ライフサイエンスコーパス: physical dependence

1 ay in mediating ethanol withdrawal symptoms (physical dependence).

2 similar to wild-type mice but fewer signs of physical dependence.

3 propensity to induce reward or aversion and physical dependence.

4 limited by the development of tolerance and physical dependence.

5 tially reduced antinociceptive tolerance and physical dependence.

6 nt the development of morphine tolerance and physical dependence.

7 awal signs, indicative of the development of physical dependence.

8 without producing cannabimimetic effects or physical dependence.

9 ays independent of these factors can mediate physical dependence.

10 changes may be involved in the expression of physical dependence.

11 eptive tolerance and the subsequent onset of physical dependence.

12 t appear to elicit opioid-like withdrawal or physical dependence.

13 lated with a reduction in the development of physical dependence.

14 s in the development of opiate tolerance and physical dependence.

15 alcohol consumption, alcohol-induced ataxia, physical dependence after chronic alcohol exposure, and

16 awal hyperalgesia is a reliable indicator of physical dependence after chronic morphine treatment.

17 nol treatment (12 days) sufficient to induce physical dependence also did not shift sensitivity or ma

18 chronic use, opiates can produce tolerance, physical dependence and addiction.

19 are expressed as adverse effects, including physical dependence and compulsive drug-seeking behavior

20 clarify complex mechanisms underlying opioid physical dependence and opioid addiction.

21 On the other hand, both physical dependence and tolerance were suppressed at MDA

22 SC, contributes to the development of opioid physical dependence and withdrawal effects.

23 diction treatment to date have addressed the physical dependence and withdrawal that accompany addict

24 leus is involved in the expression of opiate physical dependence and withdrawal, and has been charact

25 ), a noradrenergic nucleus, is implicated in physical dependence and withdrawal, whereas the ventral

26 delayed tolerance, and exacerbated morphine physical dependence and withdrawal.

27 repeated use is known to produce tolerance, physical dependence, and addiction; these properties lim

28 8) in morphine-induced analgesia, tolerance, physical dependence, and conditioned place preference, w

29 f addictive drugs: sensitization, tolerance, physical dependence, and euphoria/elation.

30 phine, elicited no respiratory depression or physical dependence, and only limited inhibition of gast

31 , chronic opioids cause analgesic tolerance, physical dependence, and opioid addiction, common clinic

32 olerance can be genetically dissociated from physical dependence, and thus provide a genetic framewor

33 symptoms, such as craving, loss of control, physical dependence, and tolerance, have been linked to

34 ratory depression, significant constipation, physical dependence, and, perhaps most important, reinfo

35 genetic background show attenuated signs of physical dependence, as measured by the classic signs of

36 tenuates development of opioid tolerance and physical dependence, as previously shown to occur during

37 naloxone-precipitated withdrawal-jumping in physical dependence assays.

38 g effects of morphine and led to exacerbated physical dependence, but also reduced their sensitivity

39 to its acute analgesic effects, and profound physical dependence by sustained activation of these rec

40 in adolescents is related to development of physical dependence, ethnicity, impulsivity, affective d

41 Chronic MAGL blockade also caused physical dependence, impaired endocannabinoid-dependent

42 ide effects such as ethanol potentiation and physical dependence in animal models.

43 Chronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism and ne

44 d neuronal inhibition but also contribute to physical dependence, including withdrawal after abrupt c

45 pears that tolerance can be dissociated from physical dependence, indicating a role for PKC and PKA t

46 Moreover, NNTA produced neither significant physical dependence nor place preference in the ED50 dos

47 delta opioid receptors in the tolerance and physical dependence of mu opioid receptor agonists, we h

48 In contrast, monkeys did not show physical dependence on BU08028.

49 ndicate that tPA mediates the development of physical dependence on ethanol by regulating NR2B-contai

50 Computational genetic analyses of physical dependence on morphine across 23 mouse strains

51 morphine-induced analgesia and tolerance and physical dependence on morphine arise have been the subj

52 inergic pathways, these results suggest that physical dependence on morphine can be suppressed to a s

53 us system--in development and maintenance of physical dependence on morphine in the mouse spinal cord

54 Interestingly, the signs of physical dependence on morphine in the transgenic mice d

55 eased GABA release frequency correlated with physical dependence on morphine measured by counting som

56 administration, the monkeys developed acute physical dependence on morphine, as manifested by precip

57 ry in these strains after the induction of a physical dependence on morphine.

58 he spinal cord contributes to development of physical dependence on morphine.

59 n is thought to represent certain aspects of physical dependence on nicotine.

60 ell as loss of place-preference activity and physical dependence on this opioid.

61 anxiolysis, and the elicitation of signs of physical dependence on withdrawal.

62 reatment, sufficient to induce tolerance and physical dependence, on GABAA receptor function was stud

63 reatment, sufficient to induce tolerance and physical dependence, on N-methyl-D-aspartate (NMDA) rece

64 xA does not depress respiration or result in physical dependence or reward behavior, suggesting it ac

65 ansport mechanism or that the development of physical dependence (or the inhibition of abstinence-ind

66 reatment, sufficient to induce tolerance and physical dependence, probably does not lead to readily d

67 The modest physical dependence produced by Delta9-THC as well as it

68 ce more slowly than morphine, showed limited physical dependence, respiratory depression, constipatio

69 antly attenuated (P<0.05) the development of physical dependence, shown by an attenuated withdrawal s

70 -4-ones were active in an acute electroshock physical dependence side effect assay in mice precluding

71 pal FIN given only during the development of physical dependence significantly increased EtOH withdra

72 e analgesia was not altered, and neither was physical dependence to chronic morphine.

73 of tests to assess analgesia, tolerance, and physical dependence to morphine.

74 gonucleotide also reduced the development of physical dependence to opiates, based on attenuation of

75 using the warm-water tail immersion test and physical dependence was evaluated by quantifying/scoring

76 he expected tolerance response, whereas less physical dependence was observed than with chronic morph

77 elf-administration, analgesic tolerance, and physical dependence, we hypothesize that decreased melan

78 mice; however, development of tolerance and physical dependence were greatly reduced.

79 l syndrome, indicative of the development of physical dependence, when they were tested in cocaine- (

80 rphine tolerance and reward without altering physical dependence, whereas the exon 4-associated trunc