ライフサイエンスコーパス: phosphorylation site

1 177 was identified as a high-probability PKC phosphorylation site.

2 ibition of Tyr kinase CK2 or by mutating the phosphorylation site.

3 ecognition determinant (BPR) flanking a Cdk1 phosphorylation site.

4 spho-sites rather than dominated by a single phosphorylation site.

5 II target sites, with Ser-46 being the major phosphorylation site.

6 erine/threonine and tyrosine as a regulatory phosphorylation site.

7 ibrium of the beta3-alpha3 loop close to the phosphorylation site.

8 f relevant sequence features that surround a phosphorylation site.

9 of which lacks the key regulatory serine 472 phosphorylation site.

10 site, and another disrupted a predicted CK1 phosphorylation site.

11 harboring a cyclin-dependent kinase 2 (CDK2) phosphorylation site.

12 vely phosphorylated, and we precisely assign phosphorylation sites.

13 k for predicting general and kinase-specific phosphorylation sites.

14 eptides, trans-membrane protein domains, and phosphorylation sites.

15 itative phosphoproteomics identified 229 PKA phosphorylation sites.

16 nd Thr-227, matching previous in vivo-mapped phosphorylation sites.

17 of CTD and are far more abundant than other phosphorylation sites.

18 is unclear, as is the role of specific APC/C phosphorylation sites.

19 tail containing clusters of serine/threonine phosphorylation sites.

20 th phospholipids and also overlaps with aPKC phosphorylation sites.

21 normal cytokinesis and acts on specific Cdk phosphorylation sites.

22 n of the receptor at all five major tyrosine phosphorylation sites.

23 Kv2.1 phosphorylation at several C-terminal phosphorylation sites.

24 ty with specificity for a subset of Cdk-type phosphorylation sites.

25 tosis onset, and dephosphorylated it at Cdk1 phosphorylation sites.

26 f mTORC1, we were able to identify six T-bet phosphorylation sites.

27 containing nuclear localization sequence and phosphorylation sites.

28 rotein pellet with 4,792 proteins with 1,072 phosphorylation sites.

29 human TRPC6 identified several novel serine phosphorylation sites.

30 Of those phosphorylation sites, 17 precede a proline, making them

31 as doubled from 189 to 396 confident, unique phosphorylation sites, 268 of which were within the pack

32 , point mutations of the BIN2-mediated CESA1 phosphorylation site abolished BIN2-dependent regulation

33 its cytoplasmic domain and mutation of these phosphorylation sites abrogates lumen formation.

34 sed to analyze trends in the localization of phosphorylation sites across cytoplasmic kinase subdomai

35 Here we map in vitro and in-cell phosphorylation sites across FUS LC We show that both ph

36 hosphorylation, and that mutation of the PKA phosphorylation site affects ciliary receptor localizati

37 for proper DSB repair, and that loss of this phosphorylation site alone is sufficient to cause a DDR

38 e, we identified Ser(36) as the major p70S6k phosphorylation site, along with a low frequency site at

39 Mutation of another predicted PKCbeta phosphorylation site also located in the phosphotyrosine

40 that MCa Thr(26) belongs to a consensus PKA phosphorylation site and can be phosphorylated by PKA bo

41 hip" that is unleashed is near the S339/S340 phosphorylation site and flanks the hydrophobic Ezrin-bi

42 , enabling a quantitative comparison of EGFR phosphorylation sites and demonstrating that receptor ph

43 er physiological conditions, are enriched in phosphorylation sites and in significant local bias towa

44 ins and thereby decreases both the number of phosphorylation sites and site occupancy.

45 The N-terminal domain of Pdc, where both phosphorylation sites and the 14-3-3-binding motifs are

46 , all of which occur close to two regulatory phosphorylation sites and the catalytic site on human Ca

47 a challenge owing to the multiple potential phosphorylation sites and their clustering in the Tau se

48 We identify five putative PKA phosphorylation sites and use site-directed mutagenesis

49 h includes more than 23,000 proteins, 20,000 phosphorylation sites, and 700 lysine acetylation sites.

50 otein features including structured domains, phosphorylation sites, and known single nucleotide varia

51 We show that evolutionarily conserved MCV LT phosphorylation sites are constitutively recognized by c

52 e regulatory sites while the lower abundance phosphorylation sites are more densely populated at the

53 This decrease in HR is specific as these phosphorylation sites are not required for NHEJ.

54 the iTSC2KO mice, we demonstrated that these phosphorylation sites are required for the role that TSC

55 Akl1 has two Fpk1 phosphorylation sites (Ark1 and Prk1 have none) and is h

56 ction allowed for localization of the P-TEFb phosphorylation site as well as characterization of the

57 GluA1 subunit of AMPAR at CAMKII, PKC or PKA phosphorylation site, as well as corresponding kinase in

58 -independent mechanism reliant on a putative phosphorylation site at S714.

59 The phosphorylation site at serine 14 of TRPC6 is embedded i

60 HTT has a highly conserved Akt phosphorylation site at serine 421, and prior work in HD

61 inal domain of LPL contains a consensus Mst1 phosphorylation site at Thr(89) We found that Mst1 can p

62 tandem mass spectrometry, we identified two phosphorylation sites at the distal C-terminal tail of t

63 Conversion of the phosphorylation sites at Thr-70 and Ser-166 to Ala resul

64 h proteins are phosphorylated with prominent phosphorylation sites between residues 500 and 600 of co

65 their specificity for a targeted Ser or Thr phosphorylation site but also by binding to linear-pepti

66 Deletion of all four conserved phosphorylation sites but not individual ones affected t

67 runcation mutant (DeltaP242) that lacked all phosphorylation sites but retained a previously suggeste

68 s have identified serine 225 in NS5A to be a phosphorylation site, but the function of this posttrans

69 ne, which is predicted to be a potential PKA phosphorylation site by at least one prediction tool, wh

70 Removal of the Mst1 phosphorylation site by mutating Thr(89) to Ala impaired

71 osphorylation on gelsolin and identified its phosphorylation sites by mass spectrometry.

72 actin-modulating proteins and located their phosphorylation sites by mass spectrometry.

73 ly encoded melanopsin lacking all C-terminal phosphorylation sites (C terminus phosphonull) leads to

74 P-binding site, RAD51-interacting domain, or phosphorylation site causes excessive binding of RAD51 t

75 utism-linked missense mutation disrupts this phosphorylation site, causing enhanced UBE3A activity in

76 Despite a shared upstream kinase and similar phosphorylation sites, Cdr2 and Ssp2 have distinct regul

77 not require any combination of potential PKA phosphorylation sites conserved in human, guinea pig, ra

78 Mutational analyses reveal multiple phosphorylation sites contributing to different extents

79 over 170,000 carefully curated nonredundant phosphorylation sites covering 18,610 proteins.

80 try analyses of DP revealed six novel serine phosphorylation sites dependent on GSK3 signaling and fo

81 e a phosphoswitch model, where two competing phosphorylation sites determine whether PER2 has a fast

82 attenuation of MARCKS using the MPS (MARCKS phosphorylation site domain) peptide synergistically int

83 For a set of phosphorylation sites (eg, PDE3A(Ser312), CALDAG-GEFI(Se

84 An RPA32 mutant lacking phosphorylation sites fails to recruit PRP19 and support

85 alysis identified serine 334 as an important phosphorylation site for Atoh1 ubiquitylation and subseq

86 Arg-354 or Ser-357, which forms a consensus phosphorylation site for basophilic kinases, markedly re

87 modification on MDMX at Ser-314, a putative phosphorylation site for the CDK4/6 kinase.

88 ase-specific substrates and their associated phosphorylation sites for 12 human kinases and kinase fa

89 ermined or computationally-predicted protein phosphorylation sites for distinctive species are becomi

90 iticum urartu DHN3s have a greater number of phosphorylation sites for protein kinase C than other ce

91 y gene expression factors contain repetitive phosphorylation sites for single kinases, but the functi

92 ocystis and Chlamydomonas lack the conserved phosphorylation site found in a C-terminal extension of

93 Using this accelerated workflow, 15367 phosphorylation sites from 13029 different phosphopeptid

94 olar lipids, polar metabolites, proteins and phosphorylation sites from a single piece of tissue.

95 Interestingly, these DNA-PKcs phosphorylation sites function in a distinct, and someti

96 ve regulatory roles for serine and threonine phosphorylation sites have yet to be fully characterized

97 Along 14628 high confidence phosphorylation sites identified in total, only 33% were

98 Of 19 native NaV1.5 phosphorylation sites identified, two C-terminal phospho

99 The specific location of the major MAP2c phosphorylation site in a region homologous to the musca

100 We report the relative importance of each phosphorylation site in inducing a functionally active o

101 hermore, alterations to Thr-104, a conserved phosphorylation site in NPF6.6, resulted in a similar hi

102 is, Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not lean, mi

103 seven amino acid sequence that contains the phosphorylation site in synaptotagmin-1, or a synaptotag

104 PKA phosphorylates TCF4 directly and a PKA phosphorylation site in TCF4 is necessary for its transc

105 The phosphorylation site in the CTR is solvent accessible an

106 We uncovered a single phosphorylation site in the licensing factor M18BP1 and

107 ia coli identified S837 as another potential phosphorylation site in vivo Mutation of all five potent

108 culture (SILAC) and quantified 1394 class I phosphorylation sites in 16 ALL xenografts.

109 teomics techniques can identify thousands of phosphorylation sites in a single experiment, the majori

110 e out a role for all conserved consensus PKA phosphorylation sites in alpha1C in beta-adrenergic stim

111 servation of three consecutive putative GSK3 phosphorylation sites in animal proteomes.

112 We characterize several phosphorylation sites in ATM that are targets of DNA-PKc

113 Moreover, loss of Jak3-mediated phosphorylation sites in beta-catenin abrogated its AJ l

114 brafish studies indicated three PKC-specific phosphorylation sites in beta-catenin that are required

115 Furthermore, we identified five phosphorylation sites in beta-tubulin that serve as subs

116 An important role of phosphorylation sites in biological crosstalk is evident

117 Mutations of Mps1 phosphorylation sites in Bub1 or Mad1 abrogate the spind

118 Our results show that the Plk1 phosphorylation sites in FoxM1b serve as a regulator for

119 thylation, and that is regulated by the Plk1 phosphorylation sites in FoxM1b.

120 Budding yeast Cdh1 carries nine Cdk phosphorylation sites in its N-terminal regulatory domai

121 ully predicted the experimentally identified phosphorylation sites in LOC_Os03g51600.1, a protein seq

122 phosphoproteomic analyses of cAMP-dependent phosphorylation sites in MA10 Leydig cells suggested tha

123 identified His(241) and Asp(61) as conserved phosphorylation sites in NarS and NarL, respectively.

124 Here, we identify three conserved phosphorylation sites in NLRP3 and demonstrate that NLRP

125 hat had enriched missense mutations at their phosphorylation sites in pan-cancer analysis.

126 Mutation of BRAF dependent phosphorylation sites in PAX3 impaired the ability of PA

127 This study examines the role of these phosphorylation sites in PCa.

128 omplexes and to highlight possible roles for phosphorylation sites in regulating interaction interfac

129 oxM1b identified a critical role of the Plk1 phosphorylation sites in regulating the binding of FoxM1

130 site in vivo Mutation of all five potential phosphorylation sites in the activation loop decreased,

131 he well-documented T202 and Y204 stimulatory phosphorylation sites in the activation T-loop of ERK1 a

132 ogether, we have identified two novel native phosphorylation sites in the C terminus of NaV1.5 that i

133 kinases, and biochemical studies identified phosphorylation sites in the C-terminal region of BRM at

134 nt hMPVs (rhMPVs) lacking either one or both phosphorylation sites in the M2-1 protein were recovered

135 Of note, mutating the phosphorylation sites in the MAD1(CTD), including Thr-71

136 nalyses to identify and quantify in situ the phosphorylation sites in the NaV1.5 proteins purified fr

137 hypothesize that positive selection of novel phosphorylation sites in the protein NS4B of the Brazili

138 s phenomenon, most of the functionally known phosphorylation sites in the steroid receptor family of

139 >800 phosphorylation data points from three phosphorylation sites in three signaling proteins over m

140 Identification of regulatory phosphorylation sites in TRPC6 and corresponding protein

141 55, Thr-159, and Ser-280 as the main mitotic phosphorylation sites in Vgll4.

142 the phosphorylation stoichiometry of >1,000 phosphorylation sites including 366 low-abundance tyrosi

143 eins, 499 of which are phosphorylated (1,109 phosphorylation sites), including both well-characterize

144 We identify a set of 115 phosphorylation sites increased during G2, termed 'early

145 l of the PEST motif or mutations in putative phosphorylation sites increased the stability of AtWRI1,

146 a mutant lacking the 5 protein kinase A or C phosphorylation sites interfered with its ability to sti

147 e have similar temporal kinetics, clustering phosphorylation sites into distinctive clusters can faci

148 -3 localization revealed that by engineering phosphorylation sites into the beta2-adrenoceptor the re

149 Here we engineer phosphorylation sites into the C-terminal tail of the be

150 Tumors also showed a reduction of phosphorylation sites involved in transcription and RNA

151 odorant-guided behaviors in Drosophila This phosphorylation site is conserved in other insects, incl

152 ties, resulting from multiple interdependent phosphorylation sites is required for a GC-A conformatio

153 tbetagamma binding surface and contains both phosphorylation sites, is restrained within the central

154 the literature and major public databases of phosphorylation sites, kinases, and disease associations

155 of an additional copy of Fus3 lacking either phosphorylation site leads to dampened signaling.

156 alanine substitutions of five potential JNK phosphorylation sites (LMO7b-5SA) or only Ser-1295 rescu

157 omoted by phosphorylation at a putative CDK1 phosphorylation site located within its microtubule-bind

158 Akt, protein kinase A, and protein kinase C phosphorylation sites located in the vicinity of the ZO-

159 ectly phosphorylates Cdc55 and Igo/ENSA, and phosphorylation site mapping and mutagenesis indicate th

160 indicate that Thr(264) in TRPV3 is a key ERK phosphorylation site mediating EGFR-induced sensitizatio

161 ant form of PDE3B that ablates the major Akt phosphorylation site, murine S273, also restored the abi

162 K3beta binding site mutant (ST2L(S446A)) and phosphorylation site mutant (ST2L(S442A)) are resistant

163 arrow-derived macrophages (BMDMs) expressing phosphorylation site mutant NLRC4 S533A had only a mild

164 of D836 to alanine in the activation loop of phosphorylation site mutants nearly completely abolished

165 Single phosphorylation site mutants still support induction of

166 -galactosidase reporter activated by Hac1(i) Phosphorylation site mutants survive low levels of endop

167 ughput genetic interaction screen with RAD55 phosphorylation site mutants.

168 and inactivation of Ire1 are not affected by phosphorylation site mutants.

169 In contrast, S301A/S319A phosphorylation site mutations greatly attenuated these

170 cell lines could highly reproduce oncogenic phosphorylation site mutations identified in primary tum

171 s mutant could be complemented by expressing phosphorylation site mutations of MKP1.

172 Incorporation of binding-site or phosphorylation-site mutations into just one protomer of

173 osphoprotein that showed eight of nine known phosphorylation sites occupied upon intact mass analysis

174 of a C-terminal extension, which harbors the phosphorylation site of GUN4 expressed in angiosperms.

175 -1 E2 mutant lacking a previously identified phosphorylation site of interest (Y102).

176 The phosphorylation site of NFAT3 was critical for epidermal

177 rmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family mem

178 Mutation of the ERK-RSK phosphorylation sites of c-Fos restrains KSHV lytic gene

179 s suggest that elimination of inhibitory Ser phosphorylation sites of IRS2 exerts short-term benefici

180 d KMT2D binding is shifted upon mutating the phosphorylation sites of NCoR or upon inhibition of the

181 Among the Mec1/Tel1 consensus phosphorylation sites of Sae2, we found that mutations o

182 ignificantly impaired in mice lacking CaMKII phosphorylation sites of TARPgamma-8.

183 AMPAR-mediated transmission requires CaMKII phosphorylation sites of TARPgamma-8.

184 In total, we identified 5983 unique phosphorylation sites of which 663 were found to be regu

185 Here, we report that the Cdk phosphorylation sites of yeast Cdh1 are organized into a

186 A knock-in mutation of the ATM phosphorylation site on E2F1 (S29A) prevents the interac

187 n-associated protein kinase (MAPK)-dependent phosphorylation site on ephrin-B3, Ser332.

188 uggesting the unique role of each individual phosphorylation site on NF-kappaB-dependent gene regulat

189 but not in S2814A mice, in which the CaMKII phosphorylation site on RyR2 was ablated.

190 Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E

191 Tyrosine-146 was identified as a unique phosphorylation site on the UWO 241 PSII subunit P-like

192 tion, mutagenesis of a significantly altered phosphorylation site on xCT (SLC7A11), the light chain o

193 1 and, furthermore, found 76 CD147-dependent phosphorylation sites on 57 proteins.

194 ve global phosphoproteomics, we identify the phosphorylation sites on 69 proteins that are direct or

195 characterization of novel nutrient-regulated phosphorylation sites on ATG13: Ser-224 and Ser-258.

196 ompensatory changes in SPAK/OSR1-independent phosphorylation sites on both NKCC2 and NCC and changes

197 eromeric TRPM7 and TRPM6 channels identified phosphorylation sites on both proteins, as well as sever

198 e cell cycle, yet mutation of Pkc1-dependent phosphorylation sites on Cdc55 and Igo2 did not cause de

199 Our findings identify the first phosphorylation sites on core clock proteins that are ac

200 However, the YopO phosphorylation sites on gelsolin and the consequences o

201 Mapping phosphorylation sites on GHSR1a and knowledge of how the

202 The results suggest that phosphorylation sites on globular, as distinct from diso

203 wever, the impact of specific PKA and CaMKII phosphorylation sites on HR is unknown.

204 effects of mutation of five "inhibitory" Ser phosphorylation sites on IRS2 function in transgenic mic

205 ned with point mutations abrogating specific phosphorylation sites on KIT.

206 this data set identifies functionally novel phosphorylation sites on known LTP-associated signaling

207 By mapping PKC phosphorylation sites on LB3 and testing the effects of

208 s study examined the influence of C-terminal phosphorylation sites on rapid desensitization of MOPr.

209 Mutation of DORN1 phosphorylation sites on RBOHD eliminates the ability of

210 The Slt2 phosphorylation sites on Rcn2 and Caf20 were determined.

211 Mutagenesis of potential serine phosphorylation sites on Sox9 was used to demonstrate th

212 ence of reports in the literature on mapping phosphorylation sites on sPPases, a database survey of v

213 The identification of phosphorylation sites on the proteasome subunits suggest

214 mass spectrometry methodologies for mapping phosphorylation sites on the tandem repeats of the RNA p

215 s a PLK1 substrate in vitro, and mapped PLK1 phosphorylation sites on this protein.

216 Previous studies identified numerous phosphorylation sites on TRPM7, but very little is known

217 activity, and we identified two direct mTOR phosphorylation sites on UVRAG (S550 and S571) that acti

218 Mutating this phosphorylation site or inhibiting Drp1 activity blocks

219 2 (HER2)- pY(1196) site, but not other HER2 phosphorylation sites or other known PTPN12 substrates.

220 med survival analysis showing that a loss of phosphorylation site pfsSNV at position 105 in MEF2A is

221 vo cAMP and twitching phenotypes of key ChpA phosphorylation site point mutants supported a scheme wh

222 under the precision-recall curve in general phosphorylation site prediction and obtains competitive

223 In silico methods for phosphorylation site prediction can provide a useful and

224 and sequence features significantly improves phosphorylation site prediction performance across all k

225 Computational methods for phosphorylation site prediction play important roles in

226 provides a powerful tool for improvement of phosphorylation site prediction.

227 g schemes to develop a rice-specific protein phosphorylation site predictor.

228 ds on DAT residue Thr-53, a proline-directed phosphorylation site previously implicated in AMPH-stimu

229 s, and 6227 phosphoproteins harboring 31,595 phosphorylation sites quantified across maize developmen

230 Loss of these phosphorylation sites reduced VPS34 lipid kinase activit

231 vidence for Ser(139) and Ser(213) as PKCbeta phosphorylation sites regulating the pro-oxidant and pro

232 rylation; however, the functions of specific phosphorylation sites remained obscure.

233 ver, the unambiguous characterization of the phosphorylation site remains a significant challenge due

234 These phosphorylation sites represent potential new targets fo

235 osures of odor, and contains a candidate PKG phosphorylation site required to tune odor sensitivity.

236 Mutation of 19 potential MRP1 phosphorylation sites revealed that HEK-Tyr920Phe/Ser921

237 Neither the phosphorylation site(s) nor the kinase(s) phosphorylatin

238 ntify the substrates directly and to map the phosphorylation site(s) of plant symbiotic receptor-like

239 In addition, mutations at the p27 phosphorylation sites S10 or T198, but not T157, abolish

240 n increasingly positive charge in a critical phosphorylation site, S318, progressively amplifies OPS

241 rs that had been mutated at protein kinase C phosphorylation sites (S396A, S402A) were used, phorbol

242 gular structure, reveals the location of two phosphorylation sites (S65 and T70).

243 1 kinase activity and enhanced stringency of phosphorylation site selection.

244 ctrometry analysis, we discovered a distinct phosphorylation site, Ser-176, on YBX1.

245 t the novel Ser-316 site and other two known phosphorylation sites, Ser-529 and Ser-536, either indiv

246 ion of a cluster of highly studied biomarker phosphorylation sites (Ser910, Ser935, Ser955 and Ser973

247 OsPP2A B'' contains three predicted CDK phosphorylation sites: Ser95, Ser102 and Ser119.

248 odulin-dependent protein kinase II-dependent phosphorylation site (serine 2814) mutated to alanine (S

249 Using phosphoproteomics, we identified three phosphorylation sites (serines 222, 235, and 238) in the

250 mutation of residues in the vicinity of the phosphorylation site, suggesting that a phosphorylation-

251 scued by a Kif2a mutated in an Aurora kinase phosphorylation site, suggesting that the phenotypes are

252 actor proteins have much larger frequency of phosphorylation sites than ordered regions, suggesting a

253 Serine 384 (S384) is the critical cyclin E phosphorylation site that stimulates Fbw7 binding and cy

254 standing of the role and interaction between phosphorylation sites that can both increase and decreas

255 main (RS1-Reg) containing multiple predicted phosphorylation sites that is responsible for this post-

256 We found 8 IKKbeta-dependent phosphorylation sites that mediate GLI1 stability.

257 phoproteomic measurements further identified phosphorylation sites that were examined using phosphomi

258 throughput identification of kinase-specific phosphorylation sites, thereby contributing to both basi

259 y low iron requires Dun1 kinase activity and phosphorylation site Thr-380 in the Dun1 activation loop

260 dies, a novel IL-2/IL-15 inducible IL-2Rbeta phosphorylation site (Thr-450) was identified.

261 RPA and to determine the effects of two UNG2 phosphorylation sites (Thr(6) and Tyr(8)) located within

262 e, we used mass spectrometry to identify the phosphorylation site Thr1160 as a PKCepsilon substrate i

263 Alanine substitution of the phosphorylation site Thr166 promoted incorporation of mu

264 We subsequently map this X. laevis LB3 phosphorylation site to a conserved site in mammalian la

265 The relative contribution of each phosphorylation site to PTEN autoinhibition and the stru

266 We assigned all phosphorylation sites to 3013 phosphoproteins, covering

267 Activation of FoxO3 by mutating phosphorylation sites to enhance its nuclear expression

268 nteracts with Brg1, and mutation of putative phosphorylation sites to non-phosphorylatable (Ser to Al

269 otential phosphorylation switches by mapping phosphorylation sites to protein-protein interactions of

270 We mapped the PKA/PKG phosphorylation sites to serine 702 on ARHGAP17 using Ph

271 omatographic tandem mass spectrometry to map phosphorylation sites to the otherwise divergent amino-t

272 46 to 148 within the S(pS/T)P motif, and the phosphorylation site was identified as residues S292 and

273 Identification of NHE3 phosphorylation sites was by iTRAQ/LC-MS/MS with TiO2 en

274 Alanine mutagenesis of each of the six phosphorylation sites was tested for the ability to impa

275 AS160 dephosphorylation on both phosphorylation sites was unaltered by PP2B or PP2C inhi

276 By mapping and mutating multiple Mto2 phosphorylation sites, we generate mto2-phosphomutant st

277 Among several putative ERK phosphorylation sites, we identified threonine 264 in th

278 and revealed that ablation of the three PKC phosphorylation sites weakens their interaction.

279 Phosphorylation sites were also identified on a subset o

280 , cells expressing RPA2 genes mutated at key phosphorylation sites were characterized.

281 predictions indicated that the MIC-regulated phosphorylation sites were chiefly modified by mTOR, as

282 Additional p12 phosphorylation sites were detected, including the late

283 Moreover, a high proportion of the regulated phosphorylation sites were found on proteins that are as

284 ype or PAK1 Y3F mutant in which these 3 JAK2 phosphorylation sites were mutated to phenylalanine.

285 Importantly, however, these phosphorylation sites were not required for an insulin-i

286 Dysregulated phosphorylation sites were quantified after affinity cap

287 substituting fourteen previously identified phosphorylation sites with either alanine or aspartate r

288 Surprisingly, 1,915 phosphorylation sites with the motif x-(S/T)-P showed in

289 n sites including 366 low-abundance tyrosine phosphorylation sites, with high reproducibility and usi

290 e of them promoting gain or loss of putative phosphorylation sites, with possible consequences for re

291 We identify a phosphorylation site within 11a that is required for som

292 RMT5 is regulated, we identified a threonine phosphorylation site within a C-terminal tail motif, whi

293 Mouse double minute 2 (MDM2) has a phosphorylation site within a lid motif at Ser17 whose p

294 his report, a novel PRL-inducible regulatory phosphorylation site within the activation segment of NE

295 increased upon mutation of two GSK-3 serine phosphorylation sites within the carboxyl-terminal domai

296 ne cluster in the vicinity of the regulatory phosphorylation sites within the myosin S2 interaction d

297 Several phosphorylation sites within the N-terminal regulatory d

298 We discovered that Reelin regulates several phosphorylation sites within the positively charged seri

299 tor) delayed AS160 dephosphorylation on both phosphorylation sites without altering Akt phosphorylati

300 howed variations in the accessibility of the phosphorylation site Y701, which corresponded to the los