ライフサイエンスコーパス: photoreactive

1 g is greater when the phagosome contents are photoreactive.

2 wherein the linkers between the two opposing photoreactive 1,8-diazaanthracene units are connected to

3 complete transporter for petrobactin (PB), a photoreactive 3,4-catecholate siderophore produced by ma

4 silicon oxide surfaces were derivatized with photoreactive 3-(hydroxymethyl)naphthalene-2-ol (NQMP) m

5 We have substituted photoreactive 5-iododeoxypyrimidines into the DNA oligon

6 Photoreactive 5-iodouridines were incorporated into the

7 A photoreactive Abeta(1-40) ligand was synthesized by subs

8 s at the margins, and then a dNMP carrying a photoreactive adduct was added to the 3'-hydroxyl group.

9 zophenone)thiophosphate] (AMPS-Succ-BP) as a photoreactive ADP analogue.

10 Previous studies used the photoreactive affinity label 3-[3H]azido-2-methyl-5-meth

11 In addition, photoreactive agent-treated monolayers of retinal microv

12 Furthermore, [gamma-(32)P]8-azido ATP, a photoreactive agonist, was effectively cross-linked to P

13 cting substructure for LPA and as a possible photoreactive alkylating agent for the LPA receptor(s).

14 urthermore, using co-immunoprecipitation and photoreactive amino acid cross-linking, we found that AD

15 Using a photoreactive amino acid incorporated into proteins, we

16 f a substance P (SP) analogue containing the photoreactive amino acid p-benzoyl-l-phenylalanine (Bpa)

17 we are using analogues of SP containing the photoreactive amino acid p-benzoyl-L-phenylalanine (Bpa)

18 ifically replaced by the genetically encoded photoreactive amino acid p-benzoylphenylalanine (Bpa).

19 Reciprocally, Hexim1 is cross-linked by a photoreactive amino acid replacing Cdk9 W193, a tryptoph

20 resulted in the incorporation of 125I at the photoreactive amino acid residue, yielding probes of hig

21 ctors that interact with TBP, the nonnatural photoreactive amino acid rho-benzoyl-phenylalanine (BPA)

22 f the peptide ligand at a site distal to the photoreactive amino acid.

23 ANQX, a photoreactive AMPA receptor antagonist, is an important

24 ligonucleotides, each of which contained the photoreactive analog 4-thiodeoxythymidine (4-thioT) at a

25 ript could be further elongated, placing the photoreactive analog at internal positions in the RNA.

26 t, 4-azido-2-nitrophenyl phosphate (ANPP), a photoreactive analog of pNPP, was used as a probe of the

27 Here, we use a photoreactive analog of propofol (2-isopropyl-5-[3-(trif

28 ing sites in a muscle-type nAChR by use of a photoreactive analog of propofol, 2-isopropyl-5-[3-(trif

29 interactions, we prepared a fully functional photoreactive analog of PTHrP, [Ile5,Bpa23,Tyr36]PTHrP-(

30 ynylphenyl) barbituric acid (S-mTFD-MPPB), a photoreactive analog of the convulsant barbiturate S-MPP

31 Azietomidate is a photoreactive analog of the general anesthetic etomidate

32 When cross-linked to alphaLbeta2, the photoreactive analog of THI0019 remained an agonist, con

33 N(6)-dATP and its photoreactive analogs AB-dATP and DB-dATP were successfu

34 iazirynylphenyl)barbituric acid (mTFD-MPAB), photoreactive analogs of 2-ethyl 1-(phenylethyl)-1H-imid

35 Photoreactive analogs of PTH singularly substituted with

36 The interactions of a photoreactive analogue of benzoylcholine, 4-azido-2,3,5,

37 In order to address this question, a photoreactive analogue of cisplatin, PtBP(6), was used t

38 Here, we report the synthesis of a photoreactive analogue of echistatin (a 49-amino acid pe

39 ynthesis of photo-leucine, a diazirine-based photoreactive analogue of leucine, and demonstrate its i

40 A nonhydrolyzable GTP photoreactive analogue, azidoanilido [alpha-32P]GTP (AAG

41 The first synthesis of two photoreactive analogues of the lipid mediator and second

42 Combining both photoreactive and inert polycations in the same film yie

43 -CN-riboflavin and 8-CN-FMN were found to be photoreactive and need to be protected from exposure to

44 and quadruplet codons including fluorescent, photoreactive and redox active amino acids, glycosylated

45 midate and a barbiturate, [(3)H]R-mTFD-MPAB, photoreactive anesthetics that bind with high selectivit

46 lar crystal of a rigid monomer bearing three photoreactive arms, photopolymerization of the crystalli

47 f thymidine in the major groove of DNA using photoreactive aryl azides attached to deoxyuridine by va

48 n of biological cysteine-Au(I) adducts and a photoreactive Au(I) complex that produces a covalent bon

49 Significantly, the photoreactive azide of IAS is positioned on the phenyl r

50 In addition to N(3)RdUTP, which has a photoreactive azido group 9 A from the uridine base, we

51 irus capsid-derived peptide ligand bearing a photoreactive azido group was specifically bound by and

52 romethyldiazirinylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and stereosel

53 ect to a damaged DNA site was assessed using photoreactive base analogues within specific DNA substra

54 ions in K(+) solution, whereas a potentially photoreactive basket conformation is favored in Na(+) so

55 pha subunit specifically photolabeled by the photoreactive batrachotoxin derivative was identified by

56 developed photoaffinity probes containing a photoreactive benzophenone derivative, p-benzoylphenylal

57 pic label in the choline methyl groups and a photoreactive benzophenone in the long-chain base, may b

58 This ligand contains a photoreactive benzophenone moiety attached to the side c

59 oy a synthetic signal peptide containing the photoreactive benzoylphenylalanine to efficiently and sp

60 t proteins interacting preferentially with a photoreactive BER intermediate can be selected from the

61 Photoreactive BH3 helices mapped both triggering and aut

62 abricated through patterning with light in a photoreactive binary blend of crosslinking acrylate and

63 levels of singlet oxygen, produced either by photoreactive chemicals or high light treatment, induces

64 erdin, found in most mammalian tissues, as a photoreactive chromophore.

65 Recently, we developed a photoreactive "clickable" probe, SAHA-BPyne, to report o

66 The most photoreactive CNTs exhibited comparable photoreactivity

67 rface itself is photochemically inert, while photoreactive component is present in the solution.

68 The hydrophobic photoreactive compound 3-trifluoromethyl-3-(m-[125I]iodo

69 Subsequent activation of the photoreactive compound by a specific wavelength of light

70 The photoreactive compound incorporated into the block copol

71 Photoreactive compounds are important tools in life scie

72 Microbial reworking also produces photoreactive compounds, with potential implications for

73 the form 3 conformation is not the principal photoreactive conformation, and that G-quadruplexes in K

74 K(+) solution are dynamic and able to access photoreactive conformations more easily than in Na(+) so

75 the kinase, we used the heterobifunctional, photoreactive cross-linker N-5-azido-2-nitrobenzoyloxysu

76 ural amino acid p-benzoyl-L-phenylalanine, a photoreactive cross-linker, we mapped interactions betwe

77 Dendrimers functionalized with photoreactive cross-linkers were internalized by HeLa ce

78 pRNAs were used to position an azidophenacyl photoreactive cross-linking agent specifically at a stra

79 We have used a sensitive photoreactive cross-linking assay to explore the substra

80 action, Tim23p molecules containing a single photoreactive cross-linking probe were imported into mit

81 spondin and fibrinogen were identified using photoreactive cross-linking to an albumin-(serotonin)(6)

82 Two new photoreactive dATP analogs, N(6)-[4-azidobenzoyl-(2-amin

83 A novel photoreactive deoxycytidine analog, 4-[N-(p-azidobenzoyl

84 Another photoreactive deoxyuridine analog was made that containe

85 nity labeling using the previously described photoreactive deoxyuridine analog, 5-[N-(pazidobenzoyl)-

86 A photoreactive derivative of famotidine has been synthesi

87 illary gland membranes with a radioiodinated photoreactive derivative of SP, p-benzoyl-L-phenylalanin

88 es of covalent attachment of radioiodinated, photoreactive derivatives of SP containing p-benzoyl-L-p

89 Photoreactive derivatives of the general anesthetic etom

90 We used a panel of photoreactive derivatives to identify the site of action

91 escribed preliminary studies on the use of a photoreactive diazirine-containing amino acid to cross-l

92 he resting channel [3H]DAF is bound with its photoreactive diazo group oriented toward deltaVal-269.

93 Using photoreactive DNA containing 5-iodo-dUMP in defined posi

94 To create the photoreactive DNA probe in situ, DNA substrates containi

95 Using photoreactive DNA probes, we provide evidence that withi

96 ge of soils using viability PCR based on the photoreactive DNA-intercalating dye propidium monoazide(

97 cene is shown, without relying on additional photoreactive dopants or alignment layers.

98 todynamic therapy (PDT), the activation of a photoreactive drug in tumor tissue with visible light, i

99 mer units present limited accessibility to a photoreactive dye.

100 because the singlet oxygen produced by these photoreactive dyes compromised ocular cellular, humoral,

101 In contrast, covalent attachment of the photoreactive ethidium analog to DNA resulted in marked

102 Here, we used a radiolabeled, photoreactive etomidate analog ([(3)H]azietomidate), whi

103 We report here that TDBzl-etomidate, a photoreactive etomidate analog, acts as a positive allos

104 Previously, photoreactive etomidate analogs identified two equivalen

105 Photoreactive etomidate derivatives labeled alphaMet-236

106 lly cross-linked to the damaged DNA when the photoreactive FAP-dCMP (exo-N-{2-[N-(4-azido-2,5-difluor

107 sly shown to exist primarily in the proposed photoreactive form 3 conformation than the sequence show

108 In this report, we utilize novel photoreactive fusion inhibitors and photoaffinity labeli

109 been facilitated by using drugs developed as photoreactive GABAAR modulators.

110 first asymmetric synthesis of novel, potent photoreactive gamma-secretase inhibitors 2 and 3 has bee

111 ditions of direct UV light activation of the photoreactive group at 312 nm.

112 In this paper, a photoreactive group at the N-terminus of the RGD-ligand

113 he oligodeoxyribonucleotide as an additional photoreactive group did not increase the photo-cross-lin

114 th different protein targets in cells, (2) a photoreactive group for UV light-induced covalent cross-

115 ntact site for an echistatin analogue with a photoreactive group in position 45, near the C-terminus

116 ted by 365 nm UV light, activates the nearby photoreactive group in the BER intermediate resulting in

117 Depending on the location of the photoreactive group in the primer, the distribution of t

118 The arylazido photoreactive group is then activated through energy tra

119 pha(V)beta(3)-ligand possessing a C-terminal photoreactive group was photo-cross-linked within beta(3

120 , an analog of THI0019 modified to contain a photoreactive group was used to demonstrate that when cr

121 es outstanding inhibitor potency, a suitable photoreactive group, and tritium at high specific activi

122 ional glycosylatable peptides containing two photoreactive groups and found that these were linked to

123 described the use of small molecules bearing photoreactive groups and latent affinity handles as full

124 In addition, we introduced photoreactive groups in the multilayer, which rendered t

125 The probes are equipped with two photoreactive groups to allow photoliberation (uncaging)

126 ffinity labeling, we attached four different photoreactive groups to DNA and examined their ability t

127 ze, chemical properties, and availability of photoreactive groups.

128 Here, we synthesize and characterize a photoreactive GTP affinity probe that covalently photocr

129 borated by an increased incorporation of the photoreactive GTP analog [gamma-32P]GTP azidoanilide int

130 Photoreactive heterotrifunctional chemical cross-linking

131 A three-dimensional bulk photoreactive hydrogel eliminates manual blotting.

132 me photobleaching, which makes granules more photoreactive, increased the effects of blue light.

133 A photoreactive inhibitor, [alpha-(32)P]-8-azidoadenosine

134 Toward this aim, we use a photoreactive, irreversible antagonist of AMPA receptors

135 These photoreactive ligands are based on cyclo Ac-[Cys-Asn-Dmt

136 studies in our laboratory using radiolabeled photoreactive ligands suggested that the steroid binding

137 This results in synthesis of a photoreactive long patch base excision repair (BER) inte

138 Rac1 mutants were fused to the photoreactive LOV (light oxygen voltage) domain from pho

139 epsilon-(5-azido-2-nitrobenzoyl)-lysyl-tRNA, photoreactive lysine residues would be incorporated in t

140 ess in the development of advanced nanoscale photoreactive, magnetic and multifunctional materials ap

141 water, suggesting differential recoveries of photoreactive moieties by solid phase extraction.

142 t distance being less than the length of the photoreactive moiety attached to the ligand.

143 The GSTABP-G features a photoreactive moiety for UV-induced covalent binding to

144 ne or alters the protein interface so that a photoreactive moiety is brought closer to the cap struct

145 solid-state reaction kinetics suggests that photoreactive molecular crystals may be useful for gener

146 Photoreactive molecules have been conjugated to TFOs to

147 the interaction of SecA with ribosome-bound photoreactive nascent chains in the absence of trigger f

148 le to determine chemical dynamics in complex photoreactive networks.

149 sed of two pyridyl-amide arms connected by a photoreactive nitrophenyl group.

150 al crosslinking strategy that incorporates a photoreactive, non-natural amino acid, p-benzoyl-l-pheny

151 of native and minimal hammerheads containing photoreactive nucleobases 6-thioguanosine, 2,6-diaminopu

152 The photoreactive nucleotide 4-thiothymidine (4ST) incorpora

153 her a phenylazide or phenyldiazirine and the photoreactive nucleotide is then enzymatically incorpora

154 sslinks in E.coli occur because of unusually photoreactive nucleotides at particular locations in the

155 Photoreactive nucleotides containing an aryl azide (AB-d

156 5 S rDNA was engineered with photoreactive nucleotides incorporated at different site

157 nthetic supercoiled DNA substrate containing photoreactive nucleotides.

158 ortance of TU in templating the olefins in a photoreactive orientation in the crystalline state.

159 Each contains a photoreactive p-benzoyl-phenylalanyl (Bpa) residue in cl

160 Four PTH analogues, containing a single photoreactive p-benzoylphenylalanine (Bpa) residue in po

161 A photoreactive peptide is synthesized that affinity-label

162 f appropriately posttranslationally modified photoreactive peptide probes of isoprene function.

163 oss-linking experiments were performed using photoreactive peptides containing the YDSI motif and pur

164 By genetically incorporating photoreactive phenyl azide, the fluorescent properties o

165 Benzoylphenylalanine, a photoreactive phenylalanine analog that can be incorpora

166 of Mg(2+), ADP, and orthovanadate (V(i)), a photoreactive phosphate analog with a trigonal bipyramid

167 RNATyr gene was extensively probed by use of photoreactive phosphodiesters, deoxyuridines, and deoxyc

168 -induced switching of the formal charge of a photoreactive polycation resulted in repulsive interlaye

169 Photoreactive polyelectrolyte multilayers (PEMs) that di

170 f which spans positions 24-26; together, the photoreactive positions flank the RGD motif.

171 d by the extent of decreased labeling by the photoreactive probe 3-(trifluoromethyl)-3-(m- [125I]iodo

172 receptor structure, we used the hydrophobic photoreactive probe 3-trifluoromethyl-3-(m-[(125)I]iodop

173 In addition, a single photoreactive probe incorporated at a unique site in act

174 A photoreactive probe was incorporated into a nascent chai

175 A photoreactive probe was incorporated into the middle of

176 For each photoreactive probe, labeled sites were identified by am

177 eavage products bear the membrane-restricted photoreactive probe, proof that surface-cleaved TNF has

178 We now demonstrate, using peptides with a photoreactive probe, that this binding is strengthened s

179 ving the design and synthesis of a clickable photoreactive probe, we demonstrated specific labeling o

180 ibe a suite of S-adenosyl homocysteine (SAH) photoreactive probes and their application in chemical p

181 future development of click chemistry-based photoreactive probes for the in situ analysis of additio

182 intermediate of ppalphaF was generated with photoreactive probes incorporated into the mature portio

183 es, the ferric form of cupriachelin exhibits photoreactive properties.

184 x-formation oligonucleotides attached with a photoreactive psoralen molecule (psoTFO) can be used to

185 Photoreactive psoralens can form interstrand crosslinks

186 we designed and radioiodinated a bioactive, photoreactive PTH agonist, (125)I-[Nle(8,18),Lys13(epsil

187 The photoreactive PTH(1-34) analogue K27 contains a benzophe

188 annel receptor site 2, was localized using a photoreactive radiolabeled batrachotoxin derivative to c

189 has led to the search for sequence-specific photoreactive reagents that can produce more genotoxic l

190 Photoreactive repair (PR) of cyclobutane pyrimidine dime

191 Transcription had no effect on photoreactive repair in transcribed and downstream regio

192 ith nearly all conserved residues within the photoreactive retinal-binding pocket in the membrane-emb

193 The newly designed tagged photoreactive RGD-containing ligands display an affinity

194 s-linking analysis of interactions between a photoreactive RNase MRP substrate and the Saccharomyces

195 ization that photoinduced bending of slender photoreactive single crystals is surprisingly common has

196 zation with photocleavable moieties or using photoreactive small-molecule ligands.

197 e has been obtained that at equilibrium, the photoreactive SP analogue (125)I-[D-Tyr(0)]Bpa(3)SP cova

198 In this study, a second photoreactive SP analogue, Bpa(4)-SP, in which the Bpa r

199 chemoproteomic strategy that uses clickable, photoreactive sterol probes in combination with quantita

200 y the demonstration several years ago that a photoreactive substrate analogue, azido-Q, covalently la

201 ween the murine mdr1b P-glycoprotein and two photoreactive Taxol analogues have been mapped by a comb

202 ne of the ammine ligands was replaced with a photoreactive tethered aryl azide ligand.

203 Derivatized SWCNTs were significantly more photoreactive than derivatized MWCNTs.

204 ence, *[LAuX](n) oligomeric species are more photoreactive than monomeric species.

205 in the labeling of L27 from the 3' end of a photoreactive tRNA at the ribosomal P site.

206 , we describe the genetic incorporation of a photoreactive Uaa into the pore of an inwardly rectifyin

207 Monomers were synthesized by connecting two photoreactive units, either sorbic acids (monomer I) or

208 glutamate receptor by genetically encoding a photoreactive unnatural amino acid (UAA).

209 sed amber codon suppression to introduce the photoreactive unnatural amino acid p-benzoyl-l-phenylala

210 We show, using a photoreactive, unnatural amino acid, that Asf1 tail resi

211 elies on a photopatternable (blue light) and photoreactive (UV light) polyacrylamide gel.