ライフサイエンスコーパス: photoreceptor cell

1 segment, the light-sensing organelle of the photoreceptor cell.

2 This accumulation can damage the photoreceptor cell.

3 ge-gated Ca(2+) channels (Cav1.4) in retinal photoreceptor cells.

4 ng the first example of dispersed high-order photoreceptor cells.

5 ontinuously supply 11-cis-retinal to retinal photoreceptor cells.

6 are the most abundant transport vesicles in photoreceptor cells.

7 le to long wavelength-sensitive (M/LWS) cone photoreceptor cells.

8 eneration of visual pigments in rod and cone photoreceptor cells.

9 yanine green may have a late toxic effect on photoreceptor cells.

10 to loss of insm1a expression than were cone photoreceptor cells.

11 er retinal layers toward the RPE and loss of photoreceptor cells.

12 rmination of photoactivated rhodopsin in rod photoreceptor cells.

13 ted ommatidial lattice and reduced number of photoreceptor cells.

14 dness caused by the dysfunction and death of photoreceptor cells.

15 p of Mendelian disorders primarily affecting photoreceptor cells.

16 s involved in generating a light response in photoreceptor cells.

17 essive production of bisretinoid by impaired photoreceptor cells.

18 ormally fast kinetics of Ca(2+) elevation in photoreceptor cells.

19 s conserved between rhabdomeric and ciliated photoreceptor cells.

20 proper development of hair cells and retinal photoreceptor cells.

21 role in retinal pigment epithelial (RPE) and photoreceptor cells.

22 characterized by progressive loss of retinal photoreceptor cells.

23 of mechanosensitive channels introduced into photoreceptor cells.

24 e to white light to assess protection of the photoreceptor cells.

25 sing exclusively the mutant rhodopsin in rod photoreceptor cells.

26 ct on RHD12, a protein found specifically in photoreceptor cells.

27 er conditions that fully bleach rod and cone photoreceptor cells.

28 ndent superoxide production in epithelia and photoreceptor cells.

29 major blood supply for the outer retina and photoreceptor cells.

30 hows properties of both retinal ganglion and photoreceptor cells.

31 nscriptional regulator of homeostasis in rod photoreceptor cells.

32 e intraflagellar transport (IFT) particle in photoreceptor cells.

33 R-183/96/182 cluster are highly expressed in photoreceptor cells.

34 disease characterized by apoptotic death of photoreceptor cells.

35 cellular trafficking of PDE6 and survival of photoreceptor cells.

36 rted to the outer segments in Rce1-deficient photoreceptor cells.

37 MP-sensitive CNG channels and stimulation of photoreceptor cells.

38 s in phototaxis behavior that is mediated by photoreceptor cells.

39 ositide 3-kinase/Akt survival pathway in rod photoreceptor cells.

40 ranes rather than to plasma membranes of rod photoreceptor cells.

41 e eye, where it is specifically expressed in photoreceptor cells.

42 ll integrity is critical for the survival of photoreceptor cells.

43 tate with the outer segments of rod and cone photoreceptor cells.

44 inal ganglion cells and connecting cilium of photoreceptor cells.

45 transport in specialized cilia of vertebrate photoreceptor cells.

46 products to the RPE and dispose of the dying photoreceptor cells.

47 associate in the outer segments of mouse rod photoreceptor cells.

48 itical component of the viability of RPE and photoreceptor cells.

49 participate in the transport of proteins in photoreceptor cells.

50 indicated that vitamin E treatment protected photoreceptor cells.

51 previously under-appreciated S1R presence in photoreceptor cells.

52 2A (IVS1-2A>G mutation) in the BBS8 gene to photoreceptor cells.

53 thus eliminating the protein specifically in photoreceptor cells.

54 Postmortem human eyes and mouse-derived photoreceptor cells (661W) were examined for Fas express

55 Photoreceptor cells achieve high sensitivity, reliably d

56 acity of Xenopus laevis retina to regenerate photoreceptor cells after cyclic light-mediated acute ro

57 unappreciated role of IRBP in protecting the photoreceptor cells against the cytotoxic effects of acc

58 We found here that, in macaque photoreceptor cells, all USH1 proteins colocalized at me

59 WDR81 is expressed in Purkinje cells and photoreceptor cells, among other CNS neurons, and like t

60 cilia-based outer segment of the vertebrate photoreceptor cell and the microvilli-based rhabdomere o

61 characterized by progressive degeneration of photoreceptor cells and a strongly decreased light respo

62 hyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment ep

63 However, ribbon synapses of photoreceptor cells and bipolar neurons in the retina ex

64 Ribbon synapses of photoreceptor cells and bipolar neurons in the retina si

65 ons in genes associated with BBS affect only photoreceptor cells and cause nonsyndromic retinitis pig

66 Synaptic transmission between light-sensory photoreceptor cells and downstream ON-bipolar neurons pl

67 yer in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role f

68 te of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long chain (>/=C2

69 In vitro systems of isolated photoreceptor cells and intact neural retina were used.

70 lp1 gene in mouse (Mus musculus) retinal rod photoreceptor cells and measured the effects on G-protei

71 voked rapid PLC-mediated contractions of the photoreceptor cells and modulated the activity of mechan

72 E8 function is necessary for the survival of photoreceptor cells and NHE8 is important for RPE cell p

73 characterized by degeneration of the retinal photoreceptor cells and progressive loss of vision.

74 eurons that receive synaptic input from cone photoreceptor cells and provide the output of the first

75 onstrate a novel transport mechanism between photoreceptor cells and RPE that does not involve canoni

76 Ribbon synapses of photoreceptor cells and second-order bipolar neurons in

77 Two retinal cell types, photoreceptor cells and the adjacent retinal pigmented e

78 The demanding physiologic functions of photoreceptor cells and the retinal pigmented epithelium

79 quential biochemical reactions that occur in photoreceptor cells and the retinal pigmented epithelium

80 nderstanding better the interactions between photoreceptor cells and the RPE, and may help in the dev

81 However, precise roles of BBS proteins in photoreceptor cells and the underlying mechanisms of pho

82 sulted in activation of Muller glia, loss of photoreceptor cells, and an increase in phosphorylated t

83 rmal ciliogenesis and differentiation in the photoreceptor cells, and that ttc26 is required for norm

84 additional visible light to the rod and cone photoreceptor cells, and thereby improve the visual syst

85 n about the function of DICER1 in mature rod photoreceptor cells, another retinal cell type that is s

86 led that chrysophanol attenuated MNU-induced photoreceptor cell apoptosis and inhibited the expressio

87 3 and Ascl1a proteins following rod and cone photoreceptor cell apoptosis.

88 In the eyes, the outer segments of photoreceptor cells appeared shortened or absent, wherea

89 ions that generate a photoreceptor and a non-photoreceptor cell are decreased in favor of symmetric t

90 The function and integrity of photoreceptor cells are dependent upon the creation and

91 The newly integrated photoreceptor cells are light-responsive with dim-flash

92 Photoreceptor cells are remarkable in their ability to a

93 he rhodopsin gene, which is expressed in rod photoreceptor cells, are a major cause of the hereditary

94 huttling of the major arrestin in Drosophila photoreceptor cells, Arrestin2 (Arr2), occurs independen

95 r cells and maintenance of some rod and cone photoreceptor cells, as identified by vimentin, recoveri

96 ning localized to the inner segments (IS) of photoreceptor cells, as well as the outer segments (OS)

97 In photoreceptor cells, associated neurons, and radial glia

98 Microarray analysis revealed loss of photoreceptor cell-associated transcripts, with preserva

99 on, indicating an essential role for Numb in photoreceptor cell biology.

100 retinal membrane guanylyl cyclase (RetGC) in photoreceptor cells, blocks RetGC catalytic activity and

101 e in the fly retina, where they are found in photoreceptor cell bodies and surrounding pigment glial

102 ne metabolites between perisynaptic glia and photoreceptor cell bodies to mediate a novel, long-dista

103 t 6 months of age, the treated eyes retained photoreceptor cell bodies, while there were no detectabl

104 ght according to the adaptation state of the photoreceptor cells by shifting the detection limit to h

105 question remains whether transplantation of photoreceptor cells can actually improve vision.

106 Cone photoreceptors cells can use 11-cis-retinal from the RPE

107 , which are destined to produce amacrine and photoreceptor cells, can be re-programmed into RGCs when

108 Mature rod photoreceptor cells contain very small nuclei with tight

109 The vertebrate photoreceptor cell contains an elaborate cilium that inc

110 se (PDE6) involved in visual transduction in photoreceptor cells contains two inhibitory gamma-subuni

111 ceptor survival and function, as measured by photoreceptor cell counts, apoptosis assays, and ERG ana

112 In photoreceptor cells, dark activation of G(q)alpha molecu

113 Photoreceptor cell death accompanying many retinal degen

114 Edaravone treatment may aid in preventing photoreceptor cell death after RD by suppressing ROS-ind

115 Oxidative stress plays an important role in photoreceptor cell death after RD.

116 inherited retinal disorder characterized by photoreceptor cell death and genetic heterogeneity.

117 d macular degeneration and induce subsequent photoreceptor cell death and permanent vision loss.

118 uthors conclude that Drgal1-L2 is induced by photoreceptor cell death and secreted by stem cells and

119 d surrounding commotio retinae with specific photoreceptor cell death and sparing of cells in the oth

120 Possible mechanisms that could lead to photoreceptor cell death are discussed.

121 PE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual l

122 The photoreceptor cell death associated with the various gen

123 indness are caused by mutations that lead to photoreceptor cell death but spare second- and third-ord

124 h pathways will be more effective at slowing photoreceptor cell death caused by elevated cGMP.

125 The extent of photoreceptor cell death declined and necrosis progresse

126 mislocalization of opsin is a major cause of photoreceptor cell death from kinesin-2 dysfunction and

127 uture investigation into retbindin's role in photoreceptor cell death in models of retinal degenerati

128 Dysfunctional RPE may ultimately lead to photoreceptor cell death in the NHE8 mutants.

129 t critical pathobiological factor leading to photoreceptor cell death in these animals is insufficien

130 tress-induced retinal pigment epithelial and photoreceptor cell death in vitro and in vivo.

131 How constitutive phototransduction causes photoreceptor cell death is poorly understood.

132 Photoreceptor cell death is the proximal cause of blindn

133 Increased photoreceptor cell death was observed when retinas lacki

134 a-1(+) cells in the subretinal space, severe photoreceptor cell death, and increased Ccl4 expression

135 and retinal pigmented epithelium, early cone photoreceptor cell death, and reduced lengths of rod out

136 group of disorders which lead to progressive photoreceptor cell death, resulting in blindness.

137 Retinal degeneration leads to progressive photoreceptor cell death, resulting in vision loss.

138 proliferating Muller glia without affecting photoreceptor cell death.

139 emistry were observed after the onset of rod photoreceptor cell death.

140 hin the endoplasmic reticulum (ER) and cause photoreceptor cell death.

141 e only model of retinal trauma with specific photoreceptor cell death.

142 e fate of misfolded P23H rhodopsin linked to photoreceptor cell death.

143 ontinuous long-term light damage, leading to photoreceptor cell death.

144 reduced photoreceptor function and increased photoreceptor cell death.

145 tion of intracellular mechanisms, leading to photoreceptor cell death.

146 ative vitreoretinopathy, and protect against photoreceptor cell death.

147 s and mutations in Drosophila PNPLA6 lead to photoreceptor cell death.

148 e to mutant rhodopsin that ultimately limits photoreceptor cell death.

149 tive optics images does not necessarily mean photoreceptor cell death.

150 inal degeneration mutants, and light-induced photoreceptor cell degeneration models), the use of Tb(3

151 system functions in patients who suffer from photoreceptor cell degeneration or related retinal disea

152 ct mechanism by which this mutation leads to photoreceptor cell degeneration remains unknown.

153 iers and affected males demonstrated RPE and photoreceptor cell degeneration.

154 e lacking the chromophore showed accelerated photoreceptor cell degeneration.

155 The further reduction of photoreceptor cell demise by co-treatment with calpastat

156 pmental apoptotic pathway is not involved in photoreceptor cell demise.

157 stress responses that together contribute to photoreceptor cell demise.

158 Photoreceptor cell densities under various conditions of

159 Rod photoreceptor cells depend completely on the output of 1

160 Photoreceptor cells depolarized normally following light

161 a basis for better understanding rhabdomeric photoreceptor cell development and function.

162 k controlling the late stages of rhabdomeric photoreceptor cell development and function.

163 ds to retina-specific enhancers and controls photoreceptor cell development.

164 nstrate that Notch signaling is required for photoreceptor cell differentiation and retinal organizat

165 ain protein, leads to a synergistic delay in photoreceptor cell differentiation in the developing eye

166 several developmental genes involved in the photoreceptor cell differentiation suggest that a role o

167 Circadian shedding of retinal photoreceptor cell discs with subsequent phagocytosis by

168 ominant retinal degeneration, in rhabdomeric photoreceptor cells disrupts morphogenesis in ways paral

169 on of the G-protein transducin in vertebrate photoreceptor cells during their recovery from light exc

170 Photoreceptor cells encode light signals over a wide ran

171 the P23H protein failed to accumulate in rod photoreceptor cell endoplasmic reticulum but instead dis

172 e slower termination in retin(1), the mutant photoreceptor cells exhibited increased endocytosis of R

173 oceeded normally in the absence of Rce1, but photoreceptor cells failed to respond to light and subse

174 ipper (Nrl) is a critical determinant of rod photoreceptor cell fate and a key regulator of rod diffe

175 cine zipper) is critical for rod versus cone photoreceptor cell fate choice during retinal developmen

176 ort the 'transcriptional dominance' model of photoreceptor cell fate determination and provide insigh

177 ription factor that dictates rod versus cone photoreceptor cell fate in the mammalian retina.

178 Here we show that Abl is required for photoreceptor cell fate maintenance, as Abl mutant photo

179 ether in gene regulatory networks to control photoreceptor cell fate specification.

180 The mechanisms that specify photoreceptor cell-fate determination, especially as reg

181 trinsic activity to suppress the alternative photoreceptor cell fates of early retinal progenitors by

182 37 donors examined, there was marked loss of photoreceptor cells for variable distances distal from t

183 the need to identify approaches to generate photoreceptors cells for future replacement therapies.

184 istered noninvasively to efficiently protect photoreceptor cells from oxidative damage.

185 e role of the STK38L pathway in neuronal and photoreceptor cell function, and suggests that genes in

186 ys an integral role in promoting rhabdomeric photoreceptor cell function.

187 tumor that expresses several markers of cone photoreceptor cells has been described earlier.

188 Retinal rod photoreceptor cells have double membrane discs located i

189 The two fundamental types of photoreceptor cells have evolved unique structures to ex

190 s between the photoreceptors and RPE because photoreceptor cells have very high energy demands, large

191 thelium (RPE), a monolayer of cells vital to photoreceptor cell health.

192 , organization and function of brain and eye photoreceptor cells in bilaterian animals.

193 dies against TTLL5 stained the basal body of photoreceptor cells in rat and the centrosome of the spe

194 results point to a potential way to generate photoreceptor cells in situ in adult mammalian eyes.

195 dent light reception in the compound eye and photoreceptor cells in the Hofbauer-Buchner eyelet.

196 adults and ultimately leads to the death of photoreceptor cells in the macular area of the neural re

197 ith two r-opsins in depolarizing rhabdomeric photoreceptor cells in the pigmented eyes of Platynereis

198 Postmitotic neurons, such as photoreceptor cells in the retina and epithelial cells i

199 Spectral absorbance of the photoreceptor cells in these sharks revealed the presenc

200 and thickening of Bruch's membrane, loss of photoreceptors, cells in subretinal space, and a reducti

201 f cells and at the connecting cilium (CC) of photoreceptor cells, indicating that SPATA7 is a ciliary

202 enesis of these compartments is integral for photoreceptor cell integrity and function.

203 atic RPE cell signaling that aims to sustain photoreceptor cell integrity and reveal potential therap

204 n in photoreceptors and RPE, thus preserving photoreceptor cell integrity.

205 al membranes of the two fundamental types of photoreceptor cells into their respective phototransduct

206 antial fraction of the visual pigment in our photoreceptor cells is bleached.

207 y of a gene playing an essential function in photoreceptor cells is derived with high specificity and

208 Phototransduction in Drosophila microvillar photoreceptor cells is mediated by a G protein-activated

209 ial reduction of RPGRIP1 levels at the CC of photoreceptor cells is observed, suggesting that SPATA7

210 Retinal degenerative disease causing loss of photoreceptor cells is the leading cause of untreatable

211 e protein from the retinal Muller glia (RMG)/photoreceptor cell junction.

212 In the retina, the photoreceptor cell layer showed the strongest beta-galac

213 rface of the inner and outer segments of the photoreceptor cell layer with variable loss of outer nuc

214 n: increased migration, translocation to the photoreceptor cell layer, proliferation, and phagocytosi

215 al endothelial cells from migrating into the photoreceptor cell layer.

216 A photoreceptor cell line, 661W, derived from a mouse reti

217 duced cell death in 661W cells, a mouse cone photoreceptor cell line, shown to express both estrogen

218 ne 661W, a mouse SV-40 T antigen transformed photoreceptor cell line.

219 itro and reduced microglial infiltration and photoreceptor cell loss after subretinal hemorrhage in v

220 deposits, severe reduction in ERG responses, photoreceptor cell loss and gliosis.

221 can help inhibit the inflammation-associated photoreceptor cell loss in late AMD, including geographi

222 a role for inflammatory responses in driving photoreceptor cell loss in subretinal hemorrhage, and it

223 inal pigment epithelium (RPE) and late-onset photoreceptor cell loss in the mutant retina.

224 Minor photoreceptor cell loss occurred in adult Mfsd2a KO mice

225 age, indicated by a significant reduction in photoreceptor cell loss, and restoration of the alpha-tr

226 cular disorders characterized by progressive photoreceptor cell loss, night blindness, constriction o

227 ession of retinoic acid-responsive genes and photoreceptor cell loss, overall leading to a reduction

228 chronic uveitis characterized by progressive photoreceptor cell loss, retinal degeneration, focal ret

229 t, as well as Purkinje cell degeneration and photoreceptor cell loss.

230 s of these ER stress markers correlated with photoreceptor cell loss.

231 including abnormal RPE cells and late-onset photoreceptor cell loss.

232 AMD in a proportion of cases and imply that photoreceptor-cell loss may contribute to the functional

233 for ocular retinoid production required for photoreceptor cell maintenance and visual function.

234 es in regulating epithelial polarity and, in photoreceptor cells, morphogenesis and stability.

235 elease, marked apoptosis was detected in the photoreceptor cell nuclei of the retina.

236 In addition, there was a reduction in cone photoreceptor cell number and cone b-wave amplitude.

237 and raised in constant dark have higher cone photoreceptor cell number, improved cone opsin localizat

238 sin ciliary trafficking, was mislocalized in photoreceptor cells of rpgrip1 mutants.

239 of Dronc in specific neurons, but not in the photoreceptor cells of the eyes of transgenic flies; sim

240 etwork in hair cells of the inner ear and in photoreceptor cells of the retina via binding to PDZ dom

241 ffort to understand genetic disorders of the photoreceptor cells of the retina, we have focused on in

242 ctivation of visual pigments in rod and cone photoreceptor cells of the retina.

243 uestion, we expressed cone PDE6alpha' in the photoreceptor cells of the retinal degeneration 10 (rd10

244 s: random reactions of vitamin A aldehyde in photoreceptor cell outer segments, and phagocytosis of d

245 , ey>CHMP2B(Intron5) flies showed defects in photoreceptor cell patterning and phototactic behavior.

246 The cGMP phosphodiesterase of rod photoreceptor cells, PDE6, is the key effector enzyme in

247 rosophila melanogaster larvae, which have 12 photoreceptor cells per hemisphere, are attracted to dis

248 Accumulating evidence suggests that photoreceptor cells play a previously unappreciated role

249 significant advance for the understanding of photoreceptor cell (PRC) evolution and development and f

250 esterase gene Pde6beta and lose rod and cone photoreceptor cells (PRC) within the first 6 wk of life,

251 tein common to both rhabdomeric and ciliated photoreceptor cells, Prominin.

252 For instance, different classes of photoreceptor cells (PRs) are distributed stochastically

253 ction of Otx2 primarily in newly postmitotic photoreceptor cells (PRs), as well as in a subset of ret

254 and HP1a are required for differentiation of photoreceptor cells R1, R6 and R7.

255 In vertebrate photoreceptor cells, rapid recovery from light excitatio

256 Here we show that Ca(2+) homeostasis in the photoreceptor cell relies on the protein calphotin.

257 he safety and efficiency of patient-specific photoreceptor cell replacement in humans.

258 Significant obstacles to advancement of photoreceptor cell-replacement include low migration rat

259 Photoreceptor cell-replacement may hold the potential fo

260 The outer segment of a vertebrate photoreceptor cell represents the most elaborate of all

261 Formation of membrane discs in photoreceptor cells requires evagination of its ciliary

262 and consequent removal from Muller glial and photoreceptor cells, results in severe and progressive r

263 ikely corresponded to histologically visible photoreceptor cell rosettes.

264 in other cell types in previous reports, in photoreceptor cells S1R was found in the nuclear envelop

265 Every day, shortly after light onset, photoreceptor cells shed approximately a tenth of their

266 Emerging evidence has linked photoreceptor cell-specific nuclear receptor (PNR/NR2E3)

267 These intronic sequences are sufficient for photoreceptor-cell-specific splicing of heterologous exo

268 of a multimerized RCSI reporter, a marker of photoreceptor cell specificity previously suggested to b

269 ic opsins are employed by different kinds of photoreceptor cells, such as ciliary vertebrate rods and

270 cally and immunohistochemically recognizable photoreceptor cells, suggesting that the mutations in th

271 be a favorable potential target to increase photoreceptor cell survival after RD.

272 etabolism plays an important role in retinal photoreceptor cell survival and apoptosis.

273 thways and adenylate cyclases (ACs) improved photoreceptor cell survival, preserved photoreceptor fun

274 tion of guanylate cyclase (GC) signaling and photoreceptor cell survival.

275 rich leads to reduction of N-Cadherin in the photoreceptor cell synapses but not of other proteins im

276 osis (LCA) is a neurodegenerative disease of photoreceptor cells that causes blindness within the fir

277 specialized morphological features of mature photoreceptor cells, the fundamental question remains wh

278 signaling proteins to the sensory cilium of photoreceptor cells, the outer segment.

279 arily in the phototransducing compartment of photoreceptor cells, the rhabdomeres.

280 n of the phototransducing compartment of the photoreceptor cells-the rhabdomeres, reminiscent of the

281 storation of the mutant gene in all diseased photoreceptor cells, thereby ensuring sufficient transdu

282 ate PKM2 to provide a metabolic advantage to photoreceptor cells, thereby promoting cell survival.

283 (all-trans-retinol) from the circulation and photoreceptor cells to produce the esterified substrate

284 d protein complex, and that apoptosis of rod photoreceptor cells triggered by protein mislocalization

285 in mediating layer-specific targeting of one photoreceptor cell type in the Drosophila visual system.

286 ployment of this protein in a highly plastic photoreceptor cell type of mixed microvillar/ciliary org

287 Drosophila photoreceptor cells use the ubiquitous G-protein-mediate

288 the Abca4(-/-) mice corresponded to reduced photoreceptor cell viability as reflected in ONL thinnin

289 esent in the inner segment of Rce1-deficient photoreceptor cells was assembled and functional.

290 hese cilia, as well as in cilia of mouse rod photoreceptor cells, was reduced significantly when KIF3

291 To determine the importance of ARL3 in rod photoreceptor cells, we generated transgenic mice expres

292 o understand the importance of AIPL1 in cone photoreceptor cells, we transgenically expressed hAIPL1

293 As both RPE and photoreceptor cells were affected, these cell types may

294 Rod photoreceptor cells were more sensitive to loss of insm1

295 of autofluorescence in the RPE suggests that photoreceptor cells were probably missing across the ret

296 process of vision is impossible without the photoreceptor cells, which have a unique structure and s

297 egulation or function of these lipids in rod photoreceptor cells, which have highly active membrane d

298 sion, that vertebrate eyes have two types of photoreceptor cells with differing sensitivity: rods for

299 e evolved from the primary cilium to provide photoreceptor cells with vast membrane surfaces for effi

300 te retina lacking the outer nuclear layer of photoreceptor cells would allow the survival, maturation