ライフサイエンスコーパス: picornavirus

1 ses) and ProPol (analogous to the 3CD of the picornaviruses).

2 genomic characterization of the first canine picornavirus.

3 rans-complementable function for 3CD for any picornavirus.

4 with the Theiler's murine encephalomyelitis picornavirus.

5 terovirus 8, Seneca Valley virus, and simian picornavirus.

6 ng infection with poliovirus, the prototypic picornavirus.

7 -OC43, but not encephalomyocarditis virus, a picornavirus.

8 enza virus, paramyxovirus, dengue virus, and picornavirus.

9 than the mature capsid, unlike in any other picornavirus.

10 common mechanism that targets these related picornaviruses.

11 own to effectively limit infectivity of many picornaviruses.

12 nome release, as is the case in many related picornaviruses.

13 ting a pathogenic role for this new group of picornaviruses.

14 ew strategies for targeting therapies to all picornaviruses.

15 or gene function, except by comparison with picornaviruses.

16 e gene sequence of SePV-1 and those of other picornaviruses.

17 g of the life cycle of sapelovirus and other picornaviruses.

18 ovide transient stability to a number of the picornaviruses.

19 for this interaction are provided for three picornaviruses.

20 -3Dpol complex that extrapolates well to all picornaviruses.

21 change of genetic elements between different picornaviruses.

22 egrin binding motifs are found in some other picornaviruses.

23 to interpret experiments with CVB3 and other picornaviruses.

24 positive-stranded RNA viruses, including all picornaviruses.

25 those observed in cells infected with other picornaviruses.

26 ovirus C (HEV-C) of the Enterovirus genus of picornaviruses.

27 es, as well as the viral proteins VP2-VP3 of picornaviruses.

28 within the protein-coding region of several picornaviruses.

29 the internal ribosome entry sites of certain picornaviruses.

30 , perhaps explored early in the evolution of picornaviruses.

31 hanism, being assembled differently to other picornaviruses.

32 netic position of the tentatively named seal picornavirus 1 (SePV-1) as an outlier to the grouping of

33 Furthermore, we found that multiple picornavirus 3A proteins copurify with the Golgi adaptor

34 ural analysis of non-covalent complexes of a picornavirus 3C(pro) with peptide substrates.

35 teinases (PLPs), termed PLP1 and PLP2, and a picornavirus 3C-like proteinase (3CLpro).

36 re, were not exhibiting characteristics of a picornavirus A particle.

37 In this review, we focus on picornaviruses, a family of positive-strand RNA viruses,

38 that hepatitis A virus (HAV), a hepatotropic picornavirus, ablates type 1 IFN responses by targeting

39 ary processes by which DAF was selected as a picornavirus accessory receptor.

40 ses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that consti

41 nterspecies and intraspecies transmission of picornaviruses among NHP, we collected fecal specimens f

42 also cleaved by 3C or 3C-like proteinases of picornavirus and artertivirus.

43 Detection of picornavirus and bacteria was associated with an additiv

44 hea, has a genomic organization typical of a picornavirus and encodes a 2,469-amino-acid polyprotein

45 Compared to picornaviruses and adenoviruses, the engineered VSVs wer

46 esents new information about receptor use by picornaviruses and highlights the importance of attainin

47 sequences within the genomic RNAs of certain picornaviruses and is required for viral translation.

48 netic divergence of SePV-1 compared to other picornaviruses and its mix of characteristics relative t

49 unctionally similar to cre elements of other picornaviruses and likely involved in templating VPg uri

50 VPg protein of caliciviruses, like those of picornaviruses and potyviruses, utilizes tyrosine in the

51 ogenetic analysis places HAV between typical picornaviruses and the insect viruses.

52 lect its position as a link between 'modern' picornaviruses and the more 'primitive' precursor insect

53 enetic relationships among all of the simian picornaviruses and to evaluate their classification, we

54 included p20VPg (analogous to the 3AB of the picornaviruses) and ProPol (analogous to the 3CD of the

55 virus, human metapneumovirus, adenoviruses, picornaviruses, and coronaviruses.

56 support divergent evolution of nodaviruses, picornaviruses, and tetraviruses from a common ancestor

57 Picornaviruses are a leading cause of human and veterina

58 Few drugs targeting picornaviruses are available, making the discovery of an

59 mechanism of RNase-protected RNA transfer in picornaviruses are discussed.

60 Picornaviruses are genetically and antigenically highly

61 Picornaviruses are important animal and human pathogens

62 Picornaviruses are responsible for a range of human and

63 Picornaviruses are simple models for such viruses, and i

64 y contrast, non-IgSF molecules, when used by picornaviruses as receptors, bind outside the canyon and

65 denoviruses, vesicular stomatitis virus, and picornaviruses as well as nonreplicating lentiviral and

66 nfected 3D(pol) transgenic mice with another picornavirus, as well as an alphaherpesvirus and a rhabd

67 possible without RNA encapsidation and that picornavirus assembly may involve an inward radial colla

68 Enterovirus 71 is a picornavirus associated with fatal neurological illness

69 In the second strategy, a picornavirus autoprocessing element was used to separate

70 investigate possible transmission of enteric picornaviruses between humans and NHP, we collected feca

71 e to determine the crystal structures of the picornavirus bovine enterovirus 2 (BEV2) and the cytopla

72 viruses, such as flaviviruses, alphaviruses, picornaviruses, bunyaviruses, and coronaviruses.

73 t MDA-5 is crucial for sensing infections by picornaviruses, but there have been no studies on the ro

74 se activity could also be produced for other picornaviruses by immunization with immature particles.

75 cornavirus-like supercluster, which includes picornaviruses, caliciviruses, and coronaviruses.

76 Diverse picornaviruses can trigger multiple human maladies, yet

77 Nonetheless, our results demonstrate that picornavirus capsid expansion is possible without RNA en

78 sential factor for folding and maturation of picornavirus capsid proteins.

79 he myristoylated, N-terminal VP4 fragment of picornavirus capsid proteins.

80 ution structure of a Fab molecule bound to a picornavirus capsid.

81 Picornaviruses carry a small number of proteins with div

82 Human enterovirus 71 is a picornavirus causing hand, foot, and mouth disease that

83 s (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cau

84 the polyhedrin subunits are more similar to picornavirus coat proteins than to the polyhedrin of cyt

85 oot-and-mouth disease virus (FMDV) and other picornaviruses comprise five major domains H-L.

86 Fifty-two picornaviruses comprising 10 distinct serotypes were det

87 Picornaviruses constitute a large group of viruses compr

88 Picornaviruses constitute a medically important family o

89 iratory syncytial virus, rhinoviruses, other picornaviruses, coronaviruses 229E and OC43, parainfluen

90 mation of the capsid and its organization in picornaviruses correlates strongly with the distribution

91 eport demonstrated that infection by another picornavirus (coxsackievirus B3) causes SRp20 to relocal

92 Unlike certain picornavirus CREs, whose function is position independen

93 in templating VPg uridylylation as in other picornaviruses, despite its significantly larger size an

94 ed with encephalomyocarditis virus (EMCV), a picornavirus detected by MDA5 and LGP2 but not RIG-I.

95 erotypes, in the zoo population, only 15% of picornaviruses detected in NHP were of human origin.

96 nthropic NHP in Bangladesh where 100% of the picornaviruses detected were of human serotypes, in the

97 12, EV115, and SV19 accounted for 88% of all picornaviruses detected.

98 Other cargo, including a closely related picornavirus, did not exhibit similar motility.

99 Picornaviruses disrupt nucleocytoplasmic trafficking pat

100 To compare picornavirus diversity between humans and NHP, the same

101 the structures illustrate that, similarly to picornaviruses, DWV forms alternate particle conformatio

102 nvestigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with al

103 phenotypically characterised mutants of the picornavirus, echovirus 7, in which these parameters wer

104 Optimal resistance to infection with picornavirus encephalomyocarditis virus is known to requ

105 Several viruses, including the RNA picornaviruses, encode factors that alter nuclear transp

106 assigned as a new species (HRV-C) within the picornavirus Enterovirus genus.

107 It remains unexplained why picornaviruses evolutionarily conserve the wasteful prod

108 It differs radically from other picornaviruses, existing in an enveloped form and being

109 e mechanisms by which separate genera of the picornavirus family achieve this shutoff differ.

110 For the picornavirus family member poliovirus, a number of funct

111 In the picornavirus family of nonenveloped RNA viruses, the req

112 ted by the finding that viral proteases from picornavirus family specifically targeted MOV10 as a pos

113 nanosecond timescale of four RdRps from the picornavirus family that exhibit 30-74% sequence identit

114 Members of the picornavirus family, including poliovirus and foot-and-m

115 Rhinovirus (RV), a ssRNA virus of the picornavirus family, is a major cause of the common cold

116 f the rhinovirus genus, which belongs to the picornavirus family, which includes clinically and econo

117 Unlike other picornaviruses, FMDV-induced autophagosomes did not colo

118 Here, we show that the picornavirus foot-and-mouth disease virus (FMDV) induces

119 ructures involved in genome packaging in the picornavirus foot-and-mouth disease virus (FMDV).

120 equences involved in genome packaging of the picornavirus foot-and-mouth disease virus.

121 Unlike other picornaviruses, for which there is strong evidence that

122 heiler's murine encephalitis virus (TMEV), a picornavirus from which it was derived.

123 ce analysis was used to identify a subset of picornaviruses from multiple genera that contain 5' UTR

124 binding protein, and test its requirement in picornavirus gene expression and propagation.

125 the polypyrimidine tract binding protein in picornavirus gene expression and strongly suggest a requ

126 es of viruses representing each of the major picornavirus genera (Enterovirus, Rhinovirus, Aphthoviru

127 the evolution of serotypes within different picornavirus genera, large-scale analysis of recombinati

128 These properties were shared with other picornavirus genera, such as the parechoviruses and erbo

129 other but distinct from viruses in all other picornavirus genera, suggesting that they may comprise a

130 ecies assignments in enteroviruses and other picornavirus genera.

131 The picornavirus genome must act as a template for both tran

132 tein complex that catalyzes this key step in picornavirus genome replication.

133 A novel picornavirus genome was sequenced, showing 42.6%, 35.2%,

134 The 5'-untranslated regions (5' UTRs) of picornavirus genomes contain an internal ribosomal entry

135 P2 is required for translation initiation on picornavirus genomes with type I internal ribosome entry

136 cre or oriI) found at different locations in picornavirus genomes.

137 Coxsackievirus B4 (CBV4), a member of the Picornavirus genus, has long been implicated in the deve

138 The replication of picornaviruses has been described to cause fragmentation

139 between that of insect viruses and mammalian picornaviruses, HAV is enigmatic in its origins.

140 (IRES) element of encephalomyocarditis virus picornavirus have been investigated by (1)H-NMR and UV m

141 Picornaviruses have 3' polyadenylated RNA genomes, but t

142 Picornaviruses have a peptide termed VPg covalently link

143 All picornaviruses have a protein, VPg, covalently linked to

144 Picornaviruses have some of the highest nucleotide subst

145 Many viruses, including picornaviruses, have the potential to infect the central

146 Unlike other picornaviruses, hepatitis A virus (HAV) is cloaked in ho

147 tify the lipid-modifying enzyme PLA2G16 as a picornavirus host factor that is required for a previous

148 be required for the replication of multiple picornaviruses; however, it is unclear whether a physica

149 f HeLa cells during infection by yet another picornavirus (human rhinovirus 16).

150 ed, identifying the first sequence-confirmed picornavirus in a marine mammal.

151 Asymptomatic presence of picornavirus in the neonatal airway is a potent activato

152 the maintenance and transmission of diverse picornaviruses in Bangladesh.

153 Here we identified two novel picornaviruses in fecal specimens of ring-tailed lemurs

154 Cadicivirus (CDV) is unique amongst picornaviruses in having a dicistronic genome with inter

155 ease virus (FMDV) differs from that of other picornaviruses in that it encodes a larger 3A protein (>

156 Picornaviruses in the cardiovirus genus express a unique

157 s afflicted annually with diseases caused by picornaviruses, including myocarditis, aseptic meningiti

158 d antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of md

159 samples obtained during an acute, moderate, picornavirus-induced exacerbation and 7 to 14 days later

160 Although picornaviruses infect most mammals, infection of a compa

161 Host translation shutoff induced in picornavirus-infected cells is a well-known phenomenon.

162 Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2D(

163 Picornavirus infection can cause Golgi fragmentation and

164 showed that hippocampal injury during acute picornavirus infection in mice is associated with calpai

165 that apoptosis of hippocampal neurons during picornavirus infection is a cell-autonomous event trigge

166 mediator of hippocampal injury during acute picornavirus infection of the brain.

167 cating that neuronal cell death during acute picornavirus infection of the CNS occurs in a non-cell-a

168 Cognitive deficits associated with CNS picornavirus infection result from injury and death of n

169 In a picornavirus infection, both an infectious and a noninfe

170 During picornavirus infection, several cellular proteins are cl

171 the viral genomic RNA replication steps of a picornavirus infection.

172 useful for neuroprotection during acute CNS picornavirus infection.

173 In contrast, many neurovirulent picornavirus infections are acute and transient, with ra

174 nism of SRp20 cellular redistribution during picornavirus infections, and they provide additional ins

175 A novel structural class of picornavirus inhibitors comprising an imidazo[1,2-b]pyri

176 Picornavirus internal ribosomal entry site (IRES)-mediat

177 ccine candidates based on the insertion of a picornavirus internal ribosome entry site (IRES) sequenc

178 We therefore sought to determine whether the picornavirus IRES could be engineered into VSV to attenu

179 ed an extensive comparison of flavivirus and picornavirus IRES elements by negative stain transmissio

180 functional initiation codon in type I and II picornavirus IRES.

181 The larger picornavirus IRESs (those of foot-and-mouth disease viru

182 The major classes of picornavirus IRESs (Types 1 and 2) have distinct structu

183 Picornavirus IRESs are classified into four structurally

184 Therefore, our data reveal how picornavirus IRESs use eIF4E-dependent and -independent

185 ffers fundamentally from initiation on these picornavirus IRESs.

186 do not occur in the two principal groups of picornavirus IRESs.

187 shutoff of host protein synthesis by certain picornaviruses is mediated, at least in part, by proteol

188 line helix structure, not seen previously in picornaviruses is present at the C terminus of VP1, a po

189 main present in Seneca valley virus (SVV), a picornavirus, is dispensable for IRES activity, while th

190 ell-surface receptors are bound by different picornaviruses, it is unclear whether common host factor

191 shown to be important in the entry of other picornaviruses, it was of interest to determine if polio

192 on that this conformation is conserved among picornaviruses led us to examine the role of this residu

193 mediated stem cell gene transfer and a novel picornavirus-like 2A peptide to link the TCR alpha- and

194 The picornavirus-like deformed wing virus (DWV) has been dir

195 arge training data set of 284 representative picornavirus-like genomic sequences with defined host or

196 cently defined and rapidly growing family of picornavirus-like RNA viruses called the Dicistroviridae

197 at a single virus or multiple viruses in the picornavirus-like supercluster by targeting 3Cpro or 3CL

198 sense RNA viruses can be classified into the picornavirus-like supercluster, which includes picornavi

199 s of individual viral proteins from multiple picornaviruses makes it possible to surmise canonical fu

200 e most commonly detected sequences were from picornaviruses, making up 59 to 88% of all viral reads,

201 e mammalian system and may shed light on how picornaviruses may have evolved between plant and animal

202 cessfully complete their replication cycles, picornaviruses modify several host proteins to alter the

203 Picornavirus mRNAs contain IRESs that sustain their tran

204 Due to their small genome size, picornaviruses must utilize host proteins to mediate cap

205 ein, is covalently attached to the 5' end of picornavirus negative- and positive-strand RNAs.

206 nonenveloped," recent studies show that some picornaviruses, notably hepatitis A virus (HAV; genus He

207 us, and encephalomyocarditis virus (EMCV), a picornavirus of the Cardiovirus genus, was completely in

208 une mediators was found in the neonates with picornavirus (P < .0001; partial least square discrimina

209 a reduction in PEF of more than 12 L/min for picornavirus (p=0.04) for high compared with low NO2 exp

210 e involvement of predicted RNA structures in picornavirus packaging and offers a readily transferable

211 n uncoating intermediate for the major human picornavirus pathogen CAV16, which reveals VP1 partly ex

212 Translation of picornavirus plus-strand RNA genomes occurs via internal

213 The structures of multiple picornavirus polymerase elongation complexes suggest tha

214 ency and specificity of VPg uridylylation by picornavirus polymerases is greatly influenced by allost

215 myelitis virus, duck hepatitis virus 1, duck picornavirus, porcine teschovirus, porcine enterovirus 8

216 is review analyzes the canonical function of picornavirus proteins involved in the alteration of apop

217 Crystal structures of all picornavirus RdRps exhibit a template-nascent RNA duplex

218 87 mutants also agree with similar data from picornavirus RdRps.

219 Picornaviruses rearrange cellular membranes to form cyto

220 on the PV surface, in comparison with other picornavirus-receptor interactions, could be a potential

221 is similar to "A" particles encountered when picornaviruses recognize a potential host cell before ge

222 Picornavirus regulatory sequences mediating cell type-sp

223 tiviral target for drug discovery.IMPORTANCE Picornaviruses remain an important family of human and a

224 The picornavirus replication complex comprises a coordinated

225 dentifies a previously undescribed aspect of picornavirus replication complex structure-function and

226 Picornavirus replication is critically dependent on the

227 Picornavirus replication is known to cause extensive rem

228 Because recombination is a natural aspect of picornavirus replication, we hypothesized that some feat

229 Infection of mammalian cells by picornaviruses results in the nucleocytoplasmic redistri

230 oxsackievirus, human rhinoviruses, and other picornaviruses reveal a putative template RNA entry chan

231 A 3' poly(A) tail is a common feature of picornavirus RNA genomes and the RNA genomes of many oth

232 Although picornavirus RNA genomes contain a 3'-terminal poly(A) t

233 Picornavirus RNA replication involves the specific synth

234 There are two protein primers involved in picornavirus RNA replication, VPg, the viral protein of

235 longation of positive- and negative-stranded picornavirus RNA.

236 lays an essential role in the replication of picornavirus RNA.

237 VPg linkage to the 5' ends of picornavirus RNAs requires production of VPg-pUpU.

238 cis-acting replication element (CRE) within picornavirus RNAs serves as a template for the uridylyla

239 vivin separately, or together linked by a 2A picornavirus self-cleaving peptide, into Ag-responding C

240 Twenty simian picornavirus serotypes are recognized, and all are prese

241 Comparison of the picornavirus serotypes detected in NHP specimens with th

242 es in the diversification process generating picornavirus serotypes that contribute to understanding

243 quence evolution generating diversity within picornavirus serotypes, in which neutral or purifying se

244 uncoating intermediate particles of several picornaviruses show limited expansion and some increased

245 ecombination contributes to the formation of picornavirus species groups and the emergence of circula

246 combination is important in the formation of picornavirus species groups and the ongoing evolution of

247 eptor interactions that are conserved across picornavirus species.

248 The picornavirus structural proteins VP0, VP1, and VP3 are b

249 essential for replication of the genomes of picornaviruses such as human rhinovirus 14 (HRV-14) and

250 CPMV), a plant virus that is a member of the picornavirus superfamily, is increasingly being used for

251 ified novel viral sequences belonging to the picornavirus superfamily, the Reoviridae, Parvoviridae,

252 of p65-RelA is the common mechanism by which picornaviruses suppress the innate immune response.

253 Our data have implications for differential picornavirus template utilization during viral translati

254 Encephalomyocarditis virus (EMCV) is a picornavirus that can cause paralysis, diabetes, and myo

255 Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver disease worldwide.

256 3' untranslated region (UTR) of an oncolytic picornavirus that causes lethal myositis in tumor-bearin

257 Enterovirus 71 (EV71) is a picornavirus that causes outbreaks of hand, foot, and mo

258 particles of human enterovirus 71 (EV71), a picornavirus that causes severe neurological disease in

259 Senecavirus A (SVA) is an emerging picornavirus that has been recently associated with an i

260 titis A virus (HAV) is an hepatotropic human picornavirus that is associated only with acute infectio

261 01) is a conditionally replication-competent picornavirus that is not pathogenic to normal human cell

262 omyelitis virus (TMEV) is a highly cytolytic picornavirus that persists in the mouse central nervous

263 r's murine encephalomyelitis virus (TMEV), a picornavirus that, in some strains of mice, results in p

264 Cardioviruses comprise a genus of picornaviruses that cause severe illnesses in rodents, b

265 s in gene order to proteins 2A and 2B of the picornaviruses; the latter is known for its membrane-ass

266 In the case of poliovirus and several other picornaviruses, these membranes are derived from subvers

267 he replication of FMDV and potentially other picornaviruses through ribonucleoprotein complex formati

268 hlight the problems caused by the ability of picornaviruses to alter the apoptotic machinery of host

269 ability of the 3A protein from 18 different picornaviruses to form a complex with PI4KIIIbeta by aff

270 Importance: The ability of replicating picornaviruses to influence the function of the secretor

271 the arsenal of poliovirus and perhaps other picornaviruses to overcome host defense mechanisms.

272 A viruses range from subtle (nodaviruses and picornaviruses) to dramatic (tetraviruses and togaviruse

273 itions in densely populated Bangladesh favor picornavirus transmission, resulting in a high rate of i

274 ignaling attenuates SRPK activity to enhance picornavirus type 1 IRES translation and favor PVSRIPO t

275 Picornavirus Type 1 IRESs comprise five principal domain

276 ised questions about the prevalence of these picornavirus types in the community, the extent of HRV d

277 Many picornaviruses use IgG-like receptors that bind in the v

278 Picornaviruses use internal ribosome entry sites (IRESs)

279 attachment suggests that this branch of the picornaviruses uses a different mechanism of genome enca

280 tion; however, it is not known whether other picornaviruses utilize SRp20 as an ITAF and direct its c

281 Picornaviruses utilize virally encoded RNA polymerase an

282 rovides insight into the architecture of the picornavirus VPg uridylylation complex.

283 core" sequence among known cre structures in picornaviruses was examined by site-directed mutagenesis

284 , MDA5, a PRR thought to recognize primarily picornaviruses, was required for recognition of MHV.

285 Picornaviruses were detected in 58 neonates (10.2%) and

286 Picornaviruses were detected in 78 of 677 (11.5%) NHP fe

287 s were positive for a picornavirus, while no picornaviruses were detected in samples from capped lang

288 The picornaviruses were detected in the stools of >40% of AF

289 The simian picornaviruses were isolated from various primate tissue

290 doubled the number of infections identified; picornaviruses were the most frequent in patients of all

291 ainfluenza, respiratory syncytial virus, and picornavirus) were examined in the Canadian Asthma Prima

292 Coxsackievirus B3 (CVB3) is a picornavirus which causes myocarditis and pancreatitis a

293 Given the precedent for other picornaviruses which use terminal sialic acids (SAs) as

294 These range from the tiny polio picornavirus, which has only 7kb of RNA genetic code tha

295 ns, or hamadryas baboons were positive for a picornavirus, while no picornaviruses were detected in s

296 Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine c

297 coalescent analyses of VP1 regions from four picornaviruses with 22 published VP1 rates to produce th

298 ively block replication of distantly related picornaviruses with minimal toxicity to cells.

299 ited during infection with several different picornaviruses, with consequences likely to have signifi

300 e protein-RNA linkage generated by different picornaviruses without impairing the integrity of viral