphoribosyl transfer reaction at equilibrium is follo

81 The overall equilibrium for the hypoxanthine phosphoribosyl transfer reaction lies far toward nucleot

82 N within the crystal lattice and undergo the phosphoribosyl transfer reaction to form product.

83 te experiments with K165Q indicated that the phosphoribosyl transfer step was fast in the forward rea

84 (QAPRTase, EC 2.4.2.19) catalyzes an unusual phosphoribosyl transfer that is linked to a decarboxylat

85 denosine/AdoHcy nucleosidase (MTAN), adenine phosphoribosyl transferase (APRT), and pyruvate orthopho

86 as a probe, the Ag precursor gene, adenosine phosphoribosyl transferase (APRT), was isolated by expre

87 Adenine phosphoribosyl transferase (APRTase) and pyruvate orthop

88 ATP phosphoribosyl transferase (ATP-PRT) joins ATP and 5-pho

89 HisG is an ATP-phosphoribosyl transferase (ATPPRTase) that catalyzes th

90 Hypoxanthine-guanine-xanthine phosphoribosyl transferase (HGXPRTase), an essential enz

91 WTK1 cells at both the hypoxanthine quanine phosphoribosyl transferase (hprt) and the thymidine kina

92 al transgene cassettes into the hypoxanthine phosphoribosyl transferase (HPRT) and Type I collagen (C

93 Utilizing the hypoxanthine guanine phosphoribosyl transferase (HPRT) as a test locus, it wa

94 els with the endogenous hypoxanthine-guanine phosphoribosyl transferase (hprt) gene and lacI transgen

95 s the mutation frequency of the hypoxanthine phosphoribosyl transferase (HPRT) gene in a TOP2-depende

96 transgene and of the endogenous hypoxanthine phosphoribosyl transferase (Hprt) gene in mouse embryoni

97 of a 14-kbp duplication in the hypoxanthine phosphoribosyl transferase (HPRT) gene, is elevated in h

98 erage, than that of the hypoxanthine-guanine phosphoribosyl transferase (Hprt) locus in Msh2-deficien

99 ere observed at the single copy hypoxanthine phosphoribosyl transferase (HPRT) locus in normal human

100 single-copy transgene into the hypoxanthine phosphoribosyl transferase (hprt) locus, we find that mi

101 unction mutation at the hypoxanthine guanine phosphoribosyl transferase (hprt) locus.

102 e (neo) into the X-linked human hypoxanthine phosphoribosyl transferase (HPRT) locus.

103 The HPRT assay measures hypoxanthine phosphoribosyl transferase (hprt) mutations, while the V

104 urine metabolic enzyme, hypoxanthine guanine phosphoribosyl transferase (HPRT).

105 inhibition of hypoxanthine-xanthine-guanine phosphoribosyl transferase (HXGPRT) expression by a chim

106 oplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase (HXGPRT) gene by insertional

107 a pharmacological inhibitor of nicotinamide phosphoribosyl transferase (NAMPT).

108 ) - a bifunctional enzyme comprising orotate phosphoribosyl transferase (OPRT) and orotidine monophos

109 pD subunit of the anthranilate synthase (AS)-phosphoribosyl transferase (PRT) complex.

110 king the crc gene are genes encoding orotate phosphoribosyl transferase (pyrE) and RNase PH (rph).

111 Quinolinic acid phosphoribosyl transferase (QAPRTase, EC 2.4.2.19) is a

112 est protective effects, whereas nicotinamide phosphoribosyl transferase and nicotinic acid phosphorib

113 Adenine phosphoribosyl transferase converts adenine to AMP and p

114 sentially all CpGs in the critical guanosine phosphoribosyl transferase core are methylated.

115 omposed of three groups consisting of HPRT1, phosphoribosyl transferase domain containing protein 1 (

116 The fact that elevated levels of quinolinate phosphoribosyl transferase enhance growth on phthalate s

117 a transgene, the bacterial xanthine guanine phosphoribosyl transferase gene (gpt), differentially ne

118 es de novo genetic mutations of hypoxanthine phosphoribosyl transferase gene in CML and non-CML cells

119 ation during necrotrophy, whereas the uracil phosphoribosyl transferase gene involved in pyrimidine s

120 mit of detection (<10(-3) fg/pg hypoxanthine phosphoribosyl transferase gene; HPRT) in both MRL/+ and

121 me with a gpt gene encoding xanthine-guanine phosphoribosyl transferase in place of the env gene, we

122 146 CAG repeats into the murine hypoxanthine phosphoribosyl transferase locus (Hprt(CAG)146), which d

123 rted into the X-linked hypo xanthine-guanine phosphoribosyl transferase locus, resulting in gene inac

124 o gene plus a partially deleted hypoxanthine phosphoribosyl transferase minigene.

125 pathway despite no increase in nicotinamide phosphoribosyl transferase or in the NR transport protei

126 oxanthine phosphoribosyl transferase/adenine phosphoribosyl transferase reaction) and subsequent slow

127 phoribosyl-1-pyrophosphate-dependent orotate phosphoribosyl transferase reaction, which depletes orot

128 hosphoribosyl transferase and nicotinic acid phosphoribosyl transferase showed moderate protective ac

129 tokine signal was normalized to hypoxanthine phosphoribosyl transferase signal obtained from the same

130 is in part due to low expression of adenine phosphoribosyl transferase under high AICAR conditions.

131 A gene coding for an enzyme (quinolinate phosphoribosyl transferase) involved in the biosynthesis

132 uencies at the hemizygous HPRT (hypoxanthine phosphoribosyl transferase) locus, but the mutation spec

133 he Hprt locus (encoding hypoxanthine guanine phosphoribosyl transferase).

134 The gene encodes hypoxanthine-guanine phosphoribosyl transferase, an enzyme involved in purine

135 HPT1 gene, encoding the hypoxanthine guanine phosphoribosyl transferase, enhances cisplatin resistanc

136 teinase 1 (TIMP-1), TIMP-2, and hypoxanthine phosphoribosyl transferase-1 (HPRT1).

137 s using interfering RNA against hypoxanthine phosphoribosyl transferase.

138 -pyrophosphate (consumed in the hypoxanthine phosphoribosyl transferase/adenine phosphoribosyl transf

139 train deficient in both hypoxanthine-guanine phosphoribosyl-transferase (HGPRT) and xanthine phosphor

140 Complete hypoxanthine-guanine phosphoribosyl-transferase (HPRT) deficiency in humans r

141 ssessing a genetically modified hypoxanthine phosphoribosyl-transferase (HPRT) with enhanced substrat

142 To obtain useful hypoxanthine phosphoribosyl-transferase (HPRT)-deficient mouse ES cel

143 evidence that only the ArsA subunit has base:phosphoribosyl-transferase activity, and propose a mecha

144 Two families of ATP phosphoribosyl transferases (ATP-PRT) join ATP and 5-pho

145 is octameric structure is unique to both the phosphoribosyl transferases and the aminoacyl-tRNA synth