ライフサイエンスコーパス: phylloquinone

1 s A(0) (a monomeric chlorophyll a) and A(1) (phylloquinone).

2 les that contain unlabeled and (18)O-labeled phylloquinone.

3 dict this behavior for a C=O mode of neutral phylloquinone.

4 um is therefore due to a C=O mode of neutral phylloquinone.

5 e non hydrogen bonded C(1)=O mode of neutral phylloquinone.

6 ntify other loci contributing to circulating phylloquinone.

7 nt change in the orientation of the measured phylloquinone.

8 ors participate in the absorption of dietary phylloquinone.

9 ied as potential determinants of circulating phylloquinone.

10 r saline, both of which contained 154 microg phylloquinone.

11 he strength of the H-bond to the PsaA-branch phylloquinone.

12 haracteristic of asymmetric H-bonding to the phylloquinone.

13 oquinone and 96.2% with 6.6% RSD for labeled phylloquinone.

14 n average of 4.7 pmol mg(-1) fresh weight of phylloquinone.

15 n of both C=O groups of one electron reduced phylloquinone.

16 carbonyl (C=O) modes of neutral and reduced phylloquinone.

17 102+/-20 nmol x h/L for the lipid group for phylloquinone; 38.6+/-7.5 nmol x h/L for the saline grou

18 dult men and women by dietary restriction of phylloquinone (40 microg/d, days 1-11) and by administra

19 sphatidylcholine films, and were assigned to phylloquinone, A(1) (E(m) = -0.54 V) and iron-sulfur clu

20 omeric chlorophyll electron acceptor (A0), a phylloquinone (A1), and three [4Fe-4S] clusters (FX/A/B)

21 dy sheds new light on the orientation of the phylloquinone acceptors in their binding pockets in PS I

22 In postmenopausal women, phylloquinone administration is not associated with chan

23 ate to isochorismate for the biosynthesis of phylloquinone, an essential cofactor for photosynthetic

24 e lack of a significant difference in plasma phylloquinone and %ucOC between the 2 groups after eithe

25 ative standard deviation (RSD) for unlabeled phylloquinone and 96.2% with 6.6% RSD for labeled phyllo

26 hat menadione is a catabolic product of oral phylloquinone and a major source of tissue menaquinone-4

27 determination of both unlabeled and labeled phylloquinone and can be applied to bioavailability stud

28 phans (W693) is predicted to be close to the phylloquinone and has been implicated in the interaction

29 egerin was associated positively with plasma phylloquinone and inversely with %ucOC.

30 ive was to compare the biological effects of phylloquinone and its hydrogenated form, dihydrophylloqu

31 A1 binding site and that the reincorporated phylloquinone and its immediate protein environment, in

32 ulations in which the C4=O carbonyl group of phylloquinone and its methyl-less analogue are hydrogen

33 eutral" infrared difference spectra for both phylloquinone and its methyl-less analogue.

34 ted the methylation step in the synthesis of phylloquinone and led to the accumulation of 2-phytyl-1,

35 Better vitamin K status (high plasma phylloquinone and low %ucOC) was associated with lower b

36 ing the dithiotreitol-dependent reduction of phylloquinone and menaquinone into their respective quin

37 Vitamin K (as phylloquinone and menaquinones) is an essential cofactor

38 neutral infrared difference spectra for both phylloquinone and plastoquinone-9, it is shown that such

39 between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated

40 t as photosynthetic pigments; plastoquinone, phylloquinone and ubiquinone (all of which contain long

41 Changes in plasma phylloquinone and vitamin K1-2,3-epoxide were no differe

42 aB are pi-stacked with the head group of the phylloquinones and are H-bonded to Ser692PsaA and Ser672

43 hat connects the binding environments of the phylloquinones and FX.

44 ouplings attributed to the 2-methyl group of phylloquinone, and (iii) the orientation of Q(-) in the

45 naphthoquinone is in the same orientation as phylloquinone, and out-of-phase, spin-echo modulation sp

46 nd Cmax values for alpha-carotene, lycopene, phylloquinone, and retinyl palmitate.

47 essing and the absorption of 1) carotenoids, phylloquinone, and tocopherols in salad vegetables and 2

48 w that undercarboxylated osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid ex

49 hlorophyll a molecules (in three pairs), two phylloquinones, and a [4Fe-4S] cluster arranged in two p

50 ve previously assigned to a C:-O mode of the phylloquinone anion in WT A1(-)/A1 FTIR DS down-shifts a

51 tic resonance (EPR) signal attributed to the phylloquinone anion radical (A(1)(-)) can be observed ei

52 ymmetric vibration of both C=O groups of the phylloquinone anion should display exactly this behavior

53 BLT1 also decreased phylloquinone apical efflux by approximately 80%.

54 group, the C=O/C-:O modes of neutral/reduced phylloquinone are indeed expected to be upshifted by at

55 ons indicate that two, structurally distinct phylloquinones are photoaccumulated.

56 icles that were incubated in the presence of phylloquinone, are found to be very similar to those obt

57 ifference in the relative bioavailability of phylloquinone, as evidenced by the lack of a significant

58 Phylloquinone-associated decreases in CAC progression we

59 Dietary phylloquinone at baseline was significantly lower in sub

60 Associations with circulating phylloquinone at P < 1 x 10(-6) were then evaluated in a

61 morphism (SNP) associations with circulating phylloquinone at P < 1 x 10(-6), including a functional

62 ant association was observed for circulating phylloquinone at the genome-wide significance level of 5

63 ution of unlabeled ((16)O) and (18)O-labeled phylloquinone back into the A(1) binding site in menB ph

64 indicates that we were able to reincorporate phylloquinone back into the A1 binding site and that the

65 ort to identify amino acid residues near the phylloquinone binding sites, all tryptophans and histidi

66 quinone radical observed by EPR occupies the phylloquinone-binding site containing PsaA-Trp(693).

67 , genes that encode for proteins involved in phylloquinone biosynthesis can be deleted.

68 Populus ICS primarily functions in phylloquinone biosynthesis, a process that can be sustai

69 that the Arabidopsis enzymes are involved in phylloquinone biosynthesis.

70 cies of cyanobacteria cluster with predicted phylloquinone biosynthetic genes.

71 hotosystem (PS) I quinone acceptor, A(1), in phylloquinone biosynthetic pathway mutants are described

72 has a weak side chain cleavage activity for phylloquinone but a strong prenylation activity for mena

73 e in the PS I variant is fully occupied with phylloquinone, but the absence of methyl hyperfine coupl

74 700-A(1) cores shows that the replacement of phylloquinone by plastoquinone-9 induces a decrease in t

75 that when intravenously administered in mice phylloquinone can enter into tissues but is not converte

76 In these subjects the fraction of plasma phylloquinone carried by LDLs and by HDLs increased prog

77 her measures of vitamin K status (ie, plasma phylloquinone concentration and percentage of ucOC) did

78 Vitamin K status [plasma phylloquinone concentration and percentage of undercarbo

79 Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, wa

80 After supplementation, serum phylloquinone concentration increased approximately 10-f

81 At baseline, the mean serum phylloquinone concentration was lower in the young than

82 Plasma phylloquinone concentrations declined 82% with dietary p

83 Plasma phylloquinone concentrations determined by LC-fluorescen

84 meal for the measurement of plasma lipid and phylloquinone concentrations in plasma and lipoprotein s

85 usly measure unlabeled and deuterium-labeled phylloquinone concentrations in plasma specimens using h

86 Plasma phylloquinone concentrations increased significantly wit

87 Plasma phylloquinone concentrations peaked at 6 h.

88 For both younger and older adults, plasma phylloquinone concentrations were higher (P < 0.001) and

89 ne-specific alkaline phosphatase (BSAP), and phylloquinone concentrations were measured at baseline a

90 s, which was assessed with the use of plasma phylloquinone concentrations, the degree of under-gamma-

91 ly higher, and the proximal intestine mucosa phylloquinone content 4 h after gavage was increased in

92 was fed throughout both cycles; however, the phylloquinone content of one of the cycles was increased

93 y reduced DHNA-CoA thioesterase activity and phylloquinone content, establishing in vivo evidence tha

94 This approach was validated for phylloquinone, cyclosporine, testosterone undecanoate, c

95 A mixed diet containing 100 micrograms phylloquinone/d was fed throughout both cycles; however,

96 lower for each additional intake of 100 mug phylloquinone/d.

97 ted for 5 d with either broccoli (377 microg phylloquinone/d; broccoli diet) or phylloquinone-fortifi

98 -dwelling postmenopausal women received 1 mg phylloquinone daily for 12 mo (experimental group), and

99 n received a placebo daily for 1 wk and then phylloquinone daily for 3 wk: 500, 1000, and 2000 micro

100 photosensitivity to high light associated to phylloquinone deficiency in cyanobacteria.

101 f structural assignments and measurements of phylloquinone-derived menadione using high resolution MS

102 In comparison with phylloquinone, dihydrophylloquinone was less absorbed an

103 at certain C=C/C-:C modes of neutral/reduced phylloquinone do not shift upon replacement of the methy

104 KORC1, the Arabidopsis enzyme did not reduce phylloquinone epoxide, and was resistant to inhibition b

105 77 microg phylloquinone/d; broccoli diet) or phylloquinone-fortified oil (417 microg/d; oil diet).

106 Phylloquinone, found in dark-green vegetables and certai

107 lder adults, the relative bioavailability of phylloquinone from a vegetable with that of a fortified

108 olled study evaluated the bioavailability of phylloquinone from an intravenous lipid emulsion.

109 suggest that the relative bioavailability of phylloquinone from vegetables is lower than that from a

110 ial dilutions of either unlabeled or labeled phylloquinone gave correlation coefficients (R) of 0.999

111 no difference in CAC progression between the phylloquinone group and the control group; the mean (+/-

112 367), there was less CAC progression in the phylloquinone group than in the control group (P = 0.03)

113 sfer, involving both the PsaA- and PsaB-side phylloquinones, has been the source of some controversy.

114 ) Q(-) has a larger g-anisotropy than native phylloquinone, (ii) Q(-) does not display the prominent

115 bond is to tie up the C(4) carbonyl group of phylloquinone in a H-bond so as to prevent protonation a

116 ifferent from that seen with the infusion of phylloquinone in a saline solution.

117 ings support a potential beneficial role for phylloquinone in glucose homeostasis in men and women.

118 mutants contain plastoquinone-9 rather than phylloquinone in the A(1) site and show altered rates of

119 imated to be 50 to 60 mV more oxidizing than phylloquinone in the A(1) site, which translates to a lo

120 In menG mutant PS I, phylloquinone in the A1 binding site is replaced with an

121 (11 men and 15 women) aged 20-78 y received phylloquinone in the amount of either 1.43 or 50 microg/

122 zation pattern shows that the orientation of phylloquinone in the PS I complexes is identical to that

123 site with an orientation similar to that of phylloquinone in the wild type, and (iii) has spectrosco

124 from the spin polarization is that of native phylloquinone in the wild type.

125 olvement of both the PsaA- and the PsaB-side phylloquinones in photosystem I electron transport.

126 With the infusions, plasma phylloquinone increased in both groups (P = 0.001).

127 Phylloquinone intake (median: 45 microg/d) was not consi

128 icant interactions between the E4 allele and phylloquinone intake and BMD or hip fracture.

129 nd longitudinal associations between dietary phylloquinone intake and type 2 diabetes in elderly subj

130 We conclude that dietary phylloquinone intake is associated with reduced risk of

131 A daily phylloquinone intake of approximately 1000 micro g is re

132 Higher phylloquinone intake was associated with greater insulin

133 by using a food-frequency questionnaire, and phylloquinone intake was estimated by using the USDA dat

134 Phylloquinone intake was not associated with fasting ins

135 otal body, lumbar spine, and hip and dietary phylloquinone intake were measured annually for 4 y.

136 ed by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circ

137 ho decreased or did not change the amount of phylloquinone intake.

138 Dietary and supplemental phylloquinone intakes were assessed by using a food-freq

139 Vitamin K1 (phylloquinone) intestinal absorption is thought to be me

140 These findings raise the question whether phylloquinone is absorbed and delivered to tissues in it

141 It is therefore surprising that each phylloquinone is hydrogen bonded at the C(4) position to

142 When the biosynthesis of phylloquinone is inhibited in Synechocystis sp. PCC 6803

143 An adult daily intake of about 100 microg of phylloquinone is recommended for the maintenance of hemo

144 Phylloquinone is the one-electron carrier at the A(1) si

145 t photosystem 1 particles in the presence of phylloquinone, it was shown in another study that phyllo

146 ha-tocopherol (E), gamma-tocopherol (E), and phylloquinone (K1) by LC-MS/MS.

147 the 11 subjects supplemented with 50 microg phylloquinone/kg, plasma lipoproteins were isolated by s

148 samples spiked with between 0.5 and 32 nmol phylloquinone/L gave average recoveries of 96.7% with 5.

149 -rich lipoproteins are the major carriers of phylloquinone, LDL and HDL may carry small fractions of

150 space narrowing (JSN) per quartile of plasma phylloquinone level for each joint, adjusting for correl

151 nts with each feature per quartile of plasma phylloquinone level.

152 creased significantly with increasing plasma phylloquinone levels (P<or=0.03 for all).

153 creased significantly with increasing plasma phylloquinone levels (PR decreased from 1.0 to 0.6, P=0.

154 For example, as plasma phylloquinone levels rose, the PR for hand OA decreased

155 be seedling lethal, to contain no detectable phylloquinone (< 0.1 pmol mg(-1) fresh weight) compared

156 ly associated with warfarin dose and altered phylloquinone metabolism.

157 More specifically, calculations on a phylloquinone model molecule with the C(4)=O group hydro

158 A phylloquinone molecule (2-methyl, 3-phytyl, 1, 4-naphtho

159 A phylloquinone molecule (2-methyl-3-phytyl-1,4-naphthoqui

160 hotosystem I from plants and cyanobacteria a phylloquinone molecule, called A1, functions as the seco

161 d with (3)P700 are observed, indicating that phylloquinone occupies the A1 site in all of the reconst

162 further understand the potential benefits of phylloquinone on bone acquisition in growing children.

163 idose warfarin and of dietary restriction of phylloquinone on hemostasis and vitamin K nutritional st

164 This could indicate that phylloquinones on both the PsaA and PsaB branches are in

165 ctron transfer, involving only the PsaA-side phylloquinone or bi-directional electron transfer, invol

166 10 d of repletion (200 microg/d) with either phylloquinone or dihydrophylloquinone.

167 ) and with the A(1) binding site occupied by phylloquinone or plastoquinone-9.

168 olism), COL22A1, CDO1, CTNAA2, and CYP4F2 (a phylloquinone oxidase), respectively.

169 By specifically labeling only the phylloquinone oxygen atoms we are able to identify bands

170 ciation of the 5q22.3 locus with circulating phylloquinone (P < 0.05).

171 provide a supplemental amount of 150 microg phylloquinone per day in addition to that present natura

172 none was defined by the difference in plasma phylloquinone, percentage serum undercarboxylated osteoc

173 Interruption of the phylloquinone (PhQ) biosynthetic pathway by interposon m

174 tion that the oxidation rates of the reduced phylloquinone (PhQ) cofactor differ by an order of magni

175 sting of a pair of chlorophylls (Chls) and a phylloquinone (PhQ).

176 Phylloquinone postprandial response was also significant

177 In vivo, the phylloquinone postprandial response was significantly hi

178 We propose that in the absence of phylloquinone, PS I recruits plastoquinone-9 into the A(

179 tigated using site-directed mutations in the phylloquinone (QK) and FX binding regions of Synnechocys

180 These observations indicate that the A(1)(-) phylloquinone radical observed by EPR occupies the phyll

181 ectra, a difference spectrum associated with phylloquinone reduction (A(1)(-) - A(1)) has been calcul

182 ue to a C=O/C-:O mode of the neutral/anionic phylloquinone, respectively.

183 iated with C=C/C-:C modes of neutral/reduced phylloquinone, respectively.

184 a metabolic unit, 15 young adults were fed a phylloquinone-restricted diet (10 microg/d) for 15 d fol

185 -type design, 13 healthy volunteers eating a phylloquinone-restricted diet for 35 d were randomly ass

186 or percentage ucOC concentrations during the phylloquinone-restricted diet or during the period of di

187 The mean value for PIVKA-II during the phylloquinone-restricted diet significantly increased 5.

188 combination of omeprazole treatment and the phylloquinone-restricted diet significantly reduced PIVK

189 one concentrations declined 82% with dietary phylloquinone restriction (P < 0.05) and were not signif

190 002) and resorption (P = 0.08) after dietary phylloquinone restriction and repletion, respectively.

191 ribute to vitamin K nutriture during dietary phylloquinone restriction, but not enough to restore nor

192 yperfine coupling of the methyl group on the phylloquinone ring, whereas the S692CPsaA mutation cause

193 To investigate the environment of the phylloquinone secondary electron acceptor A(1) within th

194 were randomly assigned to receive placebo or phylloquinone supplementation (250, 375, 500, and 1000 m

195 In substudy A, %ucOC decreased with phylloquinone supplementation (P < 0.0001); a greater re

196 entrations between participants who received phylloquinone supplementation and those who did not.

197 mma-carboxylation as assessed by response to phylloquinone supplementation and to evaluate the effect

198 Phylloquinone supplementation decreased %ucOC dose-depen

199 ntrations and 2) the effect of daily 500 mug phylloquinone supplementation for 3 y on cytokine concen

200 Phylloquinone supplementation increases osteocalcin gamm

201 Phylloquinone supplementation reduced serum osteocalcin

202 Phylloquinone supplementation reduced serum osteocalcin

203 Phylloquinone supplementation slows the progression of C

204 Randomized phylloquinone supplementation trials are needed to furth

205 h 10 by fortifying corn oil in the diet with phylloquinone (supplemented diet).

206 AC (Agatston score > 10), those who received phylloquinone supplements had 6% less progression than d

207 bidopsis mutants deficient in early steps of phylloquinone synthesis do not become autotrophic and ar

208 4-dihydroxy-2-naphthoate, an intermediate in phylloquinone synthesis downstream of the OSB-CoA ligase

209 other evidence suggests that the enzymes of phylloquinone synthesis from isochorismate may form a co

210 enzoyl-coenzyme A (OSB-CoA) ligase acting in phylloquinone synthesis.

211 esult, knockout cells contained 13-fold less phylloquinone than their wild-type counterparts and disp

212 ntified a plastidial pool of non-photoactive phylloquinone that could be involved in additional cellu

213 otosystem I (PS I) contains two molecules of phylloquinone that function as electron transfer cofacto

214 In addition, phylloquinone that has asymmetrically hydrogen bonded ca

215 s, each consisting of two chlorophylls and a phylloquinone, that potentially link the primary electro

216 Levels of plasma phylloquinone (the primary form of vitamin K) had previo

217 ssociated with concentrations of circulating phylloquinone, the primary circulating form of vitamin K

218 aphthoquinone in the biosynthetic pathway of phylloquinone, the secondary electron acceptor in photos

219 zymes of the biosynthetic pathway leading to phylloquinone, the secondary electron acceptor of photos

220 se, respectively, prevented the synthesis of phylloquinone, thereby confirming the participation of t

221 Before administration of the placebo or phylloquinone, total osteocalcin, ucOC, glucose, and ins

222 Phylloquinone uptake by Caco-2 cells was saturable and w

223 Phylloquinone uptake was then measured ex vivo using mou

224 ndercarboxylated osteocalcin (ucOC)], plasma phylloquinone, urinary gamma-carboxyglutamic acid, and p

225 e the only organisms capable of synthesizing phylloquinone (vitamin K for vertebrates), which they us

226 sary step to form the naphthoquinone ring of phylloquinone (vitamin K(1) ).

227 ctive of this study was to determine whether phylloquinone (vitamin K(1)) intake and biochemical indi

228 Phylloquinone (vitamin K(1)) is a bipartite molecule tha

229 Phylloquinone (vitamin K(1)) is a lipophilic compound pr

230 udy assessed the ability of various doses of phylloquinone (vitamin K(1)) to facilitate osteocalcin g

231 characterize the absorption and transport of phylloquinone (vitamin K1) by plasma lipoproteins.

232 Low phylloquinone (vitamin K1) intake is a potential risk fa

233 Mice have the ability to convert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K

234 The objective was to determine the effect of phylloquinone (vitamin K1) supplementation on CAC progre

235 Serum phylloquinone (vitamin K1) was measured in 296 participa

236 ylquinone (including tocopherol [vitamin E], phylloquinone [vitamin K] and plastoquinone) metabolism

237 as assessed by serial measurements of plasma phylloquinone, vitamin K1-2,3-epoxide.

238 s formulated to contain different amounts of phylloquinone was assessed in nine healthy subjects aged

239 ring the postprandial phase, > 53% of plasma phylloquinone was carried by the triacylglycerol-rich li

240 The relative bioavailability of phylloquinone was defined by the difference in plasma ph

241 Phylloquinone was extracted from plasma using hexane, fu

242 Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP

243 Plasma phylloquinone was inversely associated with NTx and oste

244 Circulating phylloquinone was measured by using reversed-phase high-

245 likely for C=O/C-:O modes of neutral/anionic phylloquinone, we have used density functional theory to

246 able concentrations of unlabeled and labeled phylloquinone were 0.05 and 0.08 pmol/injection, respect

247 hydroxyvitamin D2, 25-hydroxyvitamin D3, and phylloquinone) were 25, 17, and 0.33 nM, respectively, w

248 ron transfer from the secondary acceptor A1 (phylloquinone) were measured in mutants using time-resol

249 4-mutant plants were also able to synthesize phylloquinone when provided with 1,4-dihydroxy-2-naphtho

250 oquinone, it was shown in another study that phylloquinone will displace plastoquinone-9 in the A(1)