ライフサイエンスコーパス: phosphorylate

1 tant only activated the receptor when it was phosphorylated.

2 intracellular TMPRSS13 is predominantly non-phosphorylated.

3 capsids with no RNA or DNA) was found to be phosphorylated.

4 ering and fusion but can affect tethering if phosphorylated.

5 nctionally identified members of this family phosphorylate 3- to 7-carbon sugars or sugar derivatives

6 eukaryotic translation initiation factor 4E, phosphorylated 4E-binding protein 1, and p-S6 ribosomal

7 bly of the subsequent mitotic spindle and to phosphorylate a microtubule-associated protein important

8 ds to the NHE3 C-terminus and constitutively phosphorylates a downstream site (S719) that accounts fo

9 cally, calmodulin-dependent protein kinase I phosphorylates a RhoA-specific GEF, GEF-H1, whose phosph

10 s sampled by non phosphorylated/inactive and phosphorylated/active forms of the kinase.

11 is showed that both phosphorylated STAT3 and phosphorylated AKT expressions were significantly increa

12 phorylated extracellular receptor kinase and phosphorylated AKT levels and an increase in myocardial

13 was associated with an increase in levels of phosphorylated Akt, an indicator of phosphoinositide 3-k

14 ewy bodies cases mainly in the form of small phosphorylated alpha-synuclein aggregates that are assoc

15 Finally, a gradient of phosphorylated alpha-synuclein aggregation in synapses (

16 control subjects to analyse the presence of phosphorylated alpha-synuclein immunoreactivity at the s

17 Although phosphorylated alpha-synuclein is believed to exert toxi

18 These results indicate that phosphorylated alpha-synuclein is found at the presynapt

19 , to quantitatively investigate the synaptic phosphorylated alpha-synuclein pathology in dementia wit

20 n vitro studies, we have explored the use of phosphorylated amino acids in which the phosphate moiety

21 in methylation of arginines adjacent to M6CK-phosphorylated amino acids.

22 lones and determined that ADK is required to phosphorylate and activate 6-ETI.

23 Our results indicate that GRIKs phosphorylate and activate SnRK1 and other members of th

24 dative stress responsive kinase), which then phosphorylate and activate the renal Na-Cl cotransporter

25 inases of the Hippo tumor suppressor pathway phosphorylate and inhibit the downstream transcriptional

26 onine-protein kinases Lats1 and Lats2, which phosphorylate and inhibit the transcriptional coactivato

27 -mediated rescue, and, accordingly, Plk4 can phosphorylate and potentiate the activity of Aurora A in

28 signal-regulated kinase 1/2 (ERK1/2), which phosphorylate and stabilize p53.

29 imulation and integrate insulin signaling to phosphorylate and thus inactivate GSK3beta, resulting in

30 al deficits of tau transgenic worms, reduced phosphorylated and detergent-insoluble tau accumulation,

31 In the resting conformation, the TCR is not phosphorylated and is inactive.

32 5'-end modified transcripts that can be mono-phosphorylated and ligated to provide longer site-specif

33 ITCH is phosphorylated and thereby inhibited by inhibitor of nuc

34 RPA is hyper-phosphorylated and ubiquitylated after DNA damage.

35 The solution structures of the phosphorylated and unphosphorylated rOPN were investigat

36 Akt2 phosphorylates and inhibits HNF1alpha, thus relieving th

37 mice, we show that the cyclin D3-CDK6 kinase phosphorylates and inhibits the catalytic activity of tw

38 Fpk1 phosphorylates and stimulates flippases that translocate

39 totic inducer that promotes mitotic entry by phosphorylating and inhibiting Wee1.

40 But the meiotic defects when Dam1 is not phosphorylated are not nearly as catastrophic as when Mp

41 Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin

42 tro and in vivo, the preparation of proteins phosphorylated at predetermined sites cannot be done eas

43 ranscription and replication regulator E2 is phosphorylated at residue Y102.

44 rkably, we discovered that linker histone H1 phosphorylated at S/T18 decorated the inter-chromatid ax

45 osed to UVB and stimulated expression of p53 phosphorylated at Ser-15.

46 Drugs designed to increase the level of PS1 phosphorylated at Ser367 should be useful in the treatme

47 monstrate that CENP-A mutants that cannot be phosphorylated at Ser68 or ubiquitinated at Lys124 assem

48 ple kinases in vitro Specifically, Neto2 was phosphorylated at serine 409 (Ser-409) by Ca(2+)/calmodu

49 tream messenger insulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and olig

50 sion of insulin receptor substrate 1 (IRS-1) phosphorylated at serine residue 312 was more apparent i

51 However, when mitophagy is inhibited, p53 is phosphorylated at serine-392 by PINK1, a kinase associat

52 aborate mechanism ensures that ezrin is only phosphorylated at the plasma membrane, and with high spe

53 TIRAP is phosphorylated at Thr28 within its PBM, which leads to i

54 The identification of Rab10 phosphorylated at Thr73 as a LRRK2 inhibition marker in

55 e, we found that beta-arrestin2 binds to PKC-phosphorylated AT1R in a distinct active conformation, w

56 , gamma-H2AX and DNA damage response marker, phosphorylated ataxia telangiectasia mutated (pATM), wer

57 MST4 phosphorylates ATG4B at serine residue 383, which stimul

58 Finally, we show that VRK2 phosphorylates barrier to autointegration factor (BAF),

59 Mechanistically, we showed that FAK phosphorylates Beclin1, a core autophagy protein, on Tyr

60 lial barrier functions by AJ localization of phosphorylated beta-catenin through its interactions wit

61 indicated that phosphorylated Jak3 bound to phosphorylated beta-catenin with a dissociation constant

62 The phosphorylated beta-hairpin peptide crystallizes to form

63 thors show that the autophagy initiator ULK1 phosphorylates beta1-Ser108 on the regulatory beta1-subu

64 yn and Lyn and their activating residues are phosphorylated both before and after Toll-like receptor

65 yclin D1-CDK4 bound to p21, by independently phosphorylating both CDK4 and p21.

66 ins are able to bind second messenger kinase-phosphorylated, but inactive receptors as well.

67 We discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-

68 esis (Tea4, Mod5, Cdc15, and Cyk3) were also phosphorylated by a second kinase, the DYRK family membe

69 ry analyses also showed that the compound is phosphorylated by Cab1.

70 so two other PPs, p107 and p130, which, when phosphorylated by CDK-cyclin complexes, play a role in p

71 AR S81 is also phosphorylated by CDK1, and blocking basal CDK1-mediated

72 NS5A is known to be phosphorylated by cellular protein kinases, and in this

73 confirmed that Akl1 is hyperactive when not phosphorylated by Fpk1.

74 utated form of SOS2 lacking the T168 residue phosphorylated by GRIK1.

75 , Rab29, Rab35 and Rab43) to be specifically phosphorylated by LRRK2, with evidence for endogenous ph

76 cts to prevent inhibition of PP2A by ARPP-16 phosphorylated by MAST3.

77 hments are established even when Dam1 is not phosphorylated by Mps1, but that Mps1 phosphorylation of

78 The kinetochore scaffold Knl1, when phosphorylated by Mps1, recruits checkpoint complexes Bu

79 ary subunits of kainate receptor (KARs), are phosphorylated by multiple kinases in vitro Specifically

80 eld N(tz) AD(+) , which can be enzymatically phosphorylated by NAD(+) kinase and ATP or (tz) ATP to t

81 used for treatment of multiple sclerosis, is phosphorylated by nuclear sphingosine kinase 2, and its

82 mutating a residue in MRE11 that we show is phosphorylated by p70S6K in vitro.

83 with vitamin B5 as the starting metabolite, phosphorylated by pantothenate kinase.

84 not occur at PX(S/T)P sites, i.e., at sites phosphorylated by proline-directed kinases, which repres

85 after the activation loop of MEK1 is itself phosphorylated by Raf.

86 Instead, T207 in Smk1's activation loop is phosphorylated by the cyclin-dependent kinase (CDK)-acti

87 unit of DDK, directly associates with and is phosphorylated by the Polo-like kinase Cdc5.

88 to the rat sciatic nerve to test the role of phosphorylated C/EBPbeta (pC/EBPbeta) and its upstream p

89 Phosphorylated C/EBPbeta (pC/EBPbeta) influences AIDS pr

90 Finally, we found an enduring reduction in phosphorylated cAMP-response element binding protein lev

91 cifically inhibited the activity of UBE4B or phosphorylated CBL by blocking the E2 approximately Ub b

92 Pkc1 directly phosphorylates Cdc55 and Igo/ENSA, and phosphorylation s

93 the CB1R association with CRIP1a, but that a phosphorylated central C-terminal peptide competed for a

94 ed for association with beta-arrestin 1, and phosphorylated central or distal C-terminal peptides com

95 Together these data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3

96 In BRAFi-resistant cells, PAKs phosphorylate CRAF and MEK to reactivate ERK.

97 brain derived neurotrophic factor (BNDF) and phosphorylated CREB, both in young (3-week-old) and adul

98 es densely on the repetitive sequence of the phosphorylated CTD via its N-terminal CTD-interacting do

99 clude that the intramolecular interaction of phosphorylated DBD with the LBD enables CAR to adapt a t

100 hat serine-arginine protein kinase 2 (SRPK2) phosphorylates delta-secretase and enhances its enzymati

101 er by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domai

102 on Dsh is mediated by Nek2 kinase, which can phosphorylate Dsh and is a direct APC/C(Fzr/Cdh1) substr

103 heme deficiency and oxidative stress, and it phosphorylates eIF2alpha (eIF2alphaP), which inhibits th

104 of growth factor receptor bound 2 (GRB2) to phosphorylated epidermal growth factor receptor (EGFR) a

105 ream signalling, in particular the levels of phosphorylated ERK, and slows the growth in soft agar of

106 ssion of GM-CSF and its receptors as well as phosphorylated ERK1/2 are observed.

107 They also showed the highest expression of phosphorylated-ERK1/2 and Akt S473 proteins of all four

108 The MEK1 kinase directly phosphorylates ERK2, after the activation loop of MEK1 i

109 In these stresses, different kinases phosphorylate eukaryotic initiation factor eIF2alpha, en

110 hosphorylated mammalian target of rapamycin, phosphorylated eukaryotic translation initiation factor

111 ess and cells harboring SIRT1 that cannot be phosphorylated exhibit a high prevalence of extrachromos

112 More recently, extracellular kinases that phosphorylate extracellular serine, threonine, and tyros

113 ed amounts of reactive oxygen species, lower phosphorylated extracellular receptor kinase and phospho

114 demonstrated concomitant down-regulation of phosphorylated extracellular signal-regulated kinase and

115 Of note, a phosphorylated extracellular signal-regulated kinase+/BC

116 Cyclin-D1 and of K-Ras effectors, including phosphorylated extracellular signal-regulated kinase, ph

117 Importantly, activated AKT directly phosphorylates FAF1 at Ser 582, which disrupts the FAF1-

118 ilaments in vivo by dephosphorylation of RLC-phosphorylated filaments, disassembly of the dephosphory

119 nuclear sphingosine kinase 2, and its active phosphorylated form (FTY720-P) is an inhibitor of class

120 JNK (c-Jun N-terminal kinase)-dependent S574 phosphorylated form (p-FOXO3) has been shown to be speci

121 drocortisone on the abundance of NCC and its phosphorylated form (pNCC) as well as WNK lysine deficie

122 ated CKI1RD (a stable analogue of the labile phosphorylated form) were identical and similar to the a

123 RILPL1 specifically interacts with the LRRK2-phosphorylated forms of Rab8A and Rab10, whereas RILPL2

124 ystal structures of the unphosphorylated and phosphorylated forms of the kinase domains show no appar

125 sphorylated full-length guide strands from 5-phosphorylated forms that may associate with RNA-induced

126 results show a tumor suppressor role of AKT-phosphorylated FOXO1 in the cytoplasm and suggest that t

127 as metabolite repair enzymes, serving to re-phosphorylate free d-ribulose generated by promiscuous p

128 s assay enables separate quantitation of non-phosphorylated full-length guide strands from 5-phosphor

129 YopO phosphorylated gelsolin in the linker region between gel

130 immuno-isolation represented 16% of total 5-phosphorylated guide strands in liver, correlating with

131 devoid of Bub1 kinase activity, which cannot phosphorylate H2A at T121, are not perturbed in cohesin

132 ults indicate most CENH3 nucleosomes contain phosphorylated H2AThr133 in centromeric regions.

133 X, and a low-density core containing foci of phosphorylated H2AX (a marker of double-strand breaks) a

134 tion was preceded by a transient increase of phosphorylated heat shock protein 27, p38 mitogen-activa

135 Phosphorylated histone H2AX (gammaH2AX), a marker of DNA

136 hypoxia, cytoplasmic accumulation of Tyr359-phosphorylated hnRNP L sequesters miR-574-3p, overcoming

137 using monomeric actin as bait to recruit and phosphorylate host actin-regulating proteins.

138 forms smaller and fewer nuclear puncta than phosphorylated HP1alpha.

139 PykF is activated only by non-phosphorylated HPr, which decreases the PykF Khalf for p

140 MPK3 and MPK6 can phosphorylate ICE1, a basic-helix-loop-helix transcripti

141 n kinase 3 (MPK3) and MPK6 interact with and phosphorylate ICE1, which reduces its stability and tran

142 directly inhibits IkappaB kinases (IKKs) to phosphorylate IkappaBalpha for NF-kappaB activation, tri

143 activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chai

144 Here, we show that serine 193 (S193) is phosphorylated in Atoh1's bHLH domain in vivo Knock-in m

145 Both residues are phosphorylated in cells while only Ser200 phosphorylatio

146 unphosphorylated in complete virions, it is phosphorylated in empty virions.

147 he Hog1 SAPK in Candida albicans is robustly phosphorylated in response to a number of host-imposed s

148 Provided the MisR is constitutively phosphorylated in the misS mutant, the data suggest that

149 r function, we show that receiver dimers are phosphorylated in trans by the donor; this process requi

150 for activated C kinase (RACK1), that are not phosphorylated in uninfected cells or cells infected by

151 We found that Vgll4 is phosphorylated in vitro and in vivo by cyclin-dependent

152 We show here that ARPP-16 is also phosphorylated in vitro and in vivo by microtubule-assoc

153 controls receptor specificity, and is highly phosphorylated in vivo However, kinases that phosphoryla

154 in MAMP-triggered immunity, as it is rapidly phosphorylated in vivo upon treatment with the bacterial

155 ences corresponding to states sampled by non phosphorylated/inactive and phosphorylated/active forms

156 d Ins(1,4,5)P3 Both enzymes bound these less-phosphorylated IPs in a catalytically competent manner,

157 A notable property of highly phosphorylated isoforms of osteopontin is their ability

158 Interaction studies indicated that phosphorylated Jak3 bound to phosphorylated beta-catenin

159 we show that Polo-like kinase 1 (Plk1) also phosphorylates key factors upstream of ATM/ATR and regul

160 olecular dynamics simulations of their fully phosphorylated kinase domains.

161 to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtu

162 by unattached kinetochores, and Mps1 kinase phosphorylates KNL1 on conserved MELT motifs to generate

163 s checkpoint activation through sequentially phosphorylating Knl1, Bub1, and Mad1.

164 the protein-tyrosine kinases FAK1/PYK1 that phosphorylated LAT selectively on a single Y-171 site fo

165 ant, there was a significant decrease of the phosphorylated, likely active, forms of FoxM1.

166 inly produced in the mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

167 more, we observed that, when stably bound to phosphorylated M1R, beta-arrestin scaffolds and activate

168 ted kinase, phosphorylated protein kinase B, phosphorylated mammalian target of rapamycin, phosphoryl

169 inhibition increases steady-state levels of phosphorylated MEK1/2 in various tumor cells expressing

170 bules even in the presence of actin, whereas phosphorylated melanophilin associated with actin.

171 Biochemical assays revealed Abl phosphorylates Mical to directly amplify Mical Redox-med

172 Plk1 phosphorylated Mre11, a component of the Mre11/Rad50/Nbs

173 the 'boss' in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signa

174 her identified SYK as a critical kinase that phosphorylates MyD88, promoted MyD88-dependent signaling

175 Phosphorylated myosin light chain colocalization with ac

176 Phosphorylated neurofilament heavy chain (pNfH) levels a

177 Importantly, we showed that CDK3, NFAT3 and phosphorylated NFAT3-Ser259 were highly expressed in ski

178 contrary to previous models, assembly of RLC-phosphorylated NM2s at physiological ionic strength proc

179 ytes of sepsis patients were less capable in phosphorylating nuclear factor kappa-light-chain-enhance

180 Caspase-9 is the most heavily phosphorylated of all caspases, with phosphorylation of

181 that they interacted only with NS5A that was phosphorylated on a specific residue.

182 treated cell types, the majority of STAT2 is phosphorylated on T387 constitutively.

183 AP65-1 interacts with Aurora1 in vivo and is phosphorylated on two residues at its unfolded tail doma

184 ed by a specific pool of VE-cadherin that is phosphorylated on Y658 and bound to LGN.

185 b-resistant Kit (Kit(mut)) become fully auto-phosphorylated only on the Golgi and only if in a comple

186 xamined by mutation of NHE3-S(719) to A (not phosphorylated) or D (phosphomimetic).

187 cells; a process mediated through increased phosphorylated (p)-Akt upon stimulation with CMVpp65.

188 /eIF3A interaction is unaffected by mutating phosphorylated p190A-Tyr(308), but disrupted by a S296A

189 Overall, no differences in phosphorylated p38 MAPK, ERK1/2, Akt, and p70S6K were ob

190 Activated PKCzeta subsequently phosphorylates p38 MAPK.

191 HIPK1-PAGE4) potentiates c-Jun, whereas CLK2-phosphorylated PAGE4 (CLK2-PAGE4) attenuates c-Jun activ

192 HIPK1-phosphorylated PAGE4 (HIPK1-PAGE4) potentiates c-Jun, wh

193 odomain-Interacting Protein Kinase 1 (HIPK1) phosphorylates PAGE4 at S9 and T51, but only T51 is crit

194 we show that cyclin-dependent kinases (CDKs) phosphorylate PAH1 at serine 162, which reduces both its

195 ation, resulting in poorer autoinhibition in phosphorylated parkin.

196 coupled with mass spectrometry, we show that phosphorylated Pdc and 14-3-3 form a complex in which th

197 Western blotting of MKK2 protein and its T31 phosphorylated peptide verified the phosphoproteomic res

198 Phosphorylated peptides were identified, one from alphaS

199 tase fold that unexpectedly targets tyrosine-phosphorylated peptides.

200 Levels of phosphorylated phosphatidylinositide 3-kinase (PI3K) inc

201 are major myelin phospholipids, and several phosphorylated phosphatidylinositol species are known to

202 Ser/Thr kinases, particularly PknA in trans-phosphorylating phosphodiesterase from Mycobacterium tub

203 Phosphorylated phosphoinositide lipids (PPIs) are low-ab

204 d to as MUT9-like kinases) interact with and phosphorylate photoexcited CRY2.

205 d after infection, as well as an increase in phosphorylated PKA.

206 During exosome secretion, phosphorylated PKM2 serves as a protein kinase to phosph

207 hich mediates CD dispersion in xanthophores, phosphorylates Plin6 on conserved residues.

208 -1 is enriched in the anterior cytoplasm and phosphorylates POS-1, which is both necessary and suffic

209 Cool-associated tyrosine-phosphorylated protein 1 (Cat-1) is a signaling scaffold

210 The purified phosphorylated protein bound to a phosphotyrosine specif

211 lated extracellular signal-regulated kinase, phosphorylated protein kinase B, phosphorylated mammalia

212 To enable the synthesis of phosphorylated proteins for in vitro studies, we have ex

213 we found there were complex interactions of phosphorylated proteins in modulating cancer stemness in

214 Phosphorylated proteins play important roles in the regu

215 on the contrary, detected similar amounts of phosphorylated proteins regardless of sex or gonad devel

216 of Escherichia coli, guided by the use of a phosphorylated puromycin, to identify modified ribosomes

217 ed that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine r

218 of Rab8A and Rab10, whereas RILPL2 binds to phosphorylated Rab8A, Rab10, and Rab12.

219 s (2i ESCs) have a longer G1-phase with hypo-phosphorylated RB, implying that they have a functional

220 y targeting CDK6 and decreases the levels of phosphorylated-Rb1 and E2F-downstream targets, diminishi

221 These results demonstrate that multiply phosphorylated receptors are not required to support mos

222 r concentration of RLC-unphosphorylated and -phosphorylated recombinant mammalian NM2A, NM2B, and NM2

223 During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MR

224 The phosphorylated regulatory domain is disengaged from its

225 96A mutation, targeting the only other known phosphorylated residue in the first FF domain.

226 a hierarchical manner to create stretches of phosphorylated residues, which may be a means to amplify

227 Our studies demonstrate that Fus3 also phosphorylates Rga2 at inhibitory S/TP sites, which are

228 cription factors to form mediator complexes, phosphorylating RNA polymerase II, and by its intrinsic

229 We found that RBK1 directly phosphorylates ROP4 and ROP6, supporting the possibility

230 ss-activated kinases 1 and 2 (MSK1/2), which phosphorylate S10 in H3, inhibit up-regulation in phosph

231 horylate S10 in H3, inhibit up-regulation in phosphorylated S10 in H3 (p-S10H3) as well as fos transc

232 Remarkably, phosphorylated S164-SIRT1 and CK2 levels were also highl

233 s two to three amino acids C-terminal to the phosphorylated Ser/Thr to prime a catalytically active c

234 irreplaceable function of each of these two phosphorylated serine residues.

235 ization of peptide bonds between proline and phosphorylated serine/threonine residues.

236 Here we report that a poxvirus kinase phosphorylates serine/threonine residues in the human sm

237 increases TGF-beta signaling (i.e. increased phosphorylated SMAD-2/3 and reduced SMAD-7 expression) i

238 GFbeta Receptor (TGFbetaR)-1, TGFbetaR-2 and phosphorylated SMAD2/3 in human pulmonary arterial smoot

239 r C1q, C3d, terminal complement complex, and phosphorylated SMAD2/3, a downstream effector of TGF-bet

240 l of dialytic glucose exposure, abundance of phosphorylated SMAD2/3, and degree of vasculopathy.

241 d that Olig1 and the BMP signaling effector, phosphorylated SMADs (Sma- and Mad-related proteins) 1,

242 Ectopic expression of non-phosphorylated SNAP-23 mutant (Ser95-->Ala95) significan

243 ssay and mass spectrometry confirm that PKM2 phosphorylates SNAP-23 at Ser95.

244 bilization and transcriptional activation of phosphorylated Sox2.

245 SOX9 mRNA and protein expression as well as phosphorylated SOX9 expression in human pancreatic ducta

246 y could be activated following DNA damage to phosphorylate specific DNA repair proteins and/or that N

247 sine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosp

248 eq analysis and constitutive upregulation of phosphorylated STAT1 and STAT3 in patient lymphocytes an

249 ndii-derived ROP16 kinase, known to directly phosphorylate STAT3, a critical mediator of IL-10's anti

250 Western blot analysis showed that both phosphorylated STAT3 and phosphorylated AKT expressions

251 tion 3) inhibitor S3I-201 for periablational phosphorylated STAT3 immunohistochemistry analysis at 24

252 nsistent with expression of ESAT-6, IL-6 and phosphorylated-STAT3 in Mtb-infected mouse lungs.

253 the nucleus after the down-regulation of its phosphorylated state mediated by large tumor suppressor

254 confers location, and catalytic (C) subunits phosphorylate substrates.

255 Interestingly, we show that LRRK2 directly phosphorylates synaptojanin1 in vitro, resulting in the

256 horylated PKM2 serves as a protein kinase to phosphorylate synaptosome-associated protein 23 (SNAP-23

257 icising effects of NaCl and CaCl2 on the non-phosphorylated tapioca starch are indistinguishable from

258 blockade of p25 generation reduced levels of phosphorylated tau and increased expression of synaptoph

259 n independent association of ante mortem CSF phosphorylated tau levels with postmortem cerebral tau p

260 biomarkers (e.g., amyloid-beta40, total and phosphorylated tau protein).

261 REM2-dependent differences were observed for phosphorylated tau staining or insoluble tau levels.

262 INTERPRETATION: CSF phosphorylated-tau levels are positively associated with

263 FTLD) and (2) tauopathy patients have higher phosphorylated-tau levels compared to transactivation re

264 Attenuating Sting, phosphorylated Tbk1 and, importantly, blocking reverse t

265 -TDP patients with PGRN deficiency, CTSD and phosphorylated TDP-43 accumulated in neurons.

266 Phosphorylated TDP-43 was not associated with TDP-43 agg

267 ho-specific p-T153/Y155 antibody showed that phosphorylated TDP-43 was specifically recruited to the

268 endoplasmic reticulum stress, and insoluble phosphorylated TDP-43.

269 Phosphorylated TFEB accumulated in STUB1-deficient cells

270 overexpression of STUB1 resulted in reduced phosphorylated TFEB and increased TFEB activity.

271 ctivity by preferentially targeting inactive phosphorylated TFEB for degradation by the ubiquitin-pro

272 ferentially interacted with and ubiqutinated phosphorylated TFEB, targeting it to proteasomal degrada

273 teins greatly enhance the ability of Cdk2 to phosphorylate the key replication initiation protein tre

274 phosphorylated in vivo However, kinases that phosphorylate the TOC159 A-domain to enable protein impo

275 Src and IGF-1R phosphorylated the prometastatic molecule Annexin A2 (An

276 se specificity: a lipid kinase activity that phosphorylates the 3'-hydroxyl of phosphoinositides and

277 Lysosomal p38 MAPK directly phosphorylates the CMA receptor LAMP2A at T211 and T213,

278 We show that TAOK2 directly phosphorylates the cytoskeletal GTPase Septin7, at an ev

279 nate immune effector protein kinase R, which phosphorylates the eukaryotic initiation factor 2alpha t

280 WNK4 phosphorylates the kinases SPAK (Ste20-related proline a

281 nicotinamide riboside kinase 2 (NMRK2) that phosphorylates the nicotinamide riboside precursor is in

282 l threshold for T cell activation because it phosphorylates the TCR complex and the Zap70 kinase.

283 ion of DDK is to initiate DNA replication by phosphorylating the Mcm2-7 replicative helicase [5-7].

284 By phosphorylating the phosphoinositide- (PI) binding domai

285 Orco(S289A) mutants, unable to phosphorylate this position, have low intrinsic odorant

286 ctivity assays, we found that PIN1 binds the phosphorylated Thr(187)-Pro motif in p27 and reduces p27

287 ited by mutations that compromise binding of phosphorylated Thr-348 to an allosteric binding pocket o

288 ylation of beta-catenin, where Jak3 directly phosphorylated three tyrosine residues, viz.

289 ation, the SUMOylated ErbB4 ICD was tyrosine phosphorylated to a higher extent than unmodified ErbB4

290 Mechanistically, Nek7 interacts with and phosphorylates TRF1 on Ser114, which prevents TRF1 from

291 , reported that the side chain structures of phosphorylated tyrosine (pY) are partitioned into two co

292 tically, Akt1 physically interacted with and phosphorylated UBE2S at Thr 152, enhancing its stability

293 ingly, SOS1, ARHGEF1, and DOCK2 are tyrosine phosphorylated upon chemokine signaling with timing cohe

294 ytes and synovial cells and reduce levels of phosphorylated VEGFR1 in dorsal root ganglia.

295 es suppress OA progression, reduce levels of phosphorylated VEGFR2 in articular chondrocytes and syno

296 K1/2 pathway regulates cellular processes by phosphorylating, we first performed a SILAC phosphoprote

297 nant form of TMPRSS13 on the cell surface is phosphorylated, whereas intracellular TMPRSS13 is predom

298 eased AKT activity due to PTEN loss directly phosphorylates WHSC1 at S172, preventing WHSC1 degradati

299 We found increased expression of KIBRA and phosphorylated YAP protein in glomeruli of patients with

300 inase assays, we show that Aurora A directly phosphorylates YY1 at serine 365 in the DNA-binding doma