ライフサイエンスコーパス: phosphorylcholine

1 lyzed by sphingomyelinases into ceramide and phosphorylcholine.

2 -choline-labelled cell walls was shown to be phosphorylcholine.

3 lyzed by sphingomyelinases into ceramide and phosphorylcholine.

4 A fraction of these antibodies bound to free phosphorylcholine.

5 m infected rats and shown to be specific for phosphorylcholine.

6 5'-thymidine monophosphate and p-nitrophenyl phosphorylcholine.

7 dum lipid showed that the target of M131 was phosphorylcholine.

8 ecognition of ES-62 by target cells, because phosphorylcholine, a common pathogen-associated molecula

9 is and A. actinomycetemcomitans include anti-phosphorylcholine (alpha-PC) and beta2-glycoprotein-1-de

10 age cytokine responses, a sulfone-containing phosphorylcholine analogue (11a) was selected for testin

11 nzyme that hydrolyzes sphingomyelin (SPM) to phosphorylcholine and ceramide.

12 is first used to hydrolyze sphingomyelin to phosphorylcholine and ceramide.

13 o their equivalent 1H NMR spectra, e.g., for phosphorylcholine and phosphorylethanolamine.

14 e phospholipase A(2) inhibitor oleyloxyethyl phosphorylcholine and the CYP450 inhibitor ketoconazole.

15 ned that recognize simultaneously the hapten phosphorylcholine and the self antigen double-stranded D

16 phosphatase then generates choline from the phosphorylcholine, and the newly formed choline is then

17 ytidine diphosphate-choline as the donor for phosphorylcholine, AnkX catalyzes the transfer of phosph

18 ss contain higher concentrations of IgG anti-phosphorylcholine (anti-PC) than sera from healthy subje

19 ollowed using the chromophoric p-nitrophenyl-phosphorylcholine as a model substrate.

20 romol/min.mg toward 1-palmitoyl-sn-glycero-3-phosphorylcholine at pH 8.0 and 40 degrees C, correspond

21 entity with antibodies from the classic anti-phosphorylcholine B-cell clone, T15, which protect again

22 Therefore, the potential of phosphorylcholine-based vaccination strategies as a nove

23 Phosphorylcholine-based zotarolimus-eluting stents had l

24 fore, our findings do not support a role for phosphorylcholine-bearing antigens in immune defense aga

25 Antibodies specific for phosphorylcholine-bearing proteins of L1 larvae first ap

26 infection with T. spiralis were specific for phosphorylcholine-bearing proteins.

27 n are based on poly(2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methac

28 em is based on poly[2-(methacryloyloxy)ethyl phosphorylcholine]-block-[2-(diisopropylamino)ethyl meth

29 d the serum levels of NAbs against bacterial phosphorylcholine but not oxidized low-density lipoprote

30 ce mounted robust antibody responses against phosphorylcholine, but not protein, determinants compare

31 g, and that pchP and other genes involved in phosphorylcholine catabolism are necessary to stimulate

32 pendent manner, and binding was inhibited by phosphorylcholine (ChoP) and choline.

33 the additional LPS phase variable structures phosphorylcholine (ChoP) and sialic acid.

34 tal choline into lipopolysaccharide (LPS) as phosphorylcholine (ChoP) as well as the phase variation

35 Incorporated choline is in the form of phosphorylcholine (ChoP) based on the reactivity with th

36 The phase-variable structure phosphorylcholine (ChoP) confers susceptibility to human

37 dergoes phase variation in expression of the phosphorylcholine (ChoP) epitope, a structure present on

38 In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP

39 Phosphorylcholine (ChoP) is a common surface feature of

40 Phosphorylcholine (ChoP) is a component of the teichoic

41 Phosphorylcholine (ChoP) is a potential candidate for a

42 Phosphorylcholine (ChoP) is an antigenic component on th

43 that the LOS from H. haemolyticus contained phosphorylcholine (ChoP) less frequently than the LOS fr

44 irway infection models, we demonstrated that phosphorylcholine (ChoP) moieties that are shared by PAF

45 tures found within NTHi LOS suggested that a phosphorylcholine (ChoP) moiety was involved in adherenc

46 CRP binds to phosphorylcholine (ChoP), a constituent of eukaryotic me

47 Haemophilus influenzae, express cell-surface phosphorylcholine (ChoP), a ligand for the receptor for

48 in both licl, required for the expression of phosphorylcholine (ChoP), and lic2, a putative galactosy

49 c-1, which is required for the expression of phosphorylcholine (ChoP), is the best characterized and

50 ct express an unusual prokaryotic structure, phosphorylcholine (ChoP), on their cell surface.

51 Here, we demonstrated that the phosphorylcholine (ChoP)-containing outer membrane prote

52 ental sources onto its lipopolysaccharide as phosphorylcholine (ChoP).

53 Thus, PAFr shepherds phosphorylcholine-containing bacterial components such a

54 sly demonstrated that one such molecule, the phosphorylcholine-containing glycoprotein ES-62, acts to

55 Here we demonstrate that ES-62, a phosphorylcholine-containing glycoprotein released by th

56 cribed a filarial nematode-derived, secreted phosphorylcholine-containing glycoprotein, ES-62, with i

57 d not react with red blood cells, which have phosphorylcholine-containing lipids in their exterior me

58 Phosphorylcholine-containing secreted products (phosphor

59 enzyme activity are positively regulated by phosphorylcholine degradation products, including glycin

60 for the capsular polysaccharide (PPS14), the phosphorylcholine determinant of the cell wall C-polysac

61 ntigen-binding activities to haptens such as phosphorylcholine, dextrans, fructofuranans, or dinitrop

62 SNPE) headgroup, while the other contained a phosphorylcholine (DiC(6)SNPC) headgroup.

63 is study, we demonstrate the presence of the phosphorylcholine epitope on the lipopolysaccharides (LP

64 sphorylcholine-containing secreted products (phosphorylcholine-ES) are also released by human filaria

65 coccal pce gene encoding for a teichoic acid phosphorylcholine esterase (Pce), an enzymatic activity

66 ococcal surface proteins, and the catalytic (phosphorylcholine esterase) activity is localized on the

67 ibitor 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine (ET-18-OCH3), or by using small interf

68 o be inert toward platelets, but it bound to phosphorylcholine exposed after oxidation triggered by a

69 extracts of C. elegans' microsomes transfer phosphorylcholine from L-alpha-dipalmitoyl phosphatidylc

70 o-BMA) with blood were diminished due to the phosphorylcholine functionalities of the hydrogel, which

71 search Laboratory antigen that also contains phosphorylcholine, further indicating the specificity of

72 yelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes.

73 Our data indicate that the phosphorylcholine head group is essential for antigenici

74 id recognize lysophosphatidylcholine and the phosphorylcholine head group.

75 esence of an sn-2-oleoyl group; 2), that the phosphorylcholine headgroup independently increases mole

76 n synthesis, we successfully prepared poly(L-phosphorylcholine homoserine) with controlled chain leng

77 s lacking type IV pili, the protease, or the phosphorylcholine hydrolase are not defective for intrac

78 ., protease, acid phosphatase, p-nitrophenol phosphorylcholine hydrolase, lipase, phospholipase A, an

79 lytic enzymes metalloprotease, p-nitrophenol phosphorylcholine hydrolase, lipase, phospholipase A, an

80 pase, a phospholipase A, and a p-nitrophenyl phosphorylcholine hydrolase.

81 natural antibodies and specific tolerance to phosphorylcholine immunogens that normally recruit prote

82 ically elevated levels of diacylglycerol and phosphorylcholine in the absence of growth factors.

83 oyl-2-(5,6-epoxyisoprostane E2)-sn-glycero-3-phosphorylcholine increase interleukin-8 (IL-8) synthesi

84 d 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine induce endothelial cells to synthesize

85 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synt

86 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine induced a rapid yet sustained activati

87 Soluble phosphorylserine but not phosphorylcholine inhibits substrate cleavage.

88 Phosphorylcholine is a common epitope in antigens of bac

89 Phosphorylcholine is an important bioactive adduct to th

90 factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a major primary and secondary mess

91 palmitoyl-2-epoxyisoprostane E2-sn-glycero-3-phosphorylcholine) is the most active lipid in OxPAPC th

92 lysaccharide antibody unmasked the bacterial phosphorylcholine ligand, allowing for increased adheren

93 ted primarily to the strong hydration of the phosphorylcholine-like monomers that make up the robustl

94 anied by enhanced inward movement of several phosphorylcholine lipid probes and was associated with e

95 zed a genetic locus lic that is required for phosphorylcholine metabolism in S. pneumoniae.

96 in (SM) in mammalian cells by transferring a phosphorylcholine moiety from phosphatidylcholine to cer

97 surface proteins noncovalently bound to the phosphorylcholine moiety of the cell wall of Streptococc

98 bsence of adsorbed kininogens because of its phosphorylcholine moiety.

99 modified posttranslationally at Ser(76) by a phosphorylcholine moiety.

100 ic explanation for the abnormal responses to phosphorylcholine observed in Btk-deficient mice, and in

101 (CBPs) that are non-covalently bound to the phosphorylcholine of the teichoic acid.

102 yi, strongly supporting the concept that the phosphorylcholine oligosaccharide biosynthetic enzymes a

103 The biosynthesis in vitro of phosphorylcholine oligosaccharides in Caenorhabditis ele

104 The small molecule phosphorylcholine, or choline phosphate (ChoP), is used

105 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholip

106 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholip

107 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) and, specifically, the compo

108 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) on osteogenic signaling indu

109 dized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (Ox-PAPC), activates endothelial cells

110 dized-1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (Ox-PAPC), found in atherosclerotic le

111 h as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) and its constituents 1-palmyt

112 n of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) generates a group of bioactiv

113 es of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) in bronchioalveolar lavage fl

114 zed 1- palmitoyl-2-arachidonoyl-sn-3-glycero-phosphorylcholine (OxPAPC) on chemokine expression and l

115 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC), a component of minimally mod

116 ch as 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (OxPAPC), have been shown to inhibit s

117 ized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC), which has been shown to accu

118 e II-dependent exoenzymes is a p-nitrophenol phosphorylcholine (p-NPPC) hydrolase whose activity is o

119 ipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (PAPC), which then induced the stress-

120 obacillus actinomycetemcomitans, one bearing phosphorylcholine (PC) (strain D045D-40) and one devoid

121 Abs specific for phosphorylcholine (PC) are known to contribute to the im

122 Antibodies reactive with phosphorylcholine (PC) are ubiquitous in human sera, but

123 ute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsu

124 , specific for two determinants on R36A, the phosphorylcholine (PC) determinant of C-polysaccharide a

125 ococcal surface protein A (PspA) and for the phosphorylcholine (PC) determinant of C-polysaccharide,

126 n of the display of the virulence-associated phosphorylcholine (PC) epitope on the LOS in response to

127 oniae and house dust mite (HDM) bear similar phosphorylcholine (PC) epitopes.

128 modified (MDA-modified) LDL (MDA-LDL) or the phosphorylcholine (PC) headgroup of oxidized phospholipi

129 Phosphorylcholine (PC) is a classic T-independent Ag tha

130 tigators have demonstrated that HDMs express phosphorylcholine (PC) moieties.

131 e show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs)

132 d toward oxidation-specific epitopes such as phosphorylcholine (PC) that arise during disease-driven

133 he biology of nematodes is the attachment of phosphorylcholine (PC) to carbohydrate.

134 ominated by Abs to oxidation-associated Ags, phosphorylcholine (PC), a head group that becomes expose

135 Because phosphorylcholine (PC), a major haptenic component of te

136 Examination of the IgG2 response to phosphorylcholine (PC), a response thought to be mainly

137 In mice, antibodies directed against phosphorylcholine (PC), an epitope present on the cell w

138 ked conjugation with a simple hapten such as phosphorylcholine (PC), induces more efficient T cell st

139 to the bacterial cell wall C-PS determinant, phosphorylcholine (PC), relative to Ig responses to the

140 Using this method, we compared the phosphorylcholine (PC)- and polycation-based binding act

141 cture of this product was determined to be O-phosphorylcholine (PC)-AEA.

142 tans are variable with respect to display of phosphorylcholine (PC)-bearing antigens.

143 We have previously shown that ES-62, a phosphorylcholine (PC)-containing glycoprotein secreted

144 XCL13(-/-) mice are deficient in preexisting phosphorylcholine (PC)-specific antibodies and in their

145 Phosphorylcholine (Pc)-substituted glycans were also fou

146 ulates the production of natural Abs against phosphorylcholine (PC).

147 phenotypes by virtue of covalently attached phosphorylcholine (PC).

148 rface protein A [PspA])- and polysaccharide (phosphorylcholine [PC] determinant of teichoic acid)-spe

149 that are fully functionalized with desirable phosphorylcholine, PC, groups.

150 on period was incorporated into tissue [14C] phosphorylcholine (PCh) and [14C]phosphatidylcholine (Pt

151 odes manufacture various carbohydrate-linked phosphorylcholine (PCh)-containing molecules, including

152 Phosphorylcholine (PCho) is added to some LOS forms in a

153 e the result of phase-variable expression of phosphorylcholine (PCho) such that MAb 5G8 reacted only

154 ghout the biofilm, while variants expressing phosphorylcholine (PCho) were found within the biofilm.

155 ffected by phase variation was identified as phosphorylcholine (PCho), which is linked to the primary

156 f LOS glycoforms, including those containing phosphorylcholine (PCho).

157 ccharides containing sialic acid (NeuAc) and phosphorylcholine (PCho).

158 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine (PEIPC) and 1-palmitoyl-2-(5-oxovalero

159 oyl-2-(5,6-epoxyisoprostane E2)-sn-glycero-3-phosphorylcholine (PEIPC), accumulated in macrophages in

160 PC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine (PGPC), on Cx43 expression and phospho

161 C) and 1- palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine (PGPC), which are present in OxPAPC, M

162 phospholipids is hydrolyzed by a periplasmic phosphorylcholine phosphatase, PchP.

163 ymeric immunoglobulin receptor, or cell wall phosphorylcholine/platelet-activating factor receptor.

164 antiproliferative agent, zotarolimus, and a phosphorylcholine polymer may provide similar angiograph

165 antiproliferative agent, via a biocompatible phosphorylcholine polymer on a cobalt alloy thin-strut s

166 0 or 200 microg per stent)-coated BiodivYsio phosphorylcholine polymer stents versus uncoated stents

167 rolimus-eluting coronary stents (ZES) with a phosphorylcholine polymer versus sirolimus-eluting stent

168 Compared with SES, treatment with a phosphorylcholine polymer-based ZES is associated with s

169 1-Palmitoyl-2- (5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) and 1- palmitoyl-2-glutaroyl-s

170 ives, 1-palmitoyl-2-oxovaleroyl-sn-glycero-3-phosphorylcholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn

171 g 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC), are active components of mini

172 s 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC).

173 The phosphorylcholine product is the first to leave the acti

174 suggested that only a small fraction of the phosphorylcholine-related antibody response against T. s

175 The phosphorylcholine released by PlcH activity on phospholi

176 ), an enzymatic activity capable of removing phosphorylcholine residues from the cell wall teichoic a

177 on vascular endothelial cells and binding of phosphorylcholine residues on pneumococcal cell wall to

178 tein (Cbp) family are noncovalently bound to phosphorylcholine residues on the surface of Streptococc

179 the bacterial cell wall, specifically by the phosphorylcholine residues which serve as anchors for su

180 In contrast, the IgG anti-phosphorylcholine response, although also dependent on C

181 ce, including decreased serum IgM, poor anti-phosphorylcholine responses, and slightly reduced number

182 nylcholine (1-O-hexadec-1'-enyl-sn-glycero-3-phosphorylcholine), resulting in the production of a neu

183 with radiolabeled serine, palmitic acid, and phosphorylcholine revealed that the ultraviolet B-induce

184 While poly(L-phosphorylcholine serine) was found to be unstable upon

185 ckness and total biomass and reduced surface phosphorylcholine, similar to a luxS mutant.

186 active Stat3, and increased reactivity with phosphorylcholine, similar to murine peritoneal B-1a and

187 Monoclonal phosphorylcholine-specific IgG2c failed to protect rats

188 activated by TLR7 or TLR9 agonists produced phosphorylcholine-specific IgM.

189 heterogeneous with respect to its degree of phosphorylcholine substitution in both O-6-positions.

190 Because it is thought that phosphorylcholine substitution of oligosaccharides modul

191 cal concentration of phospholipid containing phosphorylcholine, suggesting that the epitope has both

192 to the pathogen-associated molecular pattern phosphorylcholine that results in the uptake of bacteria

193 rary of drug-like small molecules based upon phosphorylcholine, the active moiety of the anti-inflamm

194 e that is cross-reactive with both dsDNA and phosphorylcholine, the dominant hapten on the pneumococc

195 horylcholine, AnkX catalyzes the transfer of phosphorylcholine to Rab1 in a filamentation-induced by

196 egradation, and transfer of their headgroup, phosphorylcholine, to SMs.

197 dized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine), was identified in a co-regulated gro

198 of oxidized LDL, including OxPLs containing phosphorylcholine, whereas immunization with viable thym

199 rmal immune responses against Ags, including phosphorylcholine, which confer protection against Strep