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1 serines are replaced with glutamate to mimic phosphorylated protein.
2 e previous lower-resolution structure of the phosphorylated protein.
3 as Delta Np63 alpha, and it was present as a phosphorylated protein.
4 tent with a chaperoning role for this highly phosphorylated protein.
5 er reaction and decrease in stability of the phosphorylated protein.
6 also observed in the presence of the 97-kDa phosphorylated protein.
7 RasGAP, and an unidentified 145-kDa tyrosine-phosphorylated protein.
8 ipitate with an unidentified 87 kDa tyrosine-phosphorylated protein.
9 ed an additional 2 mol of phosphate into the phosphorylated protein.
10 be easily modified to evaluate any tyrosine-phosphorylated protein.
11 nd IRAK4 mRNA as well as increased total and phosphorylated protein.
12 me-mediated degradation of the mature, fully phosphorylated protein.
13 plex between c-Src and at least one tyrosine-phosphorylated protein.
14 utations resulting in lower abundance of the phosphorylated protein.
15 reflecting the experimental data, including phosphorylated proteins.
16 ern blotting with antibodies specific to the phosphorylated proteins.
17 Western blotting with antibodies specific to phosphorylated proteins.
18 motility, and alters the pattern of tyrosine phosphorylated proteins.
19 phosphate groups, such as phospholipids and phosphorylated proteins.
20 tacts containing enriched levels of tyrosine-phosphorylated proteins.
21 ellular location, and/or turnover of certain phosphorylated proteins.
22 trometric analysis of proteolytic digests of phosphorylated proteins.
23 rafts colocalized with the BCR and tyrosine-phosphorylated proteins.
24 when the SH2 domains of p85 bind to tyrosyl-phosphorylated proteins.
25 tion and proteasome-dependent degradation of phosphorylated proteins.
26 ate the conformation and function of certain phosphorylated proteins.
27 o catalyze the dephosphorylation of tyrosine-phosphorylated proteins.
28 greatly enhanced by enriching the sample of phosphorylated proteins.
29 -induced functional changes in other heavily phosphorylated proteins.
30 regulation of the turnover of sumoylated and phosphorylated proteins.
31 components paxillin, vinculin, and tyrosine-phosphorylated proteins.
32 as associated with 100- and 180-kDa tyrosine phosphorylated proteins.
33 ellular activity by binding and sequestering phosphorylated proteins.
34 tography (IMAC), which specifically binds to phosphorylated proteins.
35 oxal 5'-phosphate (PLP) and serine/threonine-phosphorylated proteins.
36 nes by lowering the levels of both total and phosphorylated proteins.
37 c kinase activity and PP2-sensitive tyrosine-phosphorylated proteins.
39 cumulation of tyrosine- and serine/threonine-phosphorylated proteins, a marked increase in cellular T
40 ppressor protein with various functions) and phosphorylated proteins (Abraxas/BACH1/CtIP), implicated
43 tified 11,552 distinct nonmodified and 2,852 phosphorylated proteins across the four root tissues.
48 AT5B mutations are associated with increased phosphorylated protein and a growth advantage to transdu
49 on the simultaneous measurement of multiple phosphorylated protein and phospholipid components in th
50 t, in dark-grown seedlings, NPH3 exists as a phosphorylated protein and that BL stimulates its dephos
51 n this study, we demonstrate that Atg29 is a phosphorylated protein and that this modification is cri
52 -gamma or IFN-beta, in that LPS induced less phosphorylated protein and the time course of induction
54 nd vinculin, have a central core of tyrosine phosphorylated proteins and are depleted of integrins at
55 in proteomics studies to effectively detect phosphorylated proteins and avoid time-consuming and exp
56 e results in decreased affinity for tyrosine-phosphorylated proteins and decreased PI3K membrane loca
57 ieval of rich biological information for the phosphorylated proteins and facilitates database annotat
58 mass spectrometry identification of tyrosine phosphorylated proteins and growth inhibition in the pre
59 ytes, M-CSF increased the levels of tyrosine-phosphorylated proteins and induced Akt activation in a
61 orylation, decreased the numbers of tyrosine-phosphorylated proteins and levels of type I collagen, a
62 ation of PI3-kinase associated with tyrosine-phosphorylated proteins and of p85/PI3-kinase associated
63 ing network describing the interaction of 11 phosphorylated proteins and phospholipids in human immun
64 tes the conformation and function of certain phosphorylated proteins and plays an important role in c
67 to both substrates and appropriate tyrosine-phosphorylated proteins and therefore can compete with t
68 Among the information were three partially phosphorylated proteins and three proteins heterozygous
69 ome mobility shift assays with both in vitro-phosphorylated proteins and with point mutants bearing n
72 s demonstrate that both Vac8p and Apg13p are phosphorylated proteins, and Apg13p phosphorylation is r
73 plicable to serine-, threonine- and tyrosine-phosphorylated proteins, and is capable of selectively i
75 th ligand stimulation, a broader spectrum of phosphorylated proteins appears compared with EGF-treate
79 the past, identifying spectral variations in phosphorylated proteins arising from either the phosphat
81 immunoprecipitates for the existence of such phosphorylated proteins as targets for barrier regulatio
83 rometric identification of a 155-kD tyrosine phosphorylated protein associated with src homologous an
84 pectrometry was used to identify three major phosphorylated proteins associated with this PSI-Cyt b(6
86 chromatin-associated proteins, with the most phosphorylated protein band being near the same molecula
87 light chain 2 were identified in the highly phosphorylated protein bands with the highest scores.
89 VCaB45 are modulated by phosphorylation; the phosphorylated protein binds up to 100-fold more calcium
92 ed with the tryptic digests of the naturally phosphorylated proteins bovine alpha- and beta-casein.
93 ide G(M1), a lipid raft marker, and tyrosine-phosphorylated proteins, but not CD45 and transferrin re
94 ells showed a small set of discrete tyrosine-phosphorylated proteins, but these proteins were not rec
95 urface antigen receptor overproduce tyrosine phosphorylated proteins; (c) lupus and lupus nephritis a
97 in a sequential gel staining procedure, the phosphorylated proteins can be visualized in the same ge
98 duced specific differences in the pattern of phosphorylated proteins, caused changes in lipid metabol
100 table differences in the pattern of tyrosine phosphorylated proteins compared with that obtained in c
101 r networks indicated differences in tyrosine phosphorylated proteins compared with the poorly aggress
107 The availability of large pools of tyrosine-phosphorylated proteins derived from normal tissues faci
108 ed by MALDI-MS was then utilized to identify phosphorylated proteins detected by autoradiography.
109 E4 in the Nova-1 pre-mRNA itself, encoding a phosphorylated protein domain, as an additional target o
110 d recombinant PP(240), and the native highly phosphorylated protein (equivalent to the PP(523) isofor
115 les (AuNPs) can then be attached to the thio-phosphorylated proteins, forming a Au-film/AuNP plasmoni
116 ion of TGF beta1, Smad2, and Samd3 and their phosphorylated protein forms, and cell cycle inhibitors,
117 e have partially purified a 105-kDa tyrosine-phosphorylated protein from platelets stimulated with ph
118 phosphorylated peptides corresponding to 449 phosphorylated proteins from 200 mug of zebrafish embryo
119 1 interacted with a small subset of tyrosine-phosphorylated proteins from lysates of the human breast
120 we performed a global profiling of tyrosine-phosphorylated proteins from mutant Kit-driven murine le
121 included redistribution of epithelial serine-phosphorylated proteins from the cytoplasm to the nucleu
122 the levels of the early apoptosis-associated phosphorylated protein, H2A-X (ser 139), as well as decr
123 have opposing effects on degradation of the phosphorylated protein; Hsp90 is protective, whereas Hsp
128 ote cell migration, as a major hyper-tyrosyl-phosphorylated protein in mouse and zebrafish models of
132 y proteomic approaches were used to identify phosphorylated proteins in a chronic pressure-induced ra
134 -Cbl is one of the most prominently tyrosine-phosphorylated proteins in Bcr-Abl-expressing cells.
136 blot analysis, enables detection of specific phosphorylated proteins in complex mixtures such as cell
137 ever, current methods for analyzing tyrosine-phosphorylated proteins in crude protein extracts provid
138 kinase) substrates indicated the presence of phosphorylated proteins in cytosolic, membrane, and nucl
139 mutant (YF-Brk) and associates with tyrosine-phosphorylated proteins in deregulated signaling complex
140 d by immunoaffinity purification of tyrosine-phosphorylated proteins in GIST cells before and after t
141 Phosphoprotein profiling identified diverse phosphorylated proteins in glutamate-treated SCs in addi
142 SHP-1 is associated with two major tyrosine-phosphorylated proteins in hematopoietic cells treated w
144 n cell culture (SILAC), to identify tyrosine phosphorylated proteins in isogenic human bronchial epit
146 we found there were complex interactions of phosphorylated proteins in modulating cancer stemness in
149 ing set of serine-, threonine-, and tyrosine-phosphorylated proteins in the Archaea that may offer ne
151 s in the rapid accumulation of many tyrosine-phosphorylated proteins in the liver and kidney of treat
154 sphoisoform-specific regulation of histidine-phosphorylated proteins in vivo, and we link these modif
156 bute in all cell cortex extensions, tyrosine-phosphorylated proteins including p190 appear to associa
157 GP Ib, and associates with several tyrosine-phosphorylated proteins including the Fc receptor gamma-
158 hich, when activated, initiates a cascade of phosphorylated proteins including the SRC family of kina
161 n removal of the PTP inhibitor, the tyrosine-phosphorylated proteins, including Lck, Fyn, Syk, Zap70,
162 ormed stable complexes with several tyrosine-phosphorylated proteins, including PLCgamma2, only in Bt
163 lls, SLAP-2 associated with several tyrosine phosphorylated proteins, including the ubiquitin ligase
164 were incubated with ATP, the peak levels of phosphorylated proteins increased in the presence of the
165 domains serve an essential role as histidine-phosphorylated protein intermediates during phosphoryl t
166 CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organiza
167 croscopy studies revealed that this tyrosine-phosphorylated protein is localized to the cytoplasmic f
169 RAP-HAP interaction in the N-terminus of the phosphorylated protein is very stable to changing soluti
172 nformation and function of a subset of these phosphorylated proteins is regulated by the prolyl isome
174 respectively, compared with the gel from non-phosphorylated protein isolate at the same ZnSO4 level,
175 at the same ZnSO4 level, suggesting that the phosphorylated protein isolate was more crosslinked by Z
176 lts, we observed >50% reduction in levels of phosphorylated protein kinase B (Akt) and H3K36me3 in bo
177 The contents of GLUT1, GLUT4, total and phosphorylated protein kinase B (Akt), phosphorylated AM
178 n analysed for cell growth and expression of phosphorylated protein kinase B (Akt/PKB) and MMAC1/PTEN
179 tenuated senescence in part by up-regulating phosphorylated protein kinase B (p-AKT) and decreasing p
180 uch as phosphatidylinositol 3-kinase (PI3K), phosphorylated protein kinase B (PKB; also known as Akt)
181 lated extracellular signal-regulated kinase, phosphorylated protein kinase B, phosphorylated mammalia
182 n chromosome 10 protein, whereas the mass of phosphorylated protein kinase B/Akt was increased by C3a
183 ociation with an increase in CaR protein and phosphorylated protein kinase C alpha and beta in caveol
184 on chelator), a possible mechanism involving phosphorylated protein kinase C alpha and iron in Nrf2-H
185 Because we observed notably high levels of phosphorylated protein kinase C alpha and its suppressio
186 ACSL1 kd adipocytes displayed an increase in phosphorylated protein kinase C and phosphorylated JNK,
189 tein were accompanied by increased levels of phosphorylated protein kinase R-like ER kinase (pPERK),
190 s: (a) the survival/rescue molecules such as phosphorylated protein kinase-like ER-resident kinase (p
193 K and its association with specific tyrosine-phosphorylated proteins may be important in insulin and
195 Termed macrophage actin-associated tyrosine-phosphorylated protein (MAYP), p37 is the major F-actin-
196 CD72 ligation induces a variety of tyrosine-phosphorylated proteins, most of which were of the same
197 was no difference in the pattern of tyrosine-phosphorylated proteins observed following stimulation o
198 lioside G(M1) and cholesterol where tyrosine phosphorylated proteins occur at late anaphase at the co
199 main of CMS bound specifically to a tyrosine-phosphorylated protein of 120 kDa, which we identified a
201 imulated by casein kinase 2 (CK2) and that a phosphorylated protein of approximately 85 kDa is presen
202 t colonic muscularis mucosae cells, tyrosine-phosphorylated proteins of approximately 60 and 125 kDa
206 t required to decrease the level of tyrosine phosphorylated proteins or of the protein tyrosine kinas
208 Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated wi
210 al immunosensor has been developed to detect phosphorylated proteins, phospho-p53(15) and phospho-p53
211 presents extracted phosphorylation objects (phosphorylated proteins, phosphorylation sites and prote
214 SHPS-1 also associates with two tyrosine-phosphorylated proteins (pp55 and pp130) and a protein t
216 crease is the appearance of several tyrosine phosphorylated proteins present only in differentiated c
218 ,4,5)P3] and Src homology 2 domain [tyrosine-phosphorylated proteins, PtdIns(3,4,5)P3] of PLC-gamma;
220 e and the interaction of AuNPs with the thio-phosphorylated proteins quantified by quartz crystal mic
221 However, after purification, the highly phosphorylated protein readily formed oligomers, whereas
222 on the contrary, detected similar amounts of phosphorylated proteins regardless of sex or gonad devel
223 14-3-3 proteins via binding serine/threonine-phosphorylated proteins regulate diverse intracellular p
224 fied protein required for NMD; (ii) SMG-2, a phosphorylated protein required for NMD in worms, yeasts
232 Diatom biomineralization involves highly phosphorylated proteins (silaffins and silacidins), anal
233 or for the selective detection of proximally phosphorylated protein sites, suitable for application i
234 ng in a less active form of PGI, whereas non-phosphorylated protein species retain cytokine activity.
235 phosphoproteins, and include several highly phosphorylated proteins such as MAP1B (33 sites) and Bas
236 es directed against known 60-70-kDa tyrosine-phosphorylated proteins suggest that pp68 may be a novel
237 he transcriptional activity of the wild-type phosphorylated protein, suggesting that the negative cha
240 trate, was originally identified as a highly phosphorylated protein that is localized to focal adhesi
241 ve identified a high-molecular-mass tyrosine-phosphorylated protein that is rapidly phosphorylated on
243 CKAP4 is a reversibly palmitoylated and phosphorylated protein that links the ER to the cytoskel
244 le minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating n
246 Phosphopeptides derived from aberrantly phosphorylated proteins that are presented on tumors and
250 ensing pathways, resulting in alterations of phosphorylated proteins that play a key role in the regu
251 aded filament proteins filensin and CP49 are phosphorylated proteins that undergo proteolytic degrada
254 n signal transduction pathways by binding to phosphorylated proteins to activate, inactivate, or sequ
255 subsequent, specific recruitment of tyrosine phosphorylated proteins to APP, including Lyn and Syk.
256 ly applicable tool to generate conditionally phosphorylated proteins to identify those whose dephosph
259 complexes, acting as E3 ligases that target phosphorylated proteins to ubiquitylation and degradatio
262 ly small; only 7% of glycosylated and 13% of phosphorylated proteins undergo global changes >2 A.
264 able of predicting the global structure of a phosphorylated protein using only knowledge of the struc
265 f signaling complexes by binding to tyrosine phosphorylated proteins using their SH2 domains and to p
266 st Dma1, relay checkpoint signals by binding phosphorylated proteins via their FHA domains and promot
267 d, nine-plex immunoassay measuring total and phosphorylated protein was constructed to measure tempor
268 n of the fusion protein at Ser(523), and the phosphorylated protein was found chiefly in the cytoplas
271 rse of this purification, a 105-kDa tyrosine-phosphorylated protein was only detected in fractions th
272 ns of a direct interaction with tubulin, the phosphorylated protein was released from microtubules.
273 scernible 2.1-fold increase in the number of phosphorylated proteins was detected when the panA gene
274 hotyrosine antibodies to enrich for tyrosine phosphorylated proteins, we have identified a novel sign
278 omes and detergent-resistant membranes, 1622 phosphorylated proteins were detected, including more th
282 hosphopeptides, corresponding to 1701 unique phosphorylated proteins, were identified and quantified.
286 A mutant trapped primarily a 97-kDa tyrosine-phosphorylated protein, which was determined to be VCP (
287 ciated with an approximately 72-kDa tyrosine-phosphorylated protein, which we identify here as G3BP,
288 B also showed increased binding of tyrosine-phosphorylated proteins, which included the negative reg
289 e EGFR was confirmed by analysis of tyrosine phosphorylated proteins, which revealed a rapid, damage-
290 ing affinity for gefitinib is weaker for the phosphorylated protein while for the oncogenic mutant, L
291 domain of the Nck adaptor can bind tyrosine-phosphorylated proteins, while its SH3 domains can modul
294 t the identification of prominently tyrosine-phosphorylated proteins with a molecular mass of approxi
295 or molecule CBL, and association of tyrosine-phosphorylated proteins with phosphatidylinositol 3-kina
297 ed by an increase in association of tyrosine-phosphorylated proteins with the adapter protein Grb2.
298 Synaptogyrins comprise a family of tyrosine-phosphorylated proteins with two neuronal (synaptogyrins
299 ed with an increase in the number of Ser/Thr-phosphorylated proteins within the newly dispersed cells
300 egulated by phosphorylation, a means to cage phosphorylated proteins would be generally applicable.
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