ライフサイエンスコーパス: pifithrin

1 Injection of alpha-pifithrin, a p53 antagonist, inhibited PGC apoptosis and

2 The p53 inhibitor pifithrin abolished the SFN-induced increase in transpor

3 Pifithrin alpha (PFTalpha) is a chemical compound isolat

4 tified the tetrahydrobenzothiazole analogue, pifithrin-alpha (2), as a p53 inhibitor that was effecti

5 l animals or wild-type p53 mice treated with pifithrin-alpha (a p53 blocker) were irradiated (five 10

6 A 24-h pretreatment with pifithrin-alpha (and continuing in the presence of insul

7 th after tGCI, we intravenously administered pifithrin-alpha (PFT).

8 ibitors of the tumor suppressor protein p53, pifithrin-alpha (PFT-alpha) and Z-1-117, are highly effe

9 The p53-specific inhibitor pifithrin-alpha (PFT-alpha) significantly reduced the ex

10 A p53 inhibitor pifithrin-alpha (PFT-alpha) was administered to stroke r

11 otective activity of the previously reported pifithrin-alpha (PFT-alpha, 1), various derivatives and

12 Pifithrin-alpha (PFTalpha) was originally thought to be

13 Inhibition of p53 by pifithrin-alpha blocked STAT3 activation and the express

14 Pifithrin-alpha completely suppressed DOX-induced activa

15 Acute inhibition of p53 with pifithrin-alpha in wild-type mice mimicked the observati

16 -Ala-Asp-fluoromethylketone or p53 inhibitor pifithrin-alpha markedly prevented mitochondrial release

17 The effects of pifithrin-alpha on p53 included inhibition of transcript

18 Inhibition of p53 by pifithrin-alpha or by RNA interference prevented mitocho

19 The p53 inhibitor pifithrin-alpha or p53 siRNA prevented both cisplatin-in

20 Repressing p53 with pifithrin-alpha or small interfering RNA increased ERK p

21 Inhibition of p53 transactivation by pifithrin-alpha or the kinase activity of ATM by either

22 short-term treatment with the p53 inhibitor Pifithrin-alpha partially and transiently rescued the my

23 Furthermore, p53 inhibitor pifithrin-alpha partially nullified the suppressive effe

24 , the inhibition of p53 by the p53 inhibitor pifithrin-alpha protected against PA-induced apoptosis.

25 stent with activation of AP-1 and NF-kappaB, pifithrin-alpha was also able to enhance the UV-induced

26 Pifithrin-alpha was protective when given up to 14 h aft

27 either by administration of a p53 inhibitor (pifithrin-alpha), or by crossing Foxe3-/- mice with p53-

28 ions in p53 as well as in cells treated with pifithrin-alpha, a chemical inhibitor of p53 that decrea

29 Injection of pifithrin-alpha, a chemical inhibitor of p53, into pregn

30 during cisplatin treatment was attenuated by pifithrin-alpha, a pharmacological inhibitor of p53, whi

31 Pifithrin-alpha, a specific inhibitor of p53, mimicked t

32 vity was confirmed using antisense c-myc and pifithrin-alpha, a specific inhibitor of p53.

33 treatment of mouse epidermal Cl41 cells with pifithrin-alpha, an inhibitor for p53-dependent transcri

34 ficiency, caused by germ-line mutation or by pifithrin-alpha, an inhibitor of p53-dependent apoptosis

35 Pifithrin-alpha, an inhibitor of the tumor suppressor pr

36 g inhibitors of p53-dependent transcription, pifithrin-alpha, and a genetic approach (overexpressing

37 Inhibition of p53 by pifithrin-alpha, attenuates citral-mediated apoptosis.

38 systemic administration of the p53 inhibitor pifithrin-alpha, compared with untreated controls.

39 eath was provided by use of a p53 inhibitor, pifithrin-alpha, in organotypic slice cultures of mouse

40 The p53 inhibitor, pifithrin-alpha, is able to attenuate the effect of prot

41 for p53 was tested using the p53 inhibitor, pifithrin-alpha, or using stable transfectants of a v-MY

42 This compound, pifithrin-alpha, protected mice from the lethal genotoxi

43 t of pol eta(-/-) mice with a p53 inhibitor, pifithrin-alpha, reduced adipocyte senescence and attenu

44 Perturbation of p53 by pifithrin-alpha, RNA interference, or genetic deletion p

45 ce the apoptosis of LNCaP cells treated with pifithrin-alpha, which prevents p53 accumulation, or of

46 f macrophages in the kidneys of p53(-/-) and pifithrin-alpha-treated mice after ischemic injury were

47 Ischemic kidneys of p53(-/-) and pifithrin-alpha-treated mice also showed reduced express

48 nally, models of peritonitis in p53(-/-) and pifithrin-alpha-treated mice confirmed the anti-inflamma

49 n p53(-/-) primary microglial cultures or in pifithrin-alpha-treated microglial BV2 cells.

50 ession of miR-192-5p were also suppressed by pifithrin-alpha.

51 +UV) could be reversed by the p53 inhibitor, pifithrin-alpha.

52 prazosin, BMY 7378, apocynin, SB 202190, and pifithrin-alpha.

53 evidence was obtained using a p53 inhibitor, pifithrin-alpha.

54 with the compound nutlin-3 and prevented by pifithrin-, an inhibitor of p53 activation.

55 ciency of p53 or pharmacologic inhibition by pifithrin impairs thrombus resolution and is associated

56 We also identified a novel CA binder, pifithrin-micro, which could not have been identified by

57 the mitochondrial translocation of p53 with pifithrin mu prevents the formation of p53/Bak complexes

58 elective for the inward-facing state) and/or pifithrin-mu (an HSP70 inhibitor) restored folding of, a

59 the heat shock protein 70 (HSP70) inhibitor pifithrin-mu such that endoplasmic reticulum export of a

60 Noribogaine or pifithrin-mu treatment supported hDAT delivery to the pr

61 y this flow-through fraction is inhibited by pifithrin-mu, a small molecule inhibitor of Hsp70, sugge

62 ligand noribogaine and the HSP70 inhibitor, pifithrin-mu.

63 g flies were treated with noribogaine and/or pifithrin-mu.

64 efficacy of administering the small-molecule pifithrin (PFT)-mu, an inhibitor of mitochondrial p53 ac

65 However, the laboratory that discovered pifithrin recently reported that the compound also inhib