ライフサイエンスコーパス: physical interaction

1 MOS1 and TCP proteins have a direct physical interaction.

2 ion of one another by virtue of their direct physical interaction.

3 sufficient for suppression of PKR via direct physical interaction.

4 n and proteasomal degradation of Vif through physical interaction.

5 f MtRS and it renders HIF-1alpha inactive by physical interaction.

6 regulation by ceftriaxone is not mediated by physical interaction.

7 efense responses by suppressing LSU2 through physical interaction.

8 e collaboration is not dependent on a stable physical interaction.

9 , this work is the first report of an Eya-Ey physical interaction.

10 nd provided quantitative insights into their physical interactions.

11 9 promotes IR by antagonizing EFTUD2 through physical interactions.

12 ectronic structure to spin Hamiltonians with physical interactions.

13 hat the predicted edges are likely bona fide physical interactions.

14 e model that has all its components based on physical interactions.

15 cells, we provide evidence for a network of physical interactions among all 44 TGCT risk SNPs and ca

16 ransgenic larvae, we directly detect in vivo physical interactions among PPK and Balboa subunits.

17 tail of ERManI was sufficient to disrupt the physical interaction and ablate NHK degradation.

18 ites in Osx or Runx2 strongly disrupts their physical interaction and cooperative transcriptional eff

19 NIH-2/3 extracellular loop required for both physical interaction and gating modulation of the AMPAR.

20 ons in BRR2 and PRP16 suppresses or enhances physical interaction and growth defects in an allele-spe

21 peptide known to activate the SERCA pump by physical interaction and provides a means for enhancing

22 criptional regulation of gene expression via physical interaction and recruitment of RNA decay machin

23 acities is discussed, mainly focusing on the physical interactions and chemical reactions.

24 lution states, as dictated by the collective physical interactions and geometric constraints.

25 k miR targets based on estimated strength of physical interactions and lack the ability to rank inter

26 uster into a densely connected subnetwork of physical interactions and many of them are epigenetic mo

27 undamental neural processes underlying human physical interactions and suggest advantages of interact

28 and caregivers with an understanding of the physical interactions and tasks to manage safety risks a

29 /3-SMIT1/2 coassembly permits cross talk via physical interaction, and may also be required for optim

30 ilarly, thalidomide inhibited the TBX5/HAND2 physical interaction, and the in silico docking revealed

31 ortantly, Scc2 cleavage eliminates Scc2-Scc4 physical interactions, and an scc2 truncation mutant tha

32 ansgenic constructs, phenotypes, genetic and physical interactions, and reagents such as stocks and c

33 ate of both Aurora and IKK kinases and their physical interactions, and the blockade of Aurora kinase

34 These physical interactions are direct, as Coy1 was efficientl

35 The associations in STRING include direct (physical) interactions, as well as indirect (functional)

36 owed that ChromNet revealed previously known physical interactions better than alternative approaches

37 ation capture revealed a long range (570 kb) physical interaction between a sub-region of the risk lo

38 Independent of phylogenetic distance, the physical interaction between an animal and its natural e

39 thin APLF that is required for mediating the physical interaction between APLF and Ku.

40 growth by apoptotic targets is dependent on physical interaction between apoptotic targets and PTECs

41 We identified a direct physical interaction between ATDC and the E3 ubiquitin l

42 Axl activation by Axl-Fc interferes with the physical interaction between Axl and FLT3.

43 We also demonstrate a physical interaction between BORIS and one of the analyz

44 We also probed a physical interaction between both proteins.

45 We provide evidence for physical interaction between both proteins.

46 Previous studies indicated that the physical interaction between C. albicans and F. nucleatu

47 a complex multifaceted mechanism underlying physical interaction between C. albicans and F. nucleatu

48 In conclusion, we demonstrate a physical interaction between calcineurin Abeta and casse

49 We further identify the physical interaction between CCAT2 and TCF7L2 resulting

50 A physical interaction between Chl1 and the cohesin comple

51 ssembly process starting from the underlying physical interaction between conductors.

52 Here, we set out to characterize the physical interaction between CRD-BP and GLI1 mRNA so as

53 binding constants of effector proteins, and physical interaction between cyclases and effectors.

54 e conclude the inhibition is achieved by the physical interaction between Dact2 and Pitx2 proteins.

55 ining entry factor usage and imply a direct, physical interaction between E1 and CLDNs.

56 activity indicates that it results from the physical interaction between ELF3 and AR and that this i

57 Further, for the first time, the physical interaction between EmoA and EmoB was observed

58 cell fractionation and confocal microscopy; physical interaction between HDAC4/Rad51/Ubc9 by immunop

59 Thus, multiple lines of evidence indicated a physical interaction between hERG1a and hERG1b, consiste

60 Physical interaction between hMOB3 and MST1 was essentia

61 lter splicing because they change the direct physical interaction between Hsh155p and Prp5p.

62 In miRNA-mediated gene silencing, the physical interaction between human Argonaute (hAgo) and

63 ECs and activates calmodulin to facilitate a physical interaction between Kruppel-like factor 2 (KLF2

64 anonical NF-kappaB pathway, which requires a physical interaction between ks-vFLIP and the IKK kinase

65 n experiments indicate that an RNA-dependent physical interaction between L1 ORF1p and A3C dimers is

66 The physical interaction between low polymeric forms of CSQ1

67 We uncover a direct physical interaction between Magi and the Ras associatio

68 The physical interaction between Malat1 and apoptotic or inf

69 Biochemical experiments establish a direct physical interaction between Mcc and the Vangl2 cytoplas

70 Co-immunoprecipitation experiments suggested physical interaction between MED14 and HIV-1 Tat protein

71 below the surface epithelium and thus permit physical interaction between microbes and dermal cells.

72 Additionally, we demonstrate physical interaction between MIF and three receptors: CX

73 in newly synthesized viral RNA and feature a physical interaction between mitochondrial membranes and

74 However, the physical interaction between Myosin and actin filaments

75 These results indicate that the physical interaction between NANOG and TET1/TET2 protein

76 the peripersonal space (PPS), mediates every physical interaction between our body and the environmen

77 In the presence of SETD6, the physical interaction between PAK4 and beta-catenin is dr

78 We reveal a physical interaction between PDGFRalpha and PDGFRbeta in

79 ured VSMCs and aneurysmal aorta demonstrated physical interaction between PKCdelta and p65 that took

80 Physical interaction between Pph3 and Mec1, mediated by

81 previously that residues not involved in the physical interaction between proteins make important con

82 regulated Ser-727 phosphorylation, whereas a physical interaction between RET/PTC3 and STAT1, followe

83 nce energy transfer) assay revealed that the physical interaction between Rho molecules expressed in

84 Together with a physical interaction between RPGR and the C-terminal dom

85 Here, we report a functional and physical interaction between RPS3 and RECQL4 and show th

86 In the described approach, the physical interaction between sets of designed nanopartic

87 (ii) Physical interaction between SIM362-364 and PML II is ne

88 nscript Antisense Intergenic RNA) mediates a physical interaction between Snail and enhancer of zeste

89 These results provide evidence of a physical interaction between specific photosystem II lig

90 This activity requires a physical interaction between Srs2 and Rad51, which stimu

91 Moreover, we show that the physical interaction between TAP2 and TPN is disrupted b

92 t in polar leaf and/or meristem development, physical interaction between target gene product and HD-

93 Here, we describe a physical interaction between TDP-43, an RNA-binding prot

94 m (ER) and the DMS were detected, suggesting physical interaction between the 2 membrane systems.

95 e demonstrate that there is a functional and physical interaction between the ABC transporter and the

96 ain were demonstrated to be required for the physical interaction between the ARC2 and LRR.

97 Indeed, we identify a physical interaction between the autoinhibitory N termin

98 y and sensorimotor interface mediating every physical interaction between the body and the environmen

99 r experiments provide strong evidence that a physical interaction between the C-terminal and catalyti

100 Our results demonstrate a direct physical interaction between the C-terminal domains of t

101 matin conformation capture (3C) identified a physical interaction between the enhancer element contai

102 ergies of >/=1 kcal/mol, indicating a close, physical interaction between the ligand and residue 195

103 2X4R in HF and is the first to demonstrate a physical interaction between the myocyte receptor and eN

104 Physical interaction between the N terminus of BK-beta1

105 also been suggested to be widespread, is the physical interaction between the promoter and 3' end of

106 The physical interaction between the proteins was confirmed

107 A physical interaction between the protomers was confirmed

108 rminal CCT/PF2 domain, which is required for physical interaction between the Ste20 kinases and the N

109 The physical interaction between the two proteins through a

110 creasing water conductance through AQP1 by a physical interaction between the two proteins.

111 ion and degradation and is implicated in the physical interaction between the two proteins.

112 d this co-localization is mediated through a physical interaction between the two TLS pols.

113 (EC) coupling in skeletal muscle requires a physical interaction between the voltage-gated calcium c

114 Here, we demonstrate that a physical interaction between the X-linked mental retarda

115 NCX, coimmunoprecipitation studies showed a physical interaction between them.

116 Thus, the Cga eRNA mediates the physical interaction between these genomic regions and d

117 d mobility similar to BRCA2, which indicates physical interaction between these proteins both before

118 anisotropy nanodisc assays revealed a direct physical interaction between TMEM219 and IL-13Ralpha2-Ch

119 tion experiments, we further demonstrate the physical interaction between Top1p and Sir2p.

120 hagy and observed a functionally significant physical interaction between transcription factor EB (TF

121 tein complementation assay revealed a direct physical interaction between TRIB1 and Foxp3 in live cel

122 Coimmunoprecipitation confirmed a physical interaction between TRPV5 and MUC1.

123 ist and presented a structural basis for the physical interaction between TSP-1 and BMP-4.

124 Various methods can provide a readout of the physical interaction between two biomolecules.

125 The physical interaction between VER2 and TaGRP2 is controll

126 ) complex (or signalosome), which involves a physical interaction between vFLIP and the modulatory su

127 methodology to systematically create binary physical interactions between a query protein and most o

128 Genetic and physical interactions between ALB4 and ALB3, and physica

129 ical interactions between ALB4 and ALB3, and physical interactions between ALB4 and cpSRP, suggest th

130 Evidence suggests physical interactions between apoE and Abeta are partial

131 In addition, we observed direct physical interactions between Blm and two telomere-bindi

132 Finally, direct physical interactions between calmodulin and TMEM16A cou

133 Physical interactions between CB1 and D2L were observed

134 tion capture technologies (e.g., Hi-C) chart physical interactions between chromatin regions on a gen

135 borated by biochemical studies demonstrating physical interactions between Coa6, Cox2, Cox12 and Sco

136 These results indicate both genetic and physical interactions between disease-linked RBPs and DN

137 i-C) allows the genome-wide interrogation of physical interactions between distal DNA regulatory elem

138 lly regulated transcription often depends on physical interactions between distal enhancers and their

139 ween nuclear structure and function, and the physical interactions between distal regulatory elements

140 Disrupting physical interactions between FAMA and RBR preferentiall

141 iquitylation reaction necessitates transient physical interactions between FBXW11 and its substrates,

142 agents not interacting with each other, (ii) physical interactions between inanimate objects, and (ii

143 ndings have important implications about the physical interactions between LPS and lipids and demonst

144 distal tips of microvilli, where they drive physical interactions between neighboring protrusions.

145 Identifying physical interactions between proteins and other molecul

146 The physical interactions between proteins constitute the ba

147 opology and intracellular localization, (vi) physical interactions between proteins from the database

148 (SIMs), protein-group SUMOylation may foster physical interactions between proteins through multiple

149 -domain interactions (DDIs) that mediate the physical interactions between proteins.

150 We identified novel physical interactions between retromer and the Saccharom

151 We identified significant physical interactions between risk regions and their pot

152 n binding domain on Kv4.3 was used to assess physical interactions between SEMA3A and Kv4.3.

153 gnetic resonance spectroscopy, we mapped the physical interactions between SERCA and both unphosphory

154 Direct physical interactions between the APE1-Polbeta, APE1-TDP

155 Moreover, physical interactions between the BBS and ADPKD proteins

156 Even in the absence of direct physical interactions between the binding partners, such

157 whether these binding site patterns reflect physical interactions between the corresponding TFs, we

158 Our findings highlight the role of the physical interactions between the cytoskeletal network a

159 These results indicate that physical interactions between the tandem C2 domains of s

160 vely, we investigated whether genetic and/or physical interactions between the two proteins could exp

161 predicted complexes have a higher number of physical interactions between their members than expecte

162 led beating rates of cardiomyocytes, and the physical interactions between these cells increased neur

163 the tissue and subcellular levels, allowing physical interactions between these proteins.

164 Physical interactions between these receptors have never

165 ex, I1 dynein failed to assemble, suggesting physical interactions between these three axonemal compl

166 This highlights the importance of physical interactions between tissues during morphogenes

167 We also uncovered new genetic and physical interactions between TRAMP and several splicing

168 this information, we defined functional and physical interactions between VAPB and proteostasis regu

169 Importantly, abrogation of the Rad53-Dbf4 physical interaction blocked Dbf4 phosphorylation and al

170 roader functional context and by considering physical interactions both within and across complexes a

171 cription complex AR-p44-Smad1, confirmed for physical interaction by co-immunoprecipitaion and functi

172 ed by proteins whose structural features and physical interactions can alter the length scale at whic

173 layers, accounting for different genetic and physical interactions, each containing thousands of prot

174 a transcriptional repressor, and BLH6-KNAT7 physical interaction enhances KNAT7 and BLH6 repression

175 A fundamental physical interaction exists across the synapse.

176 A specific physical interaction exists between the Parkinson diseas

177 xperiments, structure-function analysis, and physical interaction experiments argue that Fat negative

178 ) that distinguishes the contribution of the physical interactions from the charge-transfer (CT) "che

179 actions, the collapse allows us to probe the physical interactions governing the dimensions of disord

180 pression of PKM1 and PKM2 and their possible physical interaction in cancer cells.

181 n trans at genomic segments with evidence of physical interaction in Hi-C chromosome conformation dat

182 invasive breast carcinoma cells, where, upon physical interaction in same cell-surface complexes, MT1

183 sing optical tweezers, we tested the dynamic physical interaction in vivo.

184 ormation can alter the rates and outcomes of physical interactions in biological systems.

185 ivation-strain model calculations to analyze physical interactions in heteroaromatic azadiene-alkene

186 ne receptors (nAChRs) display functional and physical interactions in many cell types and heterologou

187 d WUS share common targets in vivo and their physical interaction is important in driving downstream

188 el of inhibition of gene expression in which physical interaction is more important than enzymatic ac

189 The molecular basis for the Rad53-Dbf4 physical interaction is not clear but occurs through the

190 d proteins of unknown function, we created a physical interaction map by measuring biophysical intera

191 interact with PCGF1 in a subsequent round of physical interaction mapping experiments.

192 ested that hub proteins in the S. cerevisiae physical interaction network are more likely to be essen

193 The resulting high-quality physical interaction network, comprising 77% of targeted

194 Here we characterize the physical interaction of ACT with FHA and provide evidenc

195 Interactome analyses further revealed the physical interaction of cavin-1 and caveolin-1 and their

196 echanisms and functional consequences of the physical interaction of channels with transporters have

197 Co-IP experiments confirmed the physical interaction of COH1 with RAB6 that preferential

198 By demonstrating a physical interaction of CPR5 with bZIP60 and bZIP28, we

199 mechanism of action revealed a preferential physical interaction of FAU with mutant CFTR, leading to

200 erformed immunoprecipitations and detected a physical interaction of IkappaB-zeta with both p50 and p

201 tein interaction analyses suggest the direct physical interaction of LIL3 with POR but not with chlor

202 iated factor-2, IRF-3/7, or IFN-beta but the physical interaction of MAVS with caspase-8 on mitochond

203 The physical interaction of Myc with the E-box DNA motif has

204 luorescence complementation assay confirms a physical interaction of NTRC with GluTR1 and CHLM.

205 CP) subunit of the F1FO-ATP synthase and the physical interaction of OSCP with amyloid beta (Abeta) i

206 Moreover, we demonstrate the physical interaction of OST1 with the inward K(+) channe

207 Thus, in different DNA contexts, the physical interaction of Rad51 with Srs2 can either stimu

208 rminus of SOCS36E, which is required for the physical interaction of SOCS36E with Dome.

209 Coimmunoprecipitation analysis revealed the physical interaction of Srb5/Med18 with the CF1 complex.

210 Thus physical interaction of TDG with PCNA through the PIP de

211 Here, we identify a gene loop involving the physical interaction of the 5' and 3' flanking regions o

212 ite of esterification is associated with the physical interaction of the major SOAT, acyl-coenzyme A:

213 We provide evidence for the genetic and physical interaction of the prion protein Rnq1 with Sup3

214 Genetic and physical interaction of the receptor-like kinases ACR4 a

215 ct Vpu-BST-2 interactions suggested that the physical interaction of Vpu with rhesus or chimpanzee BS

216 namics of the 16p11.2 network by integrating physical interactions of 16p11.2 proteins with spatiotem

217 , we investigated in vivo the functional and physical interactions of AcrAB with the closed TolC and

218 We first excluded physical interactions of both channels using radioligand

219 formation capture (4C-seq) identified direct physical interactions of elements within 11p13.

220 Determination of the physical interactions of environmental chemicals with ce

221 STZ diabetic hearts display increased physical interactions of OGA with alpha-actin, tropomyos

222 We studied genetic and physical interactions of p24alpha (Erp1, -5, and -6) and

223 investigate the role of PCGF1, we mapped the physical interactions of the protein under endogenous co

224 allow an agnostic characterization of these physical interactions on a genome-wide scale.

225 Networks formed by physical interactions or homological relationships betwe

226 Because these networks are mainly based on physical interactions, our designs could be expanded to

227 , identifying over 70 previously undescribed physical interaction partners for the complex and over 1

228 We identified 29 novel physical interaction partners of Spin and focused on the

229 These physical interactions place Usp15 in the vicinity of act

230 nd a temporal one, exhibited both social and physical interaction preference, which, in the temporal

231 The favorable physical interaction properties enable selective treatme

232 Here, we show that CPG2, through a direct physical interaction, recruits endophilin B2 (EndoB2) to

233 This altered physical interaction results in altered loading (i.e., "

234 By physical interaction, Saw1 facilitates targeting of Rad1

235 DAPK attenuated STAT3 activity directly by physical interaction shown in three-dimensional structur

236 Since physical interactions such as dispersion and polarizatio

237 are enriched for regulators with genetic or physical interactions, supporting the inference, and ide

238 We conclude that CaV1.2 Asp-181 anchors the physical interaction that facilitates the CaValpha2delta

239 Compared with physical interactions, the chemical anchorage results in

240 ation of perturbations in local chemistry or physical interactions through an impact on global dynami

241 ing of polycomb repressive complex 2 through physical interaction, thus maintaining H3K27me3 marks at

242 domain through its KRAB domain, and both its physical interaction to GR and zinc finger domain appear

243 We observed the motor adaptations during physical interactions to be mutually beneficial such tha

244 n of the peptide was essential to facilitate physical interaction via a single binding site involving

245 ate lid of mortalin were necessary for these physical interactions, which is consistent with conventi

246 ry integration by an individual, but require physical interaction with a reactive partner.

247 omain mediates abscisic acid signaling via a physical interaction with ABI5-related bZIP proteins.

248 SWCNT sidewalls, thereby reducing potential physical interaction with algal cells.

249 Here, we show that ERG, through its physical interaction with androgen receptor, induces AR

250 at least in part, dependent on their direct physical interaction with complexes responsible for modu

251 gulates ETI and the associated PCD through a physical interaction with cyclin-dependent kinase inhibi

252 an ethylene (ET)-dependent pathway involving physical interaction with different ACC SYNTHASE (ACS) i

253 Physical interaction with DVL is essential for the Wnt i

254 Physical interaction with ERAP2 changes basic enzymatic

255 (Sesn-C) modified this motif to accommodate physical interaction with GATOR2 and subsequent inhibiti

256 s LCB1/LCB2 heterodimer by >100-fold through physical interaction with LCB1/LCB2.

257 iates with CFSs in early mitosis through its physical interaction with MUS81 and promotes MUS81-depen

258 ono-ubiquitination of Myosin II promotes its physical interaction with Myosin VIIa, a protein respons

259 AR affects sodium channel function through a physical interaction with NaV1.5.

260 he H3K27me3-silencing mark, validating their physical interaction with PRC2 components.

261 disease and yeast genetic screens alter the physical interaction with Prp5p, alter branch region spe

262 n of FBH1, a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), t

263 lethality, a trait involved in virulence and physical interaction with S. aureus.

264 t7 to be mostly alpha-helical and document a physical interaction with the b6f complex through increa

265 age sensitivity that are best explained by a physical interaction with the channel gates.

266 logenetic analysis, structural similarities, physical interaction with the CMG helicase component SLD

267 uired for transcriptional repression and for physical interaction with the corepressor TOPLESS.

268 d to the distal appendages of centrioles via physical interaction with the distal appendage protein C

269 aling function, the mechanism underlying its physical interaction with the membrane remains elusive.

270 ectivity, gating, and pharmacology by direct physical interaction with the pore module.

271 indicates that their activity relies on the physical interaction with transcription factors (TFs).

272 ration of this region abolished SOB3/AHL29's physical interaction with transcription factors and resu

273 h N- and C-TADs of HIF2alpha are involved in physical interaction with USF2.

274 ping role, we found Nup98 to gain and retain physical interactions with architectural proteins upon s

275 of action of RBM5-AS1 in the WNT pathway via physical interactions with beta-catenin, helping organiz

276 phosphorylation of Akt by mTORC2 via direct physical interactions with both the kinase and the subst

277 double strand break repair (HR-DSBR) through physical interactions with BRCA1, BRCA2, and RAD51.

278 Copurification studies also identified physical interactions with CDC20, BUBR1, and other compo

279 occupies Ctcf binding sites in vivo and has physical interactions with CTCF and the cohesin subunit

280 t cellular roles, these organelles also form physical interactions with each other at sites defined a

281 e modulation of gene expression outcomes via physical interactions with effector proteins, which may

282 specific role of calcineurin in coordinating physical interactions with host cells highlights an ance

283 e known also to coordinate solute uptake via physical interactions with K(+) channels and to moderate

284 Wacky and WAC have conserved physical interactions with mTOR and its regulators, incl

285 sk locus may function as a regulatory hub by physical interactions with multiple genes important for

286 lysis of vertebrate Nab2, ZC3H14, identifies physical interactions with numerous components of the sp

287 How do physical interactions with others change our own motor b

288 that were experimentally determined to have physical interactions with Polycomb repressive complex 2

289 d51 filament formation during HR through its physical interactions with Rad55-Rad57.

290 K13 may affect RNA processing through direct physical interactions with RNA processing factors and by

291 cterial species with metabolic dependency or physical interactions with S. mutans suffered drastic re

292 centrations of SRC-3 in cells through direct physical interactions with SRC-3, and selectively induce

293 es through sensorimotor feedback produced by physical interactions with the environment.

294 al Bacteroides have evolved species-specific physical interactions with the host that mediate stable

295 ive regulator of photoperiodic flowering via physical interactions with the red-light receptor phytoc

296 Thus, physical interactions with the vascular endothelium are

297 s include CaMKII mRNA, indicating respective physical interactions with this mRNA.

298 form vital roles in visual communication and physical interactions within and between species.

299 Three-dimensional physical interactions within chromosomes dynamically reg

300 uenced by alternative cleavage sites and the physical interactions within the membrane.