ライフサイエンスコーパス: phosphoribosyltransferase

1 purine recycling enzyme hypoxanthine-guanine phosphoribosyltransferase.

2 ounts for the allosteric inhibition of MtATP-phosphoribosyltransferase.

3 ovo pathway gene, nadC, encoding quinolinate phosphoribosyltransferase.

4 eficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase.

5 D biosynthetic enzymes, namely, nicotinamide phosphoribosyltransferase.

6 at the site of the upt gene encoding uracil phosphoribosyltransferase.

7 city is funnelled exclusively through uracil phosphoribosyltransferase.

8 -glucuronidase and cytosine deaminase/uracil phosphoribosyltransferase.

9 lic factors rather by the specificity of the phosphoribosyltransferase.

10 as a fluorescent substrate for yeast adenine phosphoribosyltransferase.

11 lytically poised reaction complex for type I phosphoribosyltransferases.

12 cores, an element common to all known purine phosphoribosyltransferases.

13 a structural theme found in all known purine phosphoribosyltransferases.

14 yrophosphate has not been reported in purine phosphoribosyltransferases.

15 nished by adding nicotinic acid (NA) in a NA phosphoribosyltransferase 1 (NAPRT1)-dependent manner, b

16 target HPRT1, the gene encoding hypoxanthine phosphoribosyltransferase-1 (HPRT1), and POU5F1, the gen

17 gulated (thymidine kinase, 2.9-fold; orotate phosphoribosyltransferase, 2.3-fold; uridine monophospha

18 for the specificity of hypoxanthine-guanine phosphoribosyltransferase, a key enzyme in the purine sa

19 e generated mice overexpressing nicotinamide phosphoribosyltransferase, a rate-limiting enzyme for NA

20 1778 is a specific inhibitor of nicotinamide phosphoribosyltransferase, a rate-limiting enzyme requir

21 d characterized physically, for their uracil phosphoribosyltransferase activity and for their ability

22 ing, bioinformatic analyses, and an assay of phosphoribosyltransferase activity in Mycobacterium smeg

23 Indeed, the quinolinate (Qa) phosphoribosyltransferase activity of NadC from S. pyoge

24 B. burgdorferi showed low but detectable phosphoribosyltransferase activity with hypoxanthine eve

25 lation of pyr genes in vivo and their uracil phosphoribosyltransferase activity, which is catalyzed b

26 enhancing factor, known to have nicotinamide phosphoribosyltransferase activity.

27 show that a novel mycobacterial mannosylated phosphoribosyltransferase acts as a virulence and immuno

28 ccompanied by suppressed SIRT1, nicotinamide phosphoribosyltransferase, AGE receptor 1, and PPARgamma

29 hose without renal-risk variants; nicotinate phosphoribosyltransferase also displayed gene expression

30 The core of APRT is similar to that of other phosphoribosyltransferases, although the adenine-binding

31 circadian expression of NAMPT (nicotinamide phosphoribosyltransferase), an enzyme that provides a ra

32 rasite lacking hypoxanthine-xanthine-guanine phosphoribosyltransferase and a T. gondii cDNA library.

33 ities, Km values, and Vmax values of adenine phosphoribosyltransferase and of hypoxanthine phosphorib

34 The last two enzymes of the pathway, orotate phosphoribosyltransferase and orotidine-5-monophosphate

35 g MTA from the polyamine pathway via adenine phosphoribosyltransferase and recycling MTR to methionin

36 to FK866-mediated inhibition of nicotinamide phosphoribosyltransferase and stimulates glycolysis in c

37 cs for product formation in both the forward phosphoribosyltransferase and the reverse pyrophosphorol

38 Two of these, uridine kinase-uracil phosphoribosyltransferase and thymidine kinase, are uniq

39 is encoded on an operon with nicotinic acid phosphoribosyltransferase and, in some Pseudomonads, wit

40 Purine and pyrimidine phosphoribosyltransferases and nucleoside N-ribosyl hydr

41 SirT1, nicotinamide phosphoribosyltransferase, and NAD may, therefore, provi

42 Bacillus subtilis xpt gene encoding xanthine phosphoribosyltransferase, and the S-adenosyl-methionine

43 ily of salvage and biosynthetic enzymes, the phosphoribosyltransferases, and catalyzes the transfer o

44 Using the adenine phosphoribosyltransferase (APRT(+)) --> APRT(-) forward

45 he contrary, we found no evidence of adenine phosphoribosyltransferase (APRT) activity when parasites

46 major parallel pathways mediated by adenine phosphoribosyltransferase (APRT) and guanine phosphoribo

47 The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage ad

48 ed and nontranscribed strands of the adenine phosphoribosyltransferase (APRT) gene in Chinese hamster

49 ations in the second intron of the adenosine phosphoribosyltransferase (APRT) gene in Chinese hamster

50 lification and overexpression of the adenine phosphoribosyltransferase (APRT) gene.

51 the CpG island upstream of the mouse adenine phosphoribosyltransferase (Aprt) gene.

52 nation between direct repeats at the adenine phosphoribosyltransferase (APRT) locus in ERCC1-deficien

53 ssociated silencing of the autosomal adenine phosphoribosyltransferase (Aprt) locus occurs in primary

54 iciently repaired in both strands of adenine phosphoribosyltransferase (APRT) locus, in either a tran

55 Knockdown for adenine phosphoribosyltransferase (APRT) or nicotinamide phospho

56 was demonstrated with mutant hamster adenine phosphoribosyltransferase (aprt) transcripts that are no

57 Adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) catalyzes t

58 The adenine phosphoribosyltransferase (APRTase) from Giardia lamblia

59 Adenine phosphoribosyltransferase (APRTase) is a widely distribu

60 and relies primarily on adenine and guanine phosphoribosyltransferases (APRTase and GPRTase) constit

61 ltered expression of a gene encoding adenine phosphoribosyltransferase (APT1), an enzyme that convert

62 sis has shown that the anthranilate synthase-phosphoribosyltransferase (AS-PRT) enzyme complex, invol

63 Phosphoribosyltransferase assays revealed that, in gener

64 ial structural differences from known purine phosphoribosyltransferases at positions remote from the

65 ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzym

66 ATP-phosphoribosyltransferase (ATP-PRT), the first enzyme of

67 osteric domain.Active and inactive state ATP-phosphoribosyltransferases (ATP-PRTs) are believed to ha

68 of biomass in E. coli were identified as ATP phosphoribosyltransferase, ATP synthase, methylene-tetra

69 Unlike all known phosphoribosyltransferases, beta-RFA-P synthase catalyze

70 cleotide binding to PyrR is similar to other phosphoribosyltransferases, but Mg2+ binding differs.

71 Purine phosphoribosyltransferases catalyze the Mg2+ -dependent

72 MtATP-phosphoribosyltransferase catalyzes the first and commit

73 In de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase catalyzes the formation of oro

74 and activity of a cytosine deaminase-uracil phosphoribosyltransferase (CD-UPRT) fusion enzyme expres

75 diac-specific overexpression of nicotinamide phosphoribosyltransferase (cNAMPT) as examples.

76 void of NaMN:5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) activity was used to is

77 otide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enteric

78 onucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella enteric

79 ate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimu

80 ized by nicotinate mononucleotide (NaMN):DMB phosphoribosyltransferases (CobT in Salmonella enterica)

81 nthetic enzyme complex anthranilate synthase-phosphoribosyltransferase, composed of the TrpD and TrpE

82 The structure represents a new fold for a phosphoribosyltransferase, consisting of three continuou

83 reased dosage of NPT1, encoding a nicotinate phosphoribosyltransferase critical for the NAD(+) salvag

84 ft loss in patients with undiagnosed adenine phosphoribosyltransferase deficiency and the need for im

85 ls led to accumulation of cells with adenine phosphoribosyltransferase deficiency and UPD.

86 Adenine phosphoribosyltransferase deficiency is a rare autosomal

87 We describe a patient with adenine phosphoribosyltransferase deficiency who was diagnosed d

88 eatures associated with hypoxanthine-guanine phosphoribosyltransferase deficiency.

89 agnosis of all forms of hypoxanthine-guanine phosphoribosyltransferase deficiency.

90 phoribosyltransferase (APRT) or nicotinamide phosphoribosyltransferase did not change the antiviral a

91 fic noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, does not alter glycolysis or

92 residues required for the reorganization of phosphoribosyltransferase domain "flexible loop" that le

93 ded that the contact between Ile(335) in the phosphoribosyltransferase domain and Tyr(74) in the glut

94 Binding of PRPP to a C-terminal phosphoribosyltransferase domain is required to activate

95 on to other protein domains, such as orotate phosphoribosyltransferase, during evolution in different

96 nonucleotide:5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (EC 2.4.2.21) enzyme that synt

97 a protein called extracellular nicotinamide phosphoribosyltransferase (eNampt; also known as pre-B c

98 identified a novel mannosylated glycoprotein phosphoribosyltransferase, encoded by Rv3242c from M. tu

99 e reaction known to be catalyzed by the CobT phosphoribosyltransferase enzyme (EC 2.4.2.21).

100 a decrease in expression of the nicotinamide phosphoribosyltransferase enzyme that recycles the nicot

101 NAD+ levels by interfering with nicotinamide phosphoribosyltransferase expression rendered tumor cell

102 similarities to other members of the type 1 phosphoribosyltransferase family but do not reveal the s

103 yeast fusion gene, cytosine deaminase/uracil phosphoribosyltransferase (FCU).

104 led that the functional domain has a type II phosphoribosyltransferase fold that may be a common arch

105 ified with the micronucleus and hypoxanthine phosphoribosyltransferase forward mutation assays.

106 Guanine phosphoribosyltransferase from Giardia lamblia, a key en

107 termined the crystal structure of nicotinate phosphoribosyltransferase from Themoplasma acidophilum (

108 urification of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Thermus thermophilus (TtH

109 Orotate phosphoribosyltransferases from Plasmodium falciparum an

110 For the X-linked human hypoxanthine phosphoribosyltransferase gene (HPRT), this difference i

111 geted correction of a defective hypoxanthine phosphoribosyltransferase gene in hematopoietic progenit

112 black patients revealed that the nicotinate phosphoribosyltransferase gene, responsible for NAD bios

113 le mutation rate of the hypoxanthine-guanine phosphoribosyltransferase gene.

114 omeric sequences, and the human hypoxanthine phosphoribosyltransferase gene.

115 th and mutations at the hypoxanthine-guanine phosphoribosyltransferase gene.

116 s deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutag

117 Of the two phosphoribosyltransferase genes found in the H. pylori g

118 By investigating candidate phosphoribosyltransferase genes in the genome, we determ

119 phosphoribosyltransferase (APRT) and guanine phosphoribosyltransferase (GPRT) that constitute the pri

120 Guanine phosphoribosyltransferase (GPRTase) from Giardia lamblia

121 Hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)PRT) is crucial for the

122 Hypoxanthine-guanine-[xanthine] phosphoribosyltransferase (HG[X]PRT) is considered an im

123 ood inhibitors of human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Plasmodium falcipa

124 ty with the L. donovani hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and significant homolo

125 rines primarily through hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and xanthine phosphori

126 demonstrate that human hypoxanthine guanine phosphoribosyltransferase (HGPRT) converts T-705 into it

127 es of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HGPRT) have been determined a

128 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is the key enzyme in p

129 y was determined at the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) locus.

130 e purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) of the apicomplexan pr

131 f the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-xanthosine 5'-monophos

132 purine salvage enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

133 t salvage of guanine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

134 urine recycling enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGprt).

135 on two enzymes: a human hypoxanthine-guanine-phosphoribosyltransferase (HGPRTase) and its analogue in

136 phosphorylase (PNP) and hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) catalyze N-ribosidi

137 milar to those of human hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) despite distinct su

138 Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) from the protozoan pa

139 The hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase), a type I PRTase,

140 ine salvage by hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase).

141 e, making it a hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase).

142 e first enzyme in histidine biosynthesis ATP phosphoribosyltransferase (HisG).

143 ine biosynthetic enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) cause the intractable n

144 The hypoxanthine phosphoribosyltransferase (HPRT) from Trypanosoma cruzi,

145 toid cells in the human hypoxanthine-guanine-phosphoribosyltransferase (HPRT) gene and compared with

146 mouse ES cells having a mutant hypoxanthine phosphoribosyltransferase (Hprt) gene and grown on feede

147 moter and exon 1 of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in the mouse and h

148 e enzyme designed to target the hypoxanthine phosphoribosyltransferase (HPRT) gene located on human c

149 factor (VWF) and Flt-1, to the hypoxanthine phosphoribosyltransferase (Hprt) gene locus.

150 ectors were introduced into the hypoxanthine phosphoribosyltransferase (hprt) gene to produce substra

151 geted cells by co-targeting the hypoxanthine phosphoribosyltransferase (HPRT) gene.

152 functional, the complete human hypoxanthine phosphoribosyltransferase (HPRT) locus contained within

153 The hypoxanthine phosphoribosyltransferase (Hprt) locus has been shown to

154 tion frequencies at the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in diploid human

155 with cRSS sites at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in peripheral T c

156 somatic mutation events at the hypoxanthine phosphoribosyltransferase (HPRT) locus in peripheral T l

157 We found that hypoxanthine phosphoribosyltransferase (HPRT) mutation frequencies we

158 on the frequency of spontaneous hypoxanthine phosphoribosyltransferase (HPRT) mutations that can be d

159 sed by mutations of the hypoxanthine guanine phosphoribosyltransferase (HPRT) purine biosynthesis gen

160 mutant frequencies (Mfs) at the hypoxanthine phosphoribosyltransferase (HPRT) reporter gene in cord b

161 ns were detected in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) reporter gene in indepe

162 Here we present the hypoxanthine-guanine phosphoribosyltransferase (HPRT) reporter gene mutationa

163 through the activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT) to supply the cell with

164 romosomal disease gene encoding hypoxanthine phosphoribosyltransferase (HPRT), we monitor the relativ

165 mutations (Mfs) at the hypoxanthine-guanine phosphoribosyltransferase (HPRT)-reporter gene in childr

166 e purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).

167 hromosome-linked enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).

168 oribosyltransferase (XGPRT) and hypoxanthine phosphoribosyltransferase (HPRT).

169 Hypoxanthine phosphoribosyltransferase (HPRT1) is a key enzyme in the

170 riant aspartic acid (Asp137) in hypoxanthine phosphoribosyltransferases (HPRTs) was examined by site-

171 salvage 6-oxopurines, including hypoxanthine phosphoribosyltransferases (HPRTs), are potential target

172 enes included those for hypoxanthine-guanine phosphoribosyltransferase (hpt), adenylosuccinate syntha

173 by the enzymes hypoxanthine-xanthine-guanine phosphoribosyltransferase (HXGPRT) and adenosine kinase

174 n of T. gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase (HXGPRT) in stable transgenic

175 Conversely, mice lacking nicotinamide phosphoribosyltransferase in hepatocytes exhibited impai

176 previously unrecognized role for a conserved phosphoribosyltransferase in NAD(+) biosynthesis.

177 f transcriptional repression of nicotinamide phosphoribosyltransferase in the NAD(+) salvage pathway.

178 tween the two families of ATP-PRTs and among phosphoribosyltransferases in general, we determined the

179 imiting enzyme in this pathway, nicotinamide phosphoribosyltransferase, increases total and mitochond

180 g [NAD(+)](i) by FK866-mediated nicotinamide phosphoribosyltransferase inhibition decreased the mitog

181 7.5 MBq, intravenously) or the nicotineamide phosphoribosyltransferase inhibitor GMX1778 (100 mg/kg/w

182 he slr0788 gene is a nicotinamide-preferring phosphoribosyltransferase involved in the first step of

183 idence indicates that PBEF is a nicotinamide phosphoribosyltransferase involved in the mammalian salv

184 l filtration experiments indicate that MtATP-phosphoribosyltransferase is a hexamer in solution, in t

185 MsmRv3242c infection models, we proved that phosphoribosyltransferase is involved in mycobacterial v

186 -ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase is known to be essential for t

187 Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is a protein with several sug

188 nalysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enzyme not found

189 the NAD salvage pathway enzyme nicotinamide phosphoribosyltransferase led to changes in NAD levels,

190 mbles bacterial ComF proteins and includes a phosphoribosyltransferase-like module.

191 alpha or Yalpha and the hypoxanthine guanine phosphoribosyltransferase locus (HPRT1).

192 eporter gene 5' of the X-linked hypoxanthine phosphoribosyltransferase locus in mouse embryonic stem

193 (Tg; inserted into the hypoxanthine-guanine phosphoribosyltransferase locus) that enables inducible

194 t mutations for the selectable Aprt (adenine phosphoribosyltransferase) locus and the Atm locus to ex

195 potential new target is hypoxanthine-guanine phosphoribosyltransferase (MtHGPRT), a key enzyme of the

196 In mammals, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide monon

197 he NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (Nampt) and nicotinamide/nicot

198 pharmacological inhibitors for nicotinamide phosphoribosyltransferase (NAMPT) are promising therapeu

199 ss of cancer drugs that targets nicotinamide phosphoribosyltransferase (NAMPT) as a new strategy to i

200 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first ra

201 taining inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified

202 own-regulated expression of the nicotinamide phosphoribosyltransferase (Nampt) gene encoding the rate

203 Nicotinamide phosphoribosyltransferase (NAMPT) has been extensively s

204 enine dinucleotide (NAD(+)) via nicotinamide phosphoribosyltransferase (Nampt) has emerged as a media

205 We recently demonstrated that Nicotinamide phosphoribosyltransferase (Nampt) inhibition depletes in

206 NAD+ depletion via concomitant nicotinamide phosphoribosyltransferase (NAMPT) inhibition.

207 With the example of a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, we demonstr

208 Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme involv

209 Nicotinamide phosphoribosyltransferase (Nampt) is a promising antican

210 Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enz

211 Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enz

212 Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enz

213 Nicotinamide phosphoribosyltransferase (NAMPT) is highly evolved to c

214 Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting e

215 Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting e

216 cell nuclear antigen (PCNA) and nicotinamide phosphoribosyltransferase (Nampt) levels.

217 s of SIRT1 protein, NAD(+), and nicotinamide-phosphoribosyltransferase (NAMPT) mRNA in several cell t

218 , we report that stimulation of nicotinamide phosphoribosyltransferase (NAMPT) produced robust neurop

219 d compounds in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein were utilized

220 Human nicotinamide phosphoribosyltransferase (NAMPT) replenishes the NAD po

221 lony-enhancing factor (PBEF) or nicotinamide phosphoribosyltransferase (Nampt)) is a pleiotropic medi

222 ere raised by observations that nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in mamma

223 Nicotinamide phosphoribosyltransferase (NAMPT), an adipokine that pla

224 nucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ di

225 nhibitors, specifically against nicotinamide phosphoribosyltransferase (NAMPT), as preclinical studie

226 bition with FK866 of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), catalyzing the first

227 gnificant decrease of SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT), SIRT1 activity and ph

228 We demonstrate that nicotinamide phosphoribosyltransferase (Nampt), the equivalent enzyme

229 sustained endotoxin tolerance, nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enz

230 is derivative was found to bind nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enz

231 show that levels of NAD(+) and nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enz

232 Here, we report nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting ste

233 and we found that inhibition of nicotinamide phosphoribosyltransferase (Nampt), which synthesizes sub

234 ethyl)benzamide (CB38065, 1) is nicotinamide phosphoribosyltransferase (Nampt).

235 om nicotinamide is performed by nicotinamide phosphoribosyltransferase (Nampt).

236 Human nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12) catalyzes

237 tracellular enzymatic activity (nicotinamide phosphoribosyltransferase, Nampt) leading to NAD synthes

238 re, we show the gene encoding nicotinic acid phosphoribosyltransferase (NAPRT), a second NAD(+)-produ

239 g the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizing to NAD+

240 rate by the NAD(+) salvage pathway enzyme NA phosphoribosyltransferase (Npt1).

241 ic pathway including NtPMT1a and quinolinate phosphoribosyltransferase (NtQPT2), and lowers nicotine

242 phimurium is similar to that of other Type I phosphoribosyltransferases (nucleotide synthases) with a

243 needed for drugs targeting the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi, etiologi

244 Orotate phosphoribosyltransferase (OMP synthase, EC 2.4.2.10) fo

245 izing effects of inhibition of nicotineamide phosphoribosyltransferase on (177)Lu-DOTATATE treatment

246 (UMP) biosynthesis are catalyzed by orotate phosphoribosyltransferase (OPRT) and orotidine 5'-monoph

247 Orotate phosphoribosyltransferase (OPRT) is an indispensible com

248 Orotate phosphoribosyltransferases (OPRT) catalyze the formation

249 kinetic mechanism ascribed to yeast orotate phosphoribosyltransferase (OPRTase) has been shown to be

250 Orotate phosphoribosyltransferase (OPRTase, EC 2.4.2.10) catalyz

251 Orotate phosphoribosyltransferases (OPRTs) form and break the N-

252 Nicotinamide phosphoribosyltransferase overexpressing mice were mildl

253 alciparum (Pf) hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT).

254 Two putative nicotinic acid phosphoribosyltransferases, PncB1 (Rv1330c) and PncB2 (R

255 also harbors deficiencies in the prokaryotic phosphoribosyltransferase (PRT) activities.

256 quenching were used to monitor changes in a phosphoribosyltransferase (PRTase) "flexible loop", a "g

257 both nicotinic acid and quinolinic acid (QA) phosphoribosyltransferases (PRTase) despite low sequence

258 tial mechanism common to many related purine phosphoribosyltransferases (PRTases) with alpha-D-5-phos

259 Unlike most PRT proteins, which are phosphoribosyltransferases (PRTases), PurR lacks catalyt

260 m (Pf) and Plasmodium vivax (Pv) 6-oxopurine phosphoribosyltransferases (PRTs).

261 Quinolinate phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) cataly

262 Quinolinate phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) cataly

263 Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) forms

264 lastic astrocytes, expressed quinolinic acid phosphoribosyltransferase (QPRT) to use quinolinic acid

265 Because a required quinolinic acid phosphoribosyltransferase (QPRTase) is not encoded in it

266 R, B. caldolyticus PyrR catalyzes the uracil phosphoribosyltransferase reaction but with maximal acti

267 d HisZ are required for catalysis of the ATP phosphoribosyltransferase reaction.

268 ysis, demonstrate unique overlapping ATP and phosphoribosyltransferase sites, and establish reaction

269 ctural neighbors to APRTases are the orotate phosphoribosyltransferases, suggesting different paths o

270 er reports of Ping Pong kinetics for various phosphoribosyltransferases that do not form the phosphor

271 nly in muscle by overexpressing nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in t

272 the following His biosynthetic enzymes, ATP phosphoribosyltransferase (THG1, GenBank accession no. A

273 . maripaludis hpt gene encoding hypoxanthine phosphoribosyltransferase to confer sensitivity to the b

274 Moreover, targeting nicotinamide phosphoribosyltransferase to the mitochondria also enhan

275 These novel phosphoribosyltransferase transition states are similar

276 how high structural homology to anthranilate phosphoribosyltransferase (TrpD) and nucleoside phosphor

277 was reconstituted in vitro with anthranilate phosphoribosyltransferase (TrpD), threonine dehydratase

278 ned that the conserved uridine monophosphate phosphoribosyltransferase (UMPS), which acts in pyrimidi

279 tively encode uridine kinase (UK) and uracil phosphoribosyltransferase (UPRT) bifunctional enzymes we

280 e combination of spatially restricted uracil phosphoribosyltransferase (UPRT) expression with 4-thiou

281 Uracil phosphoribosyltransferase (UPRT) is a member of a large

282 Uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage

283 Cre-induced expression of uracil phosphoribosyltransferase (UPRT) provides spatial specif

284 l (TU) in cells expressing transgenic uracil phosphoribosyltransferase (UPRT), a method known as TU-t

285 st enzyme in pyrimidine biosynthesis, uracil phosphoribosyltransferase (UPRT), a salvage enzyme, or b

286 herichia coli cytosine deaminase (CD)/uracil phosphoribosyltransferase (UPRT).

287 PyrR also catalyzes the uracil phosphoribosyltransferase (UPRTase) reaction even though

288 PyrR is also a uracil phosphoribosyltransferase (UPRTase).

289 ss I homologue) and HPRT (human hypoxanthine phosphoribosyltransferase), was accomplished.

290 hosphoribosyltransferase and of hypoxanthine phosphoribosyltransferase were the same in extracts from

291 Mice heterozygous at Aprt (adenine phosphoribosyltransferase) were used as a model to study

292 lucuronidase and a cytosine deaminase/uracil phosphoribosyltransferase, which activate the prodrugs 9

293 63), in contrast to the hypoxanthine-guanine phosphoribosyltransferases, which use two Mg2+ ions; and

294 G. lamblia expresses an unusual purine phosphoribosyltransferase with a high specificity for gu

295 two purine salvage enzymes: xanthine-guanine phosphoribosyltransferase (XGPRT) and hypoxanthine phosp

296 Xanthine phosphoribosyltransferase (XPRT) from Leishmania donovan

297 sphoribosyl-transferase (HGPRT) and xanthine phosphoribosyltransferase (XPRT) using gene replacement

298 Recombinant LdPEX5 bound xanthine phosphoribosyltransferase (XPRT), a PTS-1 containing gly

299 osphoribosyltransferase (HGPRT) and xanthine phosphoribosyltransferase (XPRT).

300 9) mutants), yeast cytosine deaminase:uracil phosphoribosyltransferase (yCD:UPRT) and nitroreductase