ライフサイエンスコーパス: phosphorylation

1 in ligase nuclear accumulation, and iii) Fyn phosphorylation.

2 oteins and subunit modifications, especially phosphorylation.

3 es the characteristic temporal order of KaiC phosphorylation.

4 stomatal closure and its activity depends on phosphorylation.

5 FAK and decreasing VHR promoted FAK tyrosine phosphorylation.

6 d independently of Dapk1 or altered Ser-1303 phosphorylation.

7 fold is facilitated by light signals or PIF3 phosphorylation.

8 increased cell viability by decreasing SMAD2 phosphorylation.

9 l as mTORC1 hyperactivation with reduced Akt phosphorylation.

10 d levels of IL-1beta and checkpoint kinase 1 phosphorylation.

11 ll as enhanced p70S6K1 autoinhibitory domain phosphorylation.

12 and p70 S6K1 (269 +/- 41% vs. CX; P < 0.001) phosphorylation.

13 ntially regulate pocket proteins through CTD phosphorylation.

14 traction, although it did not inhibit SM RLC phosphorylation.

15 ng infection and how they may be governed by phosphorylation.

16 , and use ATP to activate substrates through phosphorylation.

17 mTOR, and Akt signaling, via PTPN13-mediated phosphorylation.

18 s associated with an increase in eIF4E(S209) phosphorylation.

19 disc proteins experiencing robust changes in phosphorylation.

20 rolled by protein ubiquitination and Ser/Thr phosphorylation.

21 protein expression, as well as IKbeta-alpha phosphorylation.

22 ocampal PSD CaMKII expression and S831 GluA1 phosphorylation.

23 atase PP2A-PP2R3B can remove this inhibitory phosphorylation.

24 , suggesting mTORC1 signaling controls their phosphorylation.

25 ependent on FADD but independent of Ser(533) phosphorylation.

26 amma-cleavage events, could also induce TrkB phosphorylation.

27 and RAF, MEK, and ERK that inhibits SOS via phosphorylation.

28 study examined whether acetylation and S574 phosphorylation act independently or in concert to regul

29 stic studies showed that HNK inhibited Stat3-phosphorylation/activation in an LKB1-dependent manner,

30 ther found that all mutations affecting auto-phosphorylation also affected neuronal migration, highli

31 r energy homeostasis independently of Thr172 phosphorylation.AMPK is involved in sensing of metabolic

32 was completely unable to stimulate GSK3beta phosphorylation, an endpoint robustly activated by the f

33 Involvement of PC1-regulated eIF2alpha phosphorylation and a PKR-eIF2alpha pathway in cell apop

34 jor coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling en

35 This combination of phosphorylation and acetylation of FOXO3a results in its

36 demonstrate iSNAP, a tool to detect tyrosine phosphorylation and activate desired protein enzymes all

37 Furthermore, VEGF/ERK signaling induces phosphorylation and activation of the ETS transcription

38 rovide an essential platform for RAS-induced phosphorylation and activation of the prosenescence tran

39 ed p38- and MK2-mediated, Nox4-promoted MRTF phosphorylation and activation.

40 ning the functional relationship between Tau phosphorylation and aggregation has proven a challenge o

41 that netrin-1 induced NF-kappaB p65(ser536) phosphorylation and c-Myc expression in vitro and in viv

42 We found that NLRX1 regulates oxidative phosphorylation and cell integrity, whereas loss of NLRX

43 We found impairments in oxidative phosphorylation and changes in TCA cycle metabolites, as

44 heral nerve regeneration via increased MAP1B phosphorylation and concomitantly reduces microtubule de

45 aninum expressing TgROP16 induced host STAT3 phosphorylation and consequent reduction of IL-12 synthe

46 ers, PLK3 is also able to catalyze alpha-syn phosphorylation and degradation in living cells.

47 n pathway activity by promoting beta-catenin phosphorylation and degradation, it also inhibited the p

48 show that VPA is a potent inhibitor of STAT3 phosphorylation and demonstrate that histone acetylation

49 plasma membrane (PM) contacts is governed by phosphorylation and dephosphorylation in response to osc

50 nd increased inhibitory PDH-E1alpha Ser(300) phosphorylation and FA oxidation.

51 We found that LF-W271A blocked ERK phosphorylation and growth in a melanoma cell line, sugg

52 ration of ESAT-6 but not CFP10 induced STAT3 phosphorylation and IL-6 expression in the mouse lungs,

53 The CDK7 inhibitor, THZ1 prevented Ser118 phosphorylation and inhibited growth of MCF7-Y537S cells

54 eport that CDK4 represses FAO through direct phosphorylation and inhibition of AMPKalpha2.

55 h cyclin-dependent kinase 1 (CDK1)-dependent phosphorylation and its autophosphorylation at an evolut

56 ule specifies a mechanism such as binding or phosphorylation and its structural requirements.

57 lles that generate energy (ATP) by oxidative phosphorylation and mediate key cellular processes such

58 xpression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fis

59 g to IKKbeta and thereby blocks IkappaBalpha phosphorylation and NF-kappaB nuclear translocation.

60 hat the opposing activities of ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation prov

61 We detected the alterations in protein phosphorylation and signaling pathways in pancreatic can

62 iT2 blunted the Pi-dependent ERK1/2-mediated phosphorylation and subsequent gene up-regulation of the

63 transducer and activator of transcription 3 phosphorylation and the expression of downstream genes,

64 er, the inhibitive effects of PDZK1 on SHP-1 phosphorylation and the tumor growth were verified in vi

65 rogation, cell survival in suspension, STAT3 phosphorylation and water solubility.

66 thway that ultimately increases nuclear CREB phosphorylation and, in most cases, expression of immedi

67 vents the inhibition of tyrosine hydroxylase phosphorylation and, thereby, of dopamine synthesis, sup

68 ion with upstream kinase LATS1, prevents its phosphorylation, and activates its transcriptional activ

69 s beta-amyloid (Abeta), reduces tau Ser(396) phosphorylation, and decreases both beta-secretase (BACE

70 tment inhibited mtDNA replication, oxidative phosphorylation, and induced cytotoxicity in a panel of

71 This limits glycolysis, increases oxidative phosphorylation, and is essential for neutrophil maturat

72 binding to mRNA is regulated by tyrosine 396 phosphorylation, and this particular modification was sh

73 ion aligned with processes such as oxidative phosphorylation, angiogenesis, and the p53 pathway.

74 Direct phosphorylation assay and mass spectrometry confirm that

75 ntified either reduced expression or loss of phosphorylation at critical residues of different classe

76 duce PIN1 polarity shifts, seemingly through phosphorylation at S1-S3.

77 Moreover, we noted that Optn phosphorylation at Ser-177 was required for autophagosom

78 support a molecular mechanism by which Neto2 phosphorylation at Ser-409 helps restrict GluK1 targetin

79 In Drosophila, mimicking phosphorylation at T3 decreased HTTex1 aggregation both

80 PIN1 phosphorylation at the basal and apical plasma membrane

81 we identify multiple sites of Mps1-regulated phosphorylation at the outer kinetochore.

82 evels and AMPK activity, as evaluated by its phosphorylation at threonine residue 172 (AMPK-Thr(P)(17

83 Ca(2+)-store depletion rapidly induces STIM1 phosphorylation at Y361 via proline-rich kinase 2 (Pyk2)

84 ) and mitogen-activated protein (MAP) kinase phosphorylation, but exhibited normal responses to subse

85 and differentiation, and the control of Brg1 phosphorylation by calcineurin, PKCbeta1, and p38 regula

86 transcriptional activation function requires phosphorylation by Cdk1 or Cdk2 that primes FoxM1b for p

87 metic residues (Ser to Glu, SE) reduced Brg1 phosphorylation by CK2.

88 Phosphorylation by Erk2 and IKK1/2 of Ser114 and Ser446

89 Histone phosphorylation by M6CK results in a dramatic decrease i

90 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A and regula

91 Phosphorylation by PKA also acts to prevent inhibition o

92 ation by Cdk1 or Cdk2 that primes FoxM1b for phosphorylation by Plk1, which triggers association with

93 g of SH2 and PTB domains can enhance protein phosphorylation by protecting the sites bound by these d

94 Ser133 phosphorylation by protein kinase A (PKA) is a well-char

95 Our findings support that delta-secretase phosphorylation by SRPK2 plays a critical role in aggrav

96 mary, our results provide evidence that Atf1 phosphorylation by the MAPK Sty1 is required for oxidati

97 ignificantly inhibited NF-kappaB p65(ser536) phosphorylation, c-Myc up-regulation and reduced cell pr

98 We conclude that phosphorylation can disrupt the binding of an E3 ubiquit

99 Either glycolysis or oxidative phosphorylation can fuel low-frequency synaptic function

100 Phosphorylation causes increases in radius, protein acce

101 proach, we now compare protein abundance and phosphorylation changes in interphase and mitotic fracti

102 in kinases or trafficking mechanisms in PIN1 phosphorylation control.

103 at histone acetylation and STAT3 tyrosine705 phosphorylation cooperate in regulating NKG2D expression

104 n of the IKKbeta2 kinase, however, neither a phosphorylation-deficient nor a phosphomimetic mutant of

105 Phosphorylation-dependent (40E8 and p396) and C-terminal

106 This phosphorylation-dependent alteration in the PDZ domain-l

107 egulation of diverse biological processes by phosphorylation-dependent protein-protein interactions.

108 he cytoplasmic gate of KdpA is linked to the phosphorylation domain of KdpB.

109 The temporal dimension of phosphorylation effects remains nonetheless poorly under

110 estion of unbound proteins and peptide-based phosphorylation enrichment.

111 How the enzyme coordinates these phosphorylation events and new C-C bond formation in the

112 for PKB, catalyzes two previously unreported phosphorylation events at Ser(476) and Ser(480) of Cbl-b

113 ors that lack cognate kinases do not rely on phosphorylation for activation and new roles for unphosp

114 es revealed that the agent inhibited pERK1/2 phosphorylation in all tumours, caused a significant dec

115 evidence for an essential role of oxidative phosphorylation in cancer.

116 mal-intensity contractions (MICs) on protein phosphorylation in mouse skeletal muscle.

117 e importance of tightly regulated CAMK2 auto-phosphorylation in neuronal function and neurodevelopmen

118 role of MT1-MMP cytoplasmic residue Thr(567) phosphorylation in regulation of metastasis-associated b

119 t membrane recruitment is sufficient for Akt phosphorylation in response to growth factors.

120 itochondrial enzyme COX10-mediated oxidative phosphorylation in T cell quiescence exit.

121 g pathways that appear independent of Thr172 phosphorylation in the kinase activation loop.

122 eking behavior and increased AMPK and p70s6k phosphorylation in the NAc core but not shell.

123 rved a substantial increase in Neto2 Ser-409 phosphorylation in the presence of CaMKII, and this phos

124 of tumor suppressor via inhibition of STAT3 phosphorylation in uterine epithelial cells, and the ant

125 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells.

126 th CM2, whose assembly is stimulated by Plk1 phosphorylation in vitro.

127 of ATP production, glycolysis and oxidative phosphorylation, in fueling presynaptic function in uncl

128 M6CK histone phosphorylation, in turn, regulates transcription by att

129 Although cytochrome c phosphorylation-in particular, at tyrosine 48-is a key m

130 parent reductions in mitochondrial oxidative phosphorylation, increases in substrate level generation

131 eir regulation of RLC phosphorylation or how phosphorylation influences individual SF mechanics.

132 Moreover, Neto2 Ser-409 phosphorylation inhibited synaptic targeting of GluK1 be

133 tivity, which appears to reflect Src-induced phosphorylation, internalization and degradation of VE-c

134 Promoter-proximal Ser2 phosphorylation is associated with a longer pol II dwell

135 iated activation of PRAS40 via threonine 246 phosphorylation is both necessary and sufficient to caus

136 Moreover, AMPK-directed SIRT1 phosphorylation is required for energy starvation-induce

137 The critical regulatory effect of phosphorylation is shown by replacement in the oocyte wi

138 FAK phosphorylation is substantially decreased in IP6K1 dele

139 ch effects were associated with an increased phosphorylation level of both Src and extracellular sign

140 kably reduced Ca(2+) leakage and lower basal phosphorylation levels of Ca(2+)-cycling proteins includ

141 in synaptic efficacy correlates with reduced phosphorylation levels of eukaryotic elongation factor 2

142 arge B-cell lymphoma patients had high basal phosphorylation levels of most measured signaling nodes,

143 -regulated kinase (ERK 1/2) activation (i.e. phosphorylation) links tumor necrosis factor alpha (TNFa

144 y CDK1, and blocking basal CDK1-mediated S81 phosphorylation markedly suppresses AR activity and init

145 The WDR5/MLL2 complex reads the H4-Y88-phosphorylation marks and deposits the transcriptionally

146 xidant N-acetylcysteine, suggesting that Y10 phosphorylation-mediated LDHA activity promotes cancer c

147 Overexpression of a phosphorylation mimetic (S226D) in young 3xTg mice stron

148 MAPKs can be diversified to recognize unique phosphorylation motifs.

149 To this end, we expressed Atf1 phosphorylation mutants from a constitutive promoter to

150 However, activation loop phosphorylation occurs via a noncanonical two-step mecha

151 We propose that phosphorylation of 53BP1 at S380 accelerates complex for

152 gulates many physiological processes through phosphorylation of a diverse array of substrates.

153 we show in a controlled in vitro system that phosphorylation of a membrane protein can trigger a chan

154 ramolecular binding that is regulated by the phosphorylation of a single tyrosine residue.

155 ily regulated via GPCR kinase (GRK)-mediated phosphorylation of activated receptors.

156 f the Brazilian lineage could interfere with phosphorylation of Akt and mTOR, impairing Akt-mTOR sign

157 ely blocked by pharmacological inhibition of phosphorylation of Akt.

158 hagy in vivo, and were preceded by increased phosphorylation of AMP activated protein kinase (Ampk) a

159 ynthase kinase 3beta (GSK3beta), followed by phosphorylation of and loss of beta-catenin from the nuc

160 heavily phosphorylated of all caspases, with phosphorylation of at least 11 distinct residues in all

161 ATG16L1 stabilization via IKKalpha-dependent phosphorylation of ATG16L1 at Ser278.

162 ced DNA damage was dependent on PKA-mediated phosphorylation of ATR on S435 which promoted ATR's inte

163 hibited decreased gamma-H2AX foci, decreased phosphorylation of ATR, and higher levels of residual 53

164 eased cytosolic calcium, in turn, led to the phosphorylation of calcium/calmodulin-dependent protein

165 n site mapping and mutagenesis indicate that phosphorylation of Cdc55 contributes to Igo/ENSA dissoci

166 IMK), which regulates actin activity through phosphorylation of cofilin, an actin-depolymerizing fact

167 ruiting PLK-1 to the NE thereby facilitating phosphorylation of critical downstream targets.

168 KO/knockdown of GSK3beta reduced inhibitory phosphorylation of CRMP2 in RGCs and improved optic nerv

169 Here we mimic phosphorylation of cytochrome c by replacing tyrosine 48

170 nd some in vitro evidence indicates that the phosphorylation of Dam1 protein by Ipl1 kinase destabili

171 PNUTS and PP1 together fine-tune the dynamic phosphorylation of DNA-PKcs after DNA damage to mediate

172 in CAL62 and HTH83 cells and suppressed the phosphorylation of downstream targets of AXL signaling s

173 onged LPS-induced activation of p38 and JNK, phosphorylation of downstream transcription factors, and

174 In double-knockout mice, constitutive phosphorylation of EIF2A and over-expression of IRGM1 re

175 score a previously unknown function for GCN2 phosphorylation of eIF2alpha and translational control i

176 sion or mTOR activity and also blocking MNK1 phosphorylation of eIF4E.

177 e, complementation test results suggest that phosphorylation of EMS1 is required for its function in

178 Ras activation and phosphorylation of ERK1/2 downstream of Ras are both gre

179 ardiomyocytes were cultured in vitro and the phosphorylation of ERK1/2, AKT, GSK3beta and protein exp

180 We show that H2S transiently increases phosphorylation of eukaryotic translation initiation fac

181 Over-expression of VHR decreased tyrosine phosphorylation of FAK and decreasing VHR promoted FAK t

182 hile inhibiting myosin light chain kinase or phosphorylation of focal adhesion kinase was ineffective

183 tion of SFKs using PP2 blocked BDNF-mediated phosphorylation of GluN2A, GluN2B, and ERK.

184 Here we show that phosphorylation of GSK3beta on Ser(389) mediated by p38

185 the kinetics of RNAi trigger delivery and 5-phosphorylation of guide strands correlating with gene k

186 cal inhibition of mTOR signaling resulted in phosphorylation of H2AX concomitant with the decrease of

187 ivated protein kinase 1/2 (MSK1/2)-catalyzed phosphorylation of histone H3 at serine 10 or 28 and exp

188 ing macrophages were accompanied by impaired phosphorylation of IL-1R-associated kinase 1 (IRAK-1), p

189 Overall, we structurally rationalize phosphorylation of Ins(1,4,5)P3 and PtdIns(4,5)P2 by HsI

190 a nucleotide exchange factor, can stimulate phosphorylation of KaiC, and how the differential affini

191 etylated it at lysine 48, which promoted the phosphorylation of LKB1 and the subsequent activation of

192 r levels of phospho-AMPK and lower levels of phosphorylation of mammalian target of rapamycin (phosph

193 The data strongly suggest that the phosphorylation of many different substrates contributes

194 -4A mutant was defective for stimulating DDK phosphorylation of Mcm2, binding to eighty-nucleotide ss

195 actosidase activity, oxidative stress, early phosphorylation of mitogen-activated protein kinases and

196 eceptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase domain-like prot

197 multiple pathways that converge to increase phosphorylation of myosin in vascular smooth muscle (VSM

198 tion) and Rho-mediated contraction (via ROCK phosphorylation of myosin light chain), which are couple

199 , the proximal tubule of females had greater phosphorylation of Na(+)/H(+) exchanger isoform 3 (NHE3)

200 kinase (NADK2, also called MNADK) catalyzes phosphorylation of NAD to yield NADP.

201 ional subclass alpha/beta leading to reduced phosphorylation of NADPH oxidase components p47 (phox) a

202 nhibits TNFalpha induced gene expression and phosphorylation of NF-kappaB.

203 The C-terminal DSP domain induced phosphorylation of occludin Ser(490) and focal adhesion

204 ation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase.

205 UTP increased the phosphorylation of p38, ERK, CREB, and Ser-727 of STAT3

206 HRV infection induces the phosphorylation of PKD, and inhibitors of this kinase ef

207 Phosphorylation of PTK6 tyrosine 342 (PY342) promotes ac

208 rostate leads to tumorigenesis and increased phosphorylation of PTK6 Y342, and disruption of Ptk6 imp

209 ompletely known, but are presumed to require phosphorylation of residues in alpha1C and C-terminal pr

210 EFS increased force and phosphorylation of RLC, CPI-17 and MLCK.

211 modulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2-S2814 residue vs. normoglycaemia

212 Phosphorylation of ser209 on eIF4E regulates the transla

213 In both genetic mouse models, expression and phosphorylation of Sestrin2, an ATF4 gene target, was in

214 went through qualitative adaptations, namely phosphorylation of several proteins, including myosin li

215 TH is highly regulated, notably by phosphorylation of several Ser/Thr residues in the N-ter

216 Specifically, phosphorylation of Sid4 by NIMA(Fin1) reduces Sid4 affin

217 novel cascade, RIT1 stimulates Akt-dependent phosphorylation of Sox2 at T118, leading to its stabiliz

218 ing microscopy, leading to integrin-mediated phosphorylation of Src and extracellular signal-regulate

219 find that hyperosmotic stress induces strong phosphorylation of Ssp2-T189 by Ssp1.

220 ion of NFkappaB and IL6 secretion, increased phosphorylation of STAT3 on Ser727, and increased expres

221 The phosphorylation of STAT5B on the JAK2-dependent Y699 sit

222 Notably, in vitro phosphorylation of the ABD closely recapitulated the pre

223 ation site compromised neither ErbB4-induced phosphorylation of the canonical signaling pathway effec

224 We show that phosphorylation of the Ctf19 kinetochore protein by a co

225 th retinoid X receptor alpha (RXRalpha), and phosphorylation of the DNA-binding domain (DBD) at Thr-3

226 of SSTCre:gamma2(f/f) mice showed decreased phosphorylation of the eukaryotic elongation factor eEF2

227 hibitor of kappaB kinase (IKK) and increased phosphorylation of the NF-kappaB subunit RelB.

228 RhoA inactivation selectively inhibited phosphorylation of the NM myosin regulatory light chain

229 ere, we report that ART treatment results in phosphorylation of the parasite eukaryotic initiation fa

230 phosphotransfer in a eukaryotic system, the phosphorylation of the receiver domain of the histidine

231 y induction of cell-cycle markers, including phosphorylation of the retinoblastoma protein and lamins

232 roteins, which are tightly regulated via the phosphorylation of their associated myosin regulatory li

233 A1-FER knockout had significant decreases in phosphorylation of these proteins.

234 tion in differentiating muscle cells through phosphorylation of threonine 372.

235 osine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-i

236 Phosphorylation of tyrosine 78 stabilizes Atoh1, increas

237 Src tyrosine kinase activity and tyrosine phosphorylation of VE-cadherin were increased in old art

238 Src activity and tyrosine phosphorylation of VE-cadherin were increased in old com

239 Sequential phosphorylations of Eco1 by CDK, DDK, and Mck1 create a

240 -affinity arrestin binding requires receptor phosphorylation, often at the receptor's C-terminal tail

241 CSR and SHM are regulated by phosphorylation on AID serine38 (pS38), but the role of

242 A1 ubiquitin-deficient mutant enhances GluA1 phosphorylation on Ser-845.

243 1 modulates HTTex1 aggregation by regulating phosphorylation on T3.

244 se kinases differ in their regulation of RLC phosphorylation or how phosphorylation influences indivi

245 However, we found no differences in phosphorylation or SHP-1 recruitment between dimeric and

246 Mitochondrial disorders affecting oxidative phosphorylation (OxPhos) are caused by mutations in both

247 While quiescent T cells use oxidative phosphorylation (OXPHOS) for energy production, and effe

248 nt, dose-dependent increase in EGFR tyrosine phosphorylation, particularly of sites corresponding to

249 capitulated the previously described in vivo phosphorylation pattern.

250 atically discover complex representations of phosphorylation patterns from the raw sequences, and hen

251 This single site phosphorylation plays an important role in the control o

252 In addition, ACSS2 S659 phosphorylation positively correlates with AMPK activity

253 gulates the expression of CBF genes, and the phosphorylation promotes the degradation of ICE1.

254 This motif is subject to GSK-3 phosphorylation, promoting ER retention, while mutation

255 transducer and activator of transcription 3 phosphorylation, reduced IL-2 production, and enhanced a

256 k between the two NDK monomers to accelerate phosphorylation-related assembly of RSs and entire flage

257 is shown by replacement in the oocyte with a phosphorylation-resistant form of GNU, which promotes PN

258 Furthermore, in vivo inhibition of STAT6 phosphorylation restores Notch1 expression in HR(+) ETPs

259 We previously showed that Ser65 phosphorylation results in a conformational change in wh

260 these changes to increased MLC2v and MYPT1/2 phosphorylation seen only in TRV120067-treated mice.

261 This regulation likely accrues from a phosphorylation-sensitive nuclear localization sequence

262 The phosphorylation site at serine 14 of TRPC6 is embedded i

263 Arg-354 or Ser-357, which forms a consensus phosphorylation site for basophilic kinases, markedly re

264 ectly phosphorylates Cdc55 and Igo/ENSA, and phosphorylation site mapping and mutagenesis indicate th

265 of D836 to alanine in the activation loop of phosphorylation site mutants nearly completely abolished

266 provides a powerful tool for improvement of phosphorylation site prediction.

267 ntify the substrates directly and to map the phosphorylation site(s) of plant symbiotic receptor-like

268 a challenge owing to the multiple potential phosphorylation sites and their clustering in the Tau se

269 oxM1b identified a critical role of the Plk1 phosphorylation sites in regulating the binding of FoxM1

270 hypothesize that positive selection of novel phosphorylation sites in the protein NS4B of the Brazili

271 ties, resulting from multiple interdependent phosphorylation sites is required for a GC-A conformatio

272 Activation of FoxO3 by mutating phosphorylation sites to enhance its nuclear expression

273 nteracts with Brg1, and mutation of putative phosphorylation sites to non-phosphorylatable (Ser to Al

274 otential phosphorylation switches by mapping phosphorylation sites to protein-protein interactions of

275 omatographic tandem mass spectrometry to map phosphorylation sites to the otherwise divergent amino-t

276 Moreover, a high proportion of the regulated phosphorylation sites were found on proteins that are as

277 tbetagamma binding surface and contains both phosphorylation sites, is restrained within the central

278 itative phosphoproteomics identified 229 PKA phosphorylation sites.

279 f mTORC1, we were able to identify six T-bet phosphorylation sites.

280 he H. pylori transcriptome for RNAs whose 5'-phosphorylation state and cellular concentration are gov

281 were present simultaneously, melanophilin's phosphorylation state enforced track selection of the Ra

282 tion of PTEN activity through changes in its phosphorylation status could uniquely regulate the conti

283 Here, we show that the phosphorylation status of NBS1 determines the repair pat

284 Alterations in the Cdk/Cdc14-dependent phosphorylation status of Spc110, or its inactivation du

285 telomere end protection and reveals how the phosphorylation status of the NBS1(S432) dictates repair

286 racellular domain of IR display higher IRS-1 phosphorylation, stronger regulation of genes in metabol

287 e present a fast method to predict potential phosphorylation switches by mapping phosphorylation site

288 encodes essential subunits of the oxidative phosphorylation system.

289 dentified proteins possess multiple sites of phosphorylation that are often clustered, where kinases

290 ing G-protein-coupled receptor kinase 2 upon phosphorylation, thereby bridging MAP kinase and G-Prote

291 our results reveal an important role of FEN1 phosphorylation to counteract oxygen-induced stress in t

292 We show that Hec1 tail phosphorylation tunes friction along polymerizing microt

293 modification (i.e. substitution with Asp or phosphorylation) "undocks" and repositions the cofilin N

294 eased in lyM-PP2A(fl/fl) mice, and increased phosphorylation was observed in MAPK pathways (p38, ERK,

295 rylation in the presence of CaMKII, and this phosphorylation was reduced in the presence of the KAR s

296 Moreover, insulin stimulation of their phosphorylation was significantly suppressed, both tempo

297 These changes in phosphorylation were dependent upon expression of PP5.

298 demands are met preferentially by oxidative phosphorylation, which can be maintained by bulk but not

299 epend on myosin regulatory light chain (RLC) phosphorylation, which is driven by myosin light chain k

300 JAK-STAT signaling through control of STAT5B phosphorylation, which provides the mechanism for circad