ライフサイエンスコーパス: phytosphingosine

1 orting a derivative of camptothecin bound to phytosphingosine.

2 oth to D-ribo-phytosphingosine and L-arabino-phytosphingosine.

3 could be suppressed by exogenous addition of phytosphingosine.

4 yzes the conversion of dihydrosphingosine to phytosphingosine.

5 by exogenous addition of the sphingoid base phytosphingosine.

6 lates the generation of a specific subset of phytosphingosine.

7 atalyzes conversion of dihydrosphingosine to phytosphingosine.

8 and dihydrosphingosine and no activity with phytosphingosine.

9 esis of phytoceramide from palmitic acid and phytosphingosine.

10 vative of the alkaloid camptothecin bound to phytosphingosine.

11 e absence of exogenous dihydrosphingosine or phytosphingosine.

12 in the accumulation of the long chain base, phytosphingosine.

13 mixture of N-hydroxyhexacosanoyl C18 and C20 phytosphingosines.

14 Phosphatidic acid (PA) and phytosphingosine 1-phosphate (phyto-S1P) both are lipid

15 , such as dihydrosphingosine 1-phosphate and phytosphingosine 1-phosphate, have also been implicated

16 ing sphingosine 1-phosphate (1a), and D-ribo-phytosphingosine 1-phosphonate (2), the isosteric phosph

17 An asymmetric synthesis of d-ribo-phytosphingosine (1) was achieved by utilizing the ProPh

18 the isosteric phosphonate analogue of D-ribo-phytosphingosine-1-phosphate (2a), were synthesized star

19 Our data show for the first time that phytosphingosine-1-phosphate (PHS-1-P) is present at a l

20 Phosphatidic acid (PA) and phytosphingosine-1-phosphate (phyto-S1P) have both been

21 d bases, such as sphingosine-1-phosphate and phytosphingosine-1-phosphate (phytoS1P) are used in plan

22 dienine [d18:2]), hydroxyceramide and LCB-P (phytosphingosine-1-phosphate [t18:0-P] and 4-hydroxy-8-s

23 Importantly, we found that phytosphingosine-1-phosphate, similar to S1P, regulates

24 further support of these findings, exogenous phytosphingosine (10 microM) was found to induce transie

25 do ester 8 via alpha-azidolactone 9 afforded phytosphingosine 1a.

26 od for the preparation of D-ribo- and L-lyxo-phytosphingosines (1a,b, respectively) and phytoceramide

27 By using a similar approach, phytosphingosine 1b was synthesized.

28 her with an improved synthesis of (2S,3S,4S)-phytosphingosine (2), are described.

29 -O-isopropylidene-d-glycerate (4) and D-ribo-phytosphingosine (3), respectively.

30 phosphonate analogue of the aminotriol lipid phytosphingosine (3), together with an improved synthesi

31 e we show that, in Saccharomyces cerevisiae, phytosphingosine, a putative sphingolipid second messeng

32 on to a synthesis of 4-deoxy-4-fluoro-L-xylo-phytosphingosine and 4-deoxy-4-fluoro-L-lyxo-phytosphing

33 Using [3H]phytosphingosine and [3H]inositol-labeled yeast sphingol

34 e 2-fold increase in ceramide containing C18-phytosphingosine and a 5-fold increase in ceramide conta

35 We propose that heat stress increases phytosphingosine and activates ubiquitin-dependent prote

36 reases were seen in two sphingoid bases, C20 phytosphingosine and C20 dihydrosphingosine, which incre

37 ecursors such as the long chain bases (LCBs) phytosphingosine and dihydrosphingosine also suppressed

38 ional studies implicated the sphingoid bases phytosphingosine and dihydrosphingosine as the likely me

39 nd two endogenous yeast sphingoid backbones, phytosphingosine and dihydrosphingosine, were found to b

40 ivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphin

41 l ketone allowed rapid access both to D-ribo-phytosphingosine and L-arabino-phytosphingosine.

42 s an enzyme that phosphorylates sphingosine, phytosphingosine and other sphingoid long-chain bases.

43 ificity for phosphorylated long-chain bases, phytosphingosine and sphingosine.

44 molecular species of dihydrosphingosines and phytosphingosines and their 1-phosphates with carbon cha

45 t increase in C20-dihydrosphingosine and C20-phytosphingosine, and a more stable 2-fold increase in c

46 ion of high levels of dihydrosphingosine and phytosphingosine, and accumulation of medium-chain ceram

47 d by glucosylsphingosine, lysosphingomyelin, phytosphingosine, and primary alkylamines with >10 carbo

48 ined phosphorus, mannosylinositol, inositol, phytosphingosines, and fatty acids in a molar ratio of 2

49 lar amounts of phosphorus, mannosylinositol, phytosphingosines, and fatty acids; their composition an

50 d equimolar amounts of phosphorus, inositol, phytosphingosines, and fatty acids; their composition an

51 t abundant long chain bases were C18 and C20 phytosphingosines, and the most abundant fatty acids wer

52 tant accumulates ceramide when fed exogenous phytosphingosine as expected for a strain lacking IPC sy

53 ha-anomeric sugars conjugated to an acylated phytosphingosine base, required presentation by antigen-

54 ulans Sur2 homolog BasA is also required for phytosphingosine biosynthesis but is also essential for

55 ngosine, N,N'-dimethyl sphingosine (DMS) and phytosphingosine but not dihydrosphingosine or sphingosi

56 Addition of phytosphingosine bypasses the requirement for serine pal

57 While introduction of the amide-motif in the phytosphingosine chain is tolerated for CD1d binding and

58 The phytosphingosine-containing alpha-galactosylceramides (a

59 at erg26-1 cells had decreased levels of the phytosphingosine-derived ceramides that are the direct p

60 Both enzymes can use phytosphingosine, dihydrosphingosine, or sphingosine as

61 Ceramides and the sphingoid bases phytosphingosine, dihydrosphingosine, sphingosine, and s

62 4p and Lcb3p to generate a localized pool of phytosphingosine distinct from phytosphingosine generate

63 phytosphingosine and 4-deoxy-4-fluoro-L-lyxo-phytosphingosine, each in five steps from Garner's aldeh

64 a 5-fold increase in ceramide containing C20-phytosphingosine following heat stress.

65 lized pool of phytosphingosine distinct from phytosphingosine generated by Sur2p.

66 ng 3-ketosphinganine, dihydrosphingosine, or phytosphingosine in the growth medium.

67 nt to cell cycle arrest induced by exogenous phytosphingosine, indicating that Cln3 acts downstream o

68 Phytosphingosine-induced proteolysis requires multiubiqu

69 ne and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymorphonuclear leukocyte (P

70 centration of C18-dihydrosphingosine and C18-phytosphingosine, more than a 100-fold transient increas

71 e APP1 transcription, whereas treatment with phytosphingosine or ceramides does not.

72 trated elevated dihydrosphingosine (DHS) and phytosphingosine (PHS) levels, and consistent with this

73 -) auxotrophs was more strongly inhibited by phytosphingosine (PHS) than was growth of Trp+ strains,

74 Phytosphingosine (PHS), a sphingoid long chain base, is

75 ong chain bases dihydrosphingosine (DHS) and phytosphingosine (PHS), and further saw that VPA increas

76 re we show that dihydrosphingosine (DHS) and phytosphingosine (PHS), two major sphingoid bases of fun

77 of the two major long chain bases is called phytosphingosine (PHS).

78 When cells were treated with exogenous phytosphingosine (PHS, 20 microm) or structurally simila

79 chain sphingoid bases dihydrosphingosine and phytosphingosine (Phyto-Sph).

80 erase, a key enzyme in generating endogenous phytosphingosine, prevents proteolysis during heat stres

81 thesis that allows swift modification of the phytosphingosine side chain by amidation of an advanced

82 Acetylsphingosine, N-acetylphytosphingosine, phytosphingosine, sphingosine, and dihydrosphingosine, b

83 Saturated long-chain fatty acids and phytosphingosine supplementation rescue the cell-cycle d

84 Its immunological activity resided in the phytosphingosine tail of the ligand.

85 atalyzes the second step in the synthesis of phytosphingosine, the long chain base found in yeast sph

86 Both ceramide and phytosphingosine, the primary sphingoid base present in

87 hingosine kinases (SPHKs) that phosphorylate phytosphingosine to generate phyto-S1P.

88 Phytosphingosine was resolved as a sharp peak with the a

89 e sphinganines are more easily accessed than phytosphingosines, which should facilitate SAR studies.

90 was a derivative of camptothecin binding to phytosphingosine, wich that is inserted into the hydroph