ライフサイエンスコーパス: phosphorylation state

1 merization and did not influence the cofilin phosphorylation state.

2 t of the chemotaxis machinery, CheA, and its phosphorylation state.

3 n factor whose activity is regulated via its phosphorylation state.

4 the number and length of acyl chains and its phosphorylation state.

5 tution with unlabeled PLB, regardless of its phosphorylation state.

6 interact directly with Spo0A to control its phosphorylation state.

7 whose structure is dependent on its tyrosine phosphorylation state.

8 HeLa cells results in alterations in the CTD phosphorylation state.

9 ansition between modes, depending on the LCC phosphorylation state.

10 ated with high-dose CAF regardless of ErbB-2 phosphorylation state.

11 icient spatial and temporal control of their phosphorylation state.

12 in a different conformation depending on its phosphorylation state.

13 r-Akt) increases PDE activity as well as its phosphorylation state.

14 s constitutively monomeric regardless of its phosphorylation state.

15 ntractile modulator, regardless of cMyBP-C's phosphorylation state.

16 availability of Robo3 without affecting its phosphorylation state.

17 at is accompanied by dramatic changes in its phosphorylation state.

18 1 by the 20S proteasome is controlled by its phosphorylation state.

19 es to the environment as a function of their phosphorylation state.

20 coded by DNM1L) is inactive, as shown by its phosphorylation state.

21 induce cell death in tobacco, independent of phosphorylation state.

22 d to intracellular RyRs, as well as in Kv2.1 phosphorylation state.

23 l biosynthesis and morphogenesis through its phosphorylation state.

24 gth regulatory function are regulated by its phosphorylation state.

25 The activity of Spo0A depends on its phosphorylation state.

26 entail more than its regulation of the NS5A phosphorylation state.

27 n the critical Thr-X-Tyr region in different phosphorylation states.

28 on of mutations, or modification of receptor phosphorylation states.

29 encoding forms of CaMKII mimicking different phosphorylation states.

30 ssing that are associated with different CTD phosphorylation states.

31 separating substrate peptides with different phosphorylation states.

32 aling pathways leading to alteration of Cx43 phosphorylation states.

33 a similar cross-species response in protein phosphorylation states 5 and 25 min after exposure to st

34 refore tested the hypothesis that Tm and its phosphorylation state affect the rate at which single ac

35 Hsp70 complexes have been implicated in tau phosphorylation state and amyloid precursor protein (APP

36 he H. pylori transcriptome for RNAs whose 5'-phosphorylation state and cellular concentration are gov

37 in cell cycle regulation dependent upon its phosphorylation state and independent of the BAD/BCL2 in

38 ated mice had a significant reduction in its phosphorylation state and insoluble fraction, which spec

39 s that enable simultaneous monitoring of the phosphorylation state and intracellular trafficking of C

40 regulator of Sct1p activity by affecting the phosphorylation state and overexpression level of Sct1p.

41 mal Scc2 function requires modulation of its phosphorylation state and suggest that scc2 phosphomimet

42 ions upstream of sigma(T) by controlling the phosphorylation state and thus anti-anti-sigma activity

43 se A (PKA) activity directly controlled both phosphorylation state and tracer coupling.

44 This pathway controls Elo2 phosphorylation state and VLCFA synthesis.

45 domain constructs differed substantially in phosphorylation states and catalytic competency, suggest

46 Upon examining phosphorylation states and expression levels of proteins

47 at the mTORC1 is regulated in its abundance, phosphorylation state, and localization in coordination

48 synapses have distinctive stoichiometry and phosphorylation state, and respond differently to pertur

49 ve to wild-type cells was an increase in the phosphorylation state, and thus activation, of activated

50 n that four forms of KaiC differing in their phosphorylation state appear in an ordered pattern arisi

51 rasensitive or switchlike responses in their phosphorylation state are not expected because the modif

52 construct, demonstrating that changes in tau phosphorylation state are not required to suppress or en

53 d that the Rex-2 C terminus and its specific phosphorylation state are required for stability and opt

54 Adenylate phosphorylation state assays and mitochondrial respirato

55 of data points per day on proteins and their phosphorylation state at individual sites.

56 Neuronal activity regulates the phosphorylation states at multiple sites on MeCP2 in pos

57 C proteins, involves a cyclic progression of phosphorylation states at Ser431 and Thr432 of KaiC.

58 in-C with its binding partners vary with its phosphorylation state, binding predominantly to myosin w

59 However, Ca(2+), pH, and the phosphorylation state can regulate Cx32 gap junction cha

60 ctly interacted with SREBP-2 and altered its phosphorylation state, causing an increase in SREBP-2 bi

61 The LeETR4 phosphorylation state closely paralleled ripening progre

62 th Tau (2N4R) in Sf9 cells in a well defined phosphorylation state containing up to approximately 20

63 We show that neither enzymatic activity nor phosphorylation state correlate with the ability to tran

64 Also, CTD interacts with host proteins in a phosphorylation state-dependent manner.

65 tate may modulate core protein functions but phosphorylation state-dependent viral or host interactio

66 E in a cell cycle-dependent manner, and its phosphorylation state dictates its interaction with TopB

67 t is required for motility, and its putative phosphorylation state dictates the ability of CtrA to ac

68 Kv2.1 phosphorylation site, we find that the phosphorylation state differs between Kv2.1 clusters on

69 Regardless of its phosphorylation state, downregulation of Flt1 also inhib

70 e we also examined the beta3 subunit and its phosphorylation state during internalization.

71 were present simultaneously, melanophilin's phosphorylation state enforced track selection of the Ra

72 er, and activator of transcription 1 (STAT1) phosphorylation state, followed by profound apoptosis of

73 Finally, we observe changes in individual phosphorylation states following a small molecule screen

74 Independently of its phosphorylation state, GRA7 associates with the rhoptry

75 1 synaptic localization, its effect on AMPAR phosphorylation state has not been explored.

76 n virion secretion, we have analyzed the CTD phosphorylation state in complete (containing the genomi

77 its elevated expression affects the nephrin phosphorylation state in diabetes.

78 ents and quantification of their 5'-terminal phosphorylation state in wild-type and mutant cells.

79 determine the concentrations of all four PLB phosphorylation states in pig cardiac tissue, with and w

80 ce supports changes in alternative splicing, phosphorylation state, interaction with tubulin, and sel

81 serine/threonine-proline (S/T-P) sites whose phosphorylation state is known to regulate CTD functions

82 The dynamic nature of the erbB1 phosphorylation state is shown by monitoring activation

83 ind that the network of possible binding and phosphorylation states is composed of over 1000 members.

84 It remains unknown how the CTD phosphorylation state may modulate core protein function

85 73, Ser-282, and Ser-302), and the residues' phosphorylation states may alter thick filament structur

86 a membrane (PM) expression of InsP(3)R-1 and phosphorylation state mutant InsP(3)R-1 to study how thi

87 protein microarrays were used to profile the phosphorylation state of 108 epitopes on 82 distinct sig

88 where a kinase and phosphatase regulate the phosphorylation state of a common substrate, and coupled

89 on effects can be reproduced by changing the phosphorylation state of a single residue: GluN2B Ser-11

90 in the cellular levels of TIP influence the phosphorylation state of a specific protein substrate of

91 aine resulted from changes in the content or phosphorylation state of actin binding proteins (ABPs) t

92 AEG-1 also affected the phosphorylation state of Akt substrates that are implica

93 A heterotrimer, PP2A(Ppp2r2d), regulates the phosphorylation state of AMP kinase by dephosphorylating

94 There were no marked differences in the phosphorylation state of AMP-activated protein kinase, A

95 The phosphorylation state of AMPAR subunits is one mechanism

96 ent with BBR did not significantly alter the phosphorylation state of AMPK in both the liver and adip

97 Unexpectedly, we found that the phosphorylation state of an evolutionarily conserved Cdk

98 This suggests that androgens can enhance the phosphorylation state of AR either by negatively regulat

99 lyses show that PTPRG activation affects the phosphorylation state of at least 31 signaling proteins.

100 by TPX2 is catalytically active and that the phosphorylation state of Aurora-A is an inaccurate surro

101 The phosphorylation state of B2AR dictates its partitioning

102 The phosphorylation state of beta2-syntrophin allosterically

103 d sensors resulting in the modulation of the phosphorylation state of BfiS in a growth-mode-dependent

104 uces prosurvival signaling by increasing the phosphorylation state of both Aurora and IKK kinases and

105 s study, we provide detailed analyses on the phosphorylation state of BRCA1 by cyclin D1/cdk4 complex

106 acellular catalytic regions can modulate the phosphorylation state of cadherin/catenin complexes.

107 However, the link between the phosphorylation state of CaMKII and the agonist-triggere

108 n basal c-Src activity, but it increased the phosphorylation state of Cav-1.

109 ics screening approach, we characterized the phosphorylation state of CDCP1 across a panel of breast

110 many response regulators, we found that the phosphorylation state of ComE does not likely play a rol

111 between CpsD and CpsC was observed, and the phosphorylation state of CpsD influenced the subsequent

112 physiology has focused on how changes in the phosphorylation state of CREB regulate the timing proces

113 The phosphorylation state of Cx35 at two regulatory phosphor

114 In the saline-control group, the basal phosphorylation state of DARPP-32 at Threonine-34 site (

115 CGS 21680, was used to determine whether the phosphorylation state of each of the following PKA targe

116 Altering the phosphorylation state of each protein causes correspondi

117 adapter protein c-Cbl and EGFR, but not the phosphorylation state of EGFR.

118 The phosphorylation state of eIF2alpha and viral protein acc

119 Eya may regulate the phosphorylation state of either itself or its transcript

120 The phosphorylation state of fascin at S39, a PKC site, cont

121 ify the mechanisms involved, we examined the phosphorylation state of focal adhesion kinase (Fak)(Ser

122 atin decondensation, RNA processing, and the phosphorylation state of fundamental cell cycle proteins

123 We demonstrate that RetS modulates the phosphorylation state of GacS by a direct and specific i

124 en together, these results indicate that the phosphorylation state of Galpha(s) is a critical determi

125 ne increases AMPAR current by modulating the phosphorylation state of GluA1 which is dependent on alp

126 ession of GluN3A-containing receptors to the phosphorylation state of GluN3A subunits, and provides a

127 ARs to calpain cleavage is determined by the phosphorylation state of GluR1 subunits, which is mediat

128 The phosphorylation state of heptapeptide repeats within the

129 JIL-1 is the major kinase controlling the phosphorylation state of histone H3S10 at interphase in

130 ed, but it is now becoming apparent that the phosphorylation state of Hsp27 may be a critical determi

131 and was associated with an alteration in the phosphorylation state of HuR.

132 e II (Pol II) correlates with changes to the phosphorylation state of its large subunit C-terminal do

133 hase and anaphase that are determined by the phosphorylation state of its Mde4 subunit.

134 pose tissue as indicated by reduction of the phosphorylation state of JNK1 and the mRNA levels of pro

135 y, BBR treatment significantly decreased the phosphorylation state of JNK1 in both hepatoma H4IIE cel

136 circadian oscillator, and it influences the phosphorylation state of KaiC during resetting of circad

137 and KaiC--that generates oscillations in the phosphorylation state of KaiC.

138 exes with stoichiometries that depend on the phosphorylation state of KaiC.

139 alled CNSProfile) to identify changes in the phosphorylation state of key neuronal phosphoproteins ev

140 We also demonstrate that although the phosphorylation state of Kv2.1 is also shaped by the act

141 his is achieved through redox control of the phosphorylation state of light-harvesting antenna comple

142 Surprisingly, the phosphorylation state of melanophilin was instead import

143 SEPW1 silencing did not change the phosphorylation state of MKK4 but increased total MKK4 p

144 The phosphorylation state of MpkA was determined post exposu

145 The phosphorylation state of MSL10 also regulated its abilit

146 We show that MSMEG_5437 influences the phosphorylation state of MSMEG_6129.

147 Impaired activity correlated with the phosphorylation state of MTHFR, with more severe mutatio

148 It causes dose-dependent reductions in the phosphorylation state of multiple proteins downstream of

149 nt nitric oxide synthesis by influencing the phosphorylation state of neuronal nitric oxide synthase.

150 (GFAP) genes in MG cells is dependent on the phosphorylation state of NFI, with hypophosphorylation o

151 protein ligase (E3), we hypothesize that the phosphorylation state of NPH3 determines the functional

152 -I does not regulate the cyclase activity or phosphorylation state of NPR-A.

153 tor sensitivity regulation in Drosophila The phosphorylation state of Orco (S289) is altered in an od

154 which plays a major role in restricting the phosphorylation state of p107 and inducing its activatio

155 While the phosphorylation state of p107 is very sensitive to force

156 The phosphorylation state of p38 mitogen activated protein k

157 Together, these studies identify the phosphorylation state of PACS-2 Ser437 as a molecular sw

158 This interaction is dependent on the phosphorylation state of PDH.

159 microwave fixation was used to preserve the phosphorylation state of phosphoproteins in brains of DF

160 Intriguingly, HIV-1 infection modulates the phosphorylation state of Pin1, enhancing its ability to

161 The phosphorylation state of pocket proteins during the cell

162 An analysis of the phosphorylation state of Pol II upon the inhibition of P

163 Although FTY720 altered the phosphorylation state of protein kinase B and p38, our d

164 ng that active site inhibitors stabilize the phosphorylation state of protein kinases B/Akt and C.

165 The phosphorylation state of proteins involved in translatio

166 ellular signaling networks by regulating the phosphorylation state of proteins.

167 However, PP5 and ERK activity regulates the phosphorylation state of Raf1 kinase, an upstream activa

168 leled ripening progress, suggesting that the phosphorylation state of receptors is implicated in ethy

169 Alteration in the phosphorylation state of receptors is likely to be an in

170 modulate the output of TCSs by affecting the phosphorylation state of response regulators.

171 rganism by devising an assay to probe the 5' phosphorylation state of RNA and by employing a self-cle

172 ation and RNA degradation are coupled to the phosphorylation state of RNA polymerase II's repeat doma

173 APII remained at the transcription site, the phosphorylation state of RNAPII was unaltered, and the t

174 Thus, NMDA-R activation alters the phosphorylation state of S783 and acts as a molecular sw

175 Our results suggest that the phosphorylation state of Sec2p can direct a switch in it

176 Environmental signals may modulate the phosphorylation state of sensor kinases (SK).

177 ion of ADAM17 in this pathway depends on the phosphorylation state of Ser-811 in its cytoplasmic doma

178 f unphosphorylated AMII, irrespective of the phosphorylation state of Ser639.

179 n and Ras transformation are mediated by the phosphorylation state of serine 727.

180 The phosphorylation state of serine 776 is also crucial for

181 tic acid is believed to be able to mimic the phosphorylation state of serine, while alanine is a comm

182 hed by GSK3 inhibitors, and dependent on the phosphorylation state of serine-154.

183 Our results suggest that the phosphorylation state of serines is likely an essential

184 array analysis revealed small changes in the phosphorylation state of several components of the Akt s

185 egulation of DAT does not correlate with the phosphorylation state of several well-studied MAP kinase

186 We also assessed alterations in the phosphorylation state of SFK targets, including GluN2A a

187 uitination of Snf1 affects the stability and phosphorylation state of Snf1, thereby affecting Snf1 ki

188 hibited partial defects in regulation of the phosphorylation state of Snf1.

189 of Wapl activity, which is controlled by the phosphorylation state of Sororin.

190 e had a substantial and common effect on the phosphorylation state of specific actin, tubulin and myo

191 The phosphorylation state of Spo0A is controlled by a multi-

192 d more specifically to the regulation of the phosphorylation state of Spo0F, a key regulatory protein

193 The phosphorylation state of SynI by Cdk5 at site 7 is regul

194 The phosphorylation state of SypE appears to regulate these

195 S264D phosphomutants, we determined that the phosphorylation state of TAF7 at S264 influences the lev

196 essing 5LO had a significant increase in the phosphorylation state of tau at S396 and S396/S404, as r

197 kinesin-1 and that this is dependent on the phosphorylation state of tau.

198 o the mechanisms involved, we determined the phosphorylation state of the activation loop residues Se

199 icial induction of sigma(B), analysis of the phosphorylation state of the anti-anti-sigma factor RsbV

200 We could show that during drug arrest the phosphorylation state of the APC changes, indicating tha

201 However, whether the phosphorylation state of the APC/C is important for its

202 emble of these results demonstrates that the phosphorylation state of the Bnip3 LIR signals either th

203 or secretion of empty virions.IMPORTANCE The phosphorylation state of the C-terminal domain (CTD) of

204 ase II (Pol II) is controlled in part by the phosphorylation state of the C-terminal domain (CTD) of

205 To profile the global tyrosine phosphorylation state of the cell, we have developed pro

206 that generates circadian oscillations in the phosphorylation state of the clock protein KaiC.

207 The sensor transmitter module controls the phosphorylation state of the cognate-response-regulator

208 lead to either LTP or LTD, depending on the phosphorylation state of the control point, T305/T306.

209 Furthermore, the phosphorylation state of the CTD regulates capsid assemb

210 i knockdown of dCDK12 in S2 cells alters the phosphorylation state of the CTD, reducing its Ser2 phos

211 ng to this site was clearly modulated by the phosphorylation state of the downstream and non-overlapp

212 of TPX2 binding, which is independent of the phosphorylation state of the enzyme.

213 mployed Phos-tag methods to characterize the phosphorylation state of the Escherichia coli response r

214 endocytosis is attributed to a change in the phosphorylation state of the GluR1 at Ser(845) as morphi

215 The phosphorylation state of the glutamate receptor subtype

216 A and activation of PKC increased the serine phosphorylation state of the HCN1 protein.

217 regulator KaiA to act on KaiC depends on the phosphorylation state of the hexamer and that KaiA and K

218 Analysis of the phosphorylation state of the insulin receptor and downst

219 hat this complex is primarily defined by the phosphorylation state of the integrin C-terminal Tyr(759

220 n transduced via the kinases controlling the phosphorylation state of the master regulator Spo0A.

221 ral phenotypes of tao mutations and that the phosphorylation state of the microtubule-binding protein

222 The phosphorylation state of the mini-titin twitchin control

223 tivation of m-calpain, without affecting the phosphorylation state of the protease.

224 sensor kinase/phosphatase that modifies the phosphorylation state of the regulator PhoP in response

225 y of a sensor or other proteins to alter the phosphorylation state of the regulator.

226 f the exon 3,4,5,6 cassette of Casp9 via the phosphorylation state of the RNA splicing factor SRp30a

227 We further demonstrate that changing the phosphorylation state of the S880 residue at the C termi

228 th myosin were inactive, irrespective of the phosphorylation state of the serines in the nonhelical t

229 f any, energy input and is controlled by the phosphorylation state of the thick filament-associated m

230 Mih1 directly modulates the phosphorylation state of the Vps26 retromer subunit; mut

231 d levels of TIP result in an increase in the phosphorylation state of this protein substrate, whereas

232 ions in deadenylation are independent of the phosphorylation state of three serines known to regulate

233 These data suggest that DEP-1 can modify the phosphorylation state of tight junction proteins and pla

234 irulence factor production was linked to the phosphorylation state of transcriptional regulator BvgA.

235 Moreover, we show that the phosphorylation state of Treslin at Ser-1000 is importan

236 oid agonist WIN 55,212-2 (WIN) regulates the phosphorylation state of TRPV1.

237 R activity was verified by a decrease in the phosphorylation state of two mTOR targets, 70-kDa riboso

238 Finally, our analyses revealed that the phosphorylation state of two Z-disc kinases (striated mu

239 The phosphorylation state of WASP and WASP-interacting prote

240 Thus, the phosphorylation state of Y1357 can function as a molecul

241 ess and low during sleep, and changes in the phosphorylation states of AMPARs, CamKII and GSK3beta ar

242 Large-scale studies of the dynamic phosphorylation states of cell signaling systems have be

243 The phosphorylation states of cPLA(2) and p38 MAP kinase and

244 eraction site of CRMP-2 and examined whether phosphorylation states of CRMP-2 affected the interactio

245 Hence, the phosphorylation states of EIN and HPr shift the binding

246 tation (ChIP) to examine the acetylation and phosphorylation states of histones H3 and H4 on Zp and R

247 transcription was regulated by the tyrosine phosphorylation states of HoxA9 and HoxA10.

248 Furthermore, distinct phosphorylation states of HuR differentially regulate tr

249 Neocortical absence of HuR alters the phosphorylation states of initiation and elongation fact

250 Modulation of phosphorylation states of ion channels is a critical ste

251 , decreased insulin signaling, increased the phosphorylation states of JNK and NFkappaB p65, and enha

252 This interaction depends upon the phosphorylation states of klp9p and ase1p.

253 ts resulted a dose-dependent increase in the phosphorylation states of many proteins.

254 Usually, monitoring the phosphorylation states of MAP kinases in vitro requires

255 restin enable arrestin to recognize plethora phosphorylation states of numerous GPCRs, contributing t

256 However, the levels of the four phosphorylation states of PLB (U-PLB, P16-PLB, P17-PLB,

257 These factors are targeted to specific phosphorylation states of the CTD that predominate at di

258 The separation of two different phosphorylation states of the Dam1 complex, generated fr

259 C1 and 2) and the subcomplexes and different phosphorylation states of the Dam1 complex.

260 The phosphorylation states of these inhibitors of ERK and DA

261 EMDT increased the phosphorylation states of Thr34-DARPP-32 and Ser845-GluR

262 complexes without affecting dimerization or phosphorylation states of Trk.

263 the rat to investigate the effect of Ser-129 phosphorylation state on dopaminergic neuron pathology.

264 differential effects of phospholamban (PLB) phosphorylation states on the activity of the sarcoplasm

265 e kinetics are also not strongly affected by phosphorylation state or dsRNA binding.

266 ent, there is a compensatory increase in the phosphorylation state or expression level of the other m

267 eded to evaluate whether alterations in PAK1 phosphorylation states, or alterations in protein expres

268 s across the dimer interface can communicate phosphorylation states over 25 A from the activation loo

269 Multiplexed NMR profiling of reporter phosphorylation states provides unique advantages for ki

270 y with the core protein depending on its CTD phosphorylation state, pulldown assays were performed us

271 ylcyclopropene rapidly influenced the LeETR4 phosphorylation state rather than protein abundance.

272 s suggest that the Cav1 expression level and phosphorylation state regulates fluid phase endocytosis

273 In contrast, the phosphorylation state, represented by phosphor-mimetic m

274 play a role in the modulation of ion channel phosphorylation states required for hyperalgesia.

275 Depletion of BAF or perturbing its phosphorylation state results not only in nuclear envelo

276 q patterns specific for different Pol II CTD phosphorylation states reveal weak co-transcriptional sp

277 Analysis of Rb1 phosphorylation states showed prolonged hyper-phosphoryl

278 that 50 different phosphopeptides had their phosphorylation state significantly altered by ABA over

279 ividual hexamers make a shorter cycle in the phosphorylation state space, which compensates for the s

280 ate Nox5 on Thr494 and Ser498 as detected by phosphorylation state-specific antibodies.

281 f phospho-Ser6 inhibitor-1, as detected by a phosphorylation state-specific antibody against the site

282 was analyzed within 30 min of hunting using phosphorylation state-specific CREB (pCREB) and CREB ant

283 ase II (Pol II) large subunit cycles through phosphorylation states that correlate with progression t

284 on to the regulation of the p38alpha and MK2 phosphorylation states that prevents phosphorylation of

285 that Hsp110 plays a critical function in tau phosphorylation state through maintenance of efficient P

286 homimetic mutation, thus linking the Thr-592 phosphorylation state to the control of SAMHD1 dNTPase a

287 wever, the ability of CaMKII and its various phosphorylation states to control spine size has not bee

288 The distribution of different PLM phosphorylation states to different pools may be explain

289 These results show that each PLB phosphorylation state uniquely alters Ca(2+) homeostasis

290 teins exhibiting changes in abundance and in phosphorylation state upon egg activation.

291 bodies was controlled by changes in peptide phosphorylation state using a kinase/phosphatase enzyme

292 activity of ICSBP is influenced by tyrosine phosphorylation state, we hypothesized that mutations in

293 ulator functions are often affected by their phosphorylation state, we investigated how phosphorylati

294 In both LVH and sham hearts, all phosphorylation states were significantly populated, but

295 bit a significant decrease in this protein's phosphorylation state, which is reversed by treatment wi

296 mingly minor one, can dramatically alter its phosphorylation state, which is significant because trun

297 associated with an abnormal membrane protein phosphorylation state, with destabilization of the membr

298 h pPKRm and pPKRd are heterogeneous in their phosphorylation states, with an average of 9 or 10 phosp

299 ences of inactivating Plk4 or perturbing its phosphorylation state within its Slimb-recognition motif

300 gap junctions can exist in widely different phosphorylation states within a single neuron, implying