ライフサイエンスコーパス: photoreceptor outer segment

1 icrovilli, which are interdigitated with the photoreceptor outer segment.

2 gue, Rom-1, to maintain the integrity of the photoreceptor outer segment.

3 rans-retinal to all-trans-retinol within the photoreceptor outer segment.

4 ation and maintenance of the light-sensitive photoreceptor outer segment.

5 unknown function surrounding the base of the photoreceptor outer segment.

6 epithelium and inner retina but an abnormal photoreceptor outer segment.

7 pace K(+) homeostasis in the vicinity of the photoreceptor outer segment.

8 ible for impeding their transport to the rod photoreceptor outer segment.

9 2cr4 verified its expression in the discs of photoreceptor outer segments.

10 nsory cilia formation and the development of photoreceptor outer segments.

11 nd by imaging the fluorescence of retinol in photoreceptor outer segments.

12 l that exceeds the reductive capacity of the photoreceptor outer segments.

13 ons in the gene for the ABCA4 transporter in photoreceptor outer segments.

14 ase 9 (HDAC9) proteins were detected in cone photoreceptor outer segments.

15 idinium bisretinoid (A2PE) that forms within photoreceptor outer segments.

16 photoreceptor function and abnormally shaped photoreceptor outer segments.

17 ze the mobility of all-trans retinol in frog photoreceptor outer segments.

18 as revealed progressive vacuolization of the photoreceptor outer segments.

19 CAR was expressed in retina except in photoreceptor outer segments.

20 d the structural and functional integrity of photoreceptor outer segments.

21 but not maintained, producing the absence of photoreceptor outer segments.

22 and GCAP1 immunostaining was absent from the photoreceptor outer segments.

23 pherin/rds protein to the disc rim region of photoreceptor outer segments.

24 ly normal CRX activity, led to shortening of photoreceptor outer segments.

25 ch localized correctly to the axoneme of the photoreceptor outer segments.

26 small extracellular compartment surrounding photoreceptor outer segments.

27 disruption of the normal organization of the photoreceptor outer segments.

28 on in the delivery of 11-cis-retinoid to the photoreceptor outer segments.

29 um, thus facilitating rhodopsin transport to photoreceptor outer segments.

30 nt of reactive Muller glia into the layer of photoreceptor outer segments.

31 or other genes that affect the integrity of photoreceptor outer segments.

32 ed to be derived primarily from phagocytosed photoreceptor outer segments.

33 neration slow (rds) mutation completely lack photoreceptor outer segments.

34 matrix at the interface between the RPE and photoreceptor outer segments.

35 ansplants did not develop parallel layers of photoreceptor outer segments.

36 minently to the microvilli that surround the photoreceptor outer segments.

37 are expressed in the retina and enriched in photoreceptor outer segments.

38 se (PDE) mediates signal transduction in the photoreceptor outer segments.

39 Anti-Yb1 also reacted with photoreceptor outer segments.

40 C-1) is a membrane guanylyl cyclase found in photoreceptor outer segments.

41 cells primarily through phagocytosis of the photoreceptor outer segments.

42 e ABCA4 gene encodes a protein localizing to photoreceptor outer segments.

43 g of PDE6 and GRK1 to their destination, the photoreceptor outer segments.

44 eflectances appeared dim, suggesting loss of photoreceptor outer segments.

45 es and endfeet, photoreceptor terminals, and photoreceptor outer segments.

46 marked functional defects in phagocytosis of photoreceptor outer segments.

47 the choroid, retinal pigment epithelium, and photoreceptor outer segments.

48 omplex was observed on endothelial cells and photoreceptor outer segments.

49 showed abnormal disc stacking and shortened photoreceptor outer segments.

50 embly and morphogenesis of the rim region of photoreceptor outer segments.

51 rate that IFT proteins extracted from bovine photoreceptor outer segments, a modified sensory cilium,

52 resulted in atypical accumulation of Rpgr in photoreceptor outer segments, abnormal photoreceptor mor

53 Despite previous reports of diffuse photoreceptor outer segment abnormalities in BVMD, our d

54 creased at night by at least two mechanisms: photoreceptor outer segment activity decreases and synap

55 r studies suggest that Grb14 translocates to photoreceptor outer segments after photobleaching of rho

56 f adhesion between RPE apical microvilli and photoreceptor outer segments also declined during peak a

57 n the cause of acute vision loss to the cone photoreceptor outer segment and will refocus the search

58 luded lamination defects, failure to develop photoreceptor outer segments and a small eye phenotype,

59 Rp1 is required for normal morphogenesis of photoreceptor outer segments and also may play a role in

60 lls are responsible for daily degradation of photoreceptor outer segments and are thus particularly s

61 ce of vacuolar structures that distorted rod photoreceptor outer segments and became more prominent w

62 e and monitor the free Mg2+ concentration in photoreceptor outer segments and examine whether the fre

63 nd their discrete localization in developing photoreceptor outer segments and ganglion cells suggests

64 of mice is associated with nondevelopment of photoreceptor outer segments and gradual death of photor

65 cle in homozygous rds/rds retinas which lack photoreceptor outer segments and heterozygous rds/+ reti

66 alled the retinoid cycle, takes place in the photoreceptor outer segments and in the retinal pigmente

67 us studies have shown that RDH8 localizes to photoreceptor outer segments and is a strong candidate f

68 have highly disorganized, short, fragmented photoreceptor outer segments and lack both rod and cone

69 Crx-/- mice do not elaborate photoreceptor outer segments and lacked rod and cone act

70 osition of debris composed of unphagocytosed photoreceptor outer segments and lipofuscin granules in

71 Shortening of photoreceptor outer segments and reduction of the outer

72 parameters of the retinal nerve fiber layer, photoreceptor outer segments and retinal pigment epithel

73 or the retinal nerve fiber layer's features, photoreceptor outer segments and retinal pigment epithel

74 It participates in cellular uptake of photoreceptor outer segments and scavenging of apoptotic

75 t-negative form of CRX failed to form proper photoreceptor outer segments and terminals.

76 Only minimal staining was detected in the photoreceptor outer segments and the optic nerve pia and

77 alled the retinoid cycle, takes place in the photoreceptor outer segments and the retinal pigment epi

78 es were observed in the outer nuclear layer, photoreceptor outer segment, and optic nerve.

79 nges; RPE were vacuolated and separated from photoreceptor outer segments, and choriocapillaris fenes

80 cerebrospinal fluid transport, generation of photoreceptor outer segments, and hedgehog signaling.

81 ibroblasts, in all retinal layers except the photoreceptor outer segments, and in the fascicles and a

82 Photoreceptor outer segments are continually renewed fro

83 The proximal portions of mammalian photoreceptor outer segments are synthesized daily by ce

84 ed changes in the optical path length of the photoreceptor outer segment as a response to an optical

85 ning the function and/or organization of the photoreceptor outer segment as reflected by the species-

86 ding cassette (ABC) family that functions in photoreceptor outer segments as a flipase of all-trans r

87 as able to reinstate phagocytosis of labeled photoreceptor outer segments at a reduced, but significa

88 hibited normal lamination, but lacked intact photoreceptor outer segments at all ages examined.

89 Excitation signals spread along photoreceptor outer segments away from the site of photo

90 aminins at photoreceptor synapses and around photoreceptor outer segments; both molecules are express

91 Sensitivity was specified at the photoreceptor outer segments by individually correcting

92 ldehyde all-trans retinal is released in rod photoreceptor outer segments by photoactivated rhodopsin

93 iv) the TLR4 participates in phagocytosis of photoreceptor outer segments by the RPE.

94 The concentration of all-trans retinol in photoreceptor outer segments can be monitored from its f

95 highly enriched in retina, and localizes to photoreceptor outer segments, ciliary complex, and horiz

96 lysosomal pH with these treatments enhanced photoreceptor outer segment clearance, demonstrating fun

97 nsducin, into and out of the light-sensitive photoreceptor outer segment compartment.

98 Photoreceptor outer segment degeneration was evident, wi

99 Loss in the photoreceptor outer segment detected by SD-OCT co-locali

100 Moreover, although mutant mikre oko photoreceptor outer segments develop only infrequently a

101 is a membrane glycoprotein essential for the photoreceptor outer segment disc morphogenesis and maint

102 lexiform layer simultaneously with the first photoreceptor outer segment discs at 60 hpf; functional

103 uter segments, and phagocytosis of discarded photoreceptor outer segment discs by RPE.

104 rin/rds), which is inserted into the rims of photoreceptor outer segment discs in a complex with rom-

105 lycoprotein is required for the formation of photoreceptor outer segment discs.

106 ase A(2) plays a role in the phagocytosis of photoreceptor outer-segment discs by the retinal pigment

107 rom-1 form a protein complex in the rims of photoreceptor outer segment disk membranes.

108 se results indicate that a rhythm of retinal photoreceptor outer segment disk shedding exists in the

109 Here, we report that the phagocytosis of photoreceptor outer segment disks by the retinal pigment

110 g photoactivated rhodopsin, which moves into photoreceptor outer segments during illumination.

111 ficient mice revealed abnormal morphology of photoreceptor outer segments during the time at which th

112 nner retina and RPE during the time at which photoreceptor outer segments elongate.

113 lar pseudodrusen were deposits juxtaposed to photoreceptor outer segments extending through the outer

114 etinal space developed parallel layers, with photoreceptor outer segments facing the host pigment epi

115 ciliary ectosomes in building the elaborate photoreceptor outer segment filled with hundreds of tigh

116 A2-PE, the A2E precursor, are formed within photoreceptor outer segments following light-induced rel

117 raflagellar transport (IFT) is essential for photoreceptor outer segment formation and maintenance, a

118 lacking ift80 function exhibited defects in photoreceptor outer segment formation and photoreceptor

119 tablish that nephrocystin-5 is essential for photoreceptor outer segment formation but is dispensable

120 ed IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.

121 5 integrin and CD36 receptors to phagocytose photoreceptor outer segment fragments (OS).

122 iurnal bursts of RPE phagocytosis that clear photoreceptor outer segment fragments (POS) shed in a ci

123 ta5 integrin-dependent phagocytosis of spent photoreceptor outer segment fragments by the retinal pig

124 he retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vi

125 oreceptors via diurnal phagocytosis of spent photoreceptor outer segment fragments.

126 apical projections to shield light-sensitive photoreceptor outer segments from photobleaching when fi

127 oplasia of the optic nerve and inhibition of photoreceptor outer segment growth.

128 When photoreceptor outer segment homogenates are preincubated

129 reviously reported and that preincubation of photoreceptor outer segment homogenates with ATP or its

130 is tightly associated with the membranes of photoreceptor outer segments; however, the nature of thi

131 on belt around the basolateral region of the photoreceptor outer segment in humans, and that defects

132 fetal retina can develop parallel layers and photoreceptor outer segments in contact with host pigmen

133 scopic examination confirmed the presence of photoreceptor outer segments in the areas affected by tr

134 al results showed Tgamma c localized to cone photoreceptor outer segments in the normal retina, where

135 required for the elaboration of rod and cone photoreceptor outer segments in the vertebrate retina; i

136 kewise, the autofluorescence of phagocytosed photoreceptor outer segments increased by lysosomal alka

137 Daily phagocytosis of spent photoreceptor outer segments is a critical maintenance f

138 Phagocytosis of daily shed photoreceptor outer segments is an important function of

139 The reduction of all-trans-retinal in photoreceptor outer segments is the first step in the re

140 pe 1 (ROS-GC1), originally identified in the photoreceptor outer segments, is a member of the subfami

141 binding protein which is highly expressed in photoreceptor outer segments, is also located in 6p21.1.

142 ApoH has been localized to the photoreceptor outer segment layer by immunocytochemistry

143 D OCT revealed an inflammatory lesion in the photoreceptor outer segment layer displacing ELM.

144 a dome-shaped hyper-reflective lesion at the photoreceptor outer segment layer disrupting the ellipso

145 pigment epithelium (RPE) to phagocytize shed photoreceptor outer segments leads to a progressive loss

146 in absence of subretinal drusenoid deposits, photoreceptor outer segment loss, RPE drusen complex vol

147 the RPE resulted in an aberrant assembly of photoreceptor outer segments, loss of fine subcellular u

148 In the mutant RPE, photoreceptor outer segment material was not effectively

149 vestigators and is recognized as an index of photoreceptor outer segment maturity, yet its antigen re

150 )-2 is a Ca2+-binding protein that regulates photoreceptor outer segment membrane guanylate cyclase (

151 ultifunctional molecule that participates in photoreceptor outer segment membrane recognition, oxidan

152 demonstrated that the formation of A2-PE in photoreceptor outer segment membrane was augmented by ex

153 -retinal and phosphatidylethanolamine in the photoreceptor outer segment membrane; (ii) further react

154 found that compartmentalization of GCAP-2 in photoreceptor outer segment membranes is Ca2+- and ionic

155 pigment epithelium (RPE) to phagocytize shed photoreceptor outer segment membranes.

156 (Pgamma kinase) in a GTP-dependent manner in photoreceptor outer segment membranes.

157 s with other phototransduction components to photoreceptor outer segment membranes.

158 n the retina, Rbpr2 loss resulted in shorter photoreceptor outer segments, mislocalization and decrea

159 naling pathways that guide the modulation of photoreceptor outer segment morphogenesis by RPE during

160 Photoreceptor outer segment morphology was abnormal in t

161 We also observed disorganized photoreceptor outer-segment morphology and defective tra

162 Disease manifests as a loss of rod photoreceptor outer segments, not singly but in microsco

163 In vertebrate photoreceptor outer segments, numerous reactions utilize

164 detected in vivo in ganglion cells, RPE, and photoreceptor outer segments of rat retina.

165 Strong PDEbeta expression was observed in photoreceptor outer segments only in treated eyes.

166 rds is required for biogenesis of vertebrate photoreceptor outer segment organelles.

167 rotein family required for normal vertebrate photoreceptor outer segment (OS) architecture.

168 rogressive rod-cone degeneration (PRCD) is a photoreceptor outer segment (OS) disc-specific protein w

169 The photoreceptor outer segment (OS) is a sensory compartmen

170 The photoreceptor outer segment (OS) is a unique modificatio

171 The photoreceptor outer segment (OS) is comprised of two com

172 Approximately 10% of the photoreceptor outer segment (OS) is turned over each day

173 marginal zone (CMZ) cell death and decreased photoreceptor outer segment (OS) length, as well as gros

174 cific tetraspanin glycoprotein essential for photoreceptor outer segment (OS) morphogenesis.

175 spanin protein that plays a pivotal role for photoreceptor outer segment (OS) structure and is involv

176 Mertk is required for the daily ingestion of photoreceptor outer segment (OS) tips.

177 Photoreceptor outer segments (OS) fail to develop proper

178 ARL13b is located exclusively in photoreceptor outer segments (OS) presumably anchored to

179 ions in the gene for ABCA4, a transporter in photoreceptor outer segments (OS) that clears retinaldeh

180 ipitate-like alterations at the level of the photoreceptor outer segments (OS) to choroidal neovascul

181 Here, we show that, in preparations of photoreceptor outer segments (OS), RGS9-1 is readily pho

182 sters are generated by and accumulate in the photoreceptor outer segments (OS), which is the retinal

183 ipid and protein in the form of phagocytized photoreceptor outer segments (OS).

184 - animals showed progressive degeneration of photoreceptor outer segments (OSs) and increased apoptos

185 Photoreceptor outer segments (OSs) are essential for our

186 the retinal pigment epithelium (RPE) of shed photoreceptor outer segments (OSs), a tissue with one of

187 for the formation of the disc/lamella rim in photoreceptor outer segments (OSs), but plays a differen

188 loys alphavbeta5 integrin to recognize spent photoreceptor outer segment particles (OS).

189 Diurnal phagocytosis of shed photoreceptor outer-segment particles by retinal pigment

190 In photoreceptor outer segments, particulate guanylyl cycla

191 rhodopsin to a change in current at the rod photoreceptor outer segment plasma membrane.

192 of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a m

193 es; and horizontal extent of the ONL and the photoreceptor outer segment (POS) interdigitation zone (

194 We show here that photoreceptor outer segment (POS) phagocytosis markedly

195 pendently inhibited RPE cell phagocytosis of photoreceptor outer segments (POS) and activated AMP-act

196 of apoptotic cells by macrophages and spent photoreceptor outer segments (POS) by retinal pigment ep

197 Phagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment ep

198 retina, life-long renewal of light-sensitive photoreceptor outer segments (POS) involves circadian sh

199 at underpin the daily phagocytic turnover of photoreceptor outer segments (POS) required for maintena

200 ed epithelium (RPE) is the clearance of shed photoreceptor outer segments (POS) through a multistep p

201 its effects measured on the uptake of bovine photoreceptor outer segments (POS), proteolysis of POS r

202 s with GC1 and promotes its targeting to the photoreceptor outer segments (POS).

203 red function is that the iPS-RPE phagocytose photoreceptor outer segments (POS).

204 in this medium could also phagocytose human photoreceptor outer segments (POS).

205 ) cells are disorganized and contact between photoreceptor outer segments (POSs) and the RPE apical s

206 Phagocytosis of shed photoreceptor outer segments (POSs) by retinal pigment e

207 and autofluorescent waste products from shed photoreceptor outer segments (POSs).

208 In the absence of phagocytic challenge with photoreceptor outer segments, postconfluent RPE cultures

209 s (53.3%), irregular hyporeflectivity in the photoreceptor outer segments (PROS) was observed in 17 e

210 he previously characterized ROS-GC1 from the photoreceptor outer segments (PROS), and its new modulat

211 synaptic proteins are correctly trafficked, photoreceptor outer segment proteins fail to be transpor

212 motors has been implicated in trafficking of photoreceptor outer segment proteins.

213 he light-activated currents generated at the photoreceptor outer segment provide an easily observed r

214 feration and migration, RPE atrophy, loss of photoreceptor outer segments, reactive gliosis, retinal

215 ific human retinal pigment epithelial (HRPE) photoreceptor outer segment recognition and oxidant prod

216 equired for morphogenesis and maintenance of photoreceptor outer segments, regions that collect light

217 Daily renewal of 10% of photoreceptor outer segments requires stringent control

218 fish consisting of disorganized rod and cone photoreceptor outer segments resulting in abnormal visua

219 Light detection by vertebrate rod photoreceptor outer segments results in the destruction

220 nterestingly, although it is associated with photoreceptor outer segments, retbindin's expression is

221 er nuclear layer (ONL) and the length of rod photoreceptor outer segment (ROS) were made.

222 RPE) and plays a role in the phagocytosis of photoreceptor outer segments (ROS), a function critical

223 ated in in vitro models of lipid rafts, from photoreceptor outer segments (ROS), and the localization

224 acid (DHA, 22:6n-3) in their plasma and rod photoreceptor outer segments (ROS).

225 adhesion), and 3) Adhesion of the RPE to the photoreceptor outer segments (RPE-POS adhesion).

226 ess to the confined space within the retinal photoreceptor outer segment signaling compartment and di

227 xhibited small eyes, kidney cysts, and short photoreceptor outer segments, some of which were disorga

228 this degeneration on the localization of two photoreceptor outer segment-specific integral membrane p

229 Development of photoreceptor outer segments stopped, and rod cells were

230 5 photoreceptor-specific knock-out mice, the photoreceptor outer segment structure was severely impai

231 mt-deficient mice trafficked normally to the photoreceptor outer segment, suggesting that the failure

232 tinal pigment epithelium (RPE) with adjacent photoreceptor outer segments that are essential for visi

233 fluorescent spots appeared to originate from photoreceptor outer segments that were arranged within r

234 f key signaling proteins into and out of the photoreceptor outer segment, the cellular compartment wh

235 matographies of a cytosolic fraction of frog photoreceptor outer segments, the Pgamma kinase activity

236 stinct scattering bands corresponding to the photoreceptor outer segment tips, RPE, and Bruch's membr

237 Photoreceptor outer-segment tips are imaged on a charge-

238 the second procedure showed that exposure of photoreceptor outer segments to light resulted in the in

239 d that constitutes .15% of all lipids in the photoreceptor outer segment, to produce beta-HB.

240 The structure of photoreceptor outer segment was compared using electron

241 olved in binding and internalization of shed photoreceptor outer segments was subjected to changes in

242 rans-retinal to all-trans-retinol within the photoreceptor outer segment, was the first visual cycle

243 e positive for S-antigen, but well-developed photoreceptor outer segments were not present.

244 Although photoreceptor outer segments were shortened by 36%, ligh

245 histochemistry localizes the PHR1 protein to photoreceptor outer segments where chemical extraction s

246 dX) is a polytopic membrane protein found in photoreceptor outer segments where it is the principal e

247 otoreceptors, rather than at the base of the photoreceptor outer segments, where PROM1 is normally lo

248 and reduction to all-trans-retinol occur in photoreceptor outer segments whereas enzymatic esterific

249 lial (RPE) cells phagocytize and digest shed photoreceptor outer segment, which provides a rich sourc

250 Vision begins in photoreceptor outer segments with light captured by opsi

251 ght exposure promotes "oxidative tagging" of photoreceptor outer segments with structurally defined c