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2 chical randomisation algorithm to daily oral pictilisib (340 mg in part 1 and 260 mg in part 2) or pl
4 atients were analysed according to presence (pictilisib 6.5 months [95% CI 3.7-9.8] vs placebo 5.1 mo
5 median progression-free survival between the pictilisib (6.6 months [95% CI 3.9-9.8]) and placebo (5.
7 mutations were not predictive of response to pictilisib, but there was significant interaction betwee
8 athways by the small-molecule PI3K inhibitor pictilisib (GDC-0941) and the MEK inhibitor cobimetinib
9 y assessed whether adding the PI3K inhibitor pictilisib (GDC-0941) can increase the antitumor effects
10 s occurred in 54 (61%) of 89 patients in the pictilisib group and 22 (28%) of 79 in the placebo group
11 s occurred in 15 (36%) of 42 patients in the pictilisib group and seven (37%) of 19 patients in the p
15 bitors with greater selectivity than that of pictilisib might be needed to improve tolerability and p
17 of this study is to establish if addition of pictilisib to fulvestrant can improve progression-free s
21 improve progression-free survival, dosing of pictilisib was limited by toxicity, potentially limiting
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